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Air transport of the patient requiring intra-aortic balloon pumping.

Air transport of the IABC patient requires a high level of skill and competence. The nurse caring for the IABP patient must be experienced in balloon pumping in a variety of settings (catheterization laboratory, operating room) and during unstable hemodynamic conditions, such as occur with arrhythmias, pacemakers, severe cardiogenic shock, and cardiac arrest. The nurse must be trained in all aspects of console operation and troubleshooting. Evanston Hospital, Evanston, Illinois, examined its experiences in ground transportation of 50 IABP patients over a 5-year period. The hospital has put forth several important principles that we have incorporated into our recommendations for air transport of the IABC patient: 1. Transport personnel should be completely familiar with the function of the IABP console; capable of handling bleeding at the balloon site, should it occur; capable of delivering intravenous medications, CPR, and ACLS; and proficient in operation of the ventilator, hemodynamic monitoring, and aerohemodynamics. 2. All patients must be stabilized before transfer. Appropriate management of hemodynamic instability and/or respiratory distress should be undertaken prior to beginning transport. 3. Medical personnel delivering care must transfer patients into and out of transport vehicles with minimal interruption of IABP. 4. Health-care professionals present during transport should be thoroughly familiar with the patient's medical status and anticipated complications. This article was not intended to teach basic principles of intra-aortic balloon pumping; rather its purpose was to discuss those characteristics of balloon pumping that are unique to flight transport and how they impact on balloon pumping. Console operation should follow manufacturer's recommendations. Table 3 summarizes features of the Aries, Datascope, Kontron, and Mansfield transport balloon pumps. Manufacturers and aircraft suppliers should be consulted for specific balloon-pump operating instructions, prior to assuming responsibility for care of the air-transport IABC patient. Well-established care plans and protocols for IABP have been published previously. Documentation of balloon-pump function during air transport is important, and can be an addenum to a standard ICU flowsheet (Fig. 4). The patient who presents at a community hospital with accelerating angina, complications following cardiac catheterization or myocardial infarction, emergency cardiac structural defects, or as a potential cardiac transplantation candidate may require institution of IABC as a life-saving intervention. Once the patient is stabilized, transport to a tertiary-care hospital that can provide advanced cardiac therapies is a logical trajectory.(ABSTRACT TRUNCATED AT 400 WORDS)

Acceleration↗

Outcome of repair of bilateral groin hernias: a prospective evaluation of 1,487 patients.

OBJECTIVE: To find out whether simultaneous repair of bilateral hernias increases the risk of recurrence compared with unilateral repair. DESIGN: Prospective study. SETTING: Swedish hospitals participating in the Swedish Hernia Register (SHR). INTERVENTIONS: Prospective collection of data from the SHR, 1992-1999 inclusive. The Cox proportional hazard test was used for calculating odds ratio (OR). MAIN OUTCOME MEASURES: Hernia repairs were followed up in a life table fashion until re-operation for recurrence or death of the patient. RESULTS: 33416 unilateral and 1487 bilateral operations on 2974 groin hernias were found. Direct hernias were more common in the bilateral than in the unilateral group, 1,825, 61% compared with 13,336, 40%, (p < 0.0001). A laparoscopic method was used for 1774 (60%) of bilateral and 3285 (10%) unilateral repairs, and 455 bilateral operations (31%) were done as day cases compared with 18376 (55%) unilateral ones (p < 0.0001 for both comparisons). The cumulative incidence of reoperation at three years for groin hernias after bilateral and unilateral repair was 4.1% (95% confidence interval 3.1% to 5.1%) and 3.4% (95% Cl 3.1% to 3.7%, respectively. After adjustment for other risk factors, the OR for reoperation for recurrence after bilateral repair was 1.2 (95% CI 0.9 to 1.5) with unilateral repair as reference. The OR for reoperation after laparoscopic bilateral repair compared with open bilateral repair was 0.9 (95% CI 0.6 to 1.4). CONCLUSIONS: Simultaneous repair of bilateral hernias does not increase the risk of reoperation for recurrence and there is no significant difference in the risk of reoperation after bilateral repair using open or laparoscopic techniques.

Hernia, Inguinal↗

Construction and implementation of NMR quantum logic gates for two spin systems.

