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PubMed2005

Intraoperative visible bubbling of air may be the first sign of venous air embolism during posterior surgery for scoliosis.

STUDY DESIGN: Case report of two children sustaining venous air embolism (VAE) during posterior surgery for scoliosis. OBJECTIVES: To report 2 cases where visible bubbling at the operative site was the first clinical indication of VAE-induced cardiovascular collapse and to raise the level of consciousness that VAE in the prone position can occur, often with serious consequences. SUMMARY OF BACKGROUND DATA: Twenty-two cases of VAE during surgery for scoliosis in the prone position have been reported. Ten were fatal and ten were in children. Visible bubbling at the operative site was noted in two published cases. METHODS: Retrospective study of 2 cases of VAE at one institution. Clinical, anesthetic, and radiographic features are presented. Details of previously published cases are reviewed and discussed. RESULTS: Both patients were girls with adolescent scoliosis who underwent prone positioned posterior spinal fusion with instrumentation. Visible bubbling of air at the thoracic aspect of the surgical site was noted near the completion of instrumentation and was the first indication of VAE. In both cases, this was clinically recognized and promptly treated. One patient survived normally and the other died. CONCLUSIONS: Visible air bubbling at the operative site may herald the onset of massive VAE during multilevel posterior spinal fusion and instrumentation. A prospective multicenter study using precordial Doppler, central venous catheter, and end-tidal CO2 is recommended to determine the true incidence of VAE in spinal deformity surgery and to evaluate monitoring and treatment methods.

Adolescent↗
PubMed2005

Reliability and validity of adapted Turkish Version of Scoliosis Research Society-22 (SRS-22) questionnaire.

STUDY DESIGN: Outcome study to determine the internal consistency, and validity of adapted Turkish version of Scoliosis Research Society-22 (SRS-22) Instrument. OBJECTIVES: To evaluate the validity and reliability of adapted Turkish Version of SRS-22 questionnaire. SUMMARY OF BACKGROUND DATA: The SRS-22 questionnaire is a widely accepted questionnaire to assess the health-related quality of life for scoliotic patients in the United States. However, its adaptation in languages other than the source language is necessary for its multinational use. METHODS: Translation/retranslation of the English version of the SRS-22 was done, and all steps for cross-cultural adaptation process were performed properly by an expert committee. Later, SRS-22 questionnaires and previously validated Short Form-36 (SF-36) outcome instruments were mailed to 82 patients who had been surgically treated for idiopathic scoliosis. All patients had a minimum of 2 years follow-up. Fifty-four patients (66%) responded to the first set of questionnaires. Forty-seven of the first time respondents returned their second survey. The average age of the 47 patients (12 male, 35 female) was 19.8 years (range, 14-31 years). The two measures of reliability as internal consistency and reproducibility were determined by Cronbach alpha statistics and intraclass correlation coefficient, respectively. Concurrent validity was measured by comparing with an already validated questionnaire (SF-36). Measurement was made using the Pearson correlation coefficient (r). RESULTS: The study demonstrated satisfactory internal consistency with high Cronbach alpha values for the four of the corresponding domains (pain, 0.72; self-image, 0.80; mental health, 0.72; and satisfaction, 0.83). However, the Cronbach alpha value for function/activity domain (0.48) was considerably lower than the original questionnaire. The intraclass correlation coefficient for the same domains was 0.80, 0.82, 0.78, 0.81, and 0.76, respectively, demonstrating a satisfactory test/retest reproducibility. Considering concurrent validity, two domains had excellent correlation (r = 0.75-1), while 9 had good correlation (r = 0.50 to 0.75), and 6 had moderate correlation (r =0.25-0.50). Based on these results, question 18 in the function/activity domain with lower Cronbach alpha value was revised while question 15 was excluded. The revised SRS-22 was given to 30 adolescent idiopathic scoliosis patients not included in the index study. The revision could improve the Cronbach alpha value for function/activity domain from 0.48 to 0.81. CONCLUSION: This study demonstrated that, if measures are to be used across cultures, the items must not only be translated well linguistically but also must be culturally adapted to maintain the content validity of the instrument at a conceptual level across different cultures. This may necessitate several validation studies to ensure and improve consistency in the content and face validity between source and target versions of a questionnaire due to difficulty in detecting subtle differences in the living habits of different cultures.

