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At least 1,189 records · Page 66Linked to original sources
PubMed2003

Remote endarterectomy: first choice in surgical treatment of long segmental SFA occlusive disease?

OBJECTIVES: to report the long term results of remote superficial femoral artery endarterectomy (RSFAE) with the MollRing Cutter for the treatment of long segmental SFA occlusive disease. DESIGN: retrospective open study. PATIENTS AND METHODS: from March 1994 to August 2000 183 RSFAEs were performed in 164 selected patients (105 males, 120 procedures) with a median age of 63 years (43-84 years). Indications for operation were disabling intermittent claudication in 129 procedures (70%), rest pain in 20 procedures (11%), and limb salvage in 34 procedures (19%). Follow up consisted of clinical evaluation, ankle-brachial index measurements and duplex scanning. RESULTS: the mean follow-up time was 29.3 months. The mean length of the endarterectomised SFAs was 31 cm (range, 17-45cm). The five year cumulative primary patency rate by means of life table analysis was 37.8+/-6.67% (SE). Percutaneous transluminal balloon angioplasty and surgical re-intervention were performed in twenty-nine and four patients respectively resulting in a primary assisted patency rate of 47.9+/-6.27%. Limb salvage was achieved in 30 of the 34 patients. Females had a statistically significant lower primary patency rate, i.e., 26 vs 45% (p -value=0.01). CONCLUSIONS: the long term results of remote SFA endarterectomy show that it is a safe, effective and durable, minimally invasive procedure. It also leaves open all other options for conventional bypass procedures. The five-year primary patency rate is at least similar to prosthetic above-knee bypass surgery.

Adult↗
PubMed2003

The relationship between socio-economic status, geography, symptomatic carotid territory disease and carotid endarterectomy.

OBJECTIVE: recent evidence suggests a strong association between socio-economic status and atherosclerosis. However, little information exists on the relationship between socio-economic status, symptomatic carotid disease and rates of carotid endarterectomy (CEA). The aim was to evaluate the Carstair Deprivation Score (CDS) of (1) patients admitted with symptomatic carotid disease, and (2) those undergoing CEA in one health board. METHOD: the CDS score was determined from the post-codes of all patients admitted with a diagnosis of transient ischaemic attack (TIA) or stroke due to cerebral infarction (ISD 9 codes 433.1, 433.09, 435, 437.1; ICD-10: 165.2, 163, 163.2, G45.1, G45.3, G45.9) between 1st April 1995 and 31st March 2000. Expected and actual rates for each of the CDS (1 to 7) were determined by direct and indirect methods of standardisation allowing for age and sex. A similar analysis was performed for patients undergoing carotid endarterectomy. Results were analysed using the Mantel-Haenszel test. Only first time admissions and CEA were included. RESULTS: 1203 patients were admitted with the main diagnosis of symptomatic carotid disease. The admission rate of symptomatic patients was less than expected in the more affluent group (Carstair 1, p < 0.005) and significantly higher in the most deprived group (Carstair 7, p < 0.001). In comparison 192 patients underwent CEA. There were no differences between the expected and actual rates of CEA in each CDS, but the rates tended to be higher in the most affluent group. Geographical variation was also demonstrated with an increased rate of CEA in those patients living in the cities and a reduced rate in those in the rural communities. CONCLUSION: patients from deprived socio-economic groups had a higher rate of symptomatic carotid disease, but this was not matched by an increased rate of CEA. This suggests that socio-economic inequalities in the prevalence of symptomatic carotid artery disease and treatment exist.

Carotid Artery Diseases↗
PubMed2006

Postoperative management of the patient undergoing pulmonary endarterectomy.

The postoperative care of the patient undergoing pulmonary endarterectomy presents challenges that occur not only with other types of cardiac surgery but also with significant respiratory system changes related to alterations in pulmonary blood flow. Postoperative mortality associated with this procedure has declined substantially over the years as a consequence of improved evaluative procedures and selective surgical referral, advances in surgical technique, and an understanding of the unique postoperative complications that may occur. However, postoperative acute lung injury and residual pulmonary hypertension continue to represent major causes of mortality associated with this procedure and represent areas where additional investigative efforts are necessary. Here we describe the unique hemodynamic and respiratory changes that occur in the postoperative pulmonary endarterectomy patient and an evidence-based approach to their optimal management.

