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[Spiral CT of the abdomen: weight-adjusted dose reduction].

AIM OF THE STUDY: The influence of weight-adjusted current application in spiral CT of the abdomen on noise was investigated in a clinical study. PATIENTS AND METHODS: In 77 routine abdominal CT investigations (120 kV, 8 mm, pitch 1.5) the patients were divided into three body-weight groups A (< 60 kg), B (60-80 kg), and C (> 80 kg). The tube current was randomized prospectively in low weight group A, either 125 mA or 150 mA, in middle and high weight groups B and C, 150, 175 or 200 mA, with a tube revolution time of one second. The noise was measured in liver, skeleton muscle, fat tissue, and bladder content for evaluation of image quality. RESULTS: The bodyweight groups differ significantly in noise, e.g., in the liver (150 mA): group A: 15.8 HU, group B: 18.9 HU, group C: 21.5 HU. The increase of tube current (150, 175, 200 mA) within a body weight group resulted in a minor decrease of noise (18.9 HU, 17.6 HU, 17.5 HU, respectively, in group B). There is a good correlation of noise with body weight, body mass index and body cross section, but not with body size. CONCLUSION: A body weight adjusted reduction of tube current is possible without an increase of noise.

Adipose Tissue↗

[Extravasation of contrast media in brain parenchyma and cerebrospinal fluid space after CT or DSA of thorax or abdomen].

PURPOSE: Analysis of clinical and CT findings in patients with signs of disruption of the blood-brain or blood-CSF barrier after i.v. or i.a. administration of non-ionic contrast media. METHODS: 1. Retrospective analysis of 8 patients with clinical and CT findings of disruption of the blood-brain or blood-CSF barrier after i.v. or i.a. administration of non-ionic contrast media (200-450 ml). 2. Prospective analysis of 30 intensive care patients with sepsis and suspected abscess, who underwent CT of the chest and abdomen with 240 ml of a non-ionic contrast medium followed by cranial CT to rule out septic lesions. RESULTS: The retrospective analysis proved that disruption of the blood-brain barrier may occur in elderly patients with risk factors after injection of higher amounts of contrast media. In the prospective study, equivalent CT phenomena were observed in 3 of 30 patients with sepsis. CONCLUSIONS: Hypoxemic and toxics damage to the blood-brain barrier as well as higher amounts of contrast media may result in extravasation of contrast medium into the CSF space, which can be demonstrated by CT. For differential diagnosis, the clinical symptoms and CT patterns of a disruption of the blood-brain or blood-CSF barrier should be known.

Adult↗

[Normal fetal growth profile--a uniform model for calculating normal curves for current head and abdomen parameters and long limb bones].

AIM: Age-related and uniformly defined standard graphs were obtained for the fetal parameters BPD, OFD, HC, ATD, ASD, AC, Fe, Ti, Fi, Hu, Ra and Ul. METHODS: Data of 2032 healthy pregnant women of sonographically confirmed gestational age were used in a prospective cross-sectional study to establish reference charts for the fetal head and abdomen and the long limb bones. Only patients with an uncomplicated pregnancy were included in the study. The gestational age at which the measurements were taken ranged from 12 to 41 completed weeks. All measurements were performed as external-to-external measurements. RESULTS: By means of a mathematical model age related standard reference ranges were calculated on the basis of a single formula. Uniformly well-defined standard graphs were obtained for all parameters. All fetal parameters showed a nonlinear fetal growth. SUMMARY: Contrary to the common methods of creating reference standards by means of high-degree polynomials, the mathematical model presented here has the advantage of characterising the course of several parameters on the basis of one single formula. This is of great importance for digitising fetal charts in commercially available ultrasound machines.

Anthropometry↗

[Clinicoradiologic significance of different study parameters in NMR tomography of the abdomen].

One hundred and nine patients have been examined with NMR tomography, including 44 examinations of the abdomen. In 35 cases, different sequences were used. In 28 patients it was possible to determine the relaxation times T1 and T2. Pathological processes showed not only different T1 and T2 values, but also different pictorial contrast. In order to extract the maximum amount of information, it is necessary to carry out NMR tomography with varying sequences.

