SEARCH · Search PubMed
Results for “CECAL DISEASES”
Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
The acute appendicitis syndrome: psychological aspects of the inflamed and non-inflamed appendix.
The aetiological importance of stressful life events and psychological characteristics was assessed amongst 280 appendicectomy patients of whom 80% were classified with 'acutely inflamed' (organic) appendicitis and 20% with 'non-inflamed' (non-organic) appendicitis. Patients were compared with a community comparison group. Specific characteristics of life stressors, namely severe goal frustration for organic patients and severe threat for non-organic patients, were the best predictors of patient outcome. Whilst psychological characteristics were not useful in discriminating between patients, depression in particular, was clearly associated with both conditions, with 38% of non-organic and 28% of organic patients with depression scores in the clinical range. As the patient's clinical depression status failed to modify the effect of the life stress predictors, it was concluded that life stress played an important role in the development of the patients GI symptoms, irrespective of their clinical depression status.
Some observations on the pathogenicity of strains of Entamoeba histolytica.
Explore the source record for details and available documents.
Effect of corticosteroid and irradiation on caecal amoebic infection in rats.
Albino rats (Wistar strain) were pretreated with corticosteroid, irradiation or both to study the effect on the outcome of amoebic infection given intracaecally. The number of animals with lesions amongst "treated" groups was not significantly different from that amongst untreated control animals (P greater than 0.05) but amoebic pathology was markedly exacerbated amongst the treated animals. It is thus thought that once the amoebic infection is established, amoebae become better established for penetration in the immuno-depressed host. The study further suggests that corticosteroid therapy could aggravate an otherwise sub-clinical amoebic infection in man.
Effect of specific and non-specific prior sensitization on the outcome of amoebic infection.
Guinea-pigs were sensitized with monoaxenic amoebic antigen (Group I), bacterial associate antigen (Group II) and axenic amoebic antigen (Group III). All animals in Group I, 95% in Group II and 70% in group III, developed caecal lesions on intra-caecal inoculation of Entamoeba histolytica trophozoites; 92.8% of control (unsensitized) animals developed lesions in their caeca. Lesions were more severe in sensitized animals than in controls. Hepatic abscesses were found in 7.6% of group I, 11.1% of group II and 7.1% of group III. No animal from the untreated but infected group developed hepatic abscess. It thus appears that specific (amoebic) and non-specific (bacterial) prior sensitization may render the host more susceptible to hepatic amoebic infection.
Inter-relationship between faecal pH and susceptibility to Entamoeba histolytica infection in rats.
Explore the source record for details and available documents.
Balantidiasis: report of a fatal case with appendicular and pulmonary involvement.
A case of fatal balantidial infection with appendicular and pulmonary involvement in a Venezuelan farmer is reported. The clinical, post-mortem and histological features are described.
Histological evolution of caecal lesions in experimental amoebiasis.
Histopathological studies in guinea-pigs infected intracaecally with Entamoeba histolytica were carried out longitudinally on days 3, 7, 11, 15, 20 and 35 after infection. Three characteristic modes of development of caecal lesions were observed. These in order of their prevalence were the classical inflammatory cellular infiltration, lymphoid hypertrophy and necrotizing colitis. Occasional amoeboma formation was observed in progesterone-treated animals. This is the first time that histological lesions which mimic the human intestinal amoebiasis have been described in the experimental animal.
Experimental amoebiasis in the guinea-pig: sequential histological abnormalities following intracaecal injection of Entamoeba histolytica.
The histological abnormalities of amoebic colitis have been well described but their evolution over a period of time has not been clearly examined. To study this, three- to four-week-old guinea-pigs were inoculated intracaecally with 80,000 to 100,000 Entamoeba histolytica trophozoites, left untreated and killed at 3, 5, 8, 11, 14 and 21 days, when the caecum was removed and the tissue sectioned and stained with H & E and PAS. Although there was considerable variation in the type of histological abnormality seen on different days of the experiment, there was a definite pattern of evolution. Initially there was diffuse infiltration of the lamina propria by lymphomononuclear cells in the presence of an intact surface epithelial lining. This was followed firstly by superficial and then by deep ulceration of the mucosa. Mucosal invasion by the trophozoites was seen only at this stage and was accompanied by tissue necrosis; the most severe abnormalities occurred on day 11. The final development was regenerative activity which was first noted on day 11, and became more prominent subsequently. The presence of cellular infiltrate in the lamina propria in the absence of trophozoites and damage to the surface epithelium, suggests that these abnormalities are not the direct effect of amoebae. It is suggested that the initial damage is caused by an enterotoxin; the trophozoites enter the mucosa only when there is a break in the surface epithelium. Once within the tissues, trophozoites aggravate the damage by their ability to phagocytose and to release cytotoxic enzymes.
