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At least 1,207 records · Page 67Linked to original sources
PubMed1977

Chemotherapy used in dermatology.

Although systemic corticosteroids have been helpful in certain dermatologic conditions, their prolonged use may be cursed with serious side effects. Currently several dermatologic, immunologic, and proliferative disorders have been helped or controlled with cytotoxic and immunosuppressive drugs. A guideline for their use is advocated and described. The short- and long-term toxicity of these drugs is presented. The most frequently prescribed therapeutic programs for psoriasis, pemphigus and bullous pemphigoid lymphoma cutis, and metastatic melanoma are outlined and discussed. Lists of the most commonly used chemotherapeutic agents and of the diseases or conditions for which they have been or are used and of dosage and toxicities are given.

Adrenal Cortex Hormones↗
PubMedDate not supplied

[The spectrum of Lyme borreliosis from the dermatologic viewpoint].

Erythema chronicum migrans, lymphadenosis benigna cutis and acrodermatitis chronica atrophicans represent the dermatological manifestations of the multi-organ disease Lyme borreliosis. Koch's requirements of evidence for an infectious disease, demonstration of the bacterium, transfer, and culture have proven Borrelia burgdorferi to be the causative agent of the above mentioned skin diseases. This justifies a penicillin therapy, that has been administered in Europe empirically for the last 30 years. Correct and prompt diagnosis is important since delayed treatment is less effective, presumably because the spirochete becomes sequestered in immune-privileged sites. Recent observations in several laboratories that antibody titers to Borrelia burgdorferi are also elevated in several other skin diseases and that the spirochete can be detected in tissue sections of different organs may imply extension of the dermatological spectrum of Lyme disease. The significance of these findings in such heterogeneous diseases as morphea, lichen sclerosus et atrophicans, etc. however awaits final examination.

Acrodermatitis↗
PubMed1977

[Significance of iontophoresis in dermatology. With special reference to the management of lymphedemas].

The development of modern medicine has very often pushed older methods of treatment to the background. It will be tried to represent the importance of iontophoresis as a special form of electrotherapy for dermatology according to studies of literature and own observations. Iontophoresis is for most of the 40 to 50 dermatologic indications named in literature without any importance for the present. This is also to be said for their diagnostic and experimental application. Because of the synergistic effect of the galvanic current and the medicament sluiced in, iontophoresis is said to be recommended following literature, for the treatment of the rest of therapeutically only with difficulty to be influenced idiopathic hyperhidrosis manuum et pedum, constitutional hypertrichosis, the lymphedema and also the induratio penis plastica and of thrombophlebitis. It will be reported about own experiences in the treatment of lymphedema.

Follow-Up Studies↗
PubMed1988

Tick-borne dermatologic diseases.

Inquiries regarding tick exposure can be important in dermatologic diagnosis and treatment since ticks can be vectors of a diversity of infectious diseases. The classic teaching is that ticks are best removed with nail polish, solvents, petrolatum, mineral oil, or a hot match. However, a recent evaluation of tick removal revealed that mechanical removal with forceps preceded and followed by disinfection is the most effective method. In most cases, should the characteristic dermatologic lesion or systemic symptoms appear, appropriate treatment should be initiated for presumptive diseases.

Animals↗
PubMed1987

[Malignant melanoma in German-speaking countries in the 80's. Initial results of the central registry for malignant melanoma of the Germany Society of Dermatology in cooperation with the federal health office].

From July 1983 to April 1987, 2834 reports of malignant melanoma (MM) were received by the Central Registry of the German Dermatological Society in Berlin from 22 departments of dermatology in the German-speaking countries. Of these, 2277 reports were documented in a data bank and evaluated. Compared to earlier reports from the 1960s and 1970s the percentage of male patients with MM was found to be increased: 41% males, 59% females. Also, the tumor occurs today at a slightly younger age: 63% of all males and 56% of all females with MM were adults 30-60 years of age. In 10% of all MM patients, MM metastases were found during their first visit (stages II-IV). In addition, 37% of all patients in stage I without metastasis had MMs that were thicker than 1.5 mm. This indicates that there is a necessity for further information and early recognition of the MM in German-speaking countries. Regarding the therapeutic approach, considerable differences were noted among the various departments. Half of the primary MM excisions were conducted under local anesthesia, the rest with general anesthesia. In about 40% of all cases, a second surgical procedure was performed for larger excisions: half of the patients were operated on with safety margins of less than 3 cm. Twenty-seven percent of the patients in stage I MM received some type of adjuvant therapy, including chemo- and/or immunotherapy. However, postsurgical management varied greatly among the different departments. The additional results regarding possible risk factors, such as sun exposure and preexisting pigmented moles, are remarkable.