Endarterectomy↗
PubMed2006

Anesthesia for pulmonary endarterectomy.

Anesthetic care for patients undergoing pulmonary endarterectomy represents one of the most challenging tasks in cardiac anesthesia. Chronic thromboembolic pulmonary hypertension with its concomitant right ventricular failure may cause hemodynamic instability during anesthetic induction and the precardiopulmonary bypass (CPB) period, and the associated comorbidities (pulmonary, hepatic) may affect the actions and metabolism of anesthetic drugs. During the CPB period, proper perfusion patterns, cerebral oxygenation, and adequate hypothermia for deep hypothermic circulatory arrest must be achieved. During the post-CPB period the anesthesiologist must be prepared to treat residual pulmonary hypertension, pulmonary edema, pulmonary bleeding, right ventricular failure, and various metabolic and cardiovascular sequelae of hypothermic circulatory arrest. This review highlights the main issues the anesthesiologist faces during pulmonary endarterectomy, as well as suggests approaches to their management.

Anesthesia↗
PubMed2006

Outcomes of pulmonary endarterectomy surgery.

Chronic thromboembolic pulmonary hypertension has emerged as one of the leading causes of severe pulmonary hypertension. This disease is estimated to occur in approximately 1 to 5% of all patients who have previously developed an acute pulmonary embolism, although the true prevalence is suspected to be much higher. Chronic thromboembolic pulmonary hypertension is characterized by intraluminal thrombus organization, fibrous stenosis, and vascular remodeling of pulmonary vessels. Pulmonary endarterectomy is an operation that is considered curative for thromboembolic pulmonary hypertension and is therefore superior to transplantation for this condition. This article focuses on the surgical outcomes of patients undergoing pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension and discusses the currently known factors that affect survival after this operation.

Aged↗
PubMed2001

Transcranial Doppler in carotid endarterectomy.

PURPOSE: To evaluate the role of transcranial Doppler monitoring in reducing the complications of carotid endarterectomy, by analysing: (1) perioperative intracerebral blood flow velocity; (2) embolic load; and (3) effect of Dextran-40 therapy on patient outcome. DESIGN: Retrospective case series. METHODS: The study cohort consisted of 30 consecutive patients undergoing 32 carotid endarterectomy procedures. Continuous transcranial Doppler (TCD) monitoring of the ipsilateral middle cerebral artery (MCA) was performed to obtain flow velocities and embolic count. Flow velocity changes were analysed in relation to electroencephalographic (EEG) changes. A Dextran-40 infusion was instituted for patients who experienced a post-arteriotomy embolic load of >50 counts/hour. RESULTS: The average middle cerebral artery velocity (MCAvel) drop on cross clamping was 46+/-12.1%, expressed as a percentage of the individual's 24-hour pre-operative value. Clamping ischaemia developed in six cases (18.8%) of which three (9.4%) demonstrated TCD changes only, and three demonstrated both TCD and EEG changes (9.4%). The average increase in MCAvel at 60-120 minutes postarteriotomy, was 18+/-17.5%; six cases developed hyperaemia. Postoperative emboli were seen in 88% of cases with 31% of patients demonstrating embolic loads of >50/hour. CONCLUSIONS: Perioperative transcranial Doppler monitoring (1) is a useful adjunct to EEG assessment of cross clamping ischaemia, providing information in real time, on MCA blood velocity deterioration that may antecede irreversible change (2) detects postoperative hyperaemic response, and (3) allows quantification of microembolic loads that, when high, have been shown to be a precursor to localised cerebral ischaemia and can be effectively treated with Dextran-40 infusion.

Adult↗
PubMed1978

[Results of endarterectomy in coronary artery surgery (author's transl)].

