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At least 1,207 records · Page 67Linked to original sources
PubMed1999

Detection of neuroendocrine feature about salivary adenoid cystic carcinoma.

OBJECTIVE: To study the possibility of neuroendocrine feature of salivary adenoid cystic carcinoma (SACC). METHODS: Immunohistochemical staining was operated in SACC with S-100 protein, neurospecific enolase (NSE), chromogranin A, and synaptophysin, which are specific and correlative with neuroendocrine cells and neoplasias. RESULTS: The positive expression of S-100, NSE, chromogranin, and synaptophysin were 42, 32, 8, and 7, respectively, in 50 cases of SACC. CONCLUSION: Neuroendocrine feature in some SACC cells is possibly indicated.

Adolescent↗
PubMed2000

[A case of adenoid cystic carcinoma of the trachea resected surgically after Nd-YAG laser therapy].

A case of primary tracheal tumor ablated by endoscopic Nd-YAG laser prior to tracheal sleeve resection was reported. A 53-year-old man had dry cough, bloody sputum and dyspnea. Bronchoscopic examination revealed polypoid tumor which located 2 cm below the vocal cords and obstructed the airway almost completely. After tumor vaporized by Nd-YAG laser, bronchoscopy type 200 could pass through the tracheal lumen and the length of the lesion was diagnosed within 4 cm. Biopsy specimen was confirmed adenoid cystic carcinoma. Cervical trachea was resected of six tracheal cartilage (first to sixth cartilage) combined with left thyroid lobe under collar incision and median sternotomy. The neck was fixed for ten days by tying the jaw to the anterior chest wall in order to reduce excessive tension to the anastomosis. Pathological examination revealed the tumor residual microscopically, 60 Gy of radiotherapy was conducted.

Carcinoma, Adenoid Cystic↗
PubMedDate not supplied

Infrequent alternations of RB pathway (Rb-p16INK4A-cyclinD1) in adenoid cystic carcinoma of salivary glands.

Retinoblastoma (Rb) tumor suppressor genes' products and of the proteins regulating its phosphorylation and function in G1 arrest, p16INK4A and cyclin D1, play important roles in the regulation of the cell cycle. Rb gene inactivation, reflected by the absence of Rb protein expression, has been reported in oral squamous cell carcinomas. p16INK4A is frequently deleted, methylated, or mutated, and cyclin D1 gene amplification in many malignancies including oral squamous cell carcinomas (SCC). These findings suggested that Rb pathway of G1 arrest are the most commonly affected genes in Oral SCC. However, alternation of Rb pathway in salivary gland tumors was not clear. In this study, the expressions of Rb, p16INK4A, and cyclin D1 alternations were analyzed by immunohistochemical assay in 5 specimens of normal salivary glands and twenty-two cases of adenoid cystic carcinomas (ACC). Proliferating cell nuclear antigen (PCNA) labelling index (P.I.) was used for the evaluation of cell proliferation. Rb was consistently expressed in normal salivary glands and ACC. Loss of p16INK4A expression was observed in three cases (13.6%) of ACC. And overexpression of cyclin D1 was observed in four cases (18.2%). The three p16INK4A absent cases were the tumors with predominantly solid pattern and those cases were overexpressed cyclin D1. The cell proliferation activities of p16INK4A absent tumors (P.I. = 24.2 +/- 2.1%) were significantly higher than those of p16INK4A present tumors (P.I. = 10.4 +/- 3.5%) (P < 0.05). Cyclin D1 expression was also related to cell proliferation (P.I. of cyclin D1 negative cases vs. cyclin D1 positive: 10.1 +/- 3.0% vs. 22.6 +/- 3.4%) (P < 0.05). These findings suggested, however, alternations of Rb pathway were infrequent events in ACC of salivary glands and inactivation of p16INK4A, cyclin D1 overexpression may be related to the high cell proliferating activity of ACC.

Adult↗
PubMed2000

Carcinosarcoma of the uterine cervix composed of an adenoid cystic carcinoma and an homologous stromal sarcoma. A case report.

A case of primary cervical carcinosarcoma is presented. The tumor occurred in a 76-year-old multiparous woman and it replaced the uterine cervix, extending to the vaginal wall and to the uterine corpus. Histologically, the carcinomatous component was exclusively an adenoid-cystic carcinoma and the sarcomatous component was an homologous stromal sarcoma. Immunohistochemically, both the carcinomatous and the sarcomatous elements were stained with smooth muscle actin. Only two other similar cases have been reported.

