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[Modification of Ca2+ metabolism in the blood cells of cattle with radiation-induced thyroid disorder after the Chernobyl nuclear power plant accident].

Increasing of Ca2+ concentration in cytoplasm and of the rate of 45Ca iflux into cows erythrocytes in 19-24 month after Chernobyl accident was revealed. Correlation between Ca2+ concentration in cytoplasm of erythrocytes and thyroxin content in plasma of cows with radioiodine damage of thyroid gland was found. Reduction of the rate of 45Ga influx into erythrocytes in cows with radiation doses of 20-60 By on thyroid gland was shown in later time after accident (3-5 years). Changes in Ca2+ permeability through membranes of erythrocytes and neutrophils after injection of 131I into calves in doses of 300 Gy and more on thyroid gland was found.

Accidents, Occupational↗

[Immune status of people participating in the clean-up of after-effects of the Chernobyl Nuclear Power Plant accident living in the industrial region of Donbass].

The examination of 286 subjects exposed to radiation hazards when taking part in liquidation of the Chernobyl accident aftereffects was performed to compare persons living under ecologically unfavourable conditions (significant air pollution due to heavy industry) against those living in relatively comfortable environment. It was found that immune status of the former displayed imbalance. In the latter immunity was much less damaged. The findings suggest a conclusion on the role of environmental factors in immunological disturbances in subjects exposed to small doses of ionizing radiation.

Accidents↗

[The efficacy of the health and hygiene measures in the cleanup of the consequences of the accident at the Chernobyl Atomic Electric Power Station].

Sanitary-hygienic measures which were carried out in units during liquidation of the Chernobyl disaster consequences have assured favourable hygienic conditions and promote the accomplishing of their mission. Questions of accommodation, water supply and meals were efficiently resolved. Most complicated were the problems of territory clearing, personnel decontamination, as well as bath and laundry service in field conditions at radioactive contamination zones. Basic trends of prophylactic work were as following: hygienic normalization and regulations, sanitary-epidemiologic control and anti-epidemic measures.

Accidents↗

[Immune system status under effect of low levels of ionizing radiation:studies within the 10 kilometer zone of accident at Chernobyl nuclear plant].

A study was made of the influence of high radiation contamination within the ten-kilometer zone of Chernobyl disaster on the structure and function of the immune system of (DBA x C57B1)F1 and DBA mice. The cumulative radiation doses with respect to gamma-radiation, were 0.024, 0.168 and 0.336 Gy. T-lymphocyte proliferation was shown the be activated with all radiation doses mentioned above but with doses of 0.024 and 0.168 Gy, helper T lymphocytes, and with 0.336 Gy, suppressor N-lymphocytes were primarily activated. So, in the former case, some effector functions of the immunity were activated, and in the latter, inhibited. It is concluded that certain hyperstimulation of the lymphoid cell formation (including the increase in T-suppressors), that is induced by long-term exposure to low-level radiation, triggers the mechanisms of autonomous regulation of the system that suppress the radiation-induced lymphocyte proliferation and inhibit the effector functions of the immunity.

Accidents, Occupational↗

[Modification of adrenergic regulation of heart function under effect of radio-ecological factors within 10-kilometer zone of the accident at Chernobyl nuclear plant].

Rats kept within the ten-kilometer zone of Chernobyl disaster over a period of 30 days exhibited a decreased heart function response to beta-adrenoreceptor stimulus, reduced density of the receptor structures in cardiomyocytes and their affinity to specific agonists. The number of beta-adrenoreceptors in myocardium cells was restored in 6 months, but their affinity and heart function response to the effect of beta-adrenoagonists remained decreased. No significant changes were observed in regulation influenced indirectly via alpha-adrenoreceptors.

Accidents, Occupational↗

[Radiation exposure of cultured tissue cells and animals (mice) within 10-kilometers zone of accident at Chernobyl nuclear plant. Effect on radiosensitivity to future radiation].

The effect of chronic low-level radiation exposure on radiosensitivity to posterior acute irradiation at high doses has been studied. Cells and mice were exposed within the ten-kilometer zone of Chernobyl disaster during various spaces of time (1-12 days), then over one or more days were additionally irradiated by doses of 1-4 Gy. It was shown that no adaptive response was developed under chronic exposure of cells and mice within the zone of disaster. On the contrary increased sensitivity to posterior irradiation was revealed. The number of cytogenetic damages of cultured tissue cells and marrow cells (chromosome aberrations and micronuclei) increases, the spectrum of aberrations being shifted to chromosome type, cells with multiaberration appearing. The decay of chromatine increases indicating an interphase death; the number of leucocytes in peripheral blood decreases.

Accidents, Occupational↗

[Retrospective survey of nursery-age children 5 years after Chernobyl].