Adolescent↗
PubMed2006

Estimating SRS-22 quality of life measures with SF-36: application in idiopathic scoliosis.

STUDY DESIGN: Comparison of a generic- with a disorder-specific health-related quality of life (HRQL) questionnaire. OBJECTIVES: To determine the association between generic- and disorder-specific questionnaire domains of similar construct. SUMMARY OF BACKGROUND DATA: Short Form-36 (SF-36), a general HRQL questionnaire, has been widely used to evaluate patients with scoliosis and related spine deformity. How it relates to the disorder-specific Scoliosis Research Society-22 (SRS-22) questionnaire is currently unknown. METHODS: Seventy-eight patients, operated at a mean age 14.5 years for idiopathic scoliosis with a mean largest Cobb of 60 degrees , completed both questionnaires at a mean of 9.25 years after surgery. RESULTS: The predictability of the SRS-22 Mental Health domain is excellent using the SF-36 Mental Health domain, from which it was adapted (R2 = 0.81). The SRS-22 Pain domain predictability using the SF-36 Bodily Pain domain is also excellent (R2 = 0.79). The SRS-22 Function domain predictability using the SF-36 Physical Component Summary domain is good (R2 = 0.64). The SRS-22 Self-Image and Management Satisfaction/Dissatisfaction domains are poorly predicted by the SF-36 General Health and Physical Component Summary domains, respectively, R2 = 0.52 and 0.54. CONCLUSION: SRS-22 Mental Health and Pain domain scores can be accurately calculated from correlating SF-36 domain scores. SRS-22 Function scores can be fairly well predicted from correlated SF-36 domain scores. Self-Image and Management Satisfaction/Dissatisfaction domain scores cannot be approximated from SF-36 domain scores.

Adolescent↗
PubMed2006

Computer-assisted algorithms improve reliability of King classification and Cobb angle measurement of scoliosis.

STUDY DESIGN: Interobserver and intraobserver reliability study of improved method to evaluate radiographs of patients with scoliosis. OBJECTIVE: To determine the reliability of a computer-assisted measurement protocol for evaluating Cobb angle and King et al classification. SUMMARY OF BACKGROUND DATA: Evaluation of scoliosis radiographs is inherently unreliable because of technical and human judgmental errors. Objective, computer-assisted evaluation tools may improve reliability. METHODS: Posteroanterior preoperative radiographic images of 27 patients with adolescent idiopathic scoliosis were each displayed on a computer screen. They were marked 3 times in random sequence by each of 5 evaluators (observers) who marked 70 standardized points on the vertebrae and sacrum in each radiograph. A computer program (Spine 2002;27:2801-5) that identified curves, calculated Cobb angles, and generated the King et al classification automatically analyzed coordinates of these points. The interobserver and intraobserver variability of the Cobb angle and King et al classification evaluations were quantified and compared with values obtained by unassisted observers. RESULTS: Average Cobb angle intraobserver standard deviation was 2.0 degrees for both the thoracic and lumbar curves (range 0.1 to 8.3 degrees for different curves). Interobserver reliability was 2.5 degrees for thoracic curves and 2.6 degrees for lumbar curves. Among the 5 observers, there was an inverse relationship between repeatability and time spent marking images, and no correlation with image quality or curve magnitude. Kappa values for the variability of the King et al classification averaged 0.85 (intraobserver). CONCLUSIONS: Variability of Cobb measurements compares favorably with previously published series. The classification was more reliable than achieved by unassisted observers evaluating the same radiographs. The same principles may be applicable to other radiographic measurement and evaluation procedures.

Algorithms↗
PubMed2006

Spinal fusion with Cotrel-Dubousset instrumentation for neuropathic scoliosis in patients with cerebral palsy.

