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At least 1,171 records · Page 65Linked to original sources
PubMed1999

Resistant mechanisms of Candida albicans to fluconazole.

OBJECTIVE: To detect the resistant mechanisms of Candida albicans to fluconazole (FCZ) at molecular biology level, since the resistance mechanisms of azole antifungal agents have been the focus of attention these years. METHODS: Thirty-two FCZ-resistant C. albicans were selected as our test strains (MICs > or = 64 micrograms/ml). With 14-alpha-demethylase gene (ERG16 gene, target enzyme encoding gene of azoles) as our object, we chose six sets of primers from the ERG16 gene to amplify the interested fragments, and conducted Southern blot hybridization, restriction fragment length polymorphism (RFLP), and single strand conformation polymorphism (SSCP) analysis for the fragments which were amplified by the six sets of primers, and pre-resistant sensitive strains were used as controls. Three representative fragments, A66, D66 and E78, were selected to be cloned and sequenced. RESULTS: The polymerase chain reaction (PCR) amplification showed that several tested strains were negative for some primers. However, our Southern blot analysis reminded that their resistance did not result from the lack of target enzyme coding gene. SSCP analysis showed that differences were noted between the resistant and sensitive strains and inter-resistant strains. Statistical analysis showed that the most variable sequence lied in the amplifier of the sixth pair of primer, and all the tested 32 strains showed positive results. In the 11 mutation points we found, five resulted in amino acid alterations. It is likely that one or more mutational alterations (alone or in combination) might lead to the expression of an enzyme highly resistant to the inhibitory action of FCZ which in turn is responsible for the FCZ resistant trait in these strains. CONCLUSION: One or more mutational alterations might lead to the azole resistant trait in this strains.

Acquired Immunodeficiency Syndrome↗
PubMed1999

Context related artefact detection in prolonged EEG recordings.

The need for reliable detection of artefacts in raw and processed EEG is widely acknowledged. Although different EEG analysis systems have been described, only few general applicable artefact recognition techniques have emerged. This paper tackles the problem of artefact detection in seven 24 h EEG recordings in the intensive care unit. ICU recordings have received less attention than, e.g. epilepsy monitoring, although recordings in this environment present an interesting application area. The EEG data used here was recorded during the difficult circumstances of an explorative ICU study. The data set includes a diverse set of EEG patterns, as well as EEG artefacts. The study investigates objective artefact detection methods based on statistical differences between signal parameters, using time-varying autoregressive modelling (AR) and Slope detection. In addition to matching the performance of artefact detection against two human observers, the study focuses on the optimal settings for context incorporation by testing the algorithms for different time windows and epoch lengths. Results indicate that a relatively short period (20-40 s) provides sufficient context information for the methods used. The combined AR and Slope detection parameters yielded good performance, detecting approximately 90% of the artefacts as indicated by the consensus score of the human observers.

Adult↗
PubMed1999

Effectiveness and quality of individual planning in residential settings: an analysis of outcomes.

Individual Habilitation Plan objectives for adults with mental retardation living in institutional or community settings were evaluated for effectiveness and quality. Effectiveness was assessed by contrasting change in relevant outcomes over time for participants with and without individual plan objectives in specified content areas. No significant change in outcomes associated with having an objective was detected for any of the content areas. Except for functionality, ratings of individual plans on all quality domains were poor. Regression analyses mostly failed to show any significant relationship between quality domain ratings and outcomes, although there was weak but inconsistent evidence for validity of the technical adequacy and data-collection quality domains. Findings present a challenge to current expectations that presence and quality of IHP objectives are associated with improved outcomes.

Adult↗
PubMed1977

Early detection of chronic simple glaucoma in general practice.

Chronic simple glaucoma, also known as open-angle glaucoma, is the cause of blindness in about 13 per cent of people on the Blind Register, and 40 per cent of these have had no treatment before registration. Patients over the age of 60 are most liable to the disease and it is rare under the age of 40; there is often a family predisposition. I carried out a routine test for the disease in 300 patients over 60 years of age in my general practice with the object of detecting chronic simple glaucoma at an early stage. Anyone with an intraocular pressure of over 23 mm of mercury in either eye was referred to a consultant ophthalmic surgeon for further investigation. Seven patients (2.3 per cent of those examined) were confirmed as suffering from chronic simple glaucoma.

Age Factors↗
PubMed2002

Analysis and processing of samples for a carbon-14 monitoring program at a radioactive waste storage site.

