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Stimulus control during conditional discrimination.

Pigeons were used to assess stimulus control during the development of a conditional discrimination. The training consisted of three stages. In Stage 1, key pecks were reinforced in the presence of a white line tilted 40 degrees to the right of vertical on a green background and non-reinforced when the same line appeared on a red background. In Stage 2, key pecks were reinforced when a white vertical line appeared on a red background and were non-reinforced in the presence of a 40 degrees slanted line on a red background. In Stage 3, key pecks were reinforced in the presence of the green background regardless of the line tilt, but were differentially reinforced in the presence of the red background (as in Stage 2). Generalization tests were conducted after each stage of training and consisted of five white lines on backgrounds that were green, red, or dark. The effects of the differential reinforcement contingencies on control by line orientation were restricted to the condition in which the red light appeared and resulted in behavioral control that could be characterized as: if red, pay closer attention to line tilt than if not red.

Animals↗

An inverse relationship between baseline fixed-interval response rate and the effects of a tandem response requirement.

Previous experiments examining the effects of adding a tandem fixed-ratio response requirement on fixed-interval schedule performance have reported inconsistent results. One variable that may account for such inconsistencies is the baseline response rate in the fixed-interval condition. This possibility was investigated in the present study. Rats were given histories with either interresponse times greater than 11 s or fixed-ratio 40 schedules of reinforcement, which engendered either relatively low or high rates of responding, respectively, in the subsequent fixed-interval condition. A tandem ratio response requirement (fixed-ratio 9) was then introduced. The effects of adding this tandem response requirement were inversely related to the baseline fixed-interval response rates; low rates of responding in the fixed-interval condition were markedly increased, whereas high rates of responding were relatively unaffected. This inverse relationship appears to be similar to the rate-dependent relations observed in behavioral pharmacology. These results may provide an explanation for the inconsistent findings reported in previous studies on tandem fixed-interval fixed-ratio schedules and suggest that principles of behavioral pharmacology research may be applicable to the study of the effects of nonpharmacological variables on schedule-controlled behavior.

Animals↗

Predictors of sexual risk behaviors among adolescent mothers in a human immunodeficiency virus prevention program.

PURPOSE: The purpose of this study was to determine the following: (1) whether adolescent mothers in a human immunodeficiency virus (HIV) prevention program had significantly greater perceived self-efficacy and perceived behavioral control to use condoms, and more favorable outcome expectancies and subjective norms regarding condom use than those in a health education control group, 3 months after intervention; and (2) the impact of the 3-month postintervention theoretical variables on intentions to use condoms at 3 months and sexual risk behaviors at 6 months. METHODS: Structural equation modeling with latent variables was used to assess the influence of theoretical variables and treatment condition using data from 496 participants (78% Latinas, 18% African-Americans) who completed questionnaires at baseline and at 3- and 6-month follow-up evaluations. RESULTS: Substantial improvements were shown by both groups, with a slight advantage for the HIV prevention group, on all theoretical variables between pretest and the follow-up evaluations. In the predictive model, the intervention group reported significantly fewer sex partners. By using intentions to use condoms as a mediator, greater self-efficacy, hedonistic beliefs, positive subjective norms, and less unprotected sex predicted intentions to use condoms, which, in turn, predicted less unprotected sex. Lower subjective norms modestly predicted multiple partners. Significant indirect paths mediated through intentions to use condoms were observed. CONCLUSIONS: These data support a relationship among several constructs from social cognitive theory and the theory of reasoned action, and subsequent sexual risk behaviors. HIV-prevention programs for adolescent mothers should be designed to include these theoretical constructs and to address contextual factors influencing their lives.

Adolescent↗

Comparison of behavior maintained by intravenous cocaine and d-amphetamine in dogs.