Aged↗
PubMed2000

[Adenoid cystic carcinoma of the prostate. Clinical case].

The authors report an extremely rare case of adenoid cystic carcinoma of the prostate. No satisfactory clinical and pathological classification exists for this tumour, creating particular difficulties for therapeutic decisions and prognosis. Descriptions of cases with excellent survival rates are reported in the literature, to the extent that this is sometimes regarded as a low-malignancy tumour, but other reports also exist of massive diffusion of the pathology with fatal consequences. Advances in the knowledge of this tumour have enabled a number of earlier pathogenetic hypotheses to be ruled out, namely its possible derivation from ectopic salivary cells, ectopic periurethral glands or metaplastic urethral mucosa, but the origin of this carcinoma is still not certain. It is also difficult to differentiate this form from the typical adenocarcinoma and to make a prognosis for survival. In the case reported here, the final diagnosis was made on the lymph node biopsy obtained during surgery, given that a preoperative biopsy was not feasible owing to the scarcity of material available. The patient received standard hormonal therapy for prostate carcinoma.

Adenocarcinoma↗
PubMed2000

[Autopsy case of adenoid cystic carcinoma of the trachea: endobronchial treatment improves quality of life].

A 67-year-old man presented with dyspnea on exertion. Bronchoscopic examination revealed a tumor arising from the middle portion of the trachea and extending to the right main bronchus. The pathological diagnosis was adenoid cystic carcinoma. Radiotherapy and subsequent endobronchial electrocautery were performed, and elicited a partial response. In the clinical course. Dumon and Ultraflex stents were placed in the trachea asynchronically. Brachytherapy and esophageal stent placement were also performed for tumor control in the trachea and esophagus. Autopsy revealed that the tumor had invaded the trachea and esophagus, and bacterial mediastinitis was also demonstrated. Because the tumor was successfully controlled during the following 4 years and 9 months, we concluded that endobronchial therapy such as stent placement or electrocautery is useful for maintaining good quality of life.

Aged↗
PubMed1997

[Molecular biology studies on metalloproteinase and tissue inhibitor of metalloproteinase expression in salivary adenoid cystic carcinoma].

In order to research the relation between metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) and metastasis of salivary adenoid cystic carcinoma (ACC). We use dot blotting to analyse the expression of MMP-2, MMP-9 and TIMP-2 in ACC-2, a cell line of ACC in palate and ACC-M, a high lung metastasis clone which cloned from ACC-2. The result showed the expression of MMP-2 and MMP-9 were higher in ACC-M than that in ACC-2, but the expression of TIMP-2 were higher in ACC-2 than that in ACC-M This suggest MMP-2 and MMP-9 can promote ACC metastasis, TIMP-2 can suppress ACC metastasis. MMP and TIMP maybe a key mechanism of ACC metastasis.

Carcinoma, Adenoid Cystic↗
PubMed2001

[A case of adenoid cystic carcinoma of the left main bronchus, which was performed carinal resection and reconstruction while the aortic arch is pulled down].

A 55-year-old woman, who had treated as bronchial asthma for eight months, was admitted to our hospital. Chest CT scan showed a mass in the left main bronchus. Bronchoscopic examination revealed a tumor obstructing the left main bronchus and invading the left lower portion of the trachea. The pathologic diagnosis was adenoid cystic carcinoma. Primary resection of the left main bronchus and the carina with the objective and one-stoma-type carinal reconstruction were performed by the left thoracotomy. We pulled down the aortic arch to obtain an operative field, and carried out the operative procedure at the upper side of the aortic arch. As the resection margin contained residual tumor, the postoperative irradiation (50 Gy) was added.

Aorta, Thoracic↗
PubMed2001

[Isolated facial palsy and occult adenoid cystic carcinoma of the parotid].

We report a case of adenoid cystic carcinoma of the parotid disclosed by facial palsy alone. No tumefaction could be detected clinically or at imaging. The diagnosis was established at surgical exploration of the facial nerve. Total extended parotidectomy was completed by radiotherapy of the tumor site.

Carcinoma, Adenoid Cystic↗
PubMedDate not supplied

Results of fast neutron therapy of adenoid cystic carcinoma of the salivary glands.

