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[Treatment of Diphyllobothrium latum and Taenia saginata infections with aminosidine (author's transl)].

Recently, it has been known that the aminosidine has marked anthelmintic efficacy against tapeworm. In this investigation, aminosidine was used for treating 14 cases with Ciphyllobothrium latum infection and 5 cases with Taenia saginata infection. Aminosidine was administered orally in a single dose of 50 mg/kg, followed by a purge after the treatment. Fourteen patients with D. latum infection and 5 patients with T. saginata infection expelled long strobila in all cases. Although only 7 scolices of 18 worms of D. latum were found in the stool and no scolex of T. saginata was found, follow-up examination for a long period showed no evidence of remaining infection with one exception of D. latum. Mild nausea, vomiting and abdominal pain were observed in only one of 19 cases given aminosidine. But in the other 18 cases, no side effects were encountered. It was concluded that aminosidine is safe, effective therapeutic agent for the treatment of cestodiasis in man.

Adolescent↗

[Mechanisms of inactivation of aminosides. Relationship to phenotype in Gram negative bacilli].

Aminosides are antibiotics essential in the treatment of gram negative bacilli infections. Phenomena of resistance related to them are amongst the best documented. For enterobacteria encountered in clinical practice, the process is usually a plasmid mediated inactivation mechanism, the dispersion of which in a hospital context may be appreciated. Precise knowledge of the modes of inactivation and the molecular sites involved has led to the production of semi-synthetic aminosides which escape the action of these enzymes. A classification of hospital bacteria according to their type of resistance is possible by virtue of the study of phenotypes and may make it possible to define the true need of these new substances.

Amikacin↗