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At least 1,189 records · Page 66Linked to original sources
PubMed1991

RECPAM: a computer program for recursive partition and amalgamation for survival data and other situations frequently occurring in biostatistics. III. Classification according to a multivariate construct. Application to data on Haemophilus influenzae type b meningitis.

The methodology of RECursive Partition and AMalgamation (RECPAM) previously presented in Parts I and II (A. Ciampi et al., Computer. Methods Progr. Biomed. 26 (1988) 239-256 and 30 (1989) 283-296) pursues its development with an application to predict long-term effects of a disease given a set of clinical information measured at the time of illness. This paper illustrates how RECPAM deals with a situation typical in Medical Informatics applied to data on Haemophilus influenzae type b meningitis.

Adolescent↗
PubMed1984

Regression analysis of nonlinear Arrhenius plots: an empirical model and a computer program.

The rates of most physical, chemical and biological processes vary with temperature and numerous instances have been reported in which Arrhenius plots of the experimental data appear to consist of two straight line segments joined by a relatively sharp break. An empirical model, based on a general hyperbola, is shown to be applicable to such systems; a nonlinear regression program is described which facilitates fitting of this function to experimental data which show either broad or sharp transitions. The program yields best estimates and standard errors of the temperature and ordinate value at the transition, and the two activation energies.

Computers↗
PubMed1994

[Ergonomics of computer programs].

There are many different factors to be taken into account while planning, designing and implementing user interface to a new programme. The most important factors are price, quality, documentation, installation and ergonomic properties of software. Ergonomic aspects are classified into two groups. One group deals with problems of direct human-computer interaction e.g. sort of dialogues, screen layout, response time. The other deals with problems of flexibility, consistency, structuring. Out of a number of ergonomic factors, some of the most important are listed in this paper.

Ergonomics↗
PubMed2004

Using the Mplus computer program to estimate models for continuous and categorical data from twins.

Historically, the focus of behavior genetic research was to obtain estimates of the sources of familial resemblance for a single phenotype. Current research strategies have moved beyond heritability estimates to the search for physiological and behavioral mechanisms by which genetic risk is translated into individual differences in behavior and disease liability. Such research questions often require multivariate designs and complex analytic models, including the analysis of continuous and categorical dependent variables within the same model. Recent advances in computer software for categorical data analysis have increased the tools available for researchers in behavior genetics. This paper describes how to use the Mplus software program (Muthén and Muthén, 1998, 2002) for the analysis of data obtained from twins. Example analyses include two- and five-group twin models for univariate and bivariate continuous and categorical variables. Data on alcoholism and age at first drink drawn from the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders are used to illustrate how Mplus can be used to analyze multiple-category variables, recode and transform variables, select subgroups for analysis, handle subjects with incomplete data, include constraints to ensure non-negative loadings, include model covariates, model sex differences, and test alternative hypotheses about mediation of genetic risk by measured variables.

Adolescent↗
PubMed1977

A computer program for fitting multimodal probability density functions.

A FORTRAN IV program is described, which may be run interactively with tutorial assistance or in batch and which allows a user to selectively fit any of seven probability density functions (p.d.f.'s) or a combination of the p.d.f.'s to a unimodal or multimodal histogram of empirical data. A "best-fit", uni- or multimodal p.d.f., which may be obtained by a method of nonlinear least squares or a generated p.d.f. may be displayed on a Tektronix 4010 terminal as a continuous curve against the background of a bar, square wave, symbol or point-plot histogram. The following, supportive statistical information is also displayed: (1) Kolmogorov-Smirnov probability of goodness of fit, (2) mean square error, (3) correlation coefficient, and (4) parameter estimates. The resident driver program and six overlayable segments have been implemented on a Digital Equipment Corporation LAB-11 minicomputer (PDP-11/20).

Computers↗
PubMed1986

A personal computer program using a 4-component logit for the evaluation of ELISA calibration curves with unknown asymptotic values.

A BASIC program is described for the calculation of ELISA calibration curves using a 4-component logit for the linearisation of the sigmoidal shape. The difficulty of estimating the four logit parameters without knowledge of upper and lower asymptotic values is overcome by statistical analysis of the experimental data. The program is run on an IBM-PC and the curves are plotted by a HP7475A plotter.

Biometry↗
PubMed1998

Emulation of an ELISA reader and quantitative image analysis using the computer program Digital-OD.

Here, we present a Microsoft Windows application that has been written to emulate a microplate reader. After scanning a standard 96-well microplate, color gradations in the slots can be analyzed quantitatively and be used for the estimation of enzyme kinetics, binding assays or concentration determination. In a test, series accuracy of the program was determined. We show that the returned optical densities correlated highly with the true concentrations (r > 0.97). Thus, the software is useful for a wide number of applications. Further, the program is easy to handle and is available free of charge.

Enzyme-Linked Immunosorbent Assay↗