The implementation of small prototype quantum computers has been studied through ensemble quantum computing via NMR measurements. In such laboratory studies it is convenient to have access to a wide array of logic gates. Here a systematic approach to reduce the logic gate to an NMR pulse sequence is introduced. This approach views the truth table for a quantum logic operation as a permutation matrix that corresponds to a propagator for an NMR transition. This propagator is then used as the starting point for the derivation of a pulse sequence. Pulse sequences for all the permutations of a four level system are reported along with implementations of representative examples on a two spin-1/2 system, 13C-labeled chloroform.

Magnetic Resonance Spectroscopy↗

Preoperative recipient data and immunosuppression levels are predictive of early patient survival after liver transplantation.

The role of donor, preoperative, intraoperative, and postoperative factors in predicting patient survival after liver transplantation was evaluated by the Bio Medicus data package on a database containing 162 variables filled with records from 100 consecutive first-liver transplant cases. Donor data did not predict outcome. Recipient preoperative data (Child status, HCV status) were predictive using life table and Cox regression methods. Recipient intraoperative data (by-pass time, warm ischemia time, delay in arterial revascularization, and packed red blood cell requirements) were predictive of outcome using life table analysis. Recipient post-operative data (rejection, sepsis, primary dysfunction, and hepatic artery thrombosis) were predictive of outcome.

Adult↗

A short cervix in women with preterm labor and intact membranes: a risk factor for microbial invasion of the amniotic cavity.

OBJECTIVE: The purpose of this study was to determine whether there was a relationship between sonographic cervical length and the presence of culture-proven microbial invasion of the amniotic cavity in women with preterm labor and intact membranes. STUDY DESIGN: Ultrasonography and amniocentesis were performed in 401 patients admitted with preterm labor (22-35 weeks) and cervical dilatation of < or = 3 cm, as assessed by digital examination. Cervical length was determined by transvaginal ultrasound at admission. Outcome variables were the presence of microbial invasion of the amniotic cavity (defined as a positive amniotic fluid culture) and the occurrence of preterm delivery before 35 weeks. Contingency tables, chi2 test, receiver-operator characteristic (ROC) curves, and logistic regression were used for statistical analysis. RESULTS: The prevalence of microbial invasion of the amniotic cavity was 7% (28/401). Spontaneous preterm delivery (< or = 35 weeks) occurred in 21.4% (82/384) of patients. ROC curve analysis showed a significant relationship between the frequency of microbial invasion of the amniotic cavity and the length of the uterine cervix (area under the curve: 0.77; P < .005). Patients with a cervical length < 15 mm had a higher rate of a positive amniotic fluid culture than patients with a cervical length > or = 15 mm (26.3% [15/57] vs. 3.8% [13/344], respectively; P < .05). Moreover, patients with a short cervix (defined as < 15 mm) were more likely to deliver spontaneously before 35 weeks, 32 weeks, within 7 days, and within 48 hours of admission ( P < .05 for all comparisons). Forty percent of patients (161/401) had a cervical length > or = 30 mm. These patients had a very low risk of microbial invasion of the amniotic cavity (1.9% [3/161]), spontaneous delivery < or = 35 weeks (4.5% [7/154]), < or = 32 weeks (2.6% [2/76]), within 7 days (1.9% [3/154]), and within 48 hours (0% [0/154]) of admission. CONCLUSION: Endovaginal ultrasonographic examination of the uterine cervix in women with preterm labor identifies patients at increased risk for intrauterine infection.

Adult↗

Inhaled anesthetics: an historical overview.

Inhalational agents have played a pivotal role in anesthesia history. The first publicly demonstrated anesthetic of the modern era, diethyl ether, was an inhalational anesthetic. The attributes of a good agent, ability to rapidly induce anesthesia, with limited side effects has led research efforts for over a hundred and fifty years. The explosion hazard was largely conquered with the development of the halogenated agents in the 1950s. Rapid emergence, with limited nausea and vomiting continue to drive discovery efforts, yet the 'modern' agents continue to improve upon those in the past. The future holds promise, but perhaps the most interesting contrast over time is the ability to rapidly introduce new agents into practice. From James Young Simpson's dinner table one evening to the operating suite the next day, modern agents take decades from first synthesis to clinical introduction.

Anesthesia↗

Use of brief depression screening tools in primary care: consideration of heterogeneity in performance in different patient groups.