Abdominal Neoplasms↗

Natural history of periprosthetic air on computerized axial tomographic examination of the abdomen following abdominal aortic aneurysm repair.

The presence of periprosthetic gas on computerized axial tomography (CT) of the abdomen following abdominal aortic reconstruction has been proposed to be a reliable indicator of prosthetic graft infection, a complication that requires intervention entailing significant mortality and morbidity. To evaluate the reliability of this finding in the early postoperative period, prosthetic grafts in 26 patients undergoing elective aneurysm repair were evaluated with postoperative CT examinations. Serial scans were obtained at mean intervals of 3, 7, and 52 days postoperatively. The presence or absence of periprosthetic air on CT scan was noted, and the results were correlated with aneurysm size as determined by preoperative ultrasound examination of the abdominal aorta or by measurements made during operation. Mean aneurysm size was 6.1 cm (range 4.5 to 10.6 cm). Periprosthetic air was demonstrated in 17 (65%) of the 26 patients studied within 1 week postoperatively. Patients with aneurysms larger than 6.0 cm were more likely to demonstrate periprosthetic air then those with smaller aneurysms (chi 2 = 5.024, p = 0.025). All patients found to have periprosthetic air had spontaneous resolution by late CT scanning obtained a mean of 52 days postoperatively (range 21 to 85 days). One patient died in the early postoperative period and two did not return for late scans. Only one patient demonstrated periprosthetic air as late as the thirty-second postoperative day, and this air had resolved by the seventieth postoperative day.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗

Low-high and high-low biphasic injection forms in computed tomography examinations of the upper abdomen.

PURPOSE: To analyze the influence of different biphasic and monophasic injection rate protocols in abdominal computed tomography (CT). MATERIAL AND METHODS: A randomized, consecutive, parallel group study was designed and conducted in 60 patients studied with the same CT helical protocol. Patients were randomly distributed into three groups: (A) monophasic (120 ml at 2.5 ml/s); (B) low-high biphasic (120 ml, first 60 ml at a rate of 2 ml/s, the other 60 ml at 2.5 ml/s); and (C) high-low biphasic (120 ml, first 60 ml at a rate of 2.5 ml/s, the other 60 ml at 2 ml/s). All patients were injected with 300 mg I/ml non-ionic contrast media at a fixed delay time of 55 s. Contrast enhancement efficacy was evaluated by attenuation coefficient measurements. RESULTS: Although non-significant, monophasic protocol enhancements were higher than biphasic protocol enhancements in all measurements except aortic bifurcation (p=0.003). At this level, biphasic protocols obtained an increased mean enhancement from 7.6% to 2.5% compared to monophasic protocols. CONCLUSION: Monophasic contrast agent injection in helical CT of the upper abdomen produces a higher enhancement of parenchymal and venous structures. No significant difference was observed between low-high and high-low biphasic protocols.

Adult↗

Diagnostic and therapeutic laparoscopy for stab wounds of the anterior abdomen.

BACKGROUND: At present, laparoscopy is used mainly as a diagnostic tool in patients with abdominal stab wounds. PATIENTS AND METHODS: Thirty-two hemodynamically stable patients with isolated stab wounds of the anterior abdomen, thought to be penetrating, were prospectively selected to undergo treatment via a laparoscopic approach. When possible, parenchymal wounds were coagulated or sealed, and wounds to the intestines were sutured or stapled. RESULTS: The results of laparoscopy were negative in 6 (18.8%) of the cases: nonpenetrating wounds in 4 cases and nonsignificant organ injury in 2 cases. A hemoperitoneum was identified in 13 (40.6%) of the cases, and significant organ injuries in 26 (81.3%) of the cases: stomach, 2; small bowel, 5; colon, 2; pancreas, 1; vascular injuries, 4; liver, 5; mesentery, 9. Laparoscopy was therapeutic in 20 (62.3%) of the cases. Conversion to open surgery was required in 6 (18.8%) of the cases. No injuries were missed, and no mortality occurred. Postoperative complications developed in 2 (6.2%) of the cases. The mean hospital stay was 4 days, with no late complications. CONCLUSIONS: Laparoscopy can avoid a number of unnecessary laparotomies and can treat most of the lesions found in hemodynamically stable patients with anterior abdominal stab wounds.

