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PubMedDate not supplied

Angulated needle placement in CT-guided percutaneous needle biopsy of the thorax.

Computed tomography (CT)-guided percutaneous needle biopsy is often necessary to evaluate small intrathoracic lesions. Not infrequently, an overlying structure such as a rib or vessel precludes insertion of the biopsy needle within the CT slice containing the lesion. Insertion and angulation of the needle at a site within an adjacent CT slice is then required. In order to determine the optimal skin-entry site and degree of angulation for biopsy needle insertion, we analyzed the geometric relationship between lesion depth, needle length, and needle angulation.

Biopsy, Needle↗
PubMed1996

iroquois: a prepattern gene that controls the formation of bristles on the thorax of Drosophila.

We have isolated a Drosophila mutant where the lateral parts of the notum are completely naked, leaving unaffected a median stripe of hairs. This mutation, iroquois (iro), defines a new gene which maps at 69D. We show that, in the presumptive lateral notum of mutant discs, sense organ precursor cells fail to form and the proneural gene scute is not expressed. The expression of a reporter gene inserted near iro suggests that iro itself is massively expressed in this region of the disc. We propose that iro is a prepattern gene essential to activate the expression of scute in the regions of the disc that will form the lateral notum.

Alleles↗
PubMed1995

Clinical introduction of a commercial treatment chair to facilitate thorax irradiation.

There are occasions when patients can benefit significantly from being treated upright. This technique is beneficial in the treatment of Hodgkin's disease when the mediastinum is involved. The main benefit is the lung volume spared resulting from narrowing of a bulky mediastinum. We purchased a commercial treatment chair to facilitate upright treatment. Clinical implementation required rigorous testing, documentation of procedures, and acknowledgment of and corresponding solutions to limitations. The purchased chair is designed to couple with the spine bar of the treatment couch, allowing patient positioning via pendant functions. The chair has no obstruction as immobilization is afforded by arm, shoulder, and knee supports, which allows isocentric treatments. An additional hydraulic mount is used for simulation. We have treated five patients thus far, including Hodgkin's disease patients with and without mediastinal involvement, and one lung cancer patient with a large lower lobe lesion. All patients have benefited by having a greater volume of lung spared (as much as 60% additional blocking) when upright simulation films are compared with supine and prone films. Immobilization has been adequate as confirmed by daily light field projections and portal films. We are routinely evaluating Hodgkin's disease patients for upright treatment. Patients treated in the chair have benefited in terms of lung volume spared without loss of immobilization. A patient with a large lower lobe lung lesion has also benefited as the tumor "dropped," thus affording lung sparing via blocking.

Equipment Design↗
PubMed2005

Utility of triple channel injection of contrast material with mixture of saline, with acquisition in the cephalic direction for arterial trees in the thorax using multislice computed tomography.

BACKGROUND: If contrast material is injected into the cubital vein, artifacts due to high concentration of the contrast material in the vein lead to deterioration of the opacification of the thoracic aorta and the major branches. We describe a new protocol employing a combination of triple channel contrast material injection and a mixture of saline with acquisition in the cephalic direction utilizing capability of 16-slice multislice CT. MATERIALS AND METHODS: Of 35 subjects who underwent thoracic CT, 18 were injected with 70 ml contrast each prior to scanning with acquisition in the cephalic direction during the injection of 30 ml contrast diluted 50/50 with saline, followed by the injection of 20 ml of saline (new protocol). Seventeen subjects were injected each with 100 ml contrast at 3 ml/s, with scanning in the caudal direction (ordinary protocol). RESULTS: In the new protocol, the major branches of the aorta and the left ventricle were more opacified, but the veins were less opacified compared with the ordinary protocol, resulting in clear delineation of the thoracic aorta and the major branches without artifacts. CONCLUSIONS: A new acquisition protocol is described in which the thoracic aorta and the major branches can be evaluated without artifact due to high CT values in the veins. Faster, more informative CT scans can be performed using diluted contrast.

Contrast Media↗
PubMed2007

Tumor and normal tissue motion in the thorax during respiration: Analysis of volumetric and positional variations using 4D CT.