STUDY DESIGN: Retrospective. OBJECTIVE: To report on the treatment of patients with cerebral palsy and neuropathic scoliosis with third-generation instrumented spinal fusion by Cotrel-Dubousset instrumentation. SUMMARY OF BACKGROUND DATA: Second-generation instrumented spinal fusion is considered the standard for progressive neuropathic scoliosis in cerebral palsy, despite high complication rates. Evidence is needed to evaluate the increasing use of third-generation instrumented spinal fusion in similar patients. METHODS: Patients with cerebral palsy and spinal deformity treated consecutively by 1 surgeon with Cotrel-Dubousset instrumentation and minimum 2-year follow-up were reviewed. An outcome questionnaire was administered at final follow-up. RESULTS: A total of 60 patients were included. Mean age was 15 years at surgery. Mean follow-up was 79 months. There were 26 anteroposterior and 34 posterior-only procedures. Correction of coronal deformity and pelvic obliquity averaged 60% and 40%, respectively. Major complications affected 13.5% of patients, and included implant loosening, deep infection, and pseudarthrosis. Minor complications affected 10% of patients. Outcome questionnaires showed marked improvements in the areas of satisfaction, function, and quality of life after surgery. CONCLUSIONS: Segmental, third-generation instrumented spinal fusion provides lasting correction of spinal deformity and improved quality of life in patients with cerebral palsy and neuropathic scoliosis, with a lower pseudarthrosis rate compared to reports on second-generation instrumented spinal fusion.

Adolescent↗
PubMed2006

Interobserver and intraobserver agreement of Lenke and King classifications for idiopathic scoliosis and the influence of level of professional training.

STUDY DESIGN: This is a blinded study of radiographs by observers with different levels of professional training. OBJECTIVES: To determine whether the level of professional training on nonmeasured and premeasured radiographs would affect reliability of Lenke's and King's classifications for adolescent idiopathic scoliosis. SUMMARY OF BACKGROUND DATA: Both classification systems have been studied for their reliability, mainly by observers with a high level of experience in orthopedics and scoliosis surgery using premeasured radiographs. METHODS: Examination of radiographs of 60 operative cases of adolescent idiopathic scoliosis was performed. On 5 occasions, 3 observers with a completely different degree of professional training measured and classified preoperative radiographs according to Lenke's or King's criteria. The results were determined by calculating the interobserver and intraobserver agreement and were quantified using two-rater and multirater kappa statistics. RESULTS: The Lenke and King classifications demonstrated poor to fair interobserver and good intraobserver agreement on nonmeasured radiographs. Both classifications demonstrated good to excellent interobserver agreement on premeasured radiographs. CONCLUSIONS: The results confirm that both classifications have a good reliability. On nonmeasured radiographs, the degree of professional training and the measurement process seem to influence the outcome. On premeasured radiographs, the interobserver agreement does not seem to be influenced by the level of professional training.

Adolescent↗
PubMed2006

Correlates of the peak height velocity in girls with idiopathic scoliosis.

STUDY DESIGN: Prospective longitudinal. OBJECTIVE: Determine correlates of the peak height velocity (PHV) in girls with idiopathic scoliosis. SUMMARY OF BACKGROUND DATA: Only identifiable retrospectively, the PHV is the most useful known maturity marker in idiopathic scoliosis. Clinically useful correlates are needed to make PHV timing helpful. METHODS: A total of 24 immature girls with idiopathic scoliosis were followed with serial heights, sexual staging, skeletal ages, spinal radiographs, insulin-like growth factor (IGF)-1, IGF binding protein-3, dehydroepiandrosterone sulfate, estradiol, bone-specific alkaline phosphatase, and osteocalcin levels. These markers were correlated to PHV timing. RESULTS: There were 14 girls who had identifiable growth peaks that averaged 10.5 +/- 1.8 cm/y at age 11.7 +/- 1 years. At the PHV, all girls were Risser 0 with open triradiate cartilages. On a skeletal age radiograph, digital uncapped phalangeal epiphyses were indicative of pre-PHV and fused epiphyses of post-PHV. Capped but unfused epiphyses were indeterminate. Tanner stage 1 for breast strongly indicates pre-PHV. Stage 3 for breast and pubic hair occurred at or after the PHV, and stage 4 always occurred after PHV. Higher IGF-1 and estradiol levels after PHV are potentially discriminatory. CONCLUSIONS: The PHV occurs during Risser 0 with open triradiate cartilages. If triradiate cartilages are open, then Tanner stages, IGF-1, estradiol levels, and the appearance of the epiphyses on a skeletal age radiograph are useful in determining status before or after PHV.