A monitoring program was undertaken to determine the levels of airborne radioactive 14CO2 in an operating waste management area, and it its vicinity. As a part of this program, alkaline microporous pellets, recently developed, were used to sample the 14CO2 in air near waste storage structures and near the waste management area. These pellets were never fully characterized for their ability to capture high levels of 14CO2, and the processing and analysis needed to be improved to provide data on recoveries and consistencies, for an eventual method validation, with independent calibrations and standards. The sample analysis scheme also had to accommodate 14CO2 levels varying from near the natural background (250 Bq kg-1 C), to potentially three to four orders of magnitude above this value, near the wastes. The porous alkaline solid pellets were used for the passive capture of airborne 14CO2 over a period of weeks, to a few months. The pellets were processed to release the captured CO2 (14CO2 and 12CO2) into a NaOH solution, which was subsequently analyzed by liquid scintillation. Processing of the pellets yielded a 14C recovery of 96.0 +/- 4.2% and a lower, but consistent total carbon recovery, i.e., 85.9 +/- 2.7 and 86.9 +/- 2.6%, for procedural blanks and standards, respectively. The detection limits for the pellet sampling and processing was sufficient to reach environmental levels. For the higher levels of 14CO2 and for 'spot' sampling, we also used air samples, pumped into a NaOH solution to trap the 14CO2. These NaOH solutions were counted directly for 14C, also by liquid scintillation. The method limits of this latter technique, although much higher than for pellet samples, also achieved the performance objective for detecting airborne 14CO2. Both sampling and processing techniques, when used together, provided sufficient flexibility to be used for low (environmental) levels and high levels, near the wastes.

Air Pollutants, Radioactive↗
PubMed2000

African-American men and intention to adhere to recommended follow-up for an abnormal prostate cancer early detection examination result.

OBJECTIVES: To assess the intention of African-American men to have the recommended follow-up in the event of an abnormal prostate cancer early detection examination and to identify the variables that help to explain adherence intention. METHODS: In the spring of 1995, we selected a random sample of 548 African-American men who were patients at the University of Chicago Health Service. The sample included men who were 40 to 70 years of age, did not have a personal history of prostate cancer, and had a working telephone number. A total of 413 men who completed the telephone survey received an invitation to consider undergoing a prostate cancer early detection examination. The survey provided data on personal background characteristics, knowledge, attitudes, and beliefs related to prostate cancer and early detection. Respondents were asked whether they would choose to have the recommended follow-up in the event of an abnormal early detection examination result. Univariate and multivariate analyses of intention to have follow-up were performed. RESULTS: An intention to have the recommended follow-up was reported by 77% of the survey respondents. The results of multivariate analyses revealed that the intention to have the follow-up was positively associated with education beyond high school (odds ratio [OR] 1.9); perceived self-efficacy related to prostate cancer screening (OR 2.1); the belief that prostate cancer can be cured (OR 3.3); the belief that prostate cancer screening should be done in the absence of prostate problems (OR 2.3); and physician support for prostate cancer screening (OR 2.1). CONCLUSIONS: African-American men who have a high school education or less may be at risk of nonadherence to recommended follow-up. Adherence also may be low among men who do not have favorable views of early detection or do not perceive strong physician support for early detection. Research is needed to determine whether intention and other factors predict actual adherence to follow-up in this population group.

Adult↗
PubMed2000

[Full-field digital mammography: a phantom study for detection of microcalcification].

OBJECTIVES: The study compares direct full-field digital mammography (FFDM) to the state-of-the-art conventional screen-film mammography (SFM) concerning the detectability of simulated microcalcifications. MATERIALS AND METHODS: The investigations were performed with a FFDM system (Senographe 2000D, GEMS) and a SFM system (Senographe DMR, GEMS, Fuji UM MA film with Fuji UM MAMMO FINE screen). An anthropomorphic breast phantom with superimposed microcalcifications (50-200 microns) was used to evaluate the detectability of microcalcifications with a confidence level ranging from 1 to 5. Contact mammograms and magnification spot views (m = 1.8) of the FFDM and SFM systems were compared. A receiver operating characteristic (ROC) analysis was performed by three well-experienced readers. RESULTS: The ROC analysis revealed a higher performance of the digital images compared to the conventional screen-film mammograms. The area under the ROC-curve (Az) in the digital contact mammograms was 0.68 versus 0.63 in the conventional technique. The results were not significantly different. In digital spot views, Az was 0.79 versus 0.70 in the conventional spot views. CONCLUSIONS: The results suggest that FFDM is at least equivalent or--as far as spot views are concerned--may be superior to conventional SFM in the detection of microcalcifications.

Breast Diseases↗
PubMed1999

Plasminogen activator inhibitor-1 and carotid intima-media thickening in patients with newly detected primary hypertension.