Heterogeneity of performance of screening tools in different patient groups has rarely been considered in the literature on depression screening in primary care. The objectives of the present study were to assess and to compare diagnostic accuracy of three screening questionnaires (Brief Patient Health Questionnaire, General Health Questionnaire-12, WHO-5) in identifying depression across various patient subpopulations and to assess the accuracy of the unaided clinical assessment of primary care physicians in the same subgroups. We conducted a cross-sectional validation study in 448 primary care patients. Two-by-two tables as well as receiver operating characteristics were applied. Results indicated that diagnostic accuracy (sensitivity, specificity) of the three screening instruments as well as of the clinical diagnoses differed in the various patient groups. Superiority of one screening tool over the other depends on the subgroup considered. Gender, age, form (subtype), and severity of depression influence the test characteristics of a screening tool. This should be considered if routine depression screening should be widely introduced. Of course, the benefit of routine screening also depends on efforts made for treatment and monitoring of patients in whom depression was diagnosed.

Adult↗

Predictors of alveolar air leaks.

Persistent air leaks are caused by the failure of the postoperative lung to achieve a configuration that is physiologically amenable to healing. The raw pulmonary surface caused by the dissection of the fissure often is separated from the pleura, and the air leak fails to close. Additionally, higher air flow thorough an alveolar-pleural fistula seems to keep the fistula open. Other factors that interfere with wound healing, such as steroid use, diabetes, or malnutrition, can result in persistence of the leak. A thoracic surgeon can minimize the incidence of air leak through meticulous surgical technique and can identify patients in whom the balance of risks (Table 1) and benefits warrant operative intervention based on an understanding of the underlying pathophysiology.

Air↗

Control of intraocular pressure after deep sclerectomy.

AIM: To study the long-term outcome of deep sclerectomy in patients with open angle glaucoma. METHODS: Prospective consecutive series of 43 eyes (38 patients) with medically uncontrolled open-angle glaucoma undergoing deep sclerectomy. All patients underwent clinical assessment before and after surgery at day 7 and at months 1, 3, 6, 12, 18, 24, 36. Surgical success was considered if the patient's intraocular pressure (IOP) < 22 mmHg and the IOP was lowered by more than 20% without the use of any medication. Kaplan-Meier survival curves were used to evaluate the success rate. RESULTS: The mean follow-up time was 28.1 +/- 8.2 months. Mean IOP decreased significantly from a preoperative value of 24.6 +/- 5.5 mmHg to a postoperative value of 18.5 +/- 4.6 mmHg at 36 months (P < 0.001). Microperforation of TDM occurred in three cases (7.0%) and ciliary body prolapse in one case (2.3%) but did not prevent completion of the operation. Postoperatively, hyphaema was detected in one case and shallow anterior chamber in another case and both were treated conservatively. Bleb encapsulation with elevation of IOP occurred in two cases (4.7%) and was treated with 5-fluorouracil subconjunctival injection. Goniopuncture with neodymium : YAG laser was performed in two cases (4.7%). There were no other late complications with the exception of failure of the operation. On the life-table analysis the success rate at 12, 24, and 30 months were 61.4, 36.6, and 18.9%, respectively. CONCLUSION: Deep sclerectomy reduced the IOP temporarily while minimising the risk of postoperative complications commonly encountered with standard trabeculectomy. However, after long-term follow-up surgery failed to maintain a low IOP.

Aged↗

Immediate coverage of exposed, denuded cranial bone with split-thickness skin grafts.

Avulsion injuries of the scalp are challenging to treat. If the periosteum is not intact and the status of local tissues does not allow local flap transposition, coverage of the exposed, denuded skull becomes a problem. Most authors have obtained a bed of granulation tissue at the site of exposed bone before skin grafting, which requires a prolonged waiting period. In 5 consecutive patients, the authors obtained coverage in a single operation by removing the outer table of the skull with a high-speed burr, followed by immediate application of a skin graft over the bleeding, cancellous bone. This resulted in stable coverage and shortened the hospital stay significantly. They describe their technique and compare it with others.

Adult↗

Radiological diagnosis of screw penetration of the hip joint in acetabular fracture reconstruction.

