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Complications of endotracheal intubation.

Tracheal intubation for airway control, once done only by anesthesiologists during surgical procedures, is now being done by physicians in other specialties and by nurses, technicians, and paramedics in areas other than the operating room. Intubation, however, does not always assure a patent airway. Unrecognized esophageal placement of endotracheal tubes is the major cause of cardiac arrest and brain damage associated with intubation. Though auscultation for breath sounds is the universally accepted method of verifying proper tube placement, recent studies indicate that it is reliable only approximately two thirds of the time in situations in which verification of proper placement is needed most and is least obvious. The usefulness of this technique merits reassessment. Identification of carbon dioxide in end-expired air is the most reliable method for verification, but instruments to detect carbon dioxide are usually immediately available only in special care and surgical suites. Mouth-to-tube insufflation with a two-way disposable microbial filter differentiates immediately between esophageal and tracheal placement and can be used in any area. Malpositioned and malfunctioning tubes cause partial or complete obstruction accompanied by varying degrees of hypoxemia and hypercapnia. Respiratory and circulatory derangements and brain damage ensue if the problem is not promptly recognized and corrected. We discuss the most common causes of tube malfunction.

Airway Obstruction↗

Detection of the liver below the costal margin: comparative value of palpation, light percussion, and auscultatory percussion.

The comparative value of palpation, light percussion, and auscultatory percussion for detecting the liver below costal margin was studied in 45 normal subjects and 20 patients. The presence of the liver 2 cm or more below the costal margin was considered abnormal, since this organ was found no more than 1 cm below in a few normal subjects only by auscultatory percussion. In the patient group, auscultatory percussion detected the liver of 12; four livers and one case of gallbladder-hydrops were detected only by this method. Also, auscultation behind the right flank during percussion identified one hydronephrotic kidney. The liver was detected by palpation in 12 patients and was found only by this method in 6 of them. Light percussion detected the liver in only 6 patients, but was useful in 2 for determining that the liver dome had been depressed in the rib cage. Results of liver function tests were abnormal in 15. These findings suggest that these methods were valuable for detecting liver diseases in patients.

Adult↗

Peripheral vascular assessment: finding your way through arteries and veins.

Vascular disease is a widespread health problem. Despite the advent of new, noninvasive and invasive testing methods, a thorough health history and physical examination remain the primary means of diagnosis. In this article, the author discusses vascular assessment of acute and critically ill patients, including inspection, palpation, and auscultation. Specific assessments for arterial disease and venous disease are discussed. A thorough vascular assessment aids in the planning and implementation of care and evaluation of response to treatment for these patients.

Auscultation↗

Time-frequency detection and analysis of wheezes during forced exhalation.

The objective of the present work was to detect and analyze wheezes by means of a highly sensitive time-frequency algorithm. Automatic measurements were compared with clinical auscultation for forced exhalation segments from 1.2 to 0 liters/second (l/s). Sensitivities between 100% and 71%, as a function of flow level related to wheezing segments detection, were achieved. Time-frequency wheeze parameters were measured for the flow range from 1.2 to 0.2 l/s. Wheezes were detected in both analyzed groups; asthmatics (N = 16) and control subjects (N = 15). Significant differences between groups were found for the mean number of wheezes detected at basal condition (p = 0.0003). Frequency parameter differences were also significant (0.0112 < p < 0.0307). All these parameters were also studied after applying a bronchodilator drug (Terbutaline). Significant differences between patient groups were found when studying the changes in the number of wheezes for each patient (p = 0.0195). Finally, limited bandwidth parameters, which measure the bronchodilator response, were also studied.

Algorithms↗

Wavelet-based enhancement of lung and bowel sounds using fractal dimension thresholding--Part II: application results.