In a series of 432 aortocoronary bypass procedures endarterectomies were performed in 58 patients (13.4%) on 60 coronary arteries. Except of two vein patch grafts all endarterectomized arteries were bypassed with a saphenous vein graft. The majority of the patients had an endarterectomy of the right coronary artery. Clinical control investigations were performed in 43 out of 47 survivors including 30 with coronary angiograms 5.2 months (mean) after surgery. 26 out of 31 endarterectomized arteries (83.9%) were open angiographically whereas the patency rate to non-endarterectomized arteries of the same patients was 86.4%. The hospital mortality was high; 11 out of 58 patients (19%) deceased. All patients who died postoperatively had a three vessel disease with diffuse coronary sclerosis. Only three had no myodardial infarction prior to surgery, seven had one to four infarctions before surgery. The relatively high mortality intends for the future a more strict revision of the indications for coronary surgical procedures. But not in all cases the preoperative coronary angiograms and ventriculograms allow a clear estimation of the local arterial conditions.

Coronary Artery Bypass↗
PubMed2005

Non-traumatic elevation techniques of the hypoglossal nerve during carotid endarterectomy: a cadaveric study.

OBJECTIVE: Ligation and dissection techniques of sternocleidomastoid artery, vein, ansa cervicalis and posterior belly of digastric muscle were developed in a cadaveric study for achieving minimally invasive elevation of the hypoglossal nerve during carotid endarterectomy and were subsequently used in patient treatment. METHODS: Carotid bifurcations, the extracranial part of the hypoglossal nerve, the sternocleidomastoid artery and vein and neighboring neurovascular structures were studied on 10 formalin-fixed adult cadaver heads (20 sides) under the surgical microscope. Landmarks and measurements for identification of the sternocleidomastoid artery and vein are described. RESULTS: The distance between the hypoglossal loop and the carotid bifurcation was measured as 14.5 - 25.2 mm (mean: 19.24 mm). 30 % of 20 sides were determined to have a Zone II-type carotid bifurcation. In 33 % of the Zone-II-type bifurcations, a low-lying hypoglossal loop was demonstrated. The sternocleidomastoid artery begins 2.2 - 3.5 mm (mean: 2.94 mm) supero-posterior from the occipital artery after the crossing point between the occipital artery and the hypoglossal nerve. The sternocleidomastoid artery and vein complex was 17.1 - 21.5 mm (mean 18.47 mm) away from the carotid bifurcation and forms a right angle with the descending hypoglossal nerve. The contribution of the sternocleidomastoid branch of the occipital artery always reaches the middle parts of the sternocleidomastoid muscle. CONCLUSION: Carotid endarterectomy through having knowledge of the normal and variable trajectories of the structures can almost always be accomplished as a safe procedure when appropriate maneuvers are applied. Dissection and ligation of the sternocleidomastoid artery, vein, ansa cervicalis and posterior belly of digastric muscle are very simple but effective techniques to obtain adequate exposure either for safe arterial reconstruction or to diminish the necessity for more complicated technical procedures.

Accessory Nerve↗
PubMed1995

[CT angiography in the follow-up after carotid endarterectomy].

PURPOSE: To prove the usefulness and clinical value of early CT angiography with maximum intensity projection after carotid endarterectomy: for demonstrating postoperative results. METHODS: In 16 patients with angiographically confirmed 20 high grade stenoses of internal carotid artery CT angiography was performed before and after carotid surgery within 7 days. The evaluation of successful surgery was related to complete plaque removal and patency of internal carotid artery after endarterectomy based on preoperative CT angiography. Classification of stenosis was performed according to the NASCET study. RESULTS: In 2/20 cases severe stenoses remained after surgery, which were demonstrated using CT angiography and confirmed by digital subtraction arteriography. 3/20 cases showed mild stenosis and 15/20 were normal. CONCLUSION: CT angiography is best suited to evaluate results after carotid surgery. The method enables delineation of complete removal of calcified plaque and patency of carotid artery.

Aged↗
PubMed1989

Early detection of cerebral ischemia during carotid endarterectomy using transcranial Doppler sonography and somatosensory evoked potentials.