PURPOSE: To investigate temporospatial variations of tumor and normal tissue during respiration in lung cancer patients. METHODS AND MATERIALS: In 14 patients, gross tumor volume (GTV) and normal tissue structures were manually contoured on four-dimensional computed tomography (4D-CT) scans. Structures were evaluated for volume changes, centroid (center of mass) motion, and phase dependence of variations relative to inspiration. Only volumetrically complete structures were used for analysis (lung in 2, heart in 8, all other structures in >10 patients). RESULTS: During respiration, the magnitude of contoured volumes varied up to 62.5% for GTVs, 25.5% for lungs, and 12.6% for hearts. The range of maximum three-dimensional centroid movement for individual patients was 1.3-24.0 mm for GTV, 2.4-7.9 mm for heart, 5.2-12.0 mm for lungs, 0.3-5.5 mm for skin markers, 2.9-10.0 mm for trachea, and 6.6-21.7 mm for diaphragm. During respiration, the centroid positions of normal structures varied relative to the centroid position of the respective GTV by 1.5-8.1 mm for heart, 2.9-9.3 mm for lungs, 1.2-9.2 mm for skin markers, 0.9-7.1 mm for trachea, and 2.7-16.4 mm for diaphragm. CONCLUSION: Using 4D-CT, volumetric changes, positional alterations as well as changes in the position of contoured structures relative to the GTV were observed with large variations between individual patients. Although the interpretation of 4D-CT data has considerable uncertainty because of 4D-CT artifacts, observer variations, and the limited acquisition time, the findings might have a significant impact on treatment planning.

Diaphragm↗
PubMed2005

Imaging of metastatic disease to the thorax.

Tumor imaging is at the forefront of radiology technology and is the focus of most cutting edge research. Radiologic applications for imaging of metastases are applied to initial staging, restaging after neoadjuvant therapy, and follow-up surveillance after therapy for tumor recurrence. CT is the routine imaging choice in staging, restaging, and detection of recurrence. Fluorodeoxyglucose-positron emission tomography has evolved as an imaging modality that further improves staging as well as the detection of recurrent and metastatic disease.

Diagnostic Imaging↗
PubMed2005

Target definition in the thorax and central nervous system.

It is the aim of conformal radiotherapy to restrict the high-dose region to the target volume as much as possible, thereby sparing the neighboring healthy tissues. However, to increase the therapeutic range, smaller margins tend to be used. This reduction of safety margins enhances the risk of unsuitable dosage because of mistaken target definition. Central nervous system (CNS) and lung cancers constitute sites that are particularly difficult to irradiate combining a large number of conceptual difficulties, allowing them to be considered as 2 particularly interesting study models. Imaging occupies an increasingly important place in these 2 types of tumors, especially with the development of new radiotherapy techniques. CNS and lung cancers represent an example of clinicopathological correlations. More specifically, CNS cancers represent an excellent model for estimation of new 3-dimensional navigational systems. For lung cancer, there is a combination of ballistic difficulties because of respiratory motion, the number and low tolerance of neighboring organs, and dosimetric difficulties because of the presence of inhomogeneities. This article reviews the main currently accepted criteria of choice justifying the size of gross tumor volume and clinical target volume margins for lung and CNS cancers.

Central Nervous System Neoplasms↗
PubMed1989

Thoracoscopy. An endoscopic look into the thorax.

A renewed interest in thoracoscopy as a diagnostic and therapeutic procedure has emerged during this decade. With thoracoscopy, the surgeon can obtain a reliable diagnosis with minimal surgical intervention. In addition, the thoracoscope can provide a route for laser treatments, the delivery of sclerosis medications, or debridement of empyema in cavities. The full potential of thoracoscopy has yet to be realized.

Humans↗
PubMed2001

Vacuum-assisted closure in the treatment of a 9-year-old child with severe and multiple dog bite injuries of the thorax.