The application of the wavelet transform-fractal dimension-based (WT-FD) filter of Part I of this paper to real bioacoustic data, which include explosive lung sounds (ELS) and explosive bowel sounds (EBS) recorded from patients with pulmonary or gastrointestinal dysfunction, respectively, is presented in this paper. The objective of the latter is the evaluation of the performance of the WT-FD filter on different types of bioacoustic signals, varying not only in their structural morphology but also in the degree of their noise contamination. As it is thoroughly described in Part I of this paper, the WT-FD filter uses the fractal dimension to form an efficient way of thresholding the WT coefficients at different resolution scales, keeping, thus, only those that can contribute to the accurate reconstruction of the ELS and EBS signals. Quantitative and qualitative analysis of the experimental results show an efficient performance of the WT-FD filter to circumvent the noise presence (100% detectability rate, 100% sensitivity, 100% specificity) by faithfully extracting the authentic structure of ELS and EBS from the background noise. The WT-FD filter does not require any noise reference signal or noise reference templates. The results from a noise stress test (mean cross-correlation index of the original and the estimated signal converging to 100%; mean normalized maximum amplitude error converging to 0.7%) prove its robustness to various noise levels (0-20 dB), enabling its potential use in similar noise cases met in everyday clinical medicine. Furthermore, the efficient performance of the WT-FD filter facilitates the physician to better interpret the auscultation findings. Due to its simplicity and low computational cost, the WT-FD filter can possibly be implemented in a real-time context to serve as a tool for the continuous ELS and EBS screening.

Adult↗

Acoustical signal properties for cardiac/respiratory activity and apneas.

Traditionally, auscultation is applied to the diagnosis of either respiratory disturbances by respiratory sounds or cardiac disturbances by cardiac sounds. In addition, for sleep apnea syndrome diagnosis, snoring sounds are also monitored. The present study was aimed at synchronous detection of all three sound components (cardiac, respiratory, and snoring) from a single spot. The sounds were analyzed with respect to the cardiorespiratory activity, and to the detection and classification of apneas. Sound signals from 30 subjects including 10 apnea patients were detected by means of a microphone connected to a chestpiece which was applied to the heart region. The complex nature of the signal was investigated using time, spectral, and statistical approaches, in connection with self-defined time-based and event-based characteristics. The results show that the obstruction is accompanied by an increase of statistically relevant spectral components in the range of 300 to 2000 Hz, however, not within the range up to 300 Hz. Signal properties are discussed with respect to different breathing types, as well as to the presence and the type of apneas. Principal component analysis of the event-based characteristics shows significant properties of the sound signal with respect to different types of apneas and different patient groups, respectively. The analysis reflects apneas with an obstructive segment and those with a central segment. In addition, aiming for an optimum detection of all three sound components, alternative regions on the thorax and on the neck were investigated on two subjects. The results suggest that the right thorax region in the seventh intercostal space and the neck are optimal regions. It is concluded that for patient assessment, extensive acoustic analysis offers a reduction in the number of required sensor components, especially with respect to compact home monitoring of apneas.

Algorithms↗

Auscultatory measurement of blood pressure performed by the doctor on duty.

A review is presented of the measurements of blood pressure on admission of 600 patients to the wards in a department of general medicine. Three doctors each examined 200 patients, distributed over two periods with an interval of one year. Large differences were found between the doctors as regards the distribution of the BPs, particularly the diastolic pressures. On the other hand, no differences were observed in the distributions during the two periods as far as the individual doctors were concerned. Great preference was shown for zero as the terminal digit and also for certain BP values. It is concluded that the observer introduces a considerable subjective factor in measuring the BP by auscultation. Correct performance of this simple procedure requires meticulous instruction.

Attitude↗

Method specificity of non-invasive blood pressure measurement: oscillometry and finger pulse pressure vs acoustic methods.