Screw penetration of the hip joint following acetabular fracture reconstruction is a relatively uncommon complication but, if not corrected, may have a catastrophic effect on the postoperative function of the hip joint. Intraoperative radiographs and postoperative standard anteroposterior (AP) radiographs frequently show super-imposition of the screws and acetabulum. Computed tomographic (CT) scanning has been the only diagnostic technique available allowing documentation of screw penetration into the hip joint. CT scan, however, can be performed only after termination of surgery. In search for a radiological view that will help in diagnosing screw penetration into the hip joint both intra- and postoperatively, we undertook a controlled study of 25 patients having either a posterior or extensile lateral surgical approach and six cadaveric specimens. A combination of a cross-table lateral view of the hip and a Judet iliac view proved more informative than AP or Judet obturator views in demonstrating absence or presence of the screw in the hip joint (if the screws were placed along the posterior wall or column). Intraoperative AP radiographs projected as a Judet obturator view were the least helpful in making this determination. When screw penetration is suspected, we recommend the use of intraoperative fluoroscopy in multiple projections or intraoperative arthrogram in the lateral projection of the pelvis. Also, Judet iliac and cross-table lateral radiographs in the operating room while the patient is still under anesthesia might exclude any screw penetration into the hip joint.

Acetabulum↗

Intramedullary nailing of acute femoral shaft fractures without a fracture table: technique of using a femoral distractor.

Intramedullary nails were placed prospectively in 25 acute femoral shaft fractures in 25 patients without the use of a fracture table. A femoral distractor was used in 21 of the 25 patients to aid in obtaining and holding a reduction. Our goals were to determine if the technique was safe and effective for insertion of intramedullary nails in a wide spectrum of femoral fractures--with no increase in morbidity when compared to the use of the more familiar fracture table--and to determine the potential complications and pitfalls of using this technique. A retrospective evaluation of the most recent 25 patients with 27 femoral fractures that underwent intramedullary nailing on a fracture table was done to compare operative time, estimated blood loss, complications, and postoperative fracture alignment. In addition to the clinical evaluation, cadaveric dissections were undertaken to determine the exact location of the proximal distractor screw in relation to the contents of the femoral triangle. The femoral nerve was a minimum of 2.5 cm, and the femoral artery a minimum of 3.0 cm from the proximal screw. In comparing the two studies, no significant difference was noted in the age of the patients, fracture types or locations, associated injuries, operative time, estimated blood loss, final fracture reduction, or nail position. No complications were encountered in the placement of the proximal femoral distraction screw. Although the distraction method is technically difficult because the reduction is obtained entirely during the procedure, there are certain situations when this technique could be employed with the benefit of decreasing intraoperative patient manipulation, thereby shortening operative time.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

A single dimension statistical evaluation of predictors in implant-overdenture treatment.

This retrospective study aims to identify factors that contribute to either a poor or excellent treatment result in implant-overdenture treatment. A total of 375 implants, in an equal number of patients were included in the study. A clinical examination was performed by 2 observers. Gingival health and oral hygiene were assessed and additional complications were noted, including implant loss. 2 outcome variables, STATUS1 and STATUS2, were constructed that were different with respect to treatment outcome, representing a poor and an excellent result, respectively. Patient variables such as age, gender, medical status and prosthetic history were collected pre-operatively with a questionnaire. Life table analyses were used to test subsets of patient and treatment variables for differences in survival distribution, both for poor or excellent results. With regard to predictors of poor results; implants in the upper jaw were associated with a poorer outcome than those placed in the lower jaw (p = 0.01). When more than 2 implants were placed, the quality of survival was also impaired (p = 0.03). Interestingly, implants in patients with a self-proclaimed history of tooth loss due to periodontitis appear to have a far poorer treatment outcome than implants placed in patients without such a history (p = 0.01). No other variables could be related to a poor result after 3 years. None of the variables could predict an excellent treatment outcome.

Age Factors↗

Elevated amniotic fluid interleukin-6 levels during the early second trimester are associated with greater risk of subsequent preterm delivery.

PROBLEM: Subclinical intra-amniotic infection is often associated with preterm delivery and may precede it by several weeks. We tested the hypothesis that Interleukin-6 (IL-6) may be elevated in the midtrimester amniotic fluid of pregnancies destined to deliver preterm. METHODS: A historical cohort study was designed to compare the amniotic fluid (AF) concentrations of IL-6 at 14-20 weeks in a group of women subsequently delivering at < or = 34 weeks (n = 13) with those of women delivering at term (n = 166). Included were singleton gestations with no evidence of fetal structural or chromosomal abnormalities, or maternal conditions known to be associated with preterm delivery (n = 179). Levels of IL-6 were measured by immunoassay and correlated with demographic and pregnancy outcome information. Statistical analysis included correlation, one-way ANOVA after log-transformation, contingency tables, logistic regression, and receiver operator characteristic (ROC) curve analysis. RESULTS: There was an inverse correlation between AF IL-6 levels at 15-20 weeks and gestational age at delivery (r = -0.16, P = 0.03). Women delivering at < or = 34 weeks had significantly higher median AF IL-6 levels (570 pg/ml versus 330 pg/ml, P < 0.0001), rate of African American race (50% versus 12%, P = 0.004), and of infants with birth weights < 10th centile (31% versus 7%, P = 0.02) than women delivering at > or = 37 weeks. Logistic regression analysis showed that IL-6 was independently associated with PTD at < or = 34 weeks after controlling for race and birth weight centiles (P = 0.039). CONCLUSIONS: AF IL-6 at 15-20 weeks can identify patients at risk for PTD at < or = 34 weeks, suggesting that a portion of PTD cases have inciting events that take place during the early second trimester.

