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PubMed1990

Cerebral abnormalities in Wilson's disease as evaluated by ultra-low-field magnetic resonance imaging and computerized image processing.

The cerebral involvement of a 13-yr-old boy with Wilson's disease was serially evaluated during the first 18 mo of D-penicillamine treatment. An ultra-low-field magnetic resonance imaging (ULF MRI) system, operating at 0.02 T, with computerized image processing was used. The half-yr period prior to the clinical diagnosis was set, the patient had showed poor school performance, emotional lability, deteriorating handwriting, progressively slow, gross, and fine motor functions, and a fixed rigid smile. No overt signs of liver disease were found. With D-penicillamine treatment (1-1.5 g/d) a continuous improvement was seen. The pretreatment MRI investigation showed pronounced pathological transformation in the basal ganglia. However, changes were seen also in most other parts of the brain indicating diffuse involvement. During treatment the computerized MR images became gradually more normal. The current magnetic resonance imaging system with computerized image processing is a sensitive and simple method for evaluation of subtle parenchymal changes of the brain.

Adolescent↗
PubMed1991

Development of a behavioral measure of mouth pain, nausea, and wellness for patients receiving radiation and chemotherapy.

Toxicities from the chemotherapy and irradiation preparative regimen for bone marrow transplantation include nausea, emesis, and oral pain. Behavioral measures were developed as alternatives to paper and pencil measures of these symptoms because patients are sometimes too ill, unavailable, or unwilling to complete self-report scales. Behavioral observations also provide supplements to self-report for these multidimensional symptoms. For 24 days during the acute phase of transplantation, nurses rated the behavior of adult patients on: (a) oral pain (for example, requests pain medication or refuses mouth examination), (b) nausea (for instance, retches or keeps emesis basin near), (c) wellness (for example, talks voluntarily or smiles), (d) verbal complaints of pain, and (e) verbal complaints of nausea. The behavioral measures demonstrated good interday reliability (range, 0.70-0.86) and construct validity as demonstrated by a multitrait, multimethod correlation matrix.

Adult↗
PubMed1995

Hemifacial spasm: successful treatment with felbamate.

Medical treatment of hemifacial spasm has generally been ineffectual. This report describes a 36-year-old man with a 7-year history of right hemifacial spasm who responded to felbamate (Felbatol) at doses of 1800-2800 mg per day. During treatment, he was able to achieve complete control of all spontaneous facial muscle spasms at rest. Activated hemifacial spasms, initiated by chewing, speaking, smiling, or grimacing were reduced in frequency and intensity of contraction by 40%-50%. Spontaneous worsening of the hemifacial spasms occurred at a dose of 3600 mg/day. Control of the hemifacial spasm was regained at a lower dose. This is the first reported use of felbamate for the control of hemifacial spasm. Microvascular decompression of the facial nerve has been the only known effective treatment for this condition. Successful felbamate therapy would provide an alternative to those patients for whom surgery is not a treatment option.

Adult↗
PubMed1994

Outcome of severe anoxic/ischemic brain injury in children.

The outcome of 25 children who had anoxic or ischemic brain injuries at 2 months to 14 years of age is reported. Follow-up was from 1 to 14 years after injury; causes were near-drowning, 11; suffocation, 7; cardiac arrest, 3; electrocution with cardiac arrest, 2; strangulation, 1; aborted sudden infant death syndrome, 1. All patients were unconscious for at least 24 hours. Of 11 remaining in vegetative states, 5 died. Seven children regained some language skills and are in special education or self-contained classrooms. Seven are profoundly impaired and show only a social smile. Cognitive and motor outcomes were correlated with the severity of injury as indicated by the duration of unconsciousness. All children who regained language skills or the ability to walk were unconscious less than 60 days. Dystonic rigidity was observed in all children who were nonambulatory. Outcome was also correlated with the cause of injury; mortality, cognitive outcome, feeding outcome, and duration of unconsciousness were all worse in children with near-drowning.

Adolescent↗
PubMed1995

Reduced emotional response of schizophrenic patients in remission during social interaction.