1. The agreement of blood pressure measurements by stethoscope auscultation (SBPa, DBPa-IV and DBPa-V), oscillometry (Dinamap; SBPo, and DBPo) and digital photoplethysmography (Finapres; SBPf, and DBPf) with the graphical analysis of the analogue microphone signals of vascular wall motion sound (SBPg and DBPg) was evaluated in eight healthy subjects in the presence of responses to the intravenous infusion of 1 microgram min-1 isoprenaline. 2. In general, there was good agreement between the SBP/DBP-measurements based on auscultatory Korotkoff-I- and IV-criteria and the reference method; the average method difference in estimating the isoprenaline responses for SBPa-SBPg was: -1.1, 95% CI: -5.4 to 3.1 mm Hg with a within-subject between-method repeatability coefficient (REP) of 11.6 mm Hg and for DBPa-IV-DBPg: 3.5, 95% CI: -0.5 to 6.5 mm Hg, REP: 11.5 mm Hg. The ausculatation of Korotkoff-V substantially overestimated the isoprenaline induced reduction of DBP: method difference DBPa-V-DBPg: -11.3, 95% CI: -17.8 to -4.7 mm Hg, REP: 31.8 mm Hg. 3. Oscillometry yielded good approximations for the SBP response to isoprenaline (average method difference SBPo-SBPg: -2.9, 95% CI: -9.0 to 3.3 mm Hg, REP: 17.6 mm Hg) but was poorly sensitive with regard to the DBP responses: method difference DBPo-DBPg: 6.5, 95% CI: -1.3 to 14.3 mm Hg, REP: 25.7 mm Hg. 4. Whilst the finger pulse pressure agreed well with regard to DBP (method difference for the DBP responses to isoprenaline: DBPf-DBPg: 1.8, 95% CI: -5.1 to 8.6 mm Hg, REP: 18.5 mm Hg) it was rather unsatisfactory with regard to SBP (method difference SBPf-SBPg: -14.1, 95% CI: -28.2 to -0.1 mm Hg, REP: 49.9 mm Hg).(ABSTRACT TRUNCATED AT 250 WORDS)

Adrenergic beta-Antagonists↗

Bronchial responsiveness to methacholine and adenosine 5'-monophosphate in atopic and non-atopic preschool children with recurrent wheezing.

BACKGROUND: It is well known that atopy is a major determinant of bronchial hyper-responsiveness (BHR) in both asymptomatic and asthmatic children. However, the relationship between atopy and BHR has not been well studied in preschool children with wheezing. BHR is usually measured by bronchial challenges using direct and indirect stimuli. OBJECTIVE: The aim of this study was to investigate whether atopic and non-atopic preschool wheezers display similar or different BHR profiles for direct and indirect stimuli. METHODS: Methacholine and adenosine 5'-monophosphate (AMP) bronchial challenges were performed in 4 to 6-year-old children with recurrent wheezing, using a modified auscultation method. The end-point was defined as the appearance of wheezing and/or oxygen desaturation. Atopy was determined to be present when a child had at least one positive reaction to a panel of 13 common airborne allergens in the presence of positive and negative controls. RESULTS: A positive response to methacholine (an end-point concentration < or =8 mg/mL) was observed in 89.3% (50/56) of atopic wheezers and in 83.8% (31/37) of non-atopic wheezers (P=0.44) for the difference. By contrast, the frequency of a positive response to AMP (an end-point concentration < or =200 mg/mL) was significantly higher in the atopic group (47/56, 83.9%) compared with the non-atopic group (12/37, 32.4%; P<0.01). CONCLUSION: While a majority of both atopic and non-atopic preschool wheezers were hyper-responsive to methacholine, atopic subjects were more hyper-responsive to AMP than non-atopic subjects. These findings suggest that atopic and non-atopic wheeze in preschool children are related to distinctive pathophysiologic pathways.

Adenosine Monophosphate↗

Tracheal sealing characteristics of pediatric cuffed tracheal tubes.

BACKGROUND: The aim of the study was to compare sealing characteristics of the new Microcuff pediatric tracheal tube featuring a high volume-low pressure (HVLP) cuff with ultrathin membrane with three conventional pediatric cuffed tracheal tubes. METHODS: After obtaining approval of the local ethical committee, 80 children aged 2-4 years were tracheally intubated with the following tubes (i.d. 4.0 mm) in random order: Microcuff P-HVLP, Mallinckrodt Hi-Contour P, Rüschelit Super Safety Clear, and Sheridan CF. Cuff pressure to prevent air leakage at standardized ventilator setting (PIP 20 cm H2O/PEEP 5 cm H2O/RR 20 min(-1)) was assessed within 5 min after intubation by auscultation of audible sounds at the mouth. Cuff pressures required with each group were compared with Kruskall-Wallis test (P < 0.05). Values are median and range. RESULTS: No significant differences in patient characteristics were found between the four groups. The Microcuff tube required significantly lower sealing pressures [11 cm H2O (6-26)] compared with the other tracheal tube brands [Mallinckrodt: 36 cm H2O (18-48); Rüschelit: 21 cm H2O (8-46); Sheridan: 26 cm H2O (18-60), (P < 0.0001)]. CONCLUSION: This preliminary investigation suggests that the new Microcuff pediatric tracheal tube with ultrathin high volume-low pressure cuff membrane allows effective tracheal sealing at very low cuff pressures. This represents a benefit for children with regard to their lower mucosal perfusion pressures compared with adult patients.