The vacuum-assisted closure (VAC; KCI International, San Antonio, TX) device is a negative pressure dressing, which we have used in the treatment of wounds with devitalized or infected tissues. Although introduced in plastic and reconstructive surgery, its use has extended to orthopedic and cardiothoracic surgical practice in the treatment of infected joint replacement and sternal wound infections, respectively. Although the VAC is becoming more widely used in surgical practice, only a small number of case reports exist in addition to the original case series by Argenta and Morykwas in 1997. Previously, the device was described in treating single wounds in adult patients. We report a case where it was successfully used to treat multiple dog bite injuries in a 9-year-old child.

Animals↗
PubMed1987

Impalement injuries to the thorax as a result of motor vehicle accidents.

We report three cases of thoracic impalement by large-diameter steel pipes as a result of motor vehicle accidents. The steel pipes were removed in all patients in the operating room under general anesthesia and controlled circumstances. Despite the dramatic nature and presentation of these injuries, all 3 patients had nonlethal injuries and have recuperated without sequelae. Orderly care with standard surgical procedures is required and will give good results.

Accidents, Traffic↗
PubMed1999

Early Islamic physicians and thorax.

Modern anatomic knowledge has developed throughout centuries with transfer of knowledge from generations to generations. Ibn-i Sina (980-1037), Razi (850-923), Davud El-Antaki (?-1008), Ali ibn Abbas (?-982), Ahmed bin Mansur (14th century), Semseddin-i Itaki (1570-1640), and Ibn-i Nafis (1210-1288) were Islamic physicians who all contributed to the understanding of anatomy. They benefited from Greek and Roman pioneers, as well as from each other. To show the situation of thoracic anatomy in early Islamic physicians, we analyzed two original manuscripts in the Süleymaniye Library and some contemporary texts. There were original drawings of the trachea, lung, and vascular system in Semseddin-i Itaki's and Ahmed bin Mansur's anatomy texts. Ibn-i Nafis's writings revealed that he was the first person to describe the pulmonary circulation. Also Ali ibn Abbas wrote that the pulmonary artery wall had two layers and these layers may have a role in constriction and relaxation of this vessel. He also stated that pulmonary veins branched together with the bronchial tree. Ahmed bin Mansur, Ali ibn Abbas, and Ibn-i Nafis each wrote that the heart has two cavities. They also added that the wall of the septum is very thick and there are no passages in between. These show that Islamic physicians had important contributions to thoracic anatomy and physiology. European physicians benefited from these contributions till the end of the 16th century.

Anatomy↗
PubMed1999

Imaging of the thorax in the management of germ cell testicular tumours.

AIM: To evaluate role of chest computed tomography (CTC) and chest radiography (CXR) in management of patients with testicular germ cell tumours (GCT). PATIENTS AND METHODS: An analysis was undertaken of staging and re-assessment CTC and CXR examinations performed on patients with GCT over a 4.5-year period. Data were obtained on clinical presentation, tumour histology, tumour marker levels and clinical course. Consensus review interpretation was combined with these data to obtain a 'standard of reference'. Sensitivity, specificity and predictive values were derived by comparison of original imaging reports to 'standard of reference'. RESULTS: Six hundred and twenty-three CTC examinations on 207 patients with GCT were included. Intrathoracic metastases were identified in 1% of seminoma patients compared with 20% of non-seminoma (NSGCT) patients. CTC was more accurate than CXR in the detection of intrathoracic metastases at 0.97, 0.96-0.98 (95% CI) compared with 0.91, 0.89-0.93. The agreement between imaging techniques and the standard of reference (determined by Kappa statistic) was respectively 0.96 for CTC and 0.65 for CXR. In GCT patients undergoing re-assessment with both CXR and CTC, CXR never detected unknown intrathoracic metastatic disease. Abdominopelvic lymphadenopathy was associated with intrathoracic metastases (P < 0.001), however re-assessment CTC did identify intrathoracic metastases in 27 cases without concurrent abdominopelvic disease. CXR was negative in 19 of these. CONCLUSION: Routine interval CXRs are unnecessary in NSGCT patients undergoing regular re-assessment CTC due to the low additional yield and limited effect on management. Re-assessment should still include CTC. In low risk, pure seminoma patients (abdominal CT and marker negative) re-assessment CTC can be safely avoided. Baseline CTC is advocated with CXR alone for re-assessment.

False Negative Reactions↗