Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Neuroectodermal Tumors, Primitive, Peripheral”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,189 records · Page 66Linked to original sources
PubMed1991

[Olfactory neuroblastoma--a report of 4 cases and review of literature].

This paper reports 4 patients with pathologically proven olfactory neuroblastoma. This tumor most commonly occurs along the medial line of the nasal cavity, base of the anterior cranial fossa, or the ethmoid sinuses. Special stain or electron-microscopy should be done routinely to ensure diagnostic accuracy if a mass at the above sites was suspected to be an olfactory neuroblastoma. Ample excision and preoperative and/or postoperative radiotherapy was recommended. The irradiation field should be large enough and the dose more than 60 Gy. The prognosis of patients in Group C of Kadish classification and children was poor. Recurrence and metastasis might still occur many years after the initial treatment, necessitating close follow-up.

Adult↗
PubMed1991

[Neuroepithelial tumors in the pediatric population].

We have studied the neuroepithelial tumors in childhood, about their epidemiological, clinical and histological aspects, the macroscopic tumoral structure and the findings obtained by magnetic resonance imaging. We stress the differential diagnosis features among the various tumoral types, based on bibliography and our own clinical experience.

Astrocytoma↗
PubMed1991

[Contribution of cytogenetics to the diagnosis of Ewing's sarcoma and small round cell tumors].

The diagnosis of the so-called "small-round-cell tumours" in children and adolescents is a troublesome problem, particularly in specific forms of the disease or/and in undifferentiated cell proliferations. Under these circumstances the finding of a specific chromosomal abnormality in the tumour cells is invaluable, specially for the diagnosis of Ewing sarcoma and primitive neuroectodermal tumours as well as alveolar rhabdomyosarcoma. The use of cytogenetics, in combination with morphological and immunohistochemical studies to identify cell differentiation markers, is either the only positive diagnostic criterion, or a complementary factor in diagnosis.

Adolescent↗
PubMed1991

[Necrotic medulloepithelioma of the eye].

An exceptionally rare case of the ciliary body medulloepithelioma is described. The distinctive feature of this case was the subtotal necrosis of the tumour. The development of necrosis is attributed to the destruction of the lens capsule and lens fibres by tumour cells. It resulted in phako--anaphylactic endophthalmitis which is likely to have been the cause of the tumour necrosis. Possible immune and autoimmune mechanisms of inflammatory--destructive changes of the eye tissue and the tumour are discussed.

Ciliary Body↗
PubMed1991

Intracranial primitive neuroectodermal tumors: experience of 7 cases with particular reference to survival.

A group of neoplasms consisting of undifferentiated neuroepithelial cells being capable of differentiating into either neuronal or glial line or both directions has been termed "Primitive Neuroectodermal Tumors (PNETs)". They have been shown to possess several similarities in clinical, radiological, and pathological features to the cerebellar medulloblastomas. The latter are well treated by surgical removal followed by radiotherapy. Therefore, we used the same regimen in treating 7 patients with intracranial PNETs and obtained an average survival of 28.7 months which is longer than those of previous reports. The analysis of our patients disclosed an optimistic view that the ideal prognosis of PNETs should be better than this.

Adolescent↗
PubMedDate not supplied

[Olfactory neuroblastoma. A clinical and morphological study].

A clinical and morphological study about neuroblastoma with olfactory differentiation are made. This study includes: TAC, vanimil mandelic acid urine determination, optic microscope, immunohistochemical technique, neuropeptidal, in situ hybridization, DNA analysis by flow cytometry and electronic microscope.

Combined Modality Therapy↗
PubMed1991

[Esthesioneuroblastomas. Could a preoperative chemotherapy improve their prognosis?].

The prognosis of malignant tumours of the olfactory epithelium of the nasal vault stays very poor. In the literature, the 5-year actuarial survival rate ranges between 50% and 65%; the 5-year recovery rate is 15% due to the high frequency of locoregional reoccurrences (60%) and metastasis (35-40%). Up to now chemotherapy was suggested as palliative treatment; but as Esthesioneuroblastomas (ETNB) appear to be sensitive to several chemotherapeutic agents (such as CDDP and 5-FU), we have decided to administer, from now on, to all patients harbouring an ETNB, an inductive chemotherapy whatever the staging and eventual diffusion of the tumour. The present paper presents our recent experience, dealing with such lesions: since 1984, 60 tumours of the ethmoid were treated in our department among which 7 ETNB (11.5%). We discuss our results concerning ETNB.

Adult↗
PubMed1991

[A case of an intracranially located esthesioneuroepithelioma].