Auscultation↗

A randomized trial of electronic fetal monitoring in preterm labor: mothers' views.

To determine if perceptions of preterm labor and birth differed between women who were monitored by electronic fetal monitoring (EFM) or by periodic auscultation, 135 subjects were randomly assigned to one of two treatment groups on admission to a tertiary perinatal care setting. The first group received external monitoring by continuous Doppler and tocodynamometer when membranes were intact, and with an internal fetal scalp electrode and pressure catheter once membranes were ruptured. The second group received periodic monitoring with a DeLee fetoscope or amplified Doppler. All women were cared for on a one-to-one basis by expert study nurses. Subjects completed a questionnaire about their labor experience during their postpartum hospital stay. There was no statistically significant difference between the two groups on the study measures [T2(7,81) = 13.65; F = 1.82; P greater than 0.05]. Forty-four percent of the variance in women's global evaluation of labor was explained by their perceptions of nursing support. These findings suggest that mothers' perceptions of their preterm labor are less influenced by the technologic interventions used than by the supportive care received from nurses.

Adolescent↗

Incidence of murmurs in the aging heart.

One hundred patients aged 60 or older were studied clinically after excluding those with cardiac enlargement, definite valvular lesions or electrocardiographic (ECG) evidence of left ventricular hypertrophy. In 30 of the the 100 patients a significant systolic murmur was heard on auscultation. Phonocardiograms (PCGs), mitral echograms and pulse tracings were obtained in 28 of these 30 patients (2 had died meanwhile), and the ECGs and chest roentgenograms were reviewed. In 23 PCG patients there was an early or midsystolic murmur, best recorded at the base of the heart and often transmiteed to the apex. Mitral valve echograms and carotid and jugular pulse tracings were normal in all cases. Chest roentgenograms revealed aortic enlargement in 83 percent of the 23 patients. In the elderly with no evidence of organic heart disease, a basal systolic murmur is probably an aortic flow phenomenon caused by either moderate aortic dilatation or minimal fibrotic fusion of one or more commissures of the aortic valve.

Age Factors↗

Evaluation of the systolic murmur in the elderly.

A common clinical entity in the elderly population is the systolic murmur detected during cardiac auscultation. Although it can occur in patients of any age group, the approach to diagnosis differs in the elderly. Two cases are presented which illustrate different pathologic processes that can result in the development of a systolic murmur. The prevalence of this entity in the elderly is highlighted, and a strategy for diagnosis is outlined.

Aged↗

Discrepancies in performing target weight assessments in haemodialysis patients.

Roberts and White (1) state that the main reason for hospitalisation of dialysis patients is due to 'fluid Volume excess'. Fluid/target weight assessments should routinely be carried out for chronic haemodialysis patients prior to each treatment by experienced renal nurses, but Welsh (2) states that the assessment of the patient and clinical skills may be underused because of poor staffing levels. Using a qualitative design study based on a group of experienced renal nurses, the author sought to determine which clinical signs and symptoms were assessed, how often they were carried out and what similarities were demonstrated. Elements such as the patient's blood pressure, evidence of peripheral oedema and dyspnoea were used as benchmarks for good practice, based on literature and the author's extensive experience. The author also believed that the standard fluid assessment could be improved by expanding the nurse's role to incorporate chest auscultation. Results demonstrated that a variety of reasons determined whether such assessments were carried out, and that there was wide variation as to what nurses considered essential in performing the assessment.

Attitude of Health Personnel↗

An investigation of the incidence of chronic obstructive pulmonary disease (COPD) in random populations of Swiss horses.