The effectiveness of i.v. injections of cocaine and d-amphetamine in maintaining schedule-controlled behavior was compared directly in dogs. Behavior was maintained under either a fixed-ratio (FR) 15, fixed-interval (FI)5-min, FI5 -min ( FR5 :S), FI15 -min, FI15 -min ( FR5 :S) or FI45 -min ( FR10 :S) schedule of reinforcement during daily experimental sessions where the maximum number of injections per session was limited to 2 to 11, depending on the schedule employed. Each drug injection was followed by a 10-min (FR schedule) or 5-min (interval schedules) timeout period to reduce the direct effects of the drugs on responding. Both cocaine and d-amphetamine maintained temporal patterns of responding characteristic of each of the schedules. Similar rates of responding were maintained by cocaine and d-amphetamine under the FR and longer (15- and 45-min) interval schedules, but cocaine maintained higher rates than did d-amphetamine under the shorter (5-min) interval schedules. Brief stimulus presentations intermittently contiguous with drug injections did not always maintain higher response rates under the second-order schedules as compared to rates maintained under the simple FI schedules, but higher rates were observed more often when stimuli were paired with cocaine than when stimuli were paired with d-amphetamine. These results suggest that cocaine and d-amphetamine can function differently as reinforcers and the differences depend, at least in part, on the schedule of reinforcement under which the drugs are presented.

Animals↗

How operant conditioning can contribute to behavioral toxicology.

Operant conditioning can contribute to the development of behavioral toxicology in many ways. Its techniques are useful in training animals in the various behaviors the toxicologist may wish to study. They make possible the sophisticated assessment of sensory functioning. Operant conditioners excel at using schedules of intermittent reinforcement to create the type of stable animal performance needed in studying substances that produce effects only after prolonged exposure. Schedule-controlled behavior also helps elucidate the precise behavioral mechanisms involved in toxicity. In the early assessment of toxic substances a judiciously chosen sample of schelule-controlled performances may provide the best estimate whether the integrity of complex operant behavior remains unchanged. The development of improved behavioral techniques and computer technology promises to bring down the cost of such assessment.

Animals↗

Pharmacologic control of aberrant behavior in the mentally retarded: toward a more rational approach.

Drugs are frequently used to control aberrant behavior in the mentally retarded. However, despite decades of research, this approach to behavioral management has had very limited success. Slow progress in this area can be attributed, in part, to the lack of a theoretical framework to guide research. The main purpose of this review is to integrate clinical research in this area with evidence concerning the neurochemical mechanisms that mediate aberrant behaviors. It is concluded that a theoretical framework that takes into account the biological mechanisms that underlie disordered behavior and the actions of drugs provides the basis for a more rational approach to the development of pharmacological therapies in the mentally retarded.

Child↗

Behavioral self-control strategies for deliberately limiting drinking among college students.

This study examined the use of behavioral self-control strategies, across specific procedures and sex, and the relationship between self-control and alcohol consumption and problem variables. A total of 456 randomly selected college students participated in a survey of campus substance use. Behavioral strategies most commonly used to deliberately limit drinking among college students were those related to limiting driving/riding when drinking, controlling time and food stimuli, and awareness of internal and external cues to control drinking. Strategies related to self-reinforcement and punishment, certain alternatives to alcohol use, and specific rate control techniques were least used by drinkers. Females were more likely than males to use all but one of the behavioral strategies. The degree of self-control practiced was associated with alcohol consumption, driving/riding after drinking, improvement in limiting drinking, health beliefs related to alcohol problems, and perceived effectiveness of behavioral strategies to limit drinking. Specific self-control strategies were found to significantly predict alcohol-related variables, with confining drinking to certain times of the week and refusing unwanted drinks the most consistent predictors.

Adult↗

Comparison of error patterns produced by scopolamine and MK-801 on repeated acquisition and transition baselines.

An understanding of the differential role of cholinergic and glutaminergic systems may be limited by the failure to move the analysis of learning impairments beyond an assessment of changes in overall accuracy. This paper reports the results of two studies in which the effects in rats of scopolamine (0.5-3.0 mg/kg IP), a cholinergic antagonist, and MK-801 (0.05-0.3 mg/kg IP), an NMDA-receptor antagonist, were compared in two different repeated learning procedures and the nature of the underlying error patterns produced by each was evaluated. The first study examined drug effects upon a repeated sequence acquisition procedure and found that while both drugs decreased overall accuracy in a dose-dependent manner, the predominant error pattern varied significantly with drug; scopolamine primarily produced skipping errors within the sequence, whereas MK-801 more prominently increased perseveration on the first and second members of the sequence. In the second study, which used a repeated transition procedure, both drugs again significantly decreased overall accuracy in a dose-dependent manner, but no consistent differences in error patterning produced by the drugs were observed. Thus, while both cholinergic and NMDA systems play a role in learning, the behavioral processes underlying the changes in overall accuracy may differ, as indicated by the differential patterns of errors produced by scopolamine and MK-801 in the repeated acquisition baseline. Furthermore, the observed differences in the underlying behavioral processes of scopolamine and MK-801 in the repeated acquisition but not on the repeated transition procedure suggest that each of the two drugs may affect more than one of the variables controlling behavior, with the relative impact of drug-related changes in controlling variables depending upon the operative contingencies of the learning task.

