[Clinico-pathological studies on multiple colorectal cancer].
Of 743 patients with colorectal cancer operated during the past 21 years, 52 with double cancer, excepting patients in whom the disease was associated with familial polyposis, were examined. A higher association of adenomas was noted in multiple carcinomas of the large intestine than in a single carcinoma. As most of the multiple carcinomas were located close to each portion, it is possible to resect the multiple tumors concomitantly during a single operative procedure. No recurrence or mortality was seen in patients with synchronous multiple carcinomas that coexisted with advanced and early cancers. However, all patients with two or more advanced cancers died a short time after the operation. In 66.7% of the cases the other organ involved in the double cancer was the stomach. When the cancers were in the early stage, long-term survival could be achieved even in the presence of synchronous double cancers. Despite the early detection of the primary cancer in metachronous double cancer, patients whose second cancer was in the advanced stage died shortly after the second operation.