Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Entropy”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,189 records · Page 66Linked to original sources

Approximate maximum entropy joint feature inference consistent with arbitrary lower-order probability constraints: application to statistical classification

We propose a new learning method for discrete space statistical classifiers. Similar to Chow and Liu (1968) and Cheeseman (1983), we cast classification/inference within the more general framework of estimating the joint probability mass function (p.m.f.) for the (feature vector, class label) pair. Cheeseman's proposal to build the maximum entropy (ME) joint p.m.f. consistent with general lower-order probability constraints is in principle powerful, allowing general dependencies between features. However, enormous learning complexity has severely limited the use of this approach. Alternative models such as Bayesian networks (BNs) require explicit determination of conditional independencies. These may be difficult to assess given limited data. Here we propose an approximate ME method, which, like previous methods, incorporates general constraints while retaining quite tractable learning. The new method restricts joint p.m.f. support during learning to a small subset of the full feature space. Classification gains are realized over dependence trees, tree-augmented naive Bayes networks, BNs trained by the Kutato algorithm, and multilayer perceptrons. Extensions to more general inference problems are indicated. We also propose a novel exact inference method when there are several missing features.

Journal Article↗

Approximate entropy of the electroencephalogram in healthy awake subjects and absence epilepsy patients.

The approximate entropy (ApEn) of signals in the electroencephalogram (EEG) was evaluated in 8 healthy volunteers and in 10 patients with absence epilepsy, both during seizure-free and seizure intervals. We estimated the nonlinearity of each 3-sec EEG segment using surrogate data methods. The mean (+/- SD) ApEn in EEG was 0.83 +/- 0.22 in healthy subjects awake with eyes closed. It was significantly lower during epileptic seizures (0.48 +/- 0.05) than during seizure-free intervals (0.80 +/- 0.13) (P < 0.001). Nonlinearity was clearly detected in EEG signals from epileptic patients during seizures but not during seizure-free intervals or in EEG signals from healthy subjects. The ApEn of EEG signals estimated over consecutive intervals could serve to determine pathological brain activity such as that occurring during absence epilepsy.

Adult↗

Specific patterns of cortical dysfunction in dementia and Parkinson's disease demonstrated by the acceleration spectrum entropy of the EEG.

Acceleration spectrum entropy (ASE) was used to quantify EEG desynchronization, which is related to cortical activation. We investigated the ASE in control and patient groups with dementia (AD) and Parkinson's disease (PD). Both patient groups had significantly lower ASE scores corresponding with less desynchronization in all cortical regions. In the AD group, the ASE was significantly lower in the parietal region. ASE was found to be a sensitive and specific measure for differentiating patient groups with AD and PD from controls and from each other.

Aged↗

Comparison of subtractive Kramers-Kronig analysis and maximum entropy model in resolving phase from finite spectral range reflectance data.

The maximum entropy model (MEM) and Kramers-Kronig (K-K) analysis were compared with the aim of phase retrieval from reflectance. The object was to test two different phase-retrieval methods when reflectance is known at a finite frequency range and data fitting is not performed beyond the finite frequency band. In addition, it was assumed that the phase is known only at one or two anchor points. As an example, we study the terahertz reflection spectrum related to a semiconductor and an optical spectrum of potassium chloride. It is shown that the MEM resolves the complex refractive index of a medium, in the vicinity of initial and final points of the spectra, better than singly and doubly subtractive K-K relations. Both methods give only satisfactory results in the event of one anchor point, but in the case of two anchor points, the MEM is better than doubly subtractive K-K. It is proposed that the MEM should be used instead of K-K analysis, for a priori information of phase at two anchor points, for the purpose of resolving the complex refractive index of a medium from reflectance with high accuracy.

Journal Article↗

Component analysis of spatial and spectral patterns in multispectral images. II. Entropy minimization.

In Part I [J. Opt. Soc. Am. A 4, 2101 (1987)] of this series, we developed a method for estimating both spatial patterns and spectral curves of components in a multispectral scene. This method does not need spatial and spectral information about the components but only multispread imagery data. The estimation is given as a feasible solution set satisfying the nonnegativity constraint for density and spectral response for all components at all pixels. In this paper, we estimate unique solutions for both the component patterns and the spectra from the feasible solution set. The solution is given by optimizing an entropy minimization criterion. This criterion enhances the spectral or spatial features of individual components. Two experimental results are shown to demonstrate the effectiveness of this method with biological and cytochemical specimens. The limitations of this method for unique pattern estimation are also discussed.

Algorithms↗

Complex dynamics and configurational entropy of spatial optical solitons in nonlocal media.

Intense light propagating in a nonlinear medium can generate an ensemble of interacting filaments of light, or spatial solitons. Using nematic liquid crystals, we demonstrate that the filaments exhibit collective behavior typical of complex systems, including the formation of clusters and soundlike vibrations, as well as the reduction of the configurational entropy, controlled by the degree of nonlocality of the medium.

Journal Article↗

The use of quantified maximum entropy methods for optimising information from electron paramagnetic resonance spectroscopy.

