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PubMed1999

[The causes of increased risk for lung cancer in the pulp and paper industry workers. The effect of smoking and exposure to chemicals].

An analysis of mortality in a cohort of workers employed in the pulp and paper industry, carried out by the authors of this presentation several years ago, indicated an increase of 22% in the risk of mortality from lung cancer. This risk decreased by only 4% after taking account of smoking. The results obtained then were considered as sufficient to undertake further studies aimed at identifying specific occupational factors responsible for an increased risk for mortality from lung cancer in the population under study. The nested case-control study, in which cases (of lung cancer) and controls were selected from the same cohort observed earlier, was approved as the most suitable method for achieving the aforesaid aim. The study covered 79 cases of deaths from lung cancer confirmed by histological and cytological or radiological examinations, and 237 'healthy' controls matched in the ratio of one to three, taking into account gender, date of birth and date of employment. A group of experts carried out in-depth analysis of exposure to harmful factors in each case of death and in each control. Using a questionnaire, specially developed for this purpose, detailed data on smoking habits among persons under study were collected. Odds ratio was used as a measure of a relative risk for death from lung cancer. A crude relative risk and risk adjusted by eliminating the effect of smoking, applying the model of conditional logistic regression, were calculated for individual exposure factors. Smoking proved to be a significant causal factor responsible for the development of lung cancer in the cohort studied. That was evidenced by relative risk accounting for 12.9 for smokers in relation to non-smokers and an enhanced risk with the increasing number of cigarettes smoked daily, the number of smoking years and an accumulated dose. The study does not confirm a hypothesis that chemical factors specific of the pulp and paper industry exert a significant effect on the risk of death from lung cancer. Odds ratios, crude and adjusted for smoking, were lower than one in all distinguished categories of exposure.

Adult↗
PubMed2000

Oral testosterone administration detected by testosterone glucuronidation measured in blood spots dried on filter paper.

BACKGROUND: Blood sampling is not a common practice for sports drug testing. Our aim was to investigate whether dried blood spots on filter paper could be an alternative to plasma samples for monitoring steroid profiles in dope testing. METHODS: We collected dried blood spots and plasma from six healthy Caucasian subjects after an oral 120-mg dose of testosterone undecanoate (TU). Nonconjugated testosterone, testosterone glucuronide (TG), androsterone glucuronide (AG), and etiocholanolone glucuronide (EtG) were measured by gas chromatography-mass spectrometry in both matrices. 17alpha-Hydroxyprogesterone (17alphaOHP) and luteinizing hormone (LH) also were measured in the plasma samples. For comparison, similar measurements were done on samples obtained from the same subjects given 25 mg of testosterone propionate (TP) plus 110 mg of testosterone enanthate (TE) intramuscularly after a wash-out period. RESULTS: After oral TU intake, TG, AG, and EtG increased sharply, whereas nonconjugated testosterone did not change significantly. Results on dried blood spots correlated well with those on plasma. The TG/testosterone ratio in blood or plasma was verified to be a sensitive and specific marker (significantly increased for up to 8 h after intake; P <0.05) for oral TU intake but not for intramuscular administration of TP plus TE. Little suppression of plasma LH and 17alphaOHP was observed after a single oral dose of TU. One subject did not show a significant increase of blood TG after oral TU intake. CONCLUSIONS: The measurement of glucuronide conjugates in blood and plasma samples is relevant for sports drug testing when analyzing the steroid profile. Dried blood spots collected on filter paper are a suitable alternative to plasma for detecting testosterone abuse.

Administration, Oral↗
PubMed2000

Influence of culture parameters on paper mill effluent decolourization by a white rot fungus Ganoderma lucidum.

Efficacy of a white rot fungus G. lucidum for reduction of colour of paper mill effluent under various growth conditions was evaluated. G. lucidum cultured in IBME medium supported maximum colour reduction on 18th day of fungal growth. The optimization of growth parameters further improved colour reduction. The 18 day old culture at 4 g/l inoculum concentration resulted in maximum decolourization (89%) of the effluent with pH adjusted to 6.5 at 35 degrees C along with maximum reduction in biological oxygen demand and chemical oxygen demand. Relative contribution of lignin peroxidase and laccase to the decolourization of paper mill effluent by G. lucidum was also observed.