Biomarkers↗
PubMed2006

Correction of neuromuscular scoliosis in patients with preexisting respiratory failure.

STUDY DESIGN: A prospective observational study in scoliosis patients who were on noninvasive night ventilation for respiratory failure. OBJECTIVE: To report the results of spinal deformity correction in a group of patients with progressive scoliosis and rare forms of muscular dystrophy/myopathy with respiratory failure who were on nocturnal ventilatory support at the time of surgery. SUMMARY OF BACKGROUND DATA: This is the first study on the results of deformity correction in a series of patients on ventilatory support. MATERIALS AND METHODS: Eight patients (6 males, 2 females) presented with progressive scoliosis and respiratory failure. The mean age at surgery was 12 years (range, 8-15 years). The mean follow-up was 48 months (range, 12-80 months). Outcome measures include lung function (spirometry), overnight pulse oximetry, Cobb angles, duration of stay in Intensive care (ICU), and the total hospital stay. RESULTS: The mean stay in the ICU was 2.7 days (range, 2-5 days). The mean hospital stay was 14.2 days (range, 10-21 days). The mean preoperative Cobb angle was 70.2 degrees (55 degrees -85 degrees ). This changed to 32 degrees (16 degrees -65 degrees ) after surgery (P = 0.0002). The mean vital capacity at the time of surgery was 20% (range, 13%-28%). The mean vital capacity of patients at last follow-up was 18% (range, 10%-31%). The desaturation noted on the preventilation overnight oximetry was reversed by nocturnal ventilation. All patients recovered well following surgery with no major cardiac or pulmonary complications. CONCLUSION: Patients with preexisting respiratory failure on nocturnal noninvasive ventilation can be safely operated for deformity correction. This can help to significantly improve their quality of life.

Adolescent↗
PubMed2006

Spinal cord monitoring in scoliosis surgery using an epidural electrode. Results of a prospective, consecutive series of 191 cases.

STUDY DESIGN: Retrospective analysis of a prospectively accrued series of 191 consecutive patients who underwent intraoperative neurophysiologic monitoring during scoliosis corrective surgery. OBJECTIVES: To compare the monitoring outcome of idiopathic and neuromuscular scoliosis. To demonstrate the usefulness of the epidural electrode. To report sensitivity and specificity of the monitoring method employed at a single institution. SUMMARY OF BACKGROUND DATA: Reports in the literature emphasized the difficulty to obtain data in neuromuscular patients. Multimodality spinal cord monitoring has been recommended. Despite their still debated composition, neurogenic motor-evoked potentials have proven their validity in clinical practice. METHODS: Somatosensory and neurogenic evoked potentials were attempted in all patients presenting for scoliosis correction between 1999 and 2005. Study patients were divided into 3 groups: group 1, idiopathic; group 2, neuromuscular; and group 3, miscellaneous origins. RESULTS: The use of the epidural electrode demonstrated significant usefulness in the ability of monitoring otherwise nonmonitored patients, especially in group 2. Inability to obtain any evoked potentials occurred in 4 cases (2.1%). Five cases were found to be true positives. An adapted and rapid intervention permitted to avoid new postoperative deficit in all cases. There was no instance of false-negative data. The overall method sensitivity was 100%, and specificity was 52.69%. CONCLUSIONS: The use of a single epidural electrode allowing somatosensory evoked potentials recording and spinal cord stimulation alternately is a safe and valid method of intraoperative monitoring.

Adolescent↗
PubMed2006

Comparison of Cobb angles in idiopathic scoliosis on standing radiographs and supine axially loaded MRI.