A quantified maximum entropy method is applied to the optimisation of analytical information from EPR spectra of free radicals. Statistically meaningful errors are produced for the positions and intensities of all spectral peaks and considerable improvements in sensitivity compared with conventional spectral enhancement procedures are obtained with measurements of the intensities of spectra of known radicals.

Algorithms↗

[Thermodynamics and muscle contraction. II. Consequences of the principle of maximization of the rate of entropy production].

For non-elastic irreversible mechanochemical machines of the muscular type, the above-mentioned principle (by H. Ziegler) leads to the following results. The velocity of shortening, v, decreases when the force F increases. The mechanical power of the system Fv, is active when 0 greater than v greater than vF=0 or 0 greater than F greater than Fv=0. At F=0 the rate of chemical reaction has the maximum and dQ/dF = -v greater than 0 (where Q is the rate of heat production). At v = 0 the rate of entropy production has the minimum and d/dv = F/A greater than 0 (where A is an affinity of the chemical reaction). The Onsager symmetry relation holds at v=0 only.

Mathematics↗

Maximum entropy modeling for mining patient medication status from free text.

Using a classification scheme of patient medication status we sought to recognize and categorize medications mentioned in the unrestricted text of clinical documents generated in clinical practice. The categories refer to the patient's status with respect to the medication such as discontinuation, start or initiation, and continuation of a given medication. This categorization is performed with a machine learning technique, Maximum Entropy (ME), that is well suited to incorporating heterogeneous sources of information necessary for classifying patient's medication status. We use hand labeled training data to generate ME models and test 5 different training feature sets. Our results show that the most optimal feature set includes a combination of the following: two words preceding and following the mention of the drug, the subject of the sentence in which the drug mention occurs, the 2 words following the subject, and a binary feature vector of lexicalized semantic cues indicative of medication status or its change. The average predictive power of a model trained on these features is approximately 89%.

Artificial Intelligence↗

Predictability of epileptic seizures: a comparative study using Lyapunov exponent and entropy based measures.

In this paper, a comparative study involving measures from the theory of chaos, namely the short-term largest Lyapunov exponent, Shannon and Kullback-Leibler entropies from information theory, has been carried out in terms of their predictability of temporal lobe epileptic seizures. These three measures are estimated from electroencephalographic (EEG) recordings with sub-dural and in-depth electrodes from various brain locations in patients with temporal lobe epilepsy. Techniques from optimization theory are applied to select optimal sets of electrodes whose dynamics is then followed over time. Results from analysis of multiple seizures in two epileptic patients with these measures are presented and compared in terms of their ability to identify pre-ictal dynamical entrainment well ahead of seizure onset time.

Algorithms↗

[Maximum entropy method and Fourier transform for wave analysis of pattern visual evoked potentials].

To estimate spectral analysis of pattern visual evoked potentials (P-VEPs) the maximum entropy method (MEM) and fast Fourier transform (FFT) were investigated. P-VEPs were recorded in 16 normal eyes using the reversal pattern of 2 c/d vertical sine wave gratings. Six temporal frequencies (2, 3, 4, 6, 8, 12 Hz) were used. MEM power spectrum with the parameter (dimension of autoregression model) which was decided final prediction error (FPE) method did not necessarily always give satisfactory results. The MEM power spectrum of transient VEP changed in manner different from that of steady state VEP as the dimension of autoregression model varied. In steady state VEP the peak of the MEM spectrum was positioned accurately at dimension 50 but in transient VEP the peak positioned accurately at a larger dimension. Both in MEM and FFT the curves of the square root of the power vs temporal frequency resembled each other and had temporal tuning with a maximum at 6 Hz. At lower temporal frequencies (2, 3 Hz) the correlation coefficient increased gradually as the harmonic component became higher (2 nd less than 4 th less than 6 h). MEM powers in the second harmonic component were highly correlated with FFT power in temporal frequency above 4Hz. These results showed that the MEM power spectrum had higher resolution than FFT and had different properties especially at lower temporal frequencies. MEM with optimum parameters should be very useful for wave analysis of P-VEPs.

Evoked Potentials, Visual↗

[Comparison of unconsciousness prediction probability with approximate entropy and bispectral index during sedation].

OBJECTIVE: To compare the unconsciousness prediction probability (Pk) estimated by approximate entropy (ApEn) and bispectral index (BIS) during the sedation produced by target-controlled infusion (TCI) of propofol. METHODS: Twenty patients (ASA class I-II) scheduled for elective lower limb operations under epidural anesthesia were studied. TCI of propofol was initiated at target plasma concentration of 0.5 microg/ml, and increased by 0.3 to 0.5 microg/ml until loss of consciousness, and then decreased until consciousness recovery. Each target plasma concentration of propofol lasted for 12 min. ApEn and BIS were recorded simultaneously during the periods of consciousness and unconsciousness every 3 min. The Pk of unconsciousness with ApEn and BIS were calculated and compared. RESULTS: ApEn was 0.84+/-0.05 in the state of consciousness and 0.71+/-0.06 upon loss of consciousness, and BIS in the corresponding stages were 80.2+/-6.2 and 67.3+/-7.9, respectively. The Pk of unconsciousness between ApEn (Pk=0.97+/-0.06) and BIS (Pk=0.91+/-0.11) did not significantly differ (P>0.05). CONCLUSION: ApEn as well as BIS is acceptable for predicting consciousness and unconsciousness produced by TCI propofol.