Biodegradation, Environmental↗
PubMedDate not supplied

Direct seal papers for horizontal form-fill-seal machine.

Direct-seal papers are designed for minimal fibre lift, where the sealing layer is incorporated into the bottom web. There are applications where they are the most appropriate economical alternative to traditional coated papers for horizontal form-fill-seal packaging. This article explores their benefits and limitations.

Cost Control↗
PubMed2001

Evaluation of culture and PCR-based assay for detection of Mycobacterium tuberculosis from sputum collected and stored on filter paper.

We evaluated the use of culture and PCR-based assay for the direct detection of Mycobacterium tuberculosis (MTB) from sputum collected and stored on filter paper at room temperature for 5 days; the results were compared with those of staining and conventional culture of fresh sputum before storage (the 'gold standard'). Out of 231 sputum specimens examined, MTB was recovered from 124 samples by culture before storage. The culture positivity rate was significantly decreased to 70% after 5 days storage. For PCR assay, a fragment of 377 bp of the IS6110 sequence was amplified and detected using three methods: first PCR product combined with agarose gel electrophoresis (AGE); first PCR product with dot blot hybridization (DBH); nested PCR with AGE. Compared with culture, the sensitivity, specificity, and efficiency for first PCR with AGE were 71.8, 100 and 84.9% respectively; PCR with DBH gave results of 89.5, 96.3 and 92.6% respectively; the same values for nested PCR were 96.0, 97.2, and 96.5% respectively. Of these three methods, nested PCR gave excellent sensitivity and specificity with no significant difference (p = 0.727) from conventional culture. The storage of sputum on filter paper and storage at room temperature for 5 days had no apparent effect on the performance of nested PCR. We propose that this collection and storage method be considered for transporting sputum specimens from peripheral health centers or from the field; specimens may be sent by post to a central point for both culture and PCR analysis by trained technicians supervised in accordance with a well-established quality control system.

Culture Techniques↗
PubMed2002

Mortality and cancer incidence in New Zealand pulp and paper mill workers.

AIMS: To evaluate mortality and cancer incidence in a cohort of workers employed in the New Zealand pulp and paper industry, and to identify the exposures responsible for any increased risk. METHODS: A total of 8456 workers employed for at least one year in three pulp and paper mills between 1978 and 1990 were followed up until 1992. The observed number of deaths and cancer cases was compared with expected numbers calculated using five-year age-specific rates for the New Zealand population. RESULTS: Vital status was determined for 81% of the cohort, and for 93% of the total person-years at risk. Mortality from all causes (standardised mortality ratios (SMR) = 0.80, 95% confidence intervals [CI] 0.71-0.89; 314 deaths), and from all malignant neoplasms (SMR = 0.95, 95% CI 0.78-1.15, 103 deaths), was lower than expected. Mortality from lung cancer (SMR = 1.33, 95% CI 0.94-1.83, 37 deaths) was marginally increased. CONCLUSIONS: No overall increase in mortality from cancer or other causes was observed in this cohort. A small increase in lung cancer risk is suggested, although this was not statistically significant. Numbers of cases were too small for detailed analyses of associations between disease and specific exposures.

Adult↗
PubMed2002

Timing of exposure to a pulp and paper effluent influences the manifestation of reproductive effects in rainbow trout.

