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[Pathological studies on epidermic and appendage tumors and tumor-like lesions--analysis of 3,425 cases].

This paper analyses 3,425 cases of epidermic and appendage tumors and tumor-like lesions. There were 2,137 cases (62.4%) of benign tumors and tumor-like lesions and 1,288 (37.6%) of malignant tumors. The incidence of benign tumors and tumor-like lesions in the epidermis (1,742 cases, 81.5%) was higher than that in the appendage (395 cases, 18.5%). The most common malignant tumor was squamous cell carcinoma (958, 74.4%) and the basal cell carcinoma (296, 23.0%) ranked second, while the malignant tumor in the appendage was very rare (34, 2.6%). The ratio of squamous cell carcinoma and basal cell carcinoma was 3.2:1. For the sex difference in general, male was slightly common than the female (1.5:1 in the benign tumors and 2.1:1 in the malignant), but in basal cell carcinoma and benign tumors of the hair follicle and sweat glands, there were more female than the male. For the age difference, the incidence of the benign tumor and tumor-like lesion were higher in the adolescence and adult, while the malignant tumors, were more prevalent in the adult and the elderly. The basal cell carcinoma was frequently seen in the old ages. For the site difference, most cases of skin tumors were located in the head and neck, but more than half of squamous cell carcinomas occurred in the penis.

Adolescent↗

[Effectiveness of the legal neoplasm prevention program in a cytological laboratory].

The test results of preventive gynecological examinations as assessed by a medium-sized cytological laboratory over a 5-year-period are reported. It is differentiated between the results found at first screening and at re-screening. Of the 34,121 women screened for the first time. 0.32% suffered from invasive cervical carcinoma or carcinoma of the corpus uteri and 0.41% from carcinoma in situ, whereas only 0.031% of the 192,089 re-screened women had invasive carcinoma and only 0.064% had carcinoma in situ. Thus the incidence of positive cases was 10 times higher with first check-ups as compared to annual follow-up screening. A retrospective inquiry with the participating physicians revealed among 116,020 cases 177 additional carcinomas ( = 0.15%), i.e. 122 breast cancers, 28 carcinomas of rectum or colon (5 primarily discovered by Haemoccult test) and 27 tumors of the skin, kidney or ovary. These results suggest the effectivity and neccessity of the Cancer Early Detection Program.

Clinical Laboratory Techniques↗

Semiparametric models for cumulative incidence functions.

In analyses of time-to-failure data with competing risks, cumulative incidence functions may be used to estimate the time-dependent cumulative probability of failure due to specific causes. These functions are commonly estimated using nonparametric methods, but in cases where events due to the cause of primary interest are infrequent relative to other modes of failure, nonparametric methods may result in rather imprecise estimates for the corresponding subdistribution. In such cases, it may be possible to model the cause-specific hazard of primary interest parametrically, while accounting for the other modes of failure using nonparametric estimators. The cumulative incidence estimators so obtained are simple to compute and are considerably more efficient than the usual nonparametric estimator, particularly with regard to interpolation of cumulative incidence at early or intermediate time points within the range of data used to fit the function. More surprisingly, they are often nearly as efficient as fully parametric estimators. We illustrate the utility of this approach in the analysis of patients treated for early stage breast cancer.

Analysis of Variance↗