BACKGROUND: Adenoid cystic carcinomas (ACC) seem to have a better response to fast neutron irradiation than to photon beam therapy because of the higher relative biological effectiveness of neutron radiation. METHODS: Between 1986 and 1995, 72 patients with ACC of the salivary glands were treated in Münster with fast neutrons. The median age was 54 years. All the patients had either recurrent or macroscopic rest tumor prior to neutron therapy. The median total dose was 15.03 Gy. Median follow-up was 50 months. RESULTS: 39.1% of the patients achieved a complete remission and 48.6% a partial remission. The survival probability was 86% after one year, 73% after two years and 53% after five years. The recurrence-free survival was 83% after one year, 71% after two years and 45% after five years. CONCLUSION: Neutron beam therapy seems to have been an effective treatment in these selected patients.

Adolescent↗
PubMed2000

The expression of E-cadherin-catenin complex in adenoid cystic carcinoma of salivary glands.

OBJECTIVE: The aim of this study was to investigate the expression of the E-cadherin-catenin (E-cad-cat) complex in human salivary adenoid cystic carcinoma (ACC) and determine the effects of E-cad-cat expression on tumor differentiation, metastasis, and invasion, as well as its clinical significance. METHODS: The expression of adhesion molecules, which included E-cadherin, alpha-catenin, and beta-catenin, on 10 cases of normal salivary glands, and 50 cases of human salivary ACC were investigated by immunohistochemistry. RESULTS: Strong and stable expression of E-cad-cat complex showed in normal salivary glands tissues. However, weaker expression and even complete absence, of the positive signals were shown on all ACC cases. Coexpression of E-cad-cat were detected in 29 (58%) of the 50 ACC specimens. Positive staining of E-cad-cat complex were detected in 7 (39%) of the 18 ACC primary sites that had aggressive phenotype of nerve and vasculature. CONCLUSION: Strong positive signals of E-cad-cat complex are shown in normal salivary glands, and the down-regulated expression were observed in ACC cases. The expression of E-cad-cat complex is associated with a more aggressive phenotype on nerve and vasculature. No association with various histopathologic subtypes was found. However, absent or low E-cad expression was observed more frequently in solid carcinomas than in cribriform or tubular carcinomas. Down-regulation of E-cad-cat complex may be associated with canceration of normal salivary glands. The expression levels of E-cad-cat were positively correlated to the differentiation of ACC tumor cells.

Antibodies, Monoclonal↗
PubMed2001

[Treatment results of patients with adenoid cystic carcinoma in the Otolaryngology Department at the University School of Medical Sciences in Poznań between 1958-1999].

In the years 1958-1999 the ENT Department at the University School of Medical Sciences in Poznań treated 125 patients suffering from adenoid cystic carcinoma located in the head and neck area. The aim of this study was to assess treatment results over a span of 41 years. The cases treated included 68 women and 57 men. The highest incidence of the disease was observed in men in their 70's--16 cases and women in their 50's--19 cases. In a majority of cases, the cancer started in major salivary glands, specifically parotid--51, submandibular--11, sublingual--4. Other places included minor salivary glands located in the palate--15, cheek--8, oral cavity--5 and tongue--4. Other glands affected by the tumor were those in the ethmoidomaxillary area--23. The treatment of choice was surgery with subsequent radiation. All patients were subjected to surgical treatment, 89 of them being subsequently radiated. Local recidivation was observed in 12 patients (i.e. 10%), metastases to neighbouring lymph nodes in 9 patients (i.e. 7%). Distant metastases affected the lungs--4 cases, liver--1 and bone--1.

Adult↗
PubMed2001

Expression of epidermal growth factor in salivary adenoid cystic carcinoma.

This study used an immunohistochemical technique to assess the expression of epidermal growth factor (EGF) in 40 specimens of salivary adenoid cystic carcinoma (ACC), 7 specimens of labial glands adjacent to mucocele, and 5 specimens of normal submandibular glands. In normal submandibular glands, immunohistochemically detectable EGF was demonstrated in all ductal segments, including intercalated, striated, and excretory duct cells. No EGF positive staining was found in acinar compartments. including serous and mucous acinar cells. In degenerated labial glands adjacent to mucocele, no EGF staining was detected in the remaining acinar and ductal cells. In salivary ACCs, positive EGF immunostaining was observed in one of the 5 (20%) ACCs with a solid pattern and in 13 of the 35 (37.1%) ACCs with a tubular-cribriform pattern. The overall EGF expression rate in 40 salivary ACCs was 35%. Positive EGF staining was predominantly found in tubular structures in the tubular ACCs and in duct-like structures in large cribriform patterns or in the stroma of the cribriform ACCs. There was no significant correlation between EGF expression in salivary ACCs and any of the clinicopathological parameters including patient age and sex, cancer location, TNM status, clinical stage, histologic type, perivascular or perineural invasion, focal necrosis of tumor, and cellular atypia. We conclude that the duct segments of the normal submandibular gland are the sites of EGF synthesis and secretion. In degenerated labial glands adjacent to mucocele, EGF synthesis is completely inhibited. Furthermore, EGF is mainly biosynthesized in cells forming tubular or duct-like structures in tubular or cribriform salivary ACCs, and EGF may play a biologic role, particularly as a mitogen in salivary ACC growth.