Cerebral function during carotid endarterectomy can reliably be monitored using somatosensory evoked potentials (SEP). Transcranial Doppler sonography (TCD) is a noninvasive method providing on-line data about cerebral hemodynamics. The combination of both techniques during carotid surgery is helpful in evaluating the hemodynamic ("input") and the functional ("output") consequences of carotid clamping within a short time. In the present report, combined TCD and SEP monitoring early detected left hemispheric ischemia in a 68-year-old woman subjected to left carotid endarterectomy. The impairment of cerebral perfusion occurred before carotid clamping due to an intraoperative thrombosis of the left internal carotid artery as could be revealed after declamping. A temporary shunt was not inserted. Postoperatively, the patient had a new transient neurological deficit. In this case, TCD correctly indicated cerebral ischemia as confirmed by SEP recording. For carotid artery surgery, combined TCD and SEP may be helpful in detecting those patients who will profit from temporary shunting if this is not done routinely.

Aged↗
PubMed1988

[5-year follow-up after endarterectomy of carotid artery thrombosis].

The long-term results of carotid endarterectomy were analysed in 119 patients, operated on between January 1979 and December 1980 (135 endarterectomies; preoperative data analysed retrospectively). 43 patients had been in stage I, 39 in stage IIa, 13 in stage IIb, 4 in stage III, and 20 in stage IV. Perioperative mortality was 0.8%, while hospital mortality was 2.5%. Transitory perioperative neurological deficits occurred in 4.2% of all patients, but no permanent ones. Five years postoperatively 44.5% had died, nearly half (43.4%) of cardiovascular disease. Cerebrovascular disease and tumour each caused 15% of deaths. During the five-year follow-up period 12% of all patients had had transitory ischaemic attacks; 16% had suffered a stroke (in 63% on the operated side). With a high prevalence of risk factors, only the quality of diabetic control (mortality rate of well controlled diabetes 38%, of poorly controlled 70%) and the risk factors heart failure and vascular occlusive disease had a significant influence on the mortality rate. But the mortality rate was significantly lowered with the use of platelet aggregation inhibitors (41.6% vs 72.7%).

Adult↗
PubMed2000

The influence of female gender on the outcome of carotid endarterectomy: a challenge to the ACAS findings.

BACKGROUND: In the Asymptomatic Carotid Endarterectomy Study (ACAS) the perioperative stroke and mortality rate was more than twice as high in women as in men, markedly reducing the long-term benefit of the operation; therefore the role of carotid endarterectomy (CEA) among women with asymptomatic carotid stenoses remains unclear. The current study was undertaken to further examine the influence of gender on the outcome of the operation. METHODS: To control for all variables except gender, the records of all patients in an academic medical center who underwent elective CEA for asymptomatic disease, performed by one surgeon employing a uniform technique, over a 7-year interval were reviewed. RESULTS: From January 1992 through September 1998, 156 CEA procedures for asymptomatic carotid stenoses were performed on 66 (44%) women (n = 68) and 83 (56%) men (n = 88). There were no differences in the prevalence of hypertension (69% vs 69%), diabetes mellitus (24% vs 19%), hyperlipidemia (47% vs 47%), or smoking (46% vs 60%) between women and men, respectively, although a history of angina (28% vs 13%, P < .05) and myocardial infarction (23% vs 6%, P < .01) was more common among men. The mean stenosis was 86% for men and 83% for women. The incidence of perioperative mortality, stroke, and transient ischemic events was 0%, 0.6%, and 0%, with no differences between women and men: 0% vs 0%, 0% vs 1.3%, and 0% vs 0%, respectively. CONCLUSIONS: These findings indicate that female gender does not adversely influence the outcome of CEA when performed for treatment of asymptomatic disease. Gender should not be a consideration in the decision to perform CEA because of asymptomatic disease.

Aged↗
PubMed2002

Early versus delayed carotid endarterectomy after a nondisabling ischemic stroke: a prospective randomized study.

