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PubMed2004

Functional informatics: convergence and integration of automation and bioinformatics.

The biopharmaceutical industry is currently being presented with opportunities to improve research and business efficiency via automation and the integration of various systems. In the examples discussed, industrial high-throughput screening systems are integrated with functional tools and bioinformatics to facilitate target and biomarker identification and validation. These integrative functional approaches generate value-added opportunities by leveraging available automation and information technologies into new applications that are broadly applicable to different types of projects, and by improving the overall research and development and business efficiency via the integration of various systems.

Automation↗
PubMed2002

[The informatics process in health: subjects discussed in articles published from 1978 to 1998].

The principal themes are described approached in goods of indexed newspapers, in two bases of available data in Internet, in the period from 1978 to 1998. Consultations were accomplished BIREME, through Internet, being used the descriptors in several orders. A total of 54 goods was obtained that were codified and tabulated. It was ended that, in the studied sample, the thematic of the researches developed on computer science in health had a profile change that passed of theoretical studies for applications in the work atmosphere.

Medical Informatics↗
PubMedDate not supplied

Rating the raters: legal exposure of trustmark authorities in the context of consumer health informatics.

There are three areas of potential legal exposure for an organization such as a trustmark authority involved in e-health quality rating. First, an e-health provider may make a complaint about negative or impliedly negative ratings rendered by the ratings body (false negative). Typically, a negative ratings complaint would rely on defamation or product disparagement causes of action. In some cases such complaints could be defended on the basis of absence of malice (US). Second, the rating body might render a positive rating on e-health data that a third party allegedly relied upon and suffered injury (false positive). While the primary cause of action would be against the e-health data provider, questions may arise as to the possible liability of the trustmark authority. For example, some US liability exposure is possible based on cases involving the potential liability of product warrantors, trade associations, and certifiers or endorsers. Third, a ratings body may face public law liability for its own web misfeasance. Several risk management approaches are possible and would not necessarily be mutually exclusive. These approaches will require careful investigation to assess their risk reduction potential and, in some cases, the introduction of legislation.

Consumer Behavior↗
PubMed2005

Breaking the translational barriers: the value of integrating biomedical informatics and translational research.

The conduct of translational health research has become a vital national enterprise. However, multiple barriers prevent the effective translation of basic science discoveries into clinical and community practice. New information technology (IT) applications could help address these barriers. Unfortunately, owing to a combination of organizational, technical, and social factors, neither physician-investigators and research staff nor their clinical and community counterparts have harnessed such applications. Recently, at the request of the Institute of Medicine's Clinical Research Roundtable, a qualitative study of these factors was conducted at several leading academic medical centers. We explore the current status of IT in the translational research domain, describe the qualitative results, and conclude with a proposed set of initiatives to further increase the integration of IT into translational research.

Biomedical Research↗
PubMedDate not supplied

Challenges and opportunities for technology assessment in medical informatics. Case study: PACS.

In this paper the basic steps of cost-effectiveness analysis (CEA) are applied in the evaluation of picture archiving and communication systems (PACS). The exercise demonstrates that evaluations of PACS have been technology-orientated, rather than problem-orientated. Moreover, many of the potential benefits of the system have been insufficiently investigated. Assessment based on the analysis of the bottlenecks in the film-based system alone appears to be quite inaccurate, as shown by the diverging outcomes of early assessment results. The development of PACS has reached a state in which the first clinical experiences are being collected. This provides an opportunity to test postulated costs and benefits. Moreover it may provide a better insight into the future potential of the technology. Experimenting with PACS is expensive. Hence, we should work together in evaluation, in order to benefit as much as possible from each other's experiences.

Cost-Benefit Analysis↗
PubMedDate not supplied

Data mining and healthcare informatics.

OBJECTIVE: To acquaint members of the Academy with a relatively recent development in the area of data exploration and statistical analysis. METHODS: A review of the concepts and methods inherent in data-mining with a special emphasis on the those methods applicable to predictive modeling. RESULTS: Data-mining is demonstrated to be a useful tool for researchers in those circumstances where large amounts of information are available. CONCLUSIONS: With the advent and proliferation of on-line data collection, truly massive databases are now available to health care researchers. In that situation, data-mining methods yield some unique opportunities to researchers who wish to develop prediction models and to establish associations.

Database Management Systems↗