Adult↗
PubMed1987

[Colchicine in dermatology].

Colchicine is one of the oldest drugs known to us. During the last few years, it has been increasingly applied in the treatment of systemic dermatoses. Particularly in dermatoses mediated by neutrophils, colchicine has settled among other therapies. With regard to Behçet's disease, it has even become the treatment of choice. The present review deals with further dermatological disorders sensitive to colchicine; in addition, we mention those dermatoses which do not show any therapeutic response to colchicine. The treatment with colchicine requires profound knowledge of the pharmacokinetics and mode of action regarding this substance, as well as the possible side effects. This knowledge allows safe and responsible treatment with colchicine. It has to be considered, however, that in the Federal Republic of Germany colchicine has not been registered for dermatological indications yet.

Behcet Syndrome↗
PubMed1987

[Development of dermatomycoses and their causative agents in the Lyons area. From an analysis of 6000 samples on Sabouraud's medium done over a 20-year period at a dermatology department].

The authors have analyzed the results of cultures in Sabouraud's agar performed over a 20-year period in 6,000 patients with lesions of the skin, skin appendages and mucosae of suspected fungal origin. Throughout this period all patients, almost exclusively urban or suburban, were seen at the Dermatology out-patient consultation of a central city hospital. The 6,000 specimens were analyzed globally, with special attention to time-related changes in the 10 groups of 6,000 specimens each whenever a significant modification was observed. The analysis was divided into two parts: a review of the fungi isolated, of the manifestations they produced and of the time-related changes in their respective prevalence; a study of the fungi responsible for the main dermatological syndromes. Out of 6,000 cultures, 2,502 strains of pathogenic fungi were isolated, representing a growth rate coefficient of 41.66 p. 100. There were 1,237 dermatophytes and 1,265 yeasts of the Candida group. However, this overall impression of two equal groups gives a wrong idea of the changes that occurred during this long period. Figure 1 clearly shows that in 20 years the number of dermatophytes increased whereas the number of Candida decreased. Figures 2 and 3 demonstrate that the rise in dermatophytes was almost exclusively due to an increase in T. rubrum and the fall in yeasts, to a decrease in Candida albicans.(ABSTRACT TRUNCATED AT 250 WORDS)

Arthrodermataceae↗
PubMed1986

Dermatologic features of the fat embolism syndrome.

Fat embolism syndrome is a life-threatening disease with cutaneous manifestations that occur most commonly after fractures of a long bone. The syndrome consists of a triad of dermatologic, pulmonic, and neurologic involvement. Because no major dermatologic journal has reviewed this syndrome in more than five years, we present a case and discuss the current approaches to the pathogenesis, diagnosis, and treatment of this often overlooked syndrome.

Adult↗
PubMed1986

[Are there indications for cyclosporin A in dermatology?].

For several years cyclosporin A has been used as an immunosuppressive agent in transplantation medicine and to avoid graft-versus-host disease. Some case reports concerning beneficial effects on different dermatoses have aroused speculation about the application of this drug in dermatology. The mode of action, a summary of the dermatologic case reports, and a discussion of the side effects of cyclosporin A are presented in this article.

Autoimmune Diseases↗
PubMed1985

Dermatologic diseases of the nail unit other than psoriasis and lichen planus.

Diseases in which involvement of the nails may be helpful in the diagnosis of dermatologic disease elsewhere include psoriasis, lichen planus, Darier's disease, alopecia areata and totalis, keratotic scabies, scleroderma, and lupus erythematosus and dermatomyositis. Dermatologic diseases in which involvement of the nail commonly occurs but is relatively nonspecific and not diagnostic include dermatitis, lichen striatus, parakeratosis pustulosa, pityriasis rubra pilaris, acrokeratosis paraneoplastica, pemphigus vulgaris, epidermolysis bullosa, porokeratosis of Mibelli, and acanthosis nigricans. These entities are described and treatments summarized as appropriate.

Acanthosis Nigricans↗
PubMed1985

An evaluation of method reporting and use in clinical trials in dermatology.