Adult↗
PubMed1997

[Study of electron microscopy histochemistry and immunohistochemistry of extracellular matrix in adenoid cystic carcinoma].

In order to determine the character of the extracellular matrix in adenoid cystic carcinoma (ACC), 22 cases of ACC of salivary gland were examined by immunohistochemical methods and 4 cases were examined by electron microscopy histochemically. Immunohistochemistry, type IV collagen and fibronectin were more intensively localized in pseudocyst space and in extracellular matrix between tumor cells. Ultrastructural study showed that the pseudocystic cells had abundant rough endoplasmic reticulum and a well-developed Golgi apparatus, some cells had muscle microfilament. There were laminin, proteoglycan and collagen fibril in the pseudocyst space. The results indicated that type IV collagen and fibronectin were the important stromal component in ACC, which may be secreted by neoplasmic myoepithelial cells.

Carcinoma, Adenoid Cystic↗
PubMed2001

Adenoid cystic carcinoma of Bartholin's gland: a case report.

OBJECTIVE: A case of adenoid cystic carcinoma (ACC) of the Bartholin's gland in a 34-year-old woman with unusual presentation and early recurrence is reported. METHODS: Clinical and histologie features were recorded. Immunohistochemical stains and cell-cycle analysis by flow cytometry technique on paraffin-embedded tumor tissue were performed. RESULTS: The tumor presented as a painful nodule in the episiotomy scar three months after delivery. Initial treatment included only wide local excision. Six months later local recurrence occurred despite clear surgical margins. Histologically a predominant "classic" cribriform growth pattern was identified. Immunoreactivity in tumor cells supported dual epithelial-myoepithelial differentiation. Estrogen and progesterone receptors were negative. The DNA histogram revealed a diploid stemline and a low S-phase fraction. CONCLUSION: ACC of the Bartholin's gland is a rare malignant tumor with great propensity for local recurrence. The optimal therapeutic approach has not been established due to the lack of well-defined prognostic parameters.

Adult↗
PubMed2001

Expression of transforming growth factor-alpha in adenoid cystic carcinoma of the salivary gland.

BACKGROUND: Transforming growth factor-alpha (TGF-alpha) is expressed in both normal and malignant epithelial cells. Although the expression of TGF-alpha has been extensively studied in some human epithelial neoplasms, its expression in adenoid cystic carcinomas (ACCs) of the salivary gland has not been reported. METHODS: This study used an immunohistochemical technique to assess the expression of TGF-alpha in 40 ACC specimens from the salivary glands, seven specimens from labial minor salivary glands adjacent to mucoceles, and five specimens from normal submandibular glands. RESULTS: In the normal submandibular gland specimens, positive TGF-alpha staining was found in all ductal segments as well as in serous and some mucous acinar cells. In labial minor salivary glands adjacent to mucoceles, positive TGF-alpha staining was found in ductal, serous acinar, serous demilune, and a few mucous acinar cells. Positive TGF-alpha immunostaining was observed in all five salivary gland ACC specimens with a solid histologic pattern, and 31 of the 35 salivary gland ACC specimens with a tubulo-cribriform histologic pattern. Overall, 36 of 40 ACCs of the salivary gland expressed TGF-alpha. Positive TGF-alpha staining was found in the salivary gland ACC specimens with solid, tubular, duct-like, and pseudocystic structures. No significant correlation was found between TGF-alpha expression in ACCs of the salivary gland and age, sex, primary cancer location, TNM status, clinical stage, prognosis, histologic type, perivascular or perineural invasion, focal necrosis of the tumor, or cellular atypia. CONCLUSIONS: This study demonstrated that ductal and acinar cells of the normal submandibular gland and of labial minor salivary glands adjacent to mucoceles are the major sites of TGF-alpha synthesis and secretion. Furthermore, TGF-alpha is biosynthesized in salivary gland ACC tumor cells, forming solid, tubular, duct-like, and pseudocystic structures. Our data suggest that TGF-alpha may play an important biologic role as a mitogen in the growth of salivary gland ACC.

Adult↗