In their paper, the authors are dealing with the effect of the Chernobyl's nuclear catastrophe (1986) for the outcome of pregnancy and some parameters of the status of health. Their empirical study is based on a sample (sample size is 1168) of pregnant of the critical year 1986, and also based on a control sample (sample size is 1068) of the year 1985. They compared the five old year children's parameters of status of health between the critical and control groups. Their retrospective epidemiologic survey is extended to study some prenatal, perinatal and childhood parameters also. Finally, they summarise the biometric evaluation of their questionnaire survey. No significant difference of health conditions of the two groups defined above was found.

Accidents↗

The psychological consequences of the Chernobyl accident--findings from the International Atomic Energy Agency Study.

In October 1989, more than 3 years after the nuclear power plant accident at Chernobyl, in the Ukraine, the Government of the Union of Soviet Socialist Republics requested that the International Atomic Energy Agency (IAEA) evaluate the medical and psychological health of residents living in areas identified as being contaminated with radioactive fallout. The IAEA designed and conducted a collaborative study to examine whether there were any measurable effects of exposure to the low levels of ionizing radiation resulting from the accident. The study, using structured interviews and IAEA laboratory equipment, collected data on more than 1,350 residents of 13 villages. IAEA clinical staff members concluded that they could not identify any health disorders in either the contaminated or nearby (uncontaminated) control villages that could be attributed directly to radiation exposure. The clinical staff, however, did note that the levels of anxiety and stress of the villagers appeared to be disproportionate to the biological significance of the levels of IAEA-measured radio-active contamination. Almost half the adults in all the villages were unsure if they had a radiation-related illness. More than 70 percent of persons in the contaminated villages wanted to move away, and approximately 83 percent believed that the government should relocate them. The IAEA effort indicates that the villagers need to be educated about their actual risks, and they need to understand what types of illnesses are, and are not, associated with exposure to radioactive contamination. Unfortunately, the villagers' needs may exceed the available resources of their local and central governments.

Accidents↗

[Mutagenesis of enzyme loci, induced in megaspores of Pinus sylvestris L. by ionizing radiation from the accident at the Chernobyl Atomic Power Plant].

Mutagenesis of alleles of 20-allozyme loci was studied using the electrophoresis methods in polyacrylamide gel in seeds of Pinus sylvestris within the 30 km zone of the Chernobyl NNP and the limits of contamination levels by Cs-137 from 5 up to 600 Cu/km (the absorbed doses being 0.5 to 10 Gy). The frequency of emergence of corresponding mutations which change the synthesis of enzymes in endosperms within the zone constituted on the average 2.7-10 per gene as compared with 0.6-10 in control version. Linear dependence was observed between low doses absorbed and the frequency of gene mutations, while in case of high doses this decreased. Genetic effectivity was 0.001 mutations/locus/Gy. Various radiosensitivity levels were shown among the loci studied. Spontaneous level of mutations frequency in P. sylvestris populations was found to be within the limits of 0.5 to 1.5 Gy under conditions of the 30 km zone. The high rate of mutagenesis was revealed in seeds of the first two post-accident reproductions.

Accidents↗

[Genetic disorders in laboratory mice, exposed in the region of the Chernobyl Atomic Power Plant four years after the accident].

Mice (CBA x C57BL)F1, of both sex and males C57BL were exposed within the 10 km zone of the Chernobyl Nuclear Power Station during 14, 22 and 34 days. Genetic damages of chronic radiation in the exposed adult mice, and in the course of embryogenesis, was studied. The gonadal absorbed radiation doses of the exposed mice varied from 0.5 to 1.5 Gy. The frequencies of dominant lethal mutations, abnormal sperm heads and reciprocal translocations linearly increase with increasing absorbed radiation doses. Among 49 males exposed at the embryonal stage one male heterozygote for reciprocal translocation was revealed. In other males of this group, reciprocal translocation yield was low. No uniform dependence of genetic effects from mice genotype was revealed.

Accidents↗

[The course of duodenal peptic ulcer in the participants in the cleanup of the aftereffects of the accident at the Chernobyl Atomic Electric Power Station].

80 liquidators of Chernobyl disaster with aggravation of duodenal ulcer were examined, as well as a control group of 70 patients. In the group of liquidators some characteristic features were disclosed, namely peculiarities in the state of abdominal mucosa and clinical course of the disease. These data were obtained in the results of hematological, immunological and biochemical researches.

Accidents↗

[A rise in the incidence of teratological changes in Plantago lanceolata L. seedlings of the 5th post-accident reproduction in the 30-kilometer area of the Chernobyl Atomic Electric Power Station].

