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PubMedDate not supplied

[Efficacy of quadruple therapy in the eradication of Helicobacter pylori and prevention of recurrent duodenal ulcer].

OBJECTIVE: We studied during a 12-months follow-up the effect of the eradication of Helicobacter pylori (Hp) on the recurrence of duodenal ulcer (DU). BACKGROUND: The eradication of Hp from the gastric mucosa has been the objective of numerous therapeutic trials for preventing DU recurrence; however, an optimal treatment has not yet been established. METHODS: 51 patients with Hp infection and active DU confirmed by endoscopy were randomized in two groups. All patients received ranitidine 300 mg daily for eight weeks. Group A (26 patients) received a 5 day course of amoxycillin 500 mg t.i.d., metronidazole 500 mg t.i.d., and furoxone 100 mg t.i.d., during the 3rd week. After ranitidine treatment, none patient of this group received further treatment. Group B (25 patients) received 150 mg of ranitidine daily during 12 months. Endoscopy was performed at the end of the first eight weeks of the ranitidine treatment as well as at the 6th and 12th month of follow-up or sooner if symptoms recurred. Two biopsies were taken from gastric antrum at each endoscopy examination for Hp detection with Giemsa and hematoxylin/eosine stains. Each patient gave informed consent and this trial was approved by the regional Ethics Committee. Statistical analysis was performed using chi 2 test. RESULTS: After eight weeks of ranitidine treatment, the ulcer of all patients from both groups was healed. The percentage of Hp eradication was 92% (24/26 pt) in group A and none in group B (p < 0.001). Recurrence of Hp infection occurred in 9/24 patients (37.5%) during a 12 months follow-up (group A) and of these, one patient had recurrence of DU. In contrast, all 25 patients of group B were persistently Hp positive and 7 developed recurrent DU (p < 0.05). Both treatments were well tolerated. CONCLUSIONS: The combined therapy with amoxycillin, metronidazole, furoxone and ranitidine is highly effective in both Hp eradication and prevention of DU recurrence.

Adolescent↗
PubMed1997

[Effect of Helicobacter pylori on gastric epithelial apoptosis].

To investigate the mechanisms by which Helicobacter pylori (Hp) induces gastric mucosal damage, gastric epithelial apoptotic index (AI) of normal gastric mucosa and Hp positive gastritis before and after anti-Hp treatment was studied with the method of terminal transferase mediated dUTP nick end labeling. The results showed that AI in Hp positive gastritis was higher than that in normal mucosa (P < 0.001). After the eradication of Hp, AI fell significantly to the normal level (P < 0.001). AI in persisting Hp positive gastritis had no statistically significant decrease after the anti-Hp treatment. There was no correlation between AI and the severity of gastritis. These results indicated that Hp could induce gastric epithelial apoptosis, which may be an important mechanism involved in gastric mucosal damage.

Adult↗
PubMed1975

[The effect of antibiotic supplementation on antibiotic resistance, transferable antibiotic resistance, morbidity, and growth in calves (author's transl)].

112 calves, divided into four groups, were given milk substitutes containing tetracycline (high-dosage feed), zinc bacitracin or Lactosat (control) and concentratesw with or without zinc bacitracin (Table I). We have investigated the incidence of antibiotic resistance and transferable antibiotic resistance in E. coli strains isolated from the faces of these calves and checked the growth and state of health in the four groups. Growth was also studies in a further ten feeding series comprising a total of 258 calves. Half this number received zinc bacitracin in milk substitute, the other half were fed milk substitute containing Lactosat, instead of antibiotics (Fig. 8). Tetracycline led to a quick increase of antibiotic-resistant straing (Fig. 4--6). This increase is significant in comparison with the other groups. Significant increases of resistance were also noted to ampicillin and chloramphenicol (Fig. 7), althoug these drugs were not used. A significant increase of the transferable resistance was also observed in the group of calves given tetracycline (Fig. 7) and to 65% at about 31/2 months after the end to 38% within 12 days (Fig. 7) and to 65% at about 31/2 months after the end of tetracycline feeding (Fig. 7). A marked increase of en-bloc transfer was also noted after completion of tetracycline feeding (Fig. 2). Up to slaughter, at the age of 6 months, no better growth was obtained with zinc-bacitracin supplement than with milk substitute without antibiotics but containing Lactosat. During the milking period the results varied between the different feeding series. In some series the mean growth in the zinc-bacitracin group was better than, in some no different from, and in other s poorer than that in the Lactosat group (TableII, Fig. 8). The only demonstrable positive effect of tetracycline supplement was a tendency twwards better health during the period of administration of the drug (Table II...

Ampicillin↗
PubMed2002

[Intestinal giardiasis. Mini-review].

Giardia intestinalis is a common parasite in our country and the rest of the world and is responsible for several clinical disturbances that include dysentery type diarrheas, recurrent abdominal pain, duodenitis, jejunitis, cholecystitis and in some cases toxemias and convulsions. In this paper we review recent concepts of intestinal giardiasis, considering the basic aspects of the biology and physiology of Giardia intestinalis, its morphology and its relationship the parasite pathogenicity. We detail the physiopathological mechanisms responsible for the different clinic manifestations of giardiasis, the specific laboratory and endoscopic methods of diagnosis and the most recent advances in the treatment and prophylaxis of this disease.

Adult↗
PubMedDate not supplied

[The physician's attitude towards infection by Helicobacter pylori in clinical practice].

AIM: To study the attitude of general practitioners and internists towards the infection with helicobacter pylori. METHODS USED: Interviews were conducted among 170 physicians. Proportions were compared using the Z test. RESULTS: Out of 170 interviewed, 152 questionnaires were completed correctly: 80.9% were general practitioners and 19% internists. All of the GPs and 84.6% of internists chose the oral-fecal as the route of transmission. Gastric ulcer was thought to be associated by 60.8% of GPs and 72.4% of internists. The least well known association was with MALT lymphoma (8.1%). Biopsy was reported as the best way to make diagnosis (54 and 72.4%). GPs reported they would treat recurring ulcers as Helicobacter pylori, while internists would treat them since the first episode. Sixty point 2 percent (60.2%) of GPs and 69% of internists are using inadequate schemes for treating Hp infections. The combination of omeprazol, amoxicillin, bismuth salts or clarithromycin was the most frequently used. CONCLUSIONS: Current knowledge regarding Helicobacter pylori infection among GPs and internists is not sufficiently understood.

Adult↗