Adult↗

Laser-based microfocused x-ray source for mammography: feasibility study.

A laser-produced plasma (LPP) x-ray source with possible application in mammography was created by focusing a laser beam on a Mo target. A Table-Top-Terawatt (TTT) laser operating at 1 J energy per pulse was employed. A dual pulse technique was used. Maximum energy transfer (approximately 10%) from laser light to hot electrons was reached at a 150 ps delay between pulses and the conversion efficiency (hard x-ray yield/laser energy input) was approximately 2 x 10(-4). The created LPP x-ray source is characterized by a very small focal spot size (tens of microns), Gaussian brightness distribution, and a very short pulse duration (a few ps). The spectral distribution of the generated x rays was measured. Images of the focal spot, using a pinhole camera, and images of a resolution pattern and a mammographic phantom were obtained. The LPP focal spot modulation transfer function for different magnification factors was calculated. We have shown that the LPP source in conjunction with a spherically bent, high throughput, crystal monochromator in a fixed-exit Rowland circle configuration can be used to created a narrow band tunable mammography system. Tunability to a specific patient breast tissue thickness and density would allow one to significantly improve contrast and resolution (exceeding 20 lp/mm) while lowering the exposure up to 50% for thicker breasts. The prospects for the LPP x-ray source for mammographic application are discussed.

Biophysical Phenomena↗

A policy for a unified meat service.

Unification of meat hygiene control in Britain would lead to an improved service in terms of hygiene and welfare and would ensure continuity from the Minister through to the abattoir meat hygiene team. This in turn would increase consumer confidence in British meat both at home and abroad, and would enable compliance with EC meat hygiene requirements for harmonisation beyond 1992. The level of veterinary supervision and control required throughout the meat plant process has not yet been fully determined by the EC. However, the BVA envisages a team approach headed by a veterinarian with the level of direct veterinary involvement tapering from farm to table. BVA envisages an agency operating along the lines of the current Veterinary Medicines Directorate, with a similar identity but relating to meat hygiene and the welfare of animals at slaughter. Such a unified system could operate more efficiently and more economically than smaller separate organisations. Such a system would ensure even application of standards, avoid duplication of activities, and save money by efficient use of staff and resources. The structure would also allow for better salaries and career prospects than smaller local authority units can provide. This would lead to recruitment and commitment of more highly qualified staff. The purpose of the reorganisation would be to establish a meat quality control service which would ensure that meat and meat products supplied to retail outlets are hygienically produced to standards set down by the EC. Such a service would replace the variable standards of local authority departments and enable MAFF to discharge its EC responsibility as the 'competent authority'.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

Interpretation of roentgenograms via interactive television.

The diagnostic quality of roentgenographic images transmitted by interactive television was evaluated. A series of 100 kidney, ureter and bladder, chest, and bone radiographs were read individually by five radiologists, both on direct viewing and on viewing a monitor image of the television signal. The latter was transmitted by microwave a distance of 28 miles, including four transmission legs. Analysis in terms of receiver operating characteristic curves and critical tables indicated that the television interpretations were of acceptable accuracy, in view of the participants' inexperience with teleradiology.

Bone and Bones↗

Avascular necrosis of the femoral head. Natural history and magnetic resonance imaging.

We studied the prognostic value of MRI in 32 radiographically normal, asymptomatic hips in 25 patients at risk of osteonecrosis from glucocorticoids or alcoholism. The early findings were band-like hypointense zones on spin-echo images. No operations were performed. Life-table survival curves showed that femoral heads in which the hypointense zone traversed the middle portion of the head were most at risk of subsequent segmental collapse.

Adolescent↗