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At least 1,189 records · Page 66Linked to original sources
PubMed1996

Voltage-dependent chloride channels: invertebrates to man.

Chloride channels are ubiquitous proteins found in invetebrates to man. Cl- is one of the most abundant biological anions and accounts for a measurable fraction of the electrical conductance of many biological membranes. Physiologically this contributes to cellular processes, including pH regulation, volume regulation, generation of the resting membrane potential, and regulation of membrane excitability. The unitary conductance of voltage-dependent Cl- channels is as diverse as the number of different types of Cl- channels described ranging from 5-450 pS. Cl- channels are highly anion selective passing at least ten anionic species, including all of the halides. Cl- channels are blocked by various agents, including aromatic acids, inorganic cations, and protons. Maintaining high resting conductance and normal excitability, regulating cell volume, and modulating hormone action are some examples of the functions of Cl- channels. Despite the large amount of data accumulated on voltage-dependent Cl- channels, identifying subsets within this class of channels with coherent biophysical features that subserve each specific function is still not possible. At present, the molecular structure for every type of functional Cl- channels has not been determined, but future identification of cloned Cl- channel structures should provide a clearer understanding of the functional properties of background Cl- channels.

Animals↗
PubMed2003

Effects of 50 Hz magnetic fields on fMLP-induced shape changes in invertebrate immunocytes: The role of calcium ion channels.

Plasma membrane Ca(2+) channels in immunocytes from the mussel Mytilus galloprovincialis exposed to 50 Hz sine wave magnetic fields (MFs) of various strengths were studied. At levels of 300 microT and above, MFs reduce shape changes in immunocytes induced by the chemotactic substance N-formyl-Meth-Leu-Phe, and this effect involves L-type Ca(2+) channels. Upon the addition of the Ca(2+) blocker verapamil to molluscan immunocytes exposed to MFs results in a synergistic cytotoxic action, while in the presence of the Ca(2+) opener SDZ-202, 791, a reactivation of the cells is observed. This suggests that, as previously reported for potassium channels, the damage to Ca(2+) channels induced by short exposure to MF at appropriate intensities is not permanent.

Animals↗
PubMed1994

Retrograde signaling and the development of transmitter release properties in the invertebrate nervous system.

The dynamics of presynaptic transmitter release are often matched to the functional properties of the postsynaptic cell. In organisms ranging from cats to crickets, evidence suggests that retrograde signaling is essential for matching these presynaptic release properties to individual postsynaptic partners. Retrograde interactions appear to control the development of presynaptic, short-term facilitation and depression.

Animals↗