Inappropriate emotional response during social interaction is a prominent feature of schizophrenia during the acute stage of illness. This study evaluates the course of reduced facial activity in schizophrenic patients in remission and compares it with healthy controls. The experimental conditions included watching two films, one inducing happy and the other sad emotional states. Each is followed by an interview eliciting happy and sad feelings. The facial actions were recorded (1) by a computer-based analysis of recordings of the skin movement and (2) by electromyography of the corrugator and zygomaticus muscles. Twenty schizophrenic patients in remission and 20 normal controls participated in the study. In contrast to previously studied acute patients, there was no overall reduction of facial expression in the upper face of schizophrenic patients in remission. Patients showed fewer movements (automatic analysis) of the lower face during the happy interview and more movements during the sad interview compared with controls. Furthermore, schizophrenic patients showed reduced zygomaticus activity (EMG) during both the happy film and the interview, suggesting a reduced ability of schizophrenic patients to express happy facial expressions, such as smiling, in the lower face. This may indicate a reduced variability in emotional response in schizophrenia.

Adult↗
PubMed1996

Discordance between patient self-reported visual analog scale pain scores and observed pain-related behavior in older children after surgery.

STUDY OBJECTIVE: To assess the correlation in an older pediatric population between patient self-reported visual analog scale (VAS) pain scores and observational pain-related behavior scores. DESIGN: Prospective, comparative study. SETTING: Inpatient surgical units of a free-standing children's hospital. PATIENTS: 30 ASA physical status I and II outpatients, 8 to 16 years of age, undergoing a variety of orthopedic, plastic, urologic, and general surgical procedures. INTERVENTIONS: Each patient underwent a single assessment of pain intensity on the first postoperative day. MEASUREMENTS AND MAIN RESULTS: Three health care providers (a clinical nurse specialist, a registered nurse with extensive pediatric experience, and a child life specialist) simultaneously generated an independent pain-related behavioral score (range of 0 = no pain to 100 = worst pain possible) based on their subjective perceptions of the patient's observed facial expression, activity level, and breathing pattern. The patient was then asked to provide a self-reported VAS pain score (range of 0 = "no pain" with a smiling face, to 100 = "worst pain ever" with a frowning face). A single set of such concurrent pain scores was obtained once from each study patient. The pain-related behavior scores displayed a satisfactory interrater reliability, with an observed interclass correlation coefficient (Cohen's kappa value) of 0.83. When compared with a patient's self-reported VAS score, the three pain related behavioral scores generated by each health care provider for a given patient exhibited both variable and minimal correlation. CONCLUSIONS: A tenuous relationship may exist between on older child's own perception of pain intensity and his or her behavioral expression of that pain as interpreted by a health care provider.

Activities of Daily Living↗
PubMed2005

The effects of computer-aided anteroposterior maxillary incisor movement on ratings of facial attractiveness.

BACKGROUND: Before planning orthodontic treatment, it is necessary to understand societal preferences for facial esthetics. The anteroposterior (AP) position of the maxillary incisors affects the appearance of the soft tissue profile and can be manipulated by orthodontic techniques. To improve the ability to predict the most suitable maxillary incisor position, numerous cephalometric and profilometric measurements have been suggested. Among them are the Six Elements to Orofacial Harmony proposed by L. F. Andrews, whereby forehead angulation is used to dictate maxillary incisor sagittal position. Our aim was to evaluate differences in preference for the AP position of the maxillary incisor between orthodontic and lay panels. METHODS: A smiling profile photograph was taken of a female subject who best fit the chosen soft tissue normative values and whose maxillary incisors were in an Element II position. The photograph was manipulated to simulate maxillary protrusion and retrusion at 1-mm increments to a maximum of +/-4 mm. Panels of orthodontists and nonorthodontists scored the attractiveness of the photographic variations according to a 100-mm visual analogue scale. RESULTS: The 4-mm retrusive photograph was significantly less desirable than all others, which suggests that, from an esthetic standpoint, it is preferable to either leave a normally protrusive maxillary dentition where it is or advance rather than retract the maxillary anterior teeth. Orthodontic training did not significantly affect the magnitude of the ratings or pattern of preference in our sample. CONCLUSIONS: Andrews' Element II provides an additional useful method to evaluate attractiveness relative to the maxillary incisor position.

Adult↗
PubMed2004

[Caustic burns. Clinical study of 24 patients with sulfuric acid burns in Cambodia].

