Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “GOLGI APPARATUS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,189 records · Page 66Linked to original sources
PubMed1978

Sequential passage of alpha2mu-globulin through the hepatic endoplasmic reticulum and Golgi apparatus during secretion.

Studies on the synthesis and secretion of the sex-dependent urinary protein, alpha2mu-globulin, have been extended by establishing its sequential passage from the rough to the smooth endoplasmic reticulum and Golgi-rich fractions of the liver of adult male rats. After injection of 14C-labeled amino acids, the maximum radioactivity of alpha2mu occurred at 20 min in the rough, 25 min in the smooth microsomes and 30 or 35 min in the Golgi-rich fractions. Radioactive alpha2mu-globulin appeared in the bloodstream and kidneys after a lag of 20--25 min. Results indicate that alpha2mu-globulin follows a secretory pathway similar to that of serum albumin.

Alpha-Globulins↗
PubMed1988

Morphologic evidence that disruption of the Golgi apparatus in PFHR 9-tumor cells causes disturbance in the traffic through this organelle.

PFHR 9 is a murine teratocarcinoma-derived tumor which produces basement membrane components. Electron microscopy of the tumor cells disclosed a disorganization of the Golgi complex whose saccules, instead of being flattened, round up into 0.13 micron-wide spherical vesicles (SV). Their shape does not permit the normal stacking of parallel cisternae, and thus these SV become intermingled with transport vesicles (TV) which measure 44 nm in diameter. The cytoplasm of these tumor cells contains numerous multivesicular bodies (MVB) of varying size (ranging from 0.3 to 2.6 micron), which occupy 7% of the cellular volume. These MBV are packed with very many small vesicles similar in all aspects to the TV, and also contain a few larger vesicles which resemble the altered Golgi saccules (SV). Since these MVB display morphologic evidence for gradual lysis of their contents and strongly react with the cytochemical method for acid phosphatase, it is assumed that MVB are autophagic vacuoles which result from the accumulation of TV. This seems to be a unique example of a disease of the Golgi stack, with consequent accumulation and disposal of this material via autophagic vacuoles.

Animals↗