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Results for “Angina Pectoris, Variant”

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At least 1,189 records · Page 66Linked to original sources
PubMed1998

Cardiac syncope due to transient coronary artery occlusion: the role of percutaneous angioplasty.

A case of cardiac syncope is presented, associated with single vessel coronary disease. The mechanism of the syncope would appear to be a ventricular arrhythmia with transmural myocardial ischaemia due to transient occlusion of the diseased coronary artery. The symptoms and electrocardiographic abnormalities were reproduced and subsequently abolished by percutaneous coronary angioplasty.

Angina Pectoris, Variant↗
PubMed2001

Glutathione attenuates coronary constriction to acetylcholine in patients with coronary spastic angina.

This study examined the effect of reduced glutathione (GSH), an important antioxidant that restores intracellular redox imbalance and prevents inactivation of endothelial-derived nitric oxide, on the abnormal vasomotor reactivity in spastic coronary arteries. The responses of epicardial diameter of the left coronary arteries to intracoronary infusion of acetylcholine (ACh; 50 microg/min) were measured by quantitative coronary angiography before and during combined intracoronary infusion of GSH (50 mg/min for 6 min) or saline as a placebo in 24 patients with coronary spastic angina and in 28 control patients. All of the spastic coronary arteries showed constrictor response to ACh, whereas the control coronary arteries as a whole showed only minimal diameter changes to ACh. GSH infusion suppressed constrictor response of epicardial diameter to ACh in patients with coronary spastic angina, whereas it had no significant effect in control subjects. Saline infusion did not have any effects. The results indicate that GSH attenuated the constrictor response to ACh in epicardial coronary arteries of patients with coronary spastic angina. GSH may have an important role in the regulation of coronary vasomotor function in patients with coronary spastic angina.

Acetylcholine↗
PubMed1988

Prinzmetal's angina associated with alcohol withdrawal.

A 39-year-old woman developed critical anginal attacks 2-7 days after abruptly stopping long-lasting excessive alcohol drinking. The coronary angiogram demonstrated spasms in the left anterior descending and the right coronary artery without signs of preexistent stenosis. In previous reports alcohol-related coronary spasm always followed ingestion of alcohol several hours before. Because of the time delay in this case, we suggest that not the intake but the withdrawal of alcohol was the factor provoking coronary spasm in our patient.

Adult↗
PubMed1989

Atypical chest pain and panic disorder.

Cardiovascular symptoms are often present in descriptions of patients with panic disorder, and are considered a central element in current diagnostic criteria. These patients often visit emergency wards complaining of chest pain or discomfort. In many cases, a possible psychiatric diagnosis is not considered, and these patients are often incorrectly diagnosed and treated. The aim of this study is to examine the presence of panic disorder in those patients who visit a general hospital emergency ward with chest pain, and are then released after no organic pathology is found. We present the results obtained from the examination of 112 patients with these characteristics who were given a structured interview developed for the diagnosis of affective and anxiety disorders. In the sample studied, panic disorder was found in 47.3% of the subjects.

Adolescent↗
PubMed1977

Angina with "normal coronary arteries". A misnomer.

Angina with "normal coronary arteries" might best be thought of as "angina with coronary dysfunction". It seems likely that this syndrome is due to inadequate regional myocardial perfusion with manifestations similar to those seen when ischemia results from occlusive coronary artery disease. The prognosis of the disorder is favorable, but occasional catastrophic events occur. It appears likely that maldistribution of perfusion results from dynamic changes affecting proximal, and perhaps distal coronary vessels, potentially mediated by vasoactive substances released from platelets precipitating or exacerbating coronary arterial spasm. Clarification of the pathogenesis of the syndrome should permit implementation of more effective therapy and prevention of the rare malignant sequelae of this disorder.

Adolescent↗
PubMed1978

Nifedipine therapy for Prinzmetal's angina.

A case is described in which nifedipine, a new coronary vasodilator, was effective in relieving attacks of Prinzmetal's angina unresponsive to conventional therapy. The extreme frequency of the anginal attacks provided evidence that lower doses of nifedipine lost their effectiveness approximately 4 hours after administration. A month after initiation of nifedipine, nitrates were withdrawn since they had been ineffective in controlling the attacks. A myocardial infarction occurred immediately, presumably due to coronary spasm.

Adult↗