Adult↗

Approximate entropy: a regularity measure for fetal heart rate analysis.

Approximate entropy (ApEn), a recently developed mathematical formula quantifying regularity, was applied to fetal heart rate (FHR) data. Three groups were analyzed: 1) 19 women had normal labors (uncomplicated course of labor, vaginal delivery, no unusual FHR tracings, and 1- and 5-minute Apgar scores of at least 7 and 9, respectively; 2) 15 women had presumed fetal distress (severe cord or late decelerations, bradycardia, or tachycardia; delivery by cesarean with both arterial and venous cord pH above 7.20); and 3) 20 women had acidotic fetuses (both venous and arterial cord pH less than 7.20). Hourly mean (+/- SD) ApEn values for the three groups were: acidotic fetuses, 0.924 +/- 0.235, 102 hours; normal fetuses, 1.051 +/- 0.145, 97 hours; and nonacidotic "distressed" fetuses, 1.043 +/- 0.147, 74 hours. The ApEn values for nonacidotic, presumed distressed fetuses were not significantly different from those of normal fetuses (P greater than .75). Acidotic fetuses had many more instances of ApEn hourly values less than 0.8 (28%, 29 of 102) than did the normal and the nonacidotic, presumed distressed fetuses combined (5%, nine of 171). The probability that ApEn was less than 0.8 was larger for acidotic fetuses than for the other groups (P less than .00003), supporting the hypothesis that extremely regular FHR patterns imply a greater likelihood of acidosis. Significant hourly deviations in ApEn generally corresponded to drug administration or to physiologic changes such as cord compression and its relief. Thus ApEn, a major departure from variability statistics, appears to be able to detect subtle and possibly important differences in heart rate that are not visually apparent.

Biometry↗

Brain's entropy partitions.

Since the brain processings can be expressed by ballistic or ramp systems, the brain entropy is herein analysed in respect to the distributions of the internal ((MS)1) and external messages ((ME)E) conveyed through the sensory systems. In such a context, it is shown that a first partition (through a primary folding) is established between the neural systems involved in the processings related with the external (RSE) and internal (BSI) environments. Indeed, secondary foldings in both RSE and BSI due to non-homogeneities in (MS)E and (MS)1 are discussed. Finally, the results are extended to the neural phenomena during the brain's embriogenic growth.

Animals↗

Maximum entropy constrained balance randomization for clinical trials.

A specialization of the biased coin clinical trial randomization schemes of Pocock and Simon (1975) and Efron (1971) is proposed which gives guidelines for the coin biasing probabilities of assignment to treatment. The scheme parameterizes the often conflicting goals of random treatment assignment and allocation for stratum balance in terms of a single trade-off parameter specifying a desired degree of determinism. Treatment radomization probabilities are obtained iteratively in an exponential form which maximizes randomization entropy subject to a specified balance constraint.

Clinical Trials as Topic↗

Calorimetric evidence for large entropy changes accompanying intermediate steps of the ATP-driven Ca2+ uptake by sarcoplasmic reticulum.

The hydrolysis of ATP catalyzed by sarcoplasmic reticulum vesicles prepared from rabbit skeletal muscle was studied by microcalorimetry in parallel with measuring the extent of hydrolysis and the level of the phosphorylated intermediate (E approximately P) of the Ca2+-ATPase in the reaction medium containing 100 mM MgCl2, 0.1 mM CaCl2, 20 mM 3-(N-morpholino)propanesulfonic acid/KOH (pH 7.1). During the first few turnovers of the enzyme catalytic cycle, when an appreciable amount of E approximately P is still present, the observed heat is much smaller than the heat expected from the amount of ATP hydrolyzed. Since the accompanying Ca2+ uptake, inclusive of Ca2+ binding to internal sites, is associated with very little heat change (Kodama, T., Kurebayashi, N., and Ogawa, Y. (1980) J. Biochem. (Tokyo) 88, 1259-1265), this result indicates that the formation of E approximately P is endothermic and hence driven by a large increase in entropy. The overall exothermicity of the ATP hydrolysis is brought about by the subsequent, strongly exothermic decomposition of E approximately P.

Animals↗

[B-form as the absolute energy minimum for DNA. Entropy nature of the B--A transition].

The B-form is characterizing by lower potential energy than A-form, especially if electrostatic term is added. For realistic values of epsilon (4; 1) spontaneous A--B-transition occurs during minimization procedure. The conclusion arises about entropy mechanism of A-form stabilization. The B--A-transition is impossible lower certain temperature for certain salt concentrations. The strong and mobile dehydratant must stimulate the A-form realization. The strong and polymeric dehydrant must stimulate the compactization of macromolecule on the basis of B-form.

Chemical Phenomena↗