Rainbow trout were exposed to a secondary treated, thermomechanical/bleached kraft pulp and paper effluent in 12,000-L, flow-through exposure tanks at an environmental research facility located at a pulp and paper mill in Kawerau, New Zealand. Trout (age, 2+ years) were obtained from a local hatchery and exposed either to upstream river water or a nominal concentration of 12% (v/v) effluent diluted in upstream river water. Three treatment groups were used: Effluent exposure that started approximately three months before gonadal growth (eight-month total exposure), effluent exposure that started approximately halfway through gonadal development (two-month total exposure), and trout exposed to reference water alone for the total duration of the experiment. Trout were sacrificed just before spawning; exposure, growth, and reproductive endpoints were assessed during and at the termination of the experiment. Reduction in growth was observed in both sexes in the eight-month treatment group relative to the river water reference treatment group. No differences were observed in condition factor or liver size in either treatment. Females in the eight-month exposure group also had significantly lower ovary weight. The two-month exposure group showed no differences from the reference group in growth or somatic indices. Estradiol and testosterone were reduced in blood samples taken from the eight-month exposure group by four months into the experiment as compared to the reference treatment. Steroid and vitellogenin levels in individual female trout from this treatment were significantly correlated with gonadosomatic indices (GSI) measured at the termination of the experiment. The GSI was not correlated strongly or consistently with pregnenolone, nor were any treatment-related pregnenolone differences observed, indicating that the steroid hormone reductions likely were not related to cholesterol side-chain cleavage. Male trout showed significant induction of vitellogenin and lower 11-ketotestosterone during the experiment (only the eight-month group was examined), but this did not result in any significant differences in testes development. Thus, this study has shown an impact of pulp mill effluent exposure on the reproductive physiology of female trout that appeared to be hormonally mediated. Furthermore, the effect could only be manifest when the exposure was initiated before the start of gonad development.

Animals↗
PubMed2002

[Determination of lead and cadmium contents in toilet paper].

Contents of pollutant elements lead and cadmium in toilet paper were determined by atomic absorption spectrometry. Both lead and cadmium has good linear relationship that lead is over the range of 0.00-10.00 micrograms.mL-1 (r = 0.9989) and cadmium is over the range of 0.00-4.00 micrograms.mL-1 (r = 0.9997). In this method, RSD is bellow 3.08% and recovery is over the range of 94.8%-104.5%. The method is simple and accurate. It can be used as monitor method of lead and cadmium in toilet paper.

Cadmium↗
PubMed2003

Physico-chemical characteristics of river Ami in relation to discharge of paper mill effluent.

The indiscriminate discharge of large volumes of highly putrescible liquid waste from the Sanjai Paper & Chemical Industries Ltd. created serious pollution problem in river Ami near Maghar town area in the district Sant Kabir Nagar of U.P., India. The river is originated from Sikahra Tal near Hallaur (Tehsil - Dumariaganj) of Siddharthnagar district U.P. and disappears into Rapti river near Kouriram of Gorakhpur district U.P. In present investigation an attempt has been made to ascertain the present water quality condition of river Ami in relation to paper mill effluent discharge. The samples were collected from the upstream and downstream of the flow-path of the river from point source of pollution by the mill. The high degree of water quality degradation is reflected by the changes in values of BOD, COD, DO, nitrogen contents and chlorides etc in downstream.

Environmental Monitoring↗
PubMed2004

Quantitative assessment of lung cancer risk in men employed in the pulp and paper industry in Poland.

OBJECTIVES: Numerous epidemiological studies have provided some evidence indicating that workers employed in the pulp and paper industry are at higher risk of death from lung cancer. The present study was undertaken to analyze lung cancer risk prediction among male workers employed in this industry. MATERIALS AND METHODS: To estimate the probability of death from lung cancer a risk prediction model with some elements of competing risks was used. The risk assessment was based on the cohort study data collected in workers involved in pulp and paper production. RESULTS: Four exposure-response relationship curves were developed adopting the age at the first occupational exposure as a criterion. The model based on the competing risk theory rendered it possible to estimate an additional risk of lung cancer related to a specific period of occupational exposure for the groups adjusted by the age of entering the cohort. For example, in the group with first exposure at the age below 29, the risk changed from 2.25 x 10(-7) during the first year of employment to 1.40 x 10(-5) after 10 years, whereas in the group of workers with first exposure at the age of 50 years, the risk changed from 6.42 x 10(-5) to 4.28 x 10(-4). In addition, the risk at first exposure at the age of 50-59 was almost two orders of magnitude higher than that in workers with first exposure at the age below 29 (6.42 x 10(-5) and 2.25 x 10(-7), respectively). CONCLUSIONS: Using the additional (absolute) risk model involving elements of competing risk theory it is possible to provide a more thorough characteristics of the relationship between the exposure level and probability of death from lung cancer.