Over a period of 12 years, 24 burns have been treated by a Cambodgian and French team (Doctors of the World). This experience has revealed some characteristics of this population: (1) a majority of young women (2/3), (2) victims of assault (20 cases). These notions are found in the medical literature particularly South East Asia. All cases are of a third degree. Every surgeon, every anesthetist should apply emergency measures which are recalled here. The aims is to close all the burns surface through a skin graft within a month. However the patients are treated 6 months to 2 years after the burn and have, at this stage, terrible sequella (22 patients). Treating them requires the coordinated efforts of a multidisciplinary specialized team. The challenge is to save the eyes, the mouth, the nose and give back a "human" face to these young burns who are often rejected because of their handicap. Enabling them to smile again is a strong commitment from the surgeon and from the patient who has to undergo multiple operations and a long treatment over the years.

Adolescent↗
PubMed2006

Physiological and cognitive effects of expressive dissonance.

Emotional well-being depends in part on affect modulation. The present study extends research on emotion regulation by assessing the physiological and cognitive effects of a novel response-focused regulation strategy, termed 'expressive dissonance.' Expressive dissonance refers to the incongruence between an emotional state (e.g., sadness) and a behavioral expression (e.g., a smile). Fifty-five participants watched a series of sad film clips in which they were asked to either naturally watch or express the opposite of what they were feeling. Results suggest that persons using the expressive dissonant strategies evidenced greater sympathetic arousal and performed worse on subsequent memory tasks than persons in the natural-watch conditions.

Adaptation, Psychological↗
PubMed2005

Physiological shift of facial skin and its influence on the change in precision of computer-assisted surgery.

Methods of recording landmarks on the facial skin without the use of markers have become increasingly accepted in image-guided surgery. However, position or muscular activity may change the skin's geometry and generate a lack of agreement between the facial contours recorded before and those recorded during the operation. In the present study, we measured this physiological shift of facial skin and evaluated its influence on the accuracy of stereotactic recording. We made laser-scans of the skin of 20 conscious patients while they were sitting and lying, both at rest and when smiling. The laser-scans were referenced to the corresponding computed tomographic dataset, and the accuracy of the recording was calculated. Gravitational or muscular shifts of the skin reduced the mean (S.D.) accuracy of recording to 1.7 (0.3)mm. The loss of accuracy was significantly correlated with the dynamic and gravitational wrinkling of the facial skin and with the body mass index of each patient.

Adolescent↗
PubMed2005

Electrical brain responses evoked by human faces in acute psychosis.

Patients with schizophrenia are known to have behavioral deficits in recognizing faces and facial expressions. However, the ability to process simple visual stimuli appears to be intact in first-episode psychosis. The aim of this study was to examine complex visual processing, especially the event-related potentials (ERPs) elicited by human faces, in early psychosis. Never-medicated patients in acute psychosis (n=18) were compared with healthy controls (n=19). Photographs of human faces were presented in a classic oddball paradigm requiring a motor response to a smiling face. Cerebral sources of ERPs were analyzed of the averaged responses, using minimum norm estimates, and dipole models. Face-sensitive response at 145 ms after the face stimuli was of significantly higher amplitude in our never-medicated patients, and the activity distribution between the groups was clearly different. At the early phase of a psychotic illness, these alterations in face-related neuronal network processes represent perceptual disturbance in psychosis, possibly including state and trait, as well as potential physiological compensatory features.

Acute Disease↗
PubMed2026

Artificial Intelligence-Driven Multi-Omics Analysis Reveals Hydroxytyrosol Targeting of the TXNIP-NLRP3 Inflammasome Axis in Traumatic Brain Injury.