Entamoeba histolytica in inbred mice: evidence of liver involvement.
Following observations that certain mouse strains appeared to be susceptible to liver invasion by Entamoeba histolytica, mouse strains CBA/HN, CBA/HN, nu/nu, CBA/HN nu/+, CBA/HN Dh/+, CBA/HN +/+, C3H/HeJ Lps/Lps and AB/H, were infected intra-intestinally with strain SAW 408 (zymodeme II) of the amoeba. A number of mice from each group died during the first 14 days with acute lesions. The remainder were killed at 4 and 6 months after infection. CBA/HN, CBA/HN Dh/+, and CBA/HN +/+ mice all had amoeba-infected livers, although only 2 mice had extensive, typical liver lesions.
Immunoepidemiology of intestinal helminth infections. 4. Immunopathology in trichuriasis: lessons from the mouse model.
The severity and consequences of human Trichuris infection vary widely. This may reflect differences in immune response. T. muris is a natural parasite of mice which provides a close, well defined, easily manipulated model for otherwise uninvestigatable aspects of this response. Normal mice reject the parasite in 3 weeks, but mice subjected to transient immunosuppression around the time of infection develop a persistent caecal infection. Sequential histopathological studies have shown that infected, normal mice develop a marked intraepithelial, mucosal, 'globule leucocyte' response, accompanied by low-level lymphocytic and histiocytic responses in the lamina propria. The reaction is maximal at 3 weeks and declines towards normal after rejection. Infected, immunosuppressed mice show a slower response with, by weeks 4 and 5, fewer 'globule leucocytes', but a chronic colitis comprising heavy, mixed, mucosal and submucosal inflammation and crypt damage accompanied by persistent parasite infection. The 'globule leucocyte' has been characterized by cytochemistry and electron microscopy as having a mast cell origin. This study, with other evidence, suggests that the replacement of a Th2 (allergic) T helper cell response by a Th1 (cell-mediated) response may result in increased severity and persistence of colitis in response to Trichuris infection.
Abdominal tuberculosis in Cairo, Egypt.
Twenty-two abdominal tuberculosis patients seen at Abbassia Fever Hospital in Cairo, Egypt from January 1990 to August 1992 are described; their mean age was 21.5 years, range 9-54 years; 17 were female. Common symptoms were fever, malaise, abdominal pain (64%) and weight loss (82%). Chest X-rays were normal in 14 patients (64%), but ultrasonography/computerized tomography of the abdomen was abnormal in 20 patients (91%), with adenopathy the usual finding. Anaemia and a raised erythrocyte sedimentation rate were present in all patients, and purified protein derivative skin test (5 Tu) was positive in 82%. Predominant abnormal physical findings were abdominal (86%), including hepatomegaly/splenomegaly and abdominal mass. Diagnosis was made from biopsy material (caseating granulomas) in 6 patients by laparotomy, 1 by laparoscopy, and 3 by cervical or supraclavicular node biopsy; and from laboratory examination of excretions in only 4 patients (acid-fast bacilli in stools of 2, mycobacteria in urine and menstrual fluid). Eight patients required presumptive diagnosis after response to specific isoniazid (+ethambutol) antituberculous therapy.
Testicular nondescent versus testicular agenesis: importance of diagnosis and correct surgical management.
Explore the source record for details and available documents.
Appendicovesical fistula.
Appendicovesical fistula is a rare complication of unrecognized appendicitis. Only 99 previous cases have been reported in the literature. We reviewed these cases and contribute an additional one with hope that increased awareness of this entity may facilitate the correct diagnosis and avoid inappropriate management.
Torsion of vermiform appendix: cause of acutely painful scrotum.
An unusual case is reported of a two-month-old infant who presented with an acutely painful swollen scrotum which at exploration was found to be secondary to a torsion of the tip of the vermiform appendix.
Appendiceal abscess and urinary retention.
Explore the source record for details and available documents.
Appendiceal granulation polyps: a complication of Mitrofanoff procedure.
Explore the source record for details and available documents.