Adult↗
PubMed2004

Fingerprint detection on counterfeit US dollar banknotes: the importance of preliminary paper examination.

Two seizures of counterfeit 100 US dollar bills related to the same indicative number were submitted for processing of latent fingerprints. On one group of notes, identifiable fingerprints could be detected by the routine application of amino acid reagents. In the second case, this technique gave no results, even on deliberately deposited prints. Fingerprints could be revealed, however, by cyanoacrylate fuming followed by magnetic powder. Comprehensive paper analysis showed that banknotes from both seizures differed remarkably by chemical composition as well as paper macroscopic properties. The difference in surface free energy (related to surface tension) of the banknotes in the two groups seemed to be the major factor responsible for the great variance in fingerprint detectability.

Crime↗
PubMed2004

The formation of colour during biological treatment of pulp and paper wastewater.

Colour discharges are gaining renewed focus in the pulp and paper industry as increasingly strict regulatory limits are placed on wastewater quality and aesthetics. In-mill process improvements, such as ECF bleaching and oxygen delignification, have decreased wastewater colour loadings. However, a survey of 12 pulp and paper mill systems found that effluent treatment using aerated stabilisation basins (ASB) leads to average increases in colour of 20-40%. In some instances, this phenomenon may even double the influent colour levels. Activated sludge systems did not produce a colour increase. The measured increases that follow ASB secondary treatment may be sufficient for a mill to fail prescribed discharge standards. A detailed field survey focusing on sections of an integrated bleached kraft mill ASB treatment system was undertaken. The average increase in colour at the final point of discharge was 45%. The major changes in colour concentration occurred in the inlet to the main treatment pond, and in polishing ponds that followed the main treatment pond. Both of these areas receive little or no aeration. No significant change was observed in the highly aerated main pond. These results, along with literature reports, suggested that redox conditions play a major role in influencing colour behaviour. To test this, two series of paired continuously stirred reactors were used to treat whole mill effluent from two ECF bleached kraft mills in parallel. The first series initially treated under anaerobic conditions, followed by an aerobic reactor, while the second series reversed this order. With the initial anaerobic stage, effluent colour increased by 18% and 19% for the first and second series respectively. Subsequent treatment by aerobic bacteria further increased colour by 14% and 6%, for a total increase of 32% and 25%. Initial aerobic treatment, however, did not lead to any significant change in colour for either effluent. Further anaerobic treatment following aerobic conditions produced only small increases in colour. These results are consistent with the ASB and activated sludge system survey, suggesting that anaerobic conditions at the head of treatment systems initiate the observed increases in effluent colour in ASB treatment systems.

Bacteria, Anaerobic↗
PubMed2004

Advanced treatment by anaerobic process followed by aerobic membrane bioreactor for effluent reuse in paper mill industry.

The operation of an activated sludge process at a paper mill (AIPM) in Hedera, Israel, was often characterized by disturbances. As part of a research and development project, a study on new biological treatment was initiated. The study included the operation of three pilot units: a. anaerobic treatment by upflow anaerobic sludge blanket (UASB); b. aerobic treatment by two pilot units including activated sludge and membrane bioreactor (MBR), which have been operated in parallel for comparison reasons. The pilot plant working on anaerobic treatment performed COD reduction from 2,365 to 755 mg/L, expressed as average values. Based on the pilot study, a full scale anaerobic treatment system has been erected. During a period of 100 days, after achieving steady state, the MBR system provided steady operation performance, while the activated sludge produced effluent characterized by oscillatory qualities. The following results, based on average values, indicate much lower suspended solids concentrations in the MBR effluent, 2.5 mg/L, as compared to 25 mg/L in the activated sludge. The ability to develop and maintain a concentration of over 11,000 mg/L of mixed liquor volatile suspended solids in the MBR enabled an intensive bioprocess at relatively high cell residence time. This study demonstrates that the anaerobic process, followed by aerobic MBR can provide effluent of high quality which can be considered for economic reuse in the paper mill industry.