Abdominal Injuries↗

Augmentation of cardiac output and carotid blood flow by chest and abdomen phased compression cardiopulmonary resuscitation.

Phased compression cardiopulmonary resuscitation, whereby the chest and abdomen are compressed sequentially, is a new approach to the classical cardiopulmonary resuscitation technique, which is based on the compression of the chest alone. Six dogs with cardiac arrest were treated by external chest and abdominal compression using a rigid plexiglas suit lined with flexible perithoracic and periabdominal bladders. Fast inflation and deflation of the two independent bladders, together with forced ventilation of the lung, generated phased pressure pulses. The physiological variables monitored throughout the experiment included central venous, left ventricular, and central arterial pressures, carotid blood flow, cardiac output, and acid base balance. The phased compression technique was performed with phased time lags of 0, 150, 300, 400, 600, 700, and 850 ms between the abdominal and thoracic pressure pulses. A random sequence of the different phased compression modes, each lasting for 3-10 minutes, was applied during the prolonged resuscitation procedure that lasted for up to 70 minutes. By starting the abdominal compression 300-400 ms before the thoracic compression the carotid flow index improved by 77% (from 13% with simultaneous compression to 23% with phased compression) and the cardiac output index increased by 65% (from 7.8% with simultaneous compression to 12.5%). The results provide insight into the chest pump concept and the role of intrathoracic and intra-abdominal pressures in generating improved blood circulation during cardiopulmonary resuscitation, and show the advantages of phased compression over chest compression alone and simultaneous chest and abdominal compression.

Animals↗

Retrotransposable elements R1 and R2 in the rDNA units of Drosophila mercatorum: abnormal abdomen revisited.

R1 and R2 retrotransposable elements are stable components of the 28S rRNA genes of arthropods. While each retrotransposition event leads to incremental losses of rDNA unit expression, little is known about the selective consequences of these elements on the host genome. Previous reports suggested that in the abnormal abdomen (aa) phenotype of Drosophila mercatorum, high levels of rDNA insertions (R1) in conjunction with the under-replication locus (ur), enable the utilization of different ecological conditions via a population level shift to younger age. We have sequenced the R1 and R2 elements of D. mercatorum and show that the levels of R1- and R2-inserted rDNA units were inaccurately scored in the original studies of aa, leading to several misinterpretations. In particular, contrary to earlier reports, aa flies differentially underreplicate R1- and R2-inserted rDNA units, like other species of Drosophila. However, aa flies do not undergo the lower level of underreplication of their functional rDNA units (general underreplication) that is seen in wild-type strains. The lack of general underreplication is expected to confer a selective advantage and, thus, can be interpreted as an adaptation to overcome high levels of R1 and R2 insertions. These results allow us to reconcile some of the apparently contradictory effects of aa and the bobbed phenotype found in other species of Drosophila.

Amino Acid Sequence↗

Effective dose evaluation for chest and abdomen X-ray tests.

The radiation doses resulting from diagnostic X-ray examinations are routinely measured in terms of entrance skin exposure (ESE). In this study, for the purpose of radiation protection, the radiation doses received from chest and abdomen X-ray tests were evaluated in terms of equivalent dose and effective dose. The dose calculations were conducted by using the MCNP Monte Carlo code and an adult hermaphrodite mathematical phantom. The effects of both operating high voltage and projection geometry on the effective dose were investigated. The absolute values of the effective doses may be provided from the national average ESE.

Body Burden↗

The rectus femoris myocutaneous flap for closure of difficult wounds of the abdomen, groin, and trochanteric areas.

The rectus femoris myocutaneous flap has proved to be an effective means of closing particularly difficult wounds in 2 patients. One patients had a massive defect in the lower abdomen, pubic, and right groin area after the radical resection of a recurrent pleomorphic liposarcoma of the spermatic cord. The second patient presented with a huge, right greater trochanteric wound measuring 15 cm in diameter. Both patients progressed to relatively uneventful primary healing.