A 1-year-8-month-old boy was admitted to our service on September 30, 1986, complaining of nausea, vomiting and consciousness disturbance lasted for about 2 weeks. In CTs, right frontal cystic mass which was homogeneously enhanced by contrast media was revealed. Neither hypervascularity nor tumor staining were seen angiographically. On October 9, 1986, total removal of the tumor was performed. The tumor was located extracerebrally in the right anterior cranial fossa, but was covered with arachnoid membrane. The tumor showed tight adhesion with falx cerebri, particularly at crista galli where an invasive infiltration was seen. Light microscopic examination demonstrated oval or spherical small cells arranged multilobularly with rosette like formation and numerous mitoses. Ultrastructurally, cilia, microvilli and junctional complexes were observed. No dense-cored secretory granules were found in the tumor cells. Immunohistochemical study on this tumor showed negative NF and GFAP; positive NSE, S-100, vimentin and keratin. From these findings, the tumor was diagnosed as esthesioneuroepithelioma. Postoperatively, irradiation and chemotherapies were also performed, and the patient showed uneventful course. On January 31, 1987, he was discharged on his foot, and no recurrent or metastatic signs could be found until the end of March of 1990.

Brain Neoplasms↗
PubMed1990

Nerve growth factor-induced differentiation of human neuroblastoma and neuroepithelioma cell lines.

A series of neuroepithelioma and neuroblastoma cell lines were screened for nerve growth factor (NGF)-induced differentiation. All three neuroepithelioma cell lines and all nine neuroblastoma cell lines with amplified N-myc oncogene did not show any apparent NGF-induced differentiation. However, neurite extension was observed for three of six neuroblastoma cell lines with single-copy N-myc oncogene. The three responsive lines had a neuronal phenotype (short processes) which was enhanced by the addition of NGF. The three nonresponsive cell lines were flat without any processes. The addition of NGF to the responsive cell lines resulted in an up-regulation of neurofilament mRNA expression. Peripherin and synapsin, two markers of terminal neuronal differentiation, were not induced. There was little effect of NGF on the rate of cell growth or colony formation on soft agar. Binding of NGF to eight of the cell lines was analyzed by the method of Scatchard. Two responsive neuroblastoma cell lines and one nonresponsive neuroepithelioma cell line expressed both low- and high-affinity binding sites. Two nonresponsive neuroblastoma cell lines expressed only a small number of high-affinity binding sites, and two other nonresponsive neuroblastoma cell lines did not detectably bind NGF. Hence, NGF-induced differentiation is confined to a particular class of neural-related tumors, and, even for these cell lines, differentiation is incomplete.

Cell Differentiation↗
PubMed1991

[The treatment procedure in olfactory (esthesioneurogenic) tumors].

In 1968-1988, eleven cases of olfactory neurogenic tumors were seen at The All-Union Center for Oncology Research, Moscow which made up 9.5% of the total of nasal cavity cancers. Morphologically, esthesioneurocytoma was diagnosed in two patients whereas esthesioneuroblastoma--in nine. Four patients received combined therapy while seven--chemotherapy and radiation. Progression of the disease was registered in 7 out of 11 patients: in 3 of 4 cases receiving combination treatment and in 4 out of 7 those treated conservatively. Four cases died within 7-29 months while 7 remain alive: two patients at 18 and 156 months following combined therapy and 5--at 18, 18, 24, 84 and 132 months after chemoradiation treatment. Radiation alone proved the best therapeutic option. Surgery is justified in cases with residual tumor as second-line procedure.

Adolescent↗
PubMed1991

[Significance of electron microscopy in the diagnosis of undifferentiated neoplasms of the nose and nasal sinuses].

Undifferentiated neoplasms of nose and nasal sinuses are very rare. They are very difficult to diagnose by both light and electron microscopies. Twelve cases of undifferentiated neoplasms of nose and nasal sinuses were collected and the morphological features under light and electron microscopes compared histologically. The results showed that correct diagnoses were only obtained in six cases by light microscopy. The other six cases were diagnosed by electron microscopy as malignant melanomas in two cases, leiomyosarcoma in one case, olfactory neuroblastomas in two cases and malignant fibrous histiocytoma in one case. It showed that a correct diagnosis for undifferentiated neoplasm of nose and nasal sinuses was impossible to obtain by light microscopy only. Poorly differentiated olfactory neuroblastoma was also difficult to diagnose under electron microscope because the neurosecretory cytoplasmic granules were not easy to find and several hours would be required to search for them under electron microscope.

Adolescent↗