It was for the first time that of the fifth year of monitoring of Plantago lanceolata L., reproduced within the thirty-kilometer zone of Chernobyl NPP disaster, the authors discovered high incidence of seedlings with various morphological abnormalities. It is suggested that the damages observed are related to the cumulative effect of radiation.

Accidents↗

[The autonomic regulation of the cardiovascular system in subjects with the autonomic dystonia syndrome subjected to ionizing radiation exposure as a result of the accident at the Chernobyl Atomic Electric Power Station].

180 males in the age of 21-50, all the participants of Chernobyl accident consequences liquidation were examined. In all individuals vegetative dystonia (VD) syndrome was diagnosed (total radiation doses 0.1-1.0 Grey according to D. Erwin method). It was established that VD syndrome differed in these persons by pronounced stages of disorders manifestation as well as by polymorphism of vegetative disturbances. These findings testify central and peripheral vegetative nervous system parts involvement. In 40.2% of cases in individuals which were examined in rest and in 56.2% after dosed physical loading the functional disorders of vegetative cardiovascular system regulation of vagal type mainly (76.5%) were revealed. Clear correlation was not observed between vegetative disorders and radiation dose value. The estimation of contribution of each of the possible pathogenic factors (exactly stressogenic, radioactive and others) in vegetative disturbances development is not possible now.

Adult↗

[Dna repair activity in children exposed to small doses of ionizing radiation as a result of the accident at the Chernobyl nuclear power station].

The repair activity of DNA was studied by variola vaccine virus reactivation and induced mutagenesis tests in the peripheral blood lymphocytes of children living in areas with an increased level of ionizing radiation due to breakdown at the Chernobyl' nuclear power station. A more profound repair disturbance was revealed in children living on strictly controlled territories and born after the disaster, compared to those born before it, and children living in areas where the radiation level does not exceed background values. The disturbances were characterized by increased induced mutagenesis and decreased reactivation of the variola vaccine virus. No changes in the degree of DNA repair synthesis were registered in any of the groups studied.

Case-Control Studies↗

[The irradiation levels of the participants in the cleanup of the aftermath of the Chernobyl accident in 1986-1987 and the verification of the dosimetric data].

It is considered the organization of individual dosimetric monitoring (IDM) within 30-km zone around Chernobyl nuclear power plant (CNPP) in 1986 for different contingents of recovery workers: the CNPP personnel, Management for Construction 605 (MC-605), military recovery workers, persons assigned to 30-km zone. It is concluded that the quality of IDM had decreased in the following series: the MC-605 personnel, the CNPP personnel, the assigned persons, and military units. The method of dosimetric data verification for recovery workers in 1986 is presented which is based on the analyses of the dependency H(delta)/In delta from delta, where delta is a step of the histogram of distribution, and H(delta) is delta-entropy of distribution. The results obtained by this method correspond to the results of the experts' estimation. It was shown that 60% of registered individual doses for the whole contingent of the recovery workers differ from the real exposure doses. Using the theory of hybrid lognormal distribution it was obtained, in our opinion, real external dose distribution for all the recovery workers. It was estimated that 7% of recovery workers received doses more than 0.25 Gy. Also, the data on values of mean and collective doses for different contingents, as well as for all persons involved in recovery operations is presented.

Absorption↗

[An assessment of the absorbed doses in cattle over the course of the first year after the accident at the Chernobyl Atomic Electric Power Station].

Absorbed doses of incorporated iodine and caesium radionuclides were evaluated in cattle animals which were within the Chernobyl accident spilling-out zone during the first year after the accident. The absorbed doses in animal thyroids were determined to range from 25 to 320 Gy. Some endemic features of this region promoted high absorbed dose accumulation in cattle thyroid. The dose per the whole body did not exceed 0.2 Gy. The absorbed doses in liver, kidney or spleen were about several cGy.

Absorption↗

[The metabolic aspects of the sequelae of the accident at the Chernobyl Atomic Electric Power Station in the course of kidney diseases].

As many as 159 patients with chronic pyelonephritis and 100 those with glomerulonephritis residing in ecologically favourable, and on contaminated territories for 6-8 years after Chernobyl accident, were examined for indices of lipid peroxidation, antioxidant system and energy exchange. The above renal disease were found to be accompanied by a rise in the activity of lipid peroxidation and accumulation of excess of their products in cellular membranes and urine. In the antioxidant system, the activity of NAD-H2-dependent factors and an inhibitor of free radical oxidation of superoxiddismutase tends to decrease. There occur changes in isoenzyme spectrum of lactate and malatedehydrogenases. The above shifts appear to be manifest in those persons having been exposed to low radiation doses. Antioxidants and stabilizers of the biological membranes were shown to be useful in correcting the above metabolic processes.

Air Pollution, Radioactive↗