Adult↗

Stab wounds of the anterior abdomen. Analysis of a management plan using local wound exploration and quantitative peritoneal lavage.

A management plan for stab wounds to the anterior abdomen incorporating local wound exploration and quantitative peritoneal lavage was applied to 572 patients. One hundred eighty-five of these patients presented with shock, peritonitis, or evisceration and underwent immediate exploratory laparotomy with the finding of an intraperitoneal organ injury in 183 (99%). The remaining 387 patients with a negative physical examination underwent exploration of the stab wound to determine fascial penetration. Wound exploration was negative in 151 of these patients and they were discharged from the emergency room. Two hundred thirty-six additional patients had penetration of the fascia and underwent peritoneal lavage. Ninety-two per cent of patients with lavage counts greater than 50,000 had an intraperitoneal organ injury. No patients with lavage counts less than 1,000 red cells had an organ injury. Forty-three per cent of patients in the intermediate group (1,000-50,000 RBCs/mm3) had an organ injury and 59% included penetration of a hollow viscus. An approach incorporating local wound exploration and quantitative peritoneal lavage followed by exploratory laparotomy for red blood cell counts greater than 1,000 should result in less than 10% negative laparotomies and no missed injuries.

Abdominal Injuries↗

Evaluation of ultrafast CT scanning of the adult abdomen.

Various measures of image quality were compared from adult abdomen scans obtained with a subsecond computed tomographic (CT) scanner (Imatron Ultrafast C-100) and a conventional third-generation whole-body scanner (GE9800). Forty images from 13 patients scanned within 2 hours of each other on both scanners were evaluated with techniques standardized as much as possible for CT exposure factors and contrast enhancement. Two observers in consensus evaluated matched anatomic levels using standard window width and level settings. Each image was graded on a scale of 1 (worst) to 5 (best) for spatial resolution, image noise, and presence and type of artifacts. Overall image quality also was graded. Averaged scores were compared between the two scanners. In all categories, scores were slightly higher for the GE9800. However, the differences in spatial resolution, presence of artifacts, overall image quality were not significant using the sign test. There was a significant difference, in favor of the GE9800, in image noise. The types of artifacts differed; the GE9800 produced more motion artifacts from bowel and surgical clips and the Imatron C-100 produced more rib shadow artifacts projecting on the liver and spleen. While the GE9800 produced abdominal images of slightly superior quality in adults, the Imatron Ultrafast C-100 was shown to produce images suitable for routine abdominal imaging in adults.

Adult↗

Acoustic prism causing sonographic duplication artifact in the upper abdomen.

A variable prism of fat frequently occurs in the anterior abdominal wall that can produce confusing double-image artifacts on sonograms. This artifact is seen most frequently in the pelvis but is also seen in the upper abdomen, and is related to anatomic variations and the size of some ultrasound transducers. Phantom studies and a review of the CT scans of 100 patients were used to document the anatomy and frequency of occurrence of this variant.

Abdominal Muscles↗

Computed tomography of the brain, liver, and upper abdomen in the staging of small cell carcinoma of the lung.

Computed tomography (CT) examinations of the brain, liver, and upper abdomen were obtained in 60 previously untreated patients with histologically proven small cell carcinoma of the lung (SCCL). These results, together with clinical findings and laboratory investigations including radionuclide scans, determined the final staging of the patients. Computed tomography changed the stage from limited to extensive disease in three patients and from extensive to limited disease in seven patients. Overall, 10 of 60 patients (16%) had their final stage altered by CT. This study indicates that CT examinations may yield valuable information in some cases of small cell lung cancer but that it is of limited value in the routine staging of these patients.

Abdominal Neoplasms↗

Recognition of gas in gallstones in routine computed tomograms of the abdomen.

In a consecutive group of 1,067 noncholecystectomized patients referred for computed tomography including the upper abdomen, gallstones were seen in 13%. In 4% of the patients with gallstones, gas-containing calculi were found. On reviewing the conventional plain films such stones were revealed in less than one-half of the patients.

Cholelithiasis↗