Animals↗

Dopamine in the nucleus accumbens: cellular actions, drug- and behavior-associated fluctuations, and a possible role in an organism's adaptive activity.

This review expounds the idea that the analysis of dopamine (DA) action on target cells under behaviorally relevant conditions and behavior-related changes in DA activity can offer new information to clarify the functional significance of mesocorticolimbic DA. In contrast to the traditional association of DA with certain behavioral processes and mechanisms (activation, arousal, conditioning, motivation, reinforcement, sensorimotor integration, etc.), evaluation of DA activity during well-controlled behaviors established by different reinforcers can provide important clues for determining the role of DA in the development and regulation of goal-directed behavior. This review summarizes the results of our microiontophoretic studies of striatal neurons in awake, unrestrained rats, particularly the action of DA on spontaneously active and glutamate (GLU)-stimulated cells, the pattern of DA-GLU interaction, and the role of tonic DA release in regulating the activity and afferent responsiveness of these units. We present the results of our iontophoretic studies of ventral tegmental area (VTA) neurons in freely moving animals suggesting the complexity and limitations in their identification as DA- and non-DA cells under behaviorally relevant conditions. We also consider technical and methodological problems related to electrophysiological and electrochemical evaluation of DA transmission in behaving animals. Finally, we discuss parallels and differences in the activity of presumed DA VTA neurons and changes of nucleus accumbens DA-dependent electrochemical signal during heroin self-administration (SA) behavior.

Animals↗

Neuronal control of locomotion in C. elegans is modified by a dominant mutation in the GLR-1 ionotropic glutamate receptor.

How simple neuronal circuits control behavior is not well understood at the molecular or genetic level. In Caenorhabditis elegans, foraging behavior consists of long, forward movements interrupted by brief reversals. To determine how this pattern is generated and regulated, we have developed novel perturbation techniques that allow us to depolarize selected neurons in vivo using the dominant glutamate receptor mutation identified in the Lurcher mouse. Transgenic worms that expressed a mutated C. elegans glutamate receptor in interneurons that control locomotion displayed a remarkable and unexpected change in their behavior-they rapidly alternated between forward and backward coordinated movement. Our findings suggest that the gating of movement reversals is controlled in a partially distributed fashion by a small subset of interneurons and that this gating is modified by sensory input.

Amino Acid Sequence↗

Steroid hormones and the brain: linking "nature" and "nurture".

Contrary to earlier belief, the genetic constitution of each cell of the body ("nature") is subject to modulation by environmental factors ("nurture") which act throughout the life of the organism to shape the individual characteristics. The nervous system adapts and changes with the environment that the organism experiences through genomic activity controlled by chemical messengers from other nerve cells and from endocrine secretions. The nervous system expresses receptors for a number of circulating hormones, and the location of these hormone receptors has revealed a great deal about the neuroanatomy of neuroendocrine and behavioral control processes. The brain controls the endocrine system through the hypothalamus and pituitary gland, and it responds to circulating hormones throughout each stage of life. These effects begin during early development (eg., sexual differentiation of the brain; effects of maternal or neonatal stress). They continue in adult life in response to cyclic events (eg., season of year; time of day, controlling reproduction and daily activity-sleep rhythms of behavior); and they also include the behavior of other animals which alters hormone output. Hormones also operate during the aging process and under conditions which induce neural damage such as hypoxia and stress. This overview summarizes involvement of steroid hormones of gonads and adrenals in many of these processes and also examines the features of the genomic activity which is modified by these hormones. This area of research is fruitful because it brings together molecular, anatomical, physiological and behavioral approaches in an attempt to understand the long-term plasticity of the nervous system.

