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At least 1,189 records · Page 66Linked to original sources
PubMed1980

Behavioral effect of selective and non-selective lesions of median raphe nucleus in the rat.

The role of the serotonergic (5-HT) system in the regulation of locomotor activity and consummatory behaviors was studied. Electrolytic and chemical (5,7-dihydroxytryptamine: 5,7-DHT) lesions were made in the median raphe nucleus (MR). The effects of these lesions on spontaneous locomotor activity, food and water intake and body weight were then studied. In these experiments, rats on an ad libitum feeding-drinking regimen were housed individually in cages with activity wheels located in a room kept at a temperature of 22 + 1 degrees C. For each rat, records were kept of its spontaneous locomotor activity, food and water intake, and body weight for 8 weeks before and after the placement of lesion in MR. It was observed that: (1) electrolytic destruction of the MR produced a permanent decrease in locomotor activity, and (2) there were a reduced food intake and a decreased spontaneous activity after intra-MR injection of 5,7-DHT.

Animals↗
PubMed1999

Effects of selective and non-selective endothelin antagonists on ischemia-reperfusion damage in the isolated perfused murine liver.

The objective of the present study was to clarify the differential effects of endothelinA (ETA) and ETB antagonism in the early phase of ischemia-reperfusion damage. Male Sprague Dawley rats were randomly divided into 4 groups: control (n = 10), bosentan (40 nM; n = 10), BQ-485 (20 nM; n = 10), and BQ-788 (50 nM; n = 10) to compare the effects of ETA or ETB or both ETA and ETB antagonists against the warm ischemia-reperfusion damage of murine livers. Isolated livers were perfused with oxygenated Krebs-Henseleit bicarbonate buffer solution and ET antagonists for 30 min before inducing warm ischemia (non-recirculating system). After 40 min without perfusate, measurements (portal pressure, O2 tensions of influent and effluent perfusate, liver enzymes, etc.) were taken up to 60 min after reperfusion. The BQ-788 group had significantly more liver damage than did the other groups, and more O2 consumption than did the bosentan group. BQ-485 and bosentan were more protective at some points after reperfusion. Antagonism of only the ETB receptors is detrimental, but antagonism of the ETA receptors appears to have a role in protecting the liver from warm ischemia-reperfusion damage in the early phase.

Alanine Transaminase↗
PubMedDate not supplied

The influence of glycoprotein hormones selected properties of selected properties of glycoprotein hormones on their absorption after intranasal administration in foxes.

The absorption of glycoprotein hormones, i.e. folitropin and lutropin, whose approximate molecular weight is 30,000 D, were estimated for the intranasal administration. The maximal hormone concentrations were observed 30 minutes after their administration. The maximal concentration of folitropin was 32% higher than the maximal concentration of lutropin. Bioavailability level for foliotropin was 138.58% compared to lutropin bioavailability level, which was considered the pattern bioavailability level (100%) in our experiments. It was established that the absorption of hormones from nasal mucous membrane depended not only on their molecular mass but also on the isoelectric point, content of carbohydrates and sialic acids. Hormonal substances of acid character, containing a greater content of carbohydrates and sialic acids (as in the case of folitropin) were absorbed from the nasal mucosa more rapidly.

Absorption↗