Traumatic brain injury (TBI) induces secondary neuroinflammation driven by oxidative stress, inflammasome activation, and immune remodeling, yet specific mechanism-guided pharmacological interventions remain limited. This study established an artificial intelligence (AI)-integrated network pharmacology and multi-omics framework to evaluate whether hydroxytyrosol (HT), an olive-derived natural polyphenol, may regulate TBI-related neuroinflammatory targets centered on the TXNIP/NLRP3 inflammasome axis. Starting from the SMILES structure of HT, potential targets were predicted using PharmMapper, SwissTargetPrediction, and the Similarity Ensemble Approach and were standardized to UniProt identifiers. TBI-associated genes were integrated from GeneCards, DisGeNET, OMIM, and the Therapeutic Target Database. The overlapping target set was analyzed using STRING-based protein-protein interaction (PPI) networks, MCODE, CytoHubba, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment. Public GEO transcriptomic datasets (GSE123831 and GSE104687) were used for cross-platform expression validation, differential expression analysis, and exploratory CIBERSORT-based immune infiltration estimation. Random forest (RF), multilayer perceptron (MLP), graph convolutional network (GCN), graph attention network (GAT), SHAP/LIME explainability analysis, LASSO inflammatory-risk scoring, and two-sample Mendelian randomization (MR) were further applied for target prioritization, immune phenotype mapping, and genetic association analysis. Seventy-three overlapping HT-TBI targets were identified. PPI and topology analyses prioritized TXNIP, NLRP3, CASP1, MAPK1, and TP53 as key hubs enriched in inflammasome activation, oxidative stress, apoptosis, and NOD-like receptor signaling. TXNIP, NLRP3, and CASP1 were consistently upregulated in both TBI transcriptomic datasets. LM22-based immune deconvolution suggested increased pro-inflammatory immune signatures and a positive TXNIP-M1 macrophage association (r&#x202f;=&#x202f;0.63, p < 0.001), which should be interpreted as a transcriptome-derived hypothesis rather than validated murine immune-cell proportions. AI-based models consistently ranked TXNIP/NLRP3 as high-contribution features under internal validation, and removal of these targets reduced model performance. A five-gene inflammatory score achieved an internally evaluated AUC of 0.87, while two-sample MR supported positive genetic associations involving TXNIP expression, TBI risk, NLRP3 and IL-1&#x3b2; expression. Collectively, these findings prioritize the TXNIP/NLRP3/CASP1 module as a computationally supported candidate mechanism through which HT may influence oxidative stress-inflammasome-immune coupling in TBI. This study provides an interpretable drug-target-pathway-phenotype framework and identifies TXNIP, NLRP3, and CASP1 as priority nodes for future experimental validation.

Artificial Intelligence↗
PubMed2024

Biochemical insights into the biodegradation mechanism of typical sulfonylureas herbicides and association with active enzymes and physiological response of fungal microbes: A multi-omics approach.

The extensive use of sulfonylurea herbicides has raised major concerns regarding their long-term soil residues and agroecological risks despite their role in agricultural protection. Microbial degradation is an important approach to remove sulfonylureas, whereas understanding the associated biodegradation mechanisms, enzymes, and physiological responses remains incomplete. Based on the rapid biodegradation of nicosulfuron by typical fungal isolate Talaromyces flavus LZM1, the dependency on cellular accumulation and environmental conditions, e.g. pH and nutrient supplies, was shown in the study. The biodegradation of nicosulfuron occurred intracellularly and followed the cascade of reactions including hydrolysis, Smile contraction rearrangement, hydroxylation, and opening of the pyrimidine ring. Besides 2-amino-4,6-dimethoxypyrimidine (ADMP) and 2-aminosulfonyl-N,N-dimethylnicotinamide (ASDM), numerous products and intermediates were newly identified and the structural forms of methoxypyrimidine and sulfonylurea bridge contraction rearrangement are predicted to be more toxic than nicosulfuron. The biodegradation should be enzymatically regulated by glycosylphosphatidylinositol transaminase (GPI-T) and P450s, which were manifested with the significant upregulation in proteomics. It is the first time that the hydrolysis of nicosulfuron into ADMP and ASDM have been associated with GPI-T. The integrated pathways of biodegradation were further elucidated through the involvement of various active enzymes. Except for the enzymatic catalysis, the physiological responses verified by metabolo-proteomics were critical not only to regulate material synthesis, uptake, utilization, and energy transfer but also to maintain antioxidant homeostasis, biodegradability, and tolerance of nicosulfuron by the differentially expressed metabolites, such as acetolactate synthase and 3-isopropylmalate dehydratase. The obtained results would help understand the biodegradation mechanism of sulfonylurea from chemicobiology and enzymology and promote the use of fungal biodegradation in pollution rehabilitation.

Herbicides↗
PubMedDate not supplied

Behavioral manifestations of autism in the first year of life.