Animals↗

A consideration of the ethics of brain death--what are the ethical guidelines for physician, family and society in dealing with brain death?

There is at present considerable confusion with respect to ethical guidelines that should govern the behavior of society and the physician confronted by problems resulting from recent attainments of medicine and science. The use of life supporting devices raises the problem of determining when death has occurred and what is proper ethical procedure in dealing with the deficient half life caused by "Brain Death." Some guidance is obtained from a consideration of the nature of life, the nature of death, the nature of man, and the essence lost in death of man. A parallel consideration of the nature of ethics, the bases of ethics and of ethical decision can be helpful. An individual may have ideals which control behavior, even elevate ethical standards; others entertain concepts that destroy social ethics. Ethics control and direct social interactions; ethics determine the quality of social behavior--ethics are established by societies not by individuals. Numerous commissions have endeavored to define the requirements of physicians for diagnosing brain death and for appropriate subsequent actions. The rationales presented, however, are not invariably accepted by lay society. The problem is created by numerous trends. Among them are the "rightest" movement which, though possessing many virtues, has its excesses such as expressed in the "right to life movement." These have not been beneficial and have necessitated "right to death movements." Opposition is also due to the fact that society's concepts of the medical profession have changed. The practice of organ transplantation has created problems. Finally, the concept of death as other than evil is no longer generally accepted. As more biological manipulations are possible ever more difficult ethical problems will arise. It is a certainty, however, that when brain death has occurred life of man and that of the individual has ended. Although others might not agree, our ethic requires us to use life assist techniques to preserve the vegetative man, the individual who can still breathe spontaneously though lacking consciousness and behavioral ability. All the codes of medical ethics state that a physician shall not kill--this does not mean he cannot permit the terminal phases of death when the essence of human life is lost. A major question is the ethical responsibility of one society toward another. Can an affluent society squander its resources in the preservation of ineffectual life in the body after "brain death" when others are without the medical assistance which would permit total living?

Attitude to Death↗

Coordinated and dissociated effects of testosterone on singing behavior and song control nuclei in canaries (Serinus canaria).

Temperate zone songbirds that breed seasonally exhibit pronounced differences in reproductive behaviors including song inside and outside the breeding season. Springlike long daylengths are associated with increases in plasma testosterone (T) concentrations, as well as with increases in singing and in the volume of several brain nuclei known to control this behavior. The mechanisms whereby T can induce changes in behavior and brain, and whether or not these effects are differentially regulated, have recently begun to be examined, as has the question of the relative contributions of T and its androgenic and estrogenic metabolites to the regulation of this seasonal behavioral and neural plasticity. In this experiment, we examined the effects of T, 5alpha-dihydrotestosterone, or 17beta-estradiol treatment on castrated male canaries housed on short days and compared neural and behavioral effects in these males to similarly-housed males given only blank implants. We observed that only T treatment was effective in eliciting significant increases in singing behavior after 11 days of hormone exposure. In addition, T alone was effective in increasing the volume of a key song production nucleus, HVC. However, at this time, none of the steroids had any effects on the volumes of two other song control nuclei, Area X of the medial striatum and the robust nucleus of the arcopallium (RA), that are efferent targets of HVC, known to be regulated by androgen in canaries and also to play a role in the control of adult song. T can thus enhance singing well before concomitant androgen-induced changes in the song control system are complete.

Androgens↗

Neurohypophyseal peptides and psychiatric diseases.

The study of neurohypophyseal function in various neuropsychiatric diseases is interesting because: (1) The main neurohypophyseal peptides vasopressin (AVP) and oxytocin (OT) share by themselves modulatory influence on behavior. (2) Hypothalamo-posterior pituitary axis is directly influenced by modifications of central neurotransmitter metabolism involved in behavior control.

Animals↗

Personal health behaviors in women who have undergone risk-reducing mastectomy.