BACKGROUND: Although many retrospective and a few prospective studies have analyzed the outcome of early and delayed carotid endarterectomy (CEA) after a recent minor or nondisabling stroke (ie, a minimal and stabilized focal neurologic deficit of acute onset persisting for more than 24 hours and not leading to a handicap or to a significant impairment of daily living activities), the optimal timing of surgery remains uncertain. The purpose of this study was to prospectively compare the perioperative death and stroke rates of CEA performed within 30 days (early group) or more than 30 days (delayed group) after a nondisabling ischemic stroke in patients with carotid bifurcation disease. METHODS: During a 4-year period, of 86 patients experiencing a minor stroke, 45 were randomized to undergo early CEA and 41 to undergo delayed CEA. All patients underwent preoperative cerebral computed tomography, duplex ultrasonographic scanning and angiography of the supra-aortic trunks. All CEAs were carotid eversion endarterectomies and were performed by the same surgeon, using deep general anesthesia, with continuous electroencephalographic monitoring for the selective shunting. The perioperative death and stroke rates were compared between the 2 groups. RESULTS: No perioperative deaths occurred in either group. No recurrent strokes occurred during the waiting period in the delayed group. The incidence of perioperative stroke was comparable in the 2 groups (1 of 45, 2% vs 1 of 41, 2%). The mean follow-up was 23 months (range, 6 to 50 months). Survival rates after 1, 2, and 3 years were similar in the 2 groups. CONCLUSIONS: Early CEA after a nondisabling ischemic stroke can be performed safely with perioperative mortality and stroke rates comparable with those of delayed CEA. The timing of surgery does not seem to influence the benefit of the CEA.

Brain Ischemia↗
PubMed1985

Use of oculopneumoplethysmography (OPG-Gee) following carotid endarterectomy.

Oculopneumoplethysmography (OPG-Gee) was performed pre- and postoperatively in 100 patients undergoing carotid endarterectomy and 14 patients undergoing nonendarterectomy procedures (aortofemoral or carotid-subclavian bypass). Absolute differences in ocular systolic pressure (OSP) were determined and results were compared with previous criteria. Twelve examinations yielded abnormal findings in the endarterectomy group. Seven patients had associated neurologic deficits and six had occlusion confirmed at reexploration. Five patients were without symptoms; two with profound depressions in OSP were reexplored and thrombosis confirmed whereas three with moderate (15 to 30 mm Hg) depressions in OSP were followed up and remained asymptomatic. Values of OSP were related to the status of the contralateral carotid artery. In the nonendarterectomized patients OSP did not change with general anesthesia or carotid clamping. OPG-Gee is a useful test to screen for postoperative carotid thrombosis. It helps select symptomatic patients with occlusions who might benefit from early reexploration. In asymptomatic patients a profound drop in OSP identifies early occlusion and may be used alone or in concert with angiography to select patients for reoperation.

Arterial Occlusive Diseases↗
PubMed1985

Continuous-wave Doppler in the intraoperative assessment of carotid endarterectomy.

A sterile 8.5 MHz continuous-wave Doppler probe was used intraoperatively to evaluate the technical result of 229 consecutive carotid endarterectomies. Primary areas of evaluation included the proximal point of plaque transection and the internal and external carotid arteries at and distal to the termination of the endarterectomy. Subjective interpretation was made of the Doppler audio signal. Signs associated with inadequate technical results were a high-frequency signal indicative of luminal narrowing with a reduction in frequency distal to the area of stenosis, absence of a Doppler signal indicating occlusion, and a weak monophasic flow signal indicating poor distal perfusion. Abnormal signals were identified in 10 internal carotid arteries (4.3%) which prompted intraoperative angiography in eight and immediate reopening of the artery in an additional two. Significant lesions were identified in seven arteries (70%). Twenty external carotid lesions (8.7%) were detected by Doppler and in 19 cases (95%) a significant stenosis or obstruction was found when the vessel was reopened. Auscultation of a continuous-wave Doppler signal with a sterile probe at operation appears to have a high positive predictive value in the identification of both internal and external carotid stenoses. It is rapid, safe, relatively inexpensive, and avoids the problems associated with routine intraoperative angiography.

Auscultation↗
PubMed1986

Durability of endarterectomy and antegrade grafts in the treatment of chronic visceral ischemia.