STUDY DESIGN: Prospective, patient controlled. OBJECTIVE: To compare Cobb angles in idiopathic scoliosis between standing radiographs and a nonradiographic procedure. SUMMARY OF BACKGROUND DATA: Repeated radiographic examinations at young age may increase the risk for breast cancer in adulthood. MRI images the spine satisfactorily but is cumbersome in standing. A harness supplying axial load to a lying subject simulates the standing radiograph appearance of the lumbar spine. METHODS: Thirty patients with idiopathic scoliosis greater than 20 degrees performed a routine posteroanterior and lateral standing thoracolumbar spine radiograph and an MRI in supine position without and with axial loading. RESULTS: Mean Cobb angle for the major curve was 31 degrees on standing radiographs, 23 degrees on nonloaded supine MRI, and 31 degrees on supine loaded MRI. Axially loaded, compared with nonloaded, MRI increased the Cobb angle by 8 degrees. The mean difference between standing radiograph and supine axially loaded MRI was 0 degrees, with an intermethodologic variation(s) of 3.4 degrees. Radiographic and MRI (axially loaded) Cobb angles correlated positively (r = 0.78). CONCLUSIONS: Axial loading on supine MRI produces coronal Cobb angles similar to standing radiographs. This is a way to acquire reliable Cobb angles without radiation in the monitoring of idiopathic scoliosis.

Adolescent↗
PubMed2005

Late paraplegia after scoliosis treatment: an uncommon diagnosis.

We report the case of a young girl treated at age 16 for a progressive scoliosis by posterior instrumented arthrodesis. Ten years later, she suddenly developed lumbar pain and paraplegia. The surgical procedure showed a mass infiltrating the vertebral canal and the dural sheath following a supralaminar hook. Histology revealed a diagnosis of leiomyosarcoma. The outcome was poor with a rapid and fatal extension of the tumor. There is nothing to justify a causal link between the scoliosis and the late onset of a malignant tumor. Nevertheless, we discuss the potential role of diagnostic irradiation consecutive to scoliosis monitoring during growth and the potential role of environmental carcinogens like metallic biomaterials. Finally, rapid intrusion of this extraspinal tumor into the dural sheath resulted in a confusing clinical picture and delayed the diagnosis and treatment of the tumor.

Adolescent↗
PubMed2005

High pulmonary risk scoliosis surgery: role of noninvasive ventilation and related techniques.

OBJECTIVE: There is little awareness among surgeons of the potential for noninvasive mechanical ventilation as an alternative to prolonged endotracheal intubation or tracheostomy for patients with neuromuscular scoliosis and ventilatory failure. These methods have not been reported for the perioperative management of scoliosis correction in patients with an inability to sustain their alveolar ventilation. METHODS: Five children with flaccid scoliosis secondary to muscular dystrophy or spinal muscular atrophy who had very high pulmonary risk were preoperatively trained in the use of noninvasive intermittent positive-pressure ventilation (IPPV) and mechanically assisted coughing prior to spinal fusion. RESULTS: All patients were extubated by the third postoperative day to noninvasive IPPV despite continuous ventilator dependence. No patient developed any postoperative pulmonary complications or required a tracheotomy. CONCLUSIONS: It is critical for the orthopedic surgeon to be aware of these noninvasive options to tracheotomy to decrease the tendency to avoid surgery for these otherwise high-risk surgical patients.

Adolescent↗
PubMed2006

Delayed postoperative paralysis in adolescent idiopathic scoliosis: management with partial removal of hardware and staged correction.

A delayed spinal epidural hematoma following scoliosis surgery is relatively uncommon but well recognized by clinical and radiographic findings. A 12-year-old girl with scoliosis measuring 80 degrees lower thoracic curve underwent anterior (T6-T12) and posterior fusion with posterior instrumentation from T2 to L1. She developed bilateral leg weakness and progressive left lower leg paralysis 24 hours later. Emergent decompression and partial removal of hardware was performed. Reinsertion of segmental instrumentation and correction of her curve was performed 2 weeks later. The patient had complete recovery of her neurologic deficits, and her correction was maintained at 85% at 4-months follow-up. The authors recognized that there should be no delay in returning the patient to surgery if neurological deficits are noticed. Exploration and decompression of "an occupying lesion" and release of cord tension by partial removal of hardware and re-instrument can achieve appropriate original correction of scoliosis and satisfactory clinical outcome.

Child↗
PubMed2006

Thoracic spinal epidural lipomatosis associated with adolescent scoliosis.