In the interest of more systematically documenting the early signs of autism, and of testing specific hypotheses regarding their underlying neurodevelopmental substrates, we have initiated a longitudinal study of high-risk infants, all of whom have an older sibling diagnosed with an autistic spectrum disorder. Our sample currently includes 150 infant siblings, including 65 who have been followed to age 24 months, who are the focus of this paper. We have also followed a comparison group of low-risk infants. Our measures include a novel observational scale (the first, to our knowledge, that is designed to assess autism-specific behavior in infants), a computerized visual orienting task, and standardized measures of temperament, cognitive and language development. Our preliminary results indicate that by 12 months of age, siblings who are later diagnosed with autism may be distinguished from other siblings and low-risk controls on the basis of: (1) several specific behavioral markers, including atypicalities in eye contact, visual tracking, disengagement of visual attention, orienting to name, imitation, social smiling, reactivity, social interest and affect, and sensory-oriented behaviors; (2) prolonged latency to disengage visual attention; (3) a characteristic pattern of early temperament, with marked passivity and decreased activity level at 6 months, followed by extreme distress reactions, a tendency to fixate on particular objects in the environment, and decreased expression of positive affect by 12 months; and (4) delayed expressive and receptive language. We discuss these findings in the context of various neural networks thought to underlie neurodevelopmental abnormalities in autism, including poor visual orienting. Over time, as we are able to prospectively study larger numbers and to examine interrelationships among both early-developing behaviors and biological indices of interest, we hope this work will advance current understanding of the neurodevelopmental origins of autism.

Age Factors↗
PubMed2005

Newborns of depressed mothers who received moderate versus light pressure massage during pregnancy.

Sixty-four neonates (M age=6.8 days) of depressed mothers who received moderate pressure massage versus light pressure massage therapy during pregnancy (month 5 through month 8) were compared on their behaviors during 15-min observations and on their performance on the Brazelton Neonatal Behavior Assessment Scale. The group of neonates whose mothers received moderate pressure massage spent a greater percent of the observation time smiling and vocalizing, and they received better scores on the orientation, motor, excitability, and depression clusters of the Brazelton scale.

Depression↗
PubMed2006

Intention or expression? Four-month-olds' reactions to a sudden still-face.

We addressed whether 4-month-old infants are primarily influenced by the expression or intention underlying a sudden still-face response by an adult social partner. Sixteen dyads of 4-month-old infants interacted with an adult who posed a still-face directed at one of the two infants. Infants' gazing and smiling responses confirm that they are primarily influenced by the emotional and contingency loss rather than the intention underlying the adult's still-face.

Adult↗
PubMed2006

Continuity of temperament from infancy to middle childhood.

Continuity of temperament from 6 months (the IBQ) to 5.5 years (the CBQ) was explored in Finnish children (n=231) within the theoretical framework deviced by Rothbart. Activity level, smiling and laughter, distress to limitations and fear showed significant differential homotypic and heterotypic continuity, while soothability and duration of orienting showed significant differential heterotypic continuity. On the level of latent superconstructs, infant positive and negative affectivity accounted for 4.6, 22.3, and 6.0% of the variance in childhood extraversion, effortful control and negative affectivity, respectively. Infant and childhood temperament clustered into profile types named "resilient", "undercontrolled", and "overcontrolled" mirroring ipsative continuity. These findings give empirical credence to Rothbart's theory by replicating and extending previous findings in significant ways.

Child, Preschool↗
PubMed2005

Could personality traits modify the response to uncorrected high hyperopia?

PURPOSE: We aimed to measure temperament and investigate personality in children with high hyperopia considering that these could modify the individual response to uncorrected high hyperopia. METHODS: Fifteen children (age range, 5 to 12 years) with orthotropia and ametropic amblyopia in the presence of uncorrected high hyperopia were identified (group 1). Among the children with refractive accommodative esotropia, 15 children (age range, 5 to 12 years) were enrolled to form group 2. We measured the temperament by using the Children's Behavior Questionnaire (CBQ) Short Form. The Children's Apperception Test (CAT-H) was also administered to all subjects. RESULTS: Regarding the temperament scales measured by CBQ, themes of discomfort, fear, and shyness were more dominant in group 2; high-intensity pleasure and smiling-laughter were dominant in group 1. However the difference was statistically significant only for fear scale (P = 0.045). CAT-H results revealed that aggression toward the parents was the most commonly encountered behavioral pattern in both groups. The children in group 1 were more likely to express passive-aggressive behavioral pattern. Obstinacy and anal period characteristics dominate in the children in group 2. Themes of narcissistic injury was more frequently expressed by these children. CONCLUSION: The temperament scales and personality traits could play a role in the modification of the individual response to uncorrected high hyperopia. This finding deserves more research in a larger study group.

Child↗