Several techniques have been used to revascularize the visceral circulation. Although initially successful, these repairs often have a significant rate of late occlusion. To determine the durability of transaortic endarterectomy (TEA) and antegrade aortovisceral grafting, we reviewed the last 67 consecutive patients operated on at the University of California, San Francisco for chronic visceral ischemia. The patients were principally middle-aged (mean, 59 years) women (76%) with atherosclerotic disease involving at least two major visceral arteries. Forty-seven patients underwent TEA; 22 patients had associated renal endarterectomy, and 15 patients had simultaneous aortic reconstructions. Twenty patients had an aortovisceral antegrade bypass placed as their only reconstruction. Two of these had concomitant aortic reconstructions. There were five perioperative deaths. Of the 62 patients available for follow-up, 60 patients who had a total of 111 major visceral branch repairs have been followed up for 6 months to 14 years (mean, 4.4 years). Four patients (7%) have had recurrent visceral ischemia. Two patients had recurrent symptoms and have been asymptomatic for nearly 5 and 6 years, respectively, after successful reoperations. Two patients had intestinal infarction and died as a result. Thirty-four patients have had follow-up aortography that showed 58 widely patent reconstructions, two asymptomatic single-vessel stenoses, and one asymptomatic occlusion. TEA and antegrade visceral bypass provided long-term relief of symptoms and prevented visceral gangrene in 56 of 60 patients (93%). The prolonged patency of these reconstructions is attributed to the following: They originate from undiseased or endarterectomized aorta, they provide optimal, nonturbulent flow, and they avoid the inherent technical pitfalls of retrograde grafting.

Adult↗
PubMed1987

Symptomatic internal carotid thrombosis after carotid endarterectomy.

During a study period from 1977 through 1984, 11 (0.4%) of 2651 patients who had undergone carotid endarterectomy at The Cleveland Clinic had early, symptomatic thrombosis of the internal carotid artery (ICA) and underwent urgent reoperations. With only two exceptions, neurologic deficits occurred after lucid intervals when the patients had recovered from general anesthesia and were discovered within the first 8 hours in three patients, within 8 to 24 hours in five patients, and on the second postoperative day in one patient. Surgical management consisted of thrombectomy alone in two patients, thrombectomy and vein patch angioplasty in eight patients, and thrombectomy of the external carotid artery with ligation of the ICA in a single patient in whom retrograde ICA flow could not be reestablished. Eight (73%) of the 11 patients recovered substantial neurologic function after reoperations, six of whom had complete or nearly complete resolution of their symptoms. One patient (9%) sustained a fatal hemorrhagic cerebral infarction. In a collected series of 41 patients from this study and other reports, prompt surgical treatment of thrombosis occurring after carotid endarterectomy was associated with clinical improvement in 61% of patients and appears to be the preferred approach to this catastrophic complication.

Carotid Artery Diseases↗
PubMed1987

Residual lesions and early recurrent stenosis after carotid endarterectomy. A serial follow-up study with duplex scanning and intravenous digital subtraction angiography.

In 109 internal carotid endarterectomies a complete serial follow-up study with ultrasonic duplex scanning was performed at 3, 6, and 12 months after operation. A duplex scan was also performed 2 years postoperatively in 75 cases. Moreover, the state of the endarterectomized carotid bifurcations was documented by intravenous digital subtraction angiography during hospitalization and at 12 months. At 3, 6, 12, and 24 months after operation the rate of significant recurrent stenosis was 6%, 12%, 6%, and 8%, respectively. Approximately half of the arteries with a significant stenosis at 1 year already demonstrated this lesion with intravenous digital subtraction angiography performed 1 week after operation. Persistent significant recurrent stenosis in the remaining arteries was probably the result of excessive myointimal proliferation. This occurred with a higher frequency in women (14.8%) than in men (4.1%). The greater number of the arteries with minimally or mildly disturbed spectral waveforms 3 months after endarterectomy spontaneously normalized or remained stable during the follow-up period. On the other hand, 40% of the arteries with a significant stenosis (diameter reduction of 50% or more) at the three-month control follow-up period increased to a more severe degree of stenosis during the first postoperative year. Most of the operated arteries did not significantly change during the second year.

Carotid Artery Diseases↗