Although a variety of neural axis abnormalities in association with idiopathic scoliosis have been reported, there are no documented cases of spinal epidural lipomatosis (SEL) in a child with scoliosis. An otherwise healthy, neurologically intact 14-year-old girl presented with spinal deformity. Radiographs confirmed a left thoracic, right lumbar Lenke class 5CN scoliosis. Preoperative magnetic resonance imaging (MRI) demonstrated extensive SEL in the thoracic spine. She underwent posterior spinal fusion with segmental instrumentation using bony anchors that did not violate the spinal canal. Intraoperative spinal cord monitoring and postoperative clinical course were uneventful. SEL should be added to the list of potential abnormalities to be looked for in children with spinal deformities undergoing preoperative MRI of the neural axis.

Adolescent↗
PubMed1981

Scoliosis in Prader-Willi syndrome.

Children with Prader-Willi syndrome frequently have musculoskeletal problems such as joint hyperlaxity, hypotonia, delayed bone age, and scoliosis. Their musculoskeletal problems are magnified by the extreme obesity most of these patients exhibit. In certain cases, such as scoliosis, the Prader-Willi patient is placed at significant risk for increased morbidity and mortality. Our paper emphasizes the accurate diagnosis of this syndrome, proper dietary management, and some guidelines regarding surgical evaluation and management of a patient with significant scoliosis.

Child↗
PubMed1983

Scoliosis due to rib osteoblastoma: report of two cases.

Two cases of osteoblastoma of a rib associated with progressive scoliosis are reported. The unusual localization of the neoplastic lesions and their close relationship to the lateral deviation of the spine suggest an etiologic basis for these patients' scoliosis. The need for early diagnosis and surgical excision of the rib lesion in the treatment of scoliosis resulting from osteoblastoma of a rib is stressed.

Bone Neoplasms↗
PubMed1983

Early echocardiographic and pulmonary function findings in idiopathic scoliosis.

Thirty-six children and adolescents with early stages of idiopathic scoliosis underwent evaluation by echocardiography and pulmonary function testing. Mildly increased pulmonary vascular resistance was inferred from an elevated ratio of right preejection period to right ventricular ejection time, an increased right ventricular dimension, and a decreased left ventricular dimension. Since neither decreased arterial oxygen saturation nor increased end-tidal expired carbon dioxide partial pressure was seen, desaturation and hypoventilation should not account for these abnormalities. Pulmonary function parameters showed no distinct patterns of abnormality. Even though the patients were divided into two groups by severity of spinal curvature, the cardiopulmonary measures did not correlate with thoracic deformity. Billowing of the mitral leaflets, termed mitral valve prolapse, was demonstrated in 25% of the subjects. Our findings suggest that cardiopulmonary and thoracic changes in idiopathic scoliosis may develop in parallel and may be expressions of a common collagen defect. However, study of sleep and exercise arterial saturation may be required to rule out intermittent hypoxemia as a precipitating factor of cor pulmonale in scoliosis.

Adolescent↗
PubMed1983

Staged correction of neuromuscular scoliosis.

Anterior release and fusion, combined with tong gravity traction and second stage L-rod instrumentation, establishes correctability and accomplishes circumferential arthrodesis of the spine in neuromuscular scoliosis. From March 1979 through April 1982, nine patients with neuromuscular scoliosis, with an average age of 16.4 years, underwent this two-stage surgical procedure. The parameters investigated included correction of scoliotic deformity, correction of pelvic decompensation, and spinal arthrodesis. The preoperative scoliotic curvature measured 81 degrees and the postoperative curve measured 29.3 degrees, an average correction of 63.8%. Pelvic obliquity was significant in five of nine patients, averaging 36.2 degrees preoperatively. Postoperatively the pelvic obliquity averaged 11.8 degrees, an average correction of 67.4%. One of two pelvic fixation rods rotated out of the pelvis of one patient; roentgenographically he appears to have fused without loss of correction. A second patient has a poor fusion mass by roentgenographic criteria, although she has lost no correction and has had no pain. This technique offers results comparable to other series reporting arthrodesis for neuromuscular scoliosis. It has the advantages of requiring no anterior instrumentation and no postoperative immobilization.

Adolescent↗