BACKGROUND: Risk-reducing mastectomy (RRM) remains an effective yet controversial modality for the primary prevention of breast cancer. Is the choice of RRM consistent with a generally proactive healthy lifestyle? METHODS: The National Prophylactic Mastectomy Registry is a volunteer database comprised of 460 women who have undergone bilateral RRM. Each patient received a questionnaire drawn from the Centers for Disease Control Behavioral Risk Factor Surveillance System. Their responses were compared with gender-specific national data from the Centers for Disease Control. RESULTS: Women in the RRM group were statistically more likely to engage in risk-reducing personal health behavior including not smoking, exercising, maintaining their health, and taking advantage of screening programs. CONCLUSIONS: Women in the registry who underwent RRM practiced a more "healthy" lifestyle than gender-matched controls. Therefore, the decision to have prophylactic surgery may have been part of a proactive approach toward their overall physical well-being.

Adult↗

Stereoselective behavioral effects of cocaine and a phenyltropane analog.

Intramuscular injections of the stereoisomers of cocaine and of its phenyltropane analog were compared for their effects on schedule-controlled behavior of squirrel monkeys. Monkeys responded by pressing a lever under a multiple schedule with alternating fixed-interval and fixed-ratio components; responding was maintained by presentation of food in some monkeys and by termination of a stimulus associated with electric shock in other monkeys. The levorotatory isomers, (-)-cocaine (0.09-2.7 mg/kg) and WIN 35,065-2 (0.006-0.2 mg/kg), had qualitatively similar effects which depended primarily on the type of component schedule (fixed-interval or fixed-ratio) that maintained responding. In the fixed-interval components, intermediate doses of each drug increased responding, whereas higher doses decreased responding. In the fixed-ratio components, each drug only decreased responding in a dose-related manner. The minimal effective dose of (-)-cocaine was about 10 times that of WIN 35,065-2. Although the dextrorotatory isomers, (+)-cocaine and WIN 35,065-3, also increased responding in the fixed-interval components and decreased responding in the fixed-ratio components in some monkeys, the doses required were 100 to 622 times the minimal effective doses of their enantiomers. The results show a high degree of stereoselectivity in the behavioral effects of both cocaine and its phenyltropane analog.

Animals↗

Psychotherapy of attention deficit hyperactivity disorder in adults--a pilot study using a structured skills training program.

In clinical practice many adult patients with attention deficit hyperactivity disorder (ADHD) ask for an additional psychotherapeutic intervention besides the medical therapy. In this paper we present a structured skill training program particularly tailored for adult patients with ADHD. The program is based on the principles of cognitive-behavioral treatment for borderline personality disorder developed by M. Linehan. It was modified to suit the special needs of adult patients with ADHD. In this exploratory pilot study we tested this program in a group setting. The following elements were presented: neurobiology of ADHD, mindfulness, chaos and control, behavior analysis, emotion regulation, depression, medication in ADHD, impulse control, stress management, dependency, ADHD in relationship and self respect. In an open study design patients were assessed clinically using psychometric scales (Attention Deficit Hyperactivity Disorder Checklist according to DSM-IV, 16 items of the SCL-90-R, Beck-Depression Inventory, visual analogue scale) prior to and following group therapy. This treatment resulted in positive outcomes in that patients improved on all psychometric scales.

Adult↗

Child abuse and the balance of power in parental relationships: an evolved domain-independent mental mechanism that accounts for behavioral variation.

Previous studies use zero-order analyses to show a link between child abuse and exposure to "stepfathers." These studies rest on a proposed evolved, domain-specific cognitive mechanism that induces adult males to abuse or kill offspring not their own and, so, contribute directly to reproductive success. However, child abuse may reflect an evolved neurological mechanism that creates behavioral plasticity and adaptability by assigning emotional weights (which in consciousness appear rationalized as costs and benefits) to choice alternatives in all behavioral domains. This mechanism should act as a selective mechanism to create enhanced ability to avoid predation (social exploitation) and to obtain access to resources, given the properties of specific ecosystems, and should control behavioral responses to variation in the balance of power in social relationships. Power equalities should elicit good treatment for both parties; power inequalities, by contrast, should elicit exploitative and coercive behavior on the part of those who hold the balance of power. This paper reports a test of both hypotheses simultaneously, controlling for a standard social science risk factor (growing up in poverty). Once we control for the balance of power in parental relationships, exposure to a stepfather and growing up in poverty show no effect on the intensity of child abuse. Powerful women negotiated affectionate behavior from their partners for both themselves and their children; powerless women's negotiations with partners usually left both themselves and their children open to violence.

Adult↗