The incidence of Chronic Obstructive Pulmonary Disease (COPD) in Switzerland was determined in three groups of horses selected at random. Group A (97 horses) and Group B (93 horses) had no history of respiratory disease, but Group C (113 horses) had a history of lower respiratory tract disease. All horses were examined by auscultation of the respiratory tract under forced breathing, endoscopic examination of the upper and lower respiratory tract, arterial blood gas analysis at rest and cytological examination of respiratory secretions (RS). Fifty-four per cent of the horses in Group A and 54.8 per cent of Group B were diagnosed as suffering clinical COPD and only 12.4 per cent of horses in Group A and 8.6 per cent in Group B had no detectable abnormalities in their lower respiratory tracts. In Group B, 19.4 per cent were considered to be suffering from parasitic pulmonary disease indicated by elevated numbers of eosinophils in their RS. Pharyngeal lymphoid hyperplasia was exhibited in 70.1 per cent of Group A and 74.2 per cent of Group B. Cytological examination of RS was useful to determine if the secretions found in the trachea originated from the upper or lower respiratory tract. Arterial blood gas analysis revealed no significant differences between healthy horses and those with subclinical or mild COPD.

Animals↗

A survey of cardiac auscultatory findings in horses.

Auscultation was used to examine 545 horses for cardiac murmurs and some arrhythmias. The most significant finding was the high prevalence of right-sided holosystolic or pansystolic plateau-type murmurs compatible with a diagnosis of tricuspid regurgitation in National Hunt racing Thoroughbreds of all ages (16.4%). This condition was found in 4.7% of flat-racing Thoroughbreds, 3.7% of non-racing Thoroughbreds and Thoroughbred crosses, and in none of the ponies examined. High prevalences of left-sided early systolic murmurs (53%), left-sided early diastolic murmurs (23%), right-sided early diastolic murmurs (22%) and second degree atrioventricular block (23%) were found in racehorses of both types.

Age Factors↗

Detection of heart murmurs using wavelet analysis and artificial neural networks.

This paper presents the algorithm and technical aspects of an intelligent diagnostic system for the detection of heart murmurs. The purpose of this research is to address the lack of effectively accurate cardiac auscultation present at the primary care physician office by development of an algorithm capable of operating within the hectic environment of the primary care office. The proposed algorithm consists of three main stages. First; denoising of input data (digital recordings of heart sounds), via Wavelet Packet Analysis. Second; input vector preparation through the use of Principal Component Analysis and block processing. Third; classification of the heart sound using an Artificial Neural Network. Initial testing revealed the intelligent diagnostic system can differentiate between normal healthy heart sounds and abnormal heart sounds (e.g., murmurs), with a specificity of 70.5% and a sensitivity of 64.7%.

Algorithms↗

Fetal distress and the condition of newborn infants.

In a prospective audit of the obstetric management of 1210 consecutive deliveries the association was investigated between the need for operative delivery for fetal distress during labour and the condition of the newborn infant. Operative delivery was performed for only 11.5% of the newborn infants with severe acidosis at birth (umbilical artery pH less than 7.12, base deficit greater than 12 mmol (mEq)/1), 24.1% of those with an Apgar score less than 7 at one minute, and 15.8% of those with both severe acidosis and a one minute Apgar score less than 7. Most of the infants delivered operatively were in a vigorous condition at birth and did not have severe acidosis. Fetal blood sampling was done in 4.0% of labours. As none of the fetal blood values were less than 7.20 and only three of the infants sampled in utero suffered severe acidosis at birth, fetal blood sampling would have had to be performed much more often to provide a useful guide to metabolic state at birth. While the large majority of "at risk" fetuses had continuous fetal heart rate monitoring in labour, this had not been provided in 48.7% of the labours of infants with severe acidosis, 38.7% of infants with a one minute Apgar score less than 7, and 47.4% of infants with both severe acidosis and a one minute Apgar score less than 7. Continuous fetal heart rate monitoring was associated with a much higher incidence of operative delivery for fetal distress than was intermittent fetal heart rate auscultation. These results suggest an urgent need to review present methods for assessing the intrapartum condition of the fetus, making the diagnosis of fetal distress, and assessing the condition of the infant at birth.

Acidosis↗