Bacteria, Aerobic↗
PubMed2005

Duration of infectivity and RNA of Venezuelan equine encephalitis, West Nile, and yellow fever viruses dried on filter paper and maintained at room temperature.

Samples of laboratory propagated Venezuelan equine encephalitis (VEE), West Nile (WN), and yellow fever (YF) viruses were blotted onto filter paper discs, air-dried, and stored at room temperature. At regular intervals over a 90-day period, the dried virus samples were eluted, tested for infectivity by culture and titration in Vero cells, and examined for viral RNA by a reverse transcriptase-polymerase chain reaction. The VEE, WN, and YF viral RNA was detected throughout the 90-day period in all samples examined. Infectious VEE virus could be recovered for up to 40 days; WN and YF viruses were cultured in Vero cells for up to 60 and 90 days, respectively. The results of this study demonstrate that viral nucleic acids and infectious virus can be recovered from arbovirus samples air-dried on filter paper and stored at room temperature for a month or more after collection. This procedure offers a simple and inexpensive method for collecting arbovirus field specimens and transporting them to diagnostic laboratories.

Base Sequence↗
PubMed2005

A field experimental study of lignin sand stabilizing material (LSSM) extracted from spent-liquor of straw pulping paper mills.

A new technique was introduced for sand stabilization and re-vegetation by use of lignin sand stabilizing material (LSSM). LSSM is a reconstructed organic compound with lignin as the most dominant component from the extracts of black-liquor issued by straw pulp paper mills. Unlike the polyvinyl acetate or foamed asphalt commonly used for dune stabilization, the new material is plant-friendly and can be used with virescence actions simultaneously. The field experimental study was conducted since 2001 in China's Northwest Ningxia Hui Autonomous Region and has been proved that LSSM is effective in stabilizing the fugitive dunes, making the arenaceous plants survive and the bare dune vegetative. The advisable solution concentration is 2% and the optimal field spraying quantity is 2.5 L/m2. The soil nutrients of the stabilized and greened dune, such as organic matter, available phosphorous and total nitrogen are all increased compared with the control treatment, which is certainly helpful to the growth of arenaceous plants. The technique is worthwhile to be popularized because it is provided not only a new method for desertification control but also an outlet for cleaning contaminants issued from the straw paper mills.

Lignin↗
PubMed1975

Improved high-resolution high-voltage paper electrophoresis system for use in screening for aminoacidopathies.

High-voltage paper electrophoresis of small samples of serum and urine at pH 6.0 resolves basic and acidic amino acids and separates them from the neutral amino acids. For separation and identification of the neutral amino acids, the appropriate area of the electrophoretogram is cut out, sewn onto a second sheet of paper, and rerun at pH 1.9. By this method, amino acids are rapidly resolved. It is suited for use with special procedures such as oxidation of biological fluid with performic acid and specific staining for confirmation of amino acid identification.

Amino Acid Metabolism, Inborn Errors↗
PubMed2005

Effect of paper mill effluent on germination of green gram (Phaseolus aureus Roxb.) and growth behaviour of it's seedlings.

Effect of paper mill effluents on Phaseolus aureus Roxb was studied. The effluent significantly inhibited germination of root and shoot length. The bio-chemical injury does not appear spontaneously but with the increase in effluent treatment there is reduction in observed biochemical parameters (chlorophyll, protein, amino acid, nuclic acids and carbohydrate) which are negatively correlated. The shoots of the seedlings were found to be resistant; whereas roots of the seedlings were susceptible to paper mill effluent treatment.

Amino Acids↗
PubMed2005

Bioremediation of pulp and paper mill effluent with Phanerochaete chrysosporium.

The present study reports on the treatment of pulp and paper mill effluent by Phanerochaete chlysosporium and the same has been compared at two different pH, 5.5 and 8.5. At both the pH, colour, COD, lignin content and total phenols of the effluent significantly declined after bioremediation. However, greater decolourisation and reduction in COD, lignin content and total phenols were observed at pH 5.5. Such bioremediated effluent of pulp and paper mill could gainfully be utilized for crop irrigation.

Biodegradation, Environmental↗