In a survey of 62 clinical trials published in four dermatology journals, recommended methodology was reported 41% of the time. Of the 62 trials, 31 were open drug trials and 27 were controlled trials. Forty-one percent of 13 recommended methodologic items were reported in these articles. The rate of reporting for these items ranged from 3% for power and method of randomization to 76% for loss to follow-up and the use of a control group. There were no differences among journals in reporting methods used. Investigators and editors are encouraged to improve the reporting and use of recommended methodology in clinical trials published in the dermatologic literature.

Clinical Trials as Topic↗
PubMed1979

Some gerontologic considerations in the practice of dermatology.

Gerontology and geriatrics are areas of increasing importance in medicine today. Although changes in the appearance and behavior of human skin have long been noted to accompany aging, physicians have only recently begun to consider the impact of such an age-associated change on the manifestations of dermatologic disease and on the dermatologic management of elderly patients. Gerontologic studies in such fields as immunology, epidermal cell kinetics, DNA damage and repair, and therapeutics are potentially of great relevance to the practicing dermatologist and deserve increased emphasis within our specialty.

Age Factors↗
PubMed1983

[Use of systemic retinoids in dermatology].

The naturally occurring retinoids (vitamin A alcohol = retinol and all-trans-retinoic acid) have been largely replaced by synthetic retinoids in recent years as systemic drugs for use in dermatology. At the present time, two synthetic retinoids are commercially available: etretinate (Tigason) and isotretinoin (Accutane). These compounds-which have a more favourable therapeutic index than the naturally occurring retinoids-ushered in a new era of dermatological therapy by their potent antikeratinizing, antiseborrhoeic (only isotretinoin) and antineoplastic action. The broadest indications for the use of these retinoids are psoriasis (etretinate) and cystic acne (isotretinoin), whereas the most dramatic effects are encountered in a number of severe ichthyosiform disorders. Another important, although at present not clearly defined role of the retinoids is in the prophylaxis of skin tumours.

Acne Vulgaris↗
PubMed1984

Dermatological problems with synthetic resins and plastics in glues. Part I.

In order to understand the medical implications of using adhesives a few remarks are made concerning forces which may be active in bonding two materials. Knowledge about the exact chemical composition of adhesives is essential for understanding possible untoward dermatological effects which are to be expected if the transition from a viscous to a solid state is based on chemical reactions between chemically active constituents. A number of examples are given about cited or suspected dermatologically untoward effects in using various types of glues and dental composite restorative resins.

Adhesives↗
PubMed1983

[Diagnostic value of electron microscopy in dermatology].

Basing themselves on their personal experience, the authors stress the main indications and the value of electron microscopy in dermatology. In some cases it provides an indispensable adjunct to standard light microscopy (tumor pathology, cutaneous lymphoma, collagenosis, storage diseases, etc). In other cases, it provides greater insight into dermatological affections, such as pigmentation disorders or bullae. Ultrastructural studies should therefore often be included in a thorough morphological examination of a skin biopsy.

Humans↗
PubMed1984

[Dermatologic radiotherapy--today, yesterday, tomorrow].

Dermatologic therapy with ionising radiation has changed in the last 30 years. Adapted to the limitations of the area of indication, the improved radiotechnique, as well as the stricter working conditions, it is still today an important therapeutic method. As there are to be expected increased numbers of malignant diseases of the skin, radiotherapy will be an essential part of dermatologic tumor therapy in the near future.

Basal Cell Carcinoma↗
PubMed1982

[Experimental and clinical studies of fortimicin in the field of dermatology].

1. Fortimicin (KW-1070) was found to be similar to amikacin in vitro activity against S. aureus of 27 strains and S. epidermidis of 17 strains isolated in dermatological field. 2. Serum and skin levels of the drug were determined in rats. Mean serum levels (n = 4) were 4.91 mcg/ml at 1/4 hour, 2.40 mcg/ml at 1/2 hour, 2.40 mcg/ml at 1 hour and 0.51 mcg/ml at 2 hours. The corresponding skin levels were 2.15 mcg/g, 2.27 mcg/g, 0.83 mcg/g and 0.19 mcg/g. 3. Seven cases with dermatological infections were treated with fortimicin. No side effects were observed both in subjective and in laboratory findings.

Aged↗
PubMed1981

[Chemical carcinogens and their relevance for cancer induction in man with special reference to dermatological problems (author's transl)].

The problem of iatrogenic carcinogenesis is treated with special reference to dermatological dispensings. The problem of arsenic as a drug, of cytostatic drugs, antimycotic drugs and external dispensings is discussed. The chance to induce cancer by medical treatment in dermatology is considered to be very low since arsenic has been eliminated.

Acridines↗