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At least 1,189 records · Page 66Linked to original sources
PubMed1994

[Semi-supine cardiopulmonary stress test in middle-aged probands with healthy hearts].

Normal values for cardiopulmonary bicycle exercise testing in semisupine position using a ramping protocol in a middle-aged group of untrained men and women are presented. We exercised 23 men and 16 women aged from 33 to 66 years without evidence of cardiopulmonary or cardiovascular disease and normal findings during complete heart catheterization. Clinical findings, x-ray, resting and exercise ECG, and laboratory findings were normal. Exercise testing was performed using a ramping protocol with a work rate increase of 20 watts/min. Respiratory gas analysis (breath-to-breath method) was performed and oxygen uptake (VO2), carbon-dioxide production (VCO2), and minute ventilation (VE) were determined at maximal work load and at the ventilatory anaerobic threshold. Work rate increase and heart rate were continuously monitored. From these data oxygen pulse, the respiratory quotient (RQ), and the ventilatory equivalents VE/VO2 and VE/VCO2 were derived. Furthermore, the VO2 to work rate ratio, and the VO2 to heart rate ratio were analyzed. Maximal VO2 was within the 95% confidence interval of predicted VO2max. The anaerobic threshold (V-slope method) was 60% of VO2 max at the RQ of 0.81 for men and 66% of VO2max at the RQ of 0.84 for women. The O2 pulse was 100% of the age predicted value. The VO2 to work rate ratio was 10.7 +/- 1.4 for men and 9.7 +/- 1.2 ml/watts/min for women (p < 0.05). The slope of heart rate to VO2 from rest to peak exercise as a measure of chronotropic competence was nonlinear in 59% of the subjects.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1996

[Functional therapy using a laced ankle brace in supination trauma of the ankle joint with lesions of the capsule-ligament apparatus].

Based on the results of comparable studies, patients of the Kantonsspital Liestal, who had sustained injuries of the lateral capsulo-ligamentous structures of the ankle are treated with early functional therapy. Osseous lesions are excluded prior for treatment. Since 1990 a special ankle brace with laces is used. A standardised questionnaire was developed for follow-up. Subjects of interest were: the patients individual experience regarding treatment method and the patients subjective feelings regarding stability, remaining symptoms and limitations in daily activity. 89 questionnaires were returned. 91% rated the treatment as excellent or good. 15% reported a chronic instability. Only 1 patient underwent secondary reconstruction of the lateral ankle ligaments.

Adolescent↗
PubMed1988

Comparison of the acute haemodynamic effects of bopindolol and propranolol at rest and during supine exercise.

The acute cardiovascular effects of two beta-adrenoceptor blocking agents, bopindolol and propranolol, were compared in a randomized study in 16 male patients with coronary heart disease. All patients had had an uncomplicated acute myocardial infarction at least 8 weeks earlier. The two drugs reduced the arterial blood pressure to the same extent, both at rest and during exercise. As heart rate and stroke volume were also decreased, cardiac output was reduced, whereas systemic vascular resistance was increased at rest and during exercise. Left ventricular filling pressure was increased. No statistically significant differences in these variables were seen between the two groups.

Adrenergic beta-Antagonists↗
PubMedDate not supplied

Atrial natriuretic peptide decreases hepatic and cardiac blood content, but increases intestinal blood content in supine humans.

The authors evaluated in humans whether atrial natriuretic peptide (ANP) alters the regional distribution of blood in capacitance vessels. Eight healthy male volunteers (mean age: 30 years, range: 24-39) were studied twice. On different days and in a randomized, double blind fashion they received either alpha h-ANP (99-126), 25 micrograms intravenously followed by infusion of 0.1 microgram kg-1 min-1, or vehicle. Changes of regional blood content in heart, liver, and intestine were evaluated at 3-min intervals using autologous radioactively (99mTc) labeled red cells. Calf circumference (strain gauge), central venous pressure, and heart rate were recorded continuously while arterial pressure (oscillometry), hematocrit, ANP and cGMP plasma concentrations were determined intermittently. Exogenous ANP increased plasma concentrations of ANP (49 pg ml-1 +/- 8 SE to 614 +/- 190) and cGMP (1.7 pmol ml-1 +/- 0.2 to 30.8 +/- 4.4). This elicited significant and profound decreases in liver (-11%) and cardiac (-10%) radioactivity, contrasted by a smaller but significant increase (+4%) of intestinal radioactivity. These changes became gradually apparent about 15 min during ANP administration and reached their nadir at the end of the infusion period. Central venous pressure significantly decreased by 3.4 cm H2O and calf volume by 0.3 ml/100 ml while hematocrit increased by 2.6%. All changes were at least partly reversed when ANP administration ceased. Of note, two subjects developed a near syncope with abrupt bradycardia and arterial hypotension following an initial gradual decrease in cardiac counts and central venous pressure. We conclude that in humans ANP markedly alters the regional blood distribution in the capacitance vasculature as blood content decreased profoundly in both heart and liver, but increased in the intestine, albeit to a lesser extent. Accordingly, a redistribution of blood away from the heart represents another unique mechanism by which ANP can exert its cardiovascular actions.

Adult↗
PubMed1995

Cardiac output variations in supine resting subjects during head-out cold water immersion.

Five men, aged 31.2 years (SD 2.3), under semi-nude conditions and resting in a dorsal reclining position, were exposed to thermoneutral air for 30 min, followed immediately by a cold water (15 degrees C) immersion for 60 min. Cardiac output was measured using a dual-beam Doppler flow meter. During immersion in cold water, cardiac frequency (fc) showed an initial bradycardia. The lowest values were reached at about 10 min after immersion, 58.3 (SD 2.5) to 48.3 (SD 7.8) beats min-1 (P < 0.05). By the 20th min of exposure, fc had gradually risen to 70.0 beats min-1 (SD 6.6, P < 0.05). This change could be due to the inhibition of the initial vagal reflex by increased catecholamine concentration. Stroke volume (Vs) was significantly increased (P < 0.05) during the whole cold immersion period. Cardiac output, increased from 3.57 (SD 0.50) to 6.26 (SD 1.33) l min-1 (P < 0.05) and its change with time was a function of both Vs and fc. On the other hand, systolic flow acceleration was unchanged during the period of immersion. The changes in the respiratory variables (ventilation, oxygen uptake, carbon dioxide output and respiratory exchange ratio) during immersion showed an initial hyperventilation followed, as immersion proceeded, by a slower metabolic increase due to shivering.

Adult↗