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At least 1,189 records · Page 66Linked to original sources
PubMed1993

Mid-life onset of dietary restriction extends life and prolongs cognitive functioning.

Fourteen-month-old C57BL/6 (NIA) mice were placed on a nutritionally complete diet providing 139.4 kcal/week. Over a 2-month period the food ration of experimental mice (AE) was reduced to 85 kcal/week, where it remained for the duration of the study. An aged control group (AC) continued with the higher calorie diet. At age 22 months, AC mice and half of the AE mice (AE22) were given a battery of behavioral tests. The remaining AE mice (AE25) were given the test battery at age 25 months. Also, a middle-aged control group (MC) was tested at age 13 months. Midlife onset caloric restriction (CR) increased longevity and preserved strength, coordination, and spontaneous alternation behavior, and altered responses to enclosed alleys. A spatial discrimination in the Morris water maze and a spatial delayed matching-to-sample water-escape task were insensitive to age and diet. The aged mice were adversely affected by testing.

Aging↗
PubMed1984

How depressing life is--life-long morbidity risk for depressive disorder in the general population.

We present estimates of lifetime risk and of cumulative risk up to each age for depressive disorder for the population of an inner city area (Camberwell, SE London). Estimates are based on an incidence study for the year 1976 which drew from the records of a case register. The estimates of lifetime risk obtained, 12% for men and 20% for women, are similar to those previously published in the literature. Inception risk by age and risks for in-patient treatment are also presented for men and women. The method of calculation is discussed and we show how to obtain an upper limit for the effect of the increased mortality associated with the disorder. We noted an apparent decline over the 'seventies' in inception rates for depression, and we consider the comparability of our statistics with risks calculated using complete psychiatric history data.

Adolescent↗
PubMed2006

When giving life starts to take the life out of you: women's experiences of depression after childbirth.

OBJECTIVE: To capture the missing voices of mothers who are suffering postnatal depression. DESIGN: Qualitative methodology using in-depth interviews. SETTING: Melbourne, Victoria, Australia. PARTICIPANTS: 10 women who had been clinically diagnosed and admitted to a large hospital mother and baby unit in Australia. FINDINGS: Stigma is frequently attached to women who are unhappy after the birth of their child, because they are not coping with the demands of motherhood or do not instantly bond with, and love, their baby. As a result, postnatal depression can be a terrifying and isolating experience for women. It is also a complex illness with varying degrees, reasons for onset and medical treatments. IMPLICATIONS FOR PRACTICE: In this study, we have captured the emotions and feelings of women first hand, allowing us and health-care practitioners who are treating women to truly understand this debilitating illness. It is hoped that, in making the wider community aware of depression after childbirth, fewer women will suffer in silence.

Adaptation, Psychological↗