OBJECTIVE: To investigate the correlation between ultrasonographically evaluated intima-media thickness (IMT) of common carotid artery (CCA) and cardiovascular risk factors for subjects with newly detected, uncomplicated and untreated primary hypertension. METHODS: The study population consisted of 200 subjects (123 men and 77 women, aged 46+/-7.5 years). Blood pressure was measured in the clinical setting and by 24 h noninvasive ambulatory monitoring. Fasting levels of blood glucose, plasma lipids and lipoproteins, fibrinogen and plasminogen activator inhibitor (PAI)-1 were measured. Ultrasound examination included measurement of far-wall intima-media complex of CCA and morphologic evaluation of occurrence of plaques in carotid and femoral bifurcations. RESULTS: The prevalence of greater than normal IMT (mean IMT > or =0.80 mm) was 22%. Significant univariate correlations to the dichotomy between normal and greater than normal mean IMT were detected for age, smoking, level of LDL cholesterol, level of PAI-1 and total ultrasonographic score. Multivariate logistic regression analysis confirmed the associations between greater than normal mean IMT and plasma concentrations of LDL cholesterol and PAI-1 as well as total ultrasonographic score. CONCLUSION: Greater than normal IMT of CCA was more strictly related to other cardiovascular risk factors than it was to blood pressure and was strongly associated with the occurrence of atherosclerotic plaques in carotid and femoral arteries. The role of PAI-1 in intima-media thickening that is emerging suggests that fibrinolytic balance is an important determinant of vessel-wall homeostasis in hypertensive patients.

Adult↗
PubMed2006

The sensitivity and specificity of nonmydriatic digital stereoscopic retinal imaging in detecting diabetic retinopathy.

OBJECTIVE: The objective of this study was to determine the sensitivity and specificity of Joslin Vision Network nonmydriatic digital stereoscopic retinal imaging (NMDSRI) as a screening tool in detecting diabetic retinopathy. RESEARCH DESIGN AND METHODS: We reviewed the records of 244 patients with diabetes who had a dilated funduscopic examination (DFE) and NMDSRI done within 1 year of each other at four locations in the metropolitan Washington, DC, area. The images were transmitted through a local area network to a central reading location where they were graded by a single retinal specialist. RESULTS: Images of 482 eyes from 243 patients were included in the study. Four images did not transmit, and 35% of the images were not gradable. Of the remaining 311 eyes, there was 86% agreement in the grading between NMDSRI and DFE: 227 eyes with no diabetic retinopathy and 40 eyes with diabetic retinopathy. In 46 eyes (15%) there was a disagreement between gradings made by the two techniques. NMDSRI detected diabetic retinopathy in 35 eyes reported as normal by DFE, and in the remaining 11 eyes, the DFE grade was one grade higher than the NMDSRI grade. Adjudicated nonconcordant examinations were within one grade. In the 76 eyes with diabetic retinopathy, retinal thickness could not be assessed in 17 (21%) eyes. When the NMDSRI result was gradable, the overall sensitivity of NMDSRI was 98% and the specificity was 100% for retinopathy within one grade of the DFE. In the limited number of eyes that had diabetic retinopathy with macular edema (six), agreement with the clinical examination was 100%. CONCLUSIONS: NMDSRI is a sensitive and specific method for the screening and diagnosis of diabetic retinopathy, which may help improve compliance with the standards of eye care for patients with diabetes.

Aged↗
PubMed1999

Assessment of contrast sensitivity in children aged 3 years 9 months - 6 years with normal vision, visual impairment due to ocular disease and strabismic amblyopia.

The contrast sensitivity function was assessed in children and adults with normal vision, visual impairment due to ocular disease, and strabismic amblyopia. The methods used were: the LH contrast vision test and the ability to detect raisins, puffed rice and white and black sugar strands against a white and black background. The aim of the study was to see whether any of the tests could be used in the detection of subnormal vision, and to compare the results between the different groups of patients. The following parameters of contrast sensitivity function (CSF) were measured with the LH-test: the maximum contrast sensitivity, the total area of CSF, and the area of 8 spatial frequency bands. Difficulty in detecting an object with low versus high contrast was measured with the sugar strands. Subjects with subnormal vision due to ocular disease and strabismic amblyopia had lower contrast sensitivity than subjects with normal vision measured as the total area of the CSF or the area of a specific frequency band. However, the maximum contrast sensitivity value that could be measured with the test was not significantly different between the groups. No subject had difficulties in the detection of raisins and puffed rice on a white and black background. Difficulties in detecting sugar strands on a white background were not seen in the normal children, but approximately 65% of the children with visual impairment had difficulties, as did approximately 25% of the children and adults with strabismus. Most of these subjects also had low visual acuity, but there was no correlation between the level of reduction of visual acuity and the difficulty in detecting sugar strands.

Adult↗
PubMed2004

Comparison of scanning laser polarimetry using variable corneal compensation and retinal nerve fiber layer photography for detection of glaucoma.

OBJECTIVE: To compare retinal nerve fiber layer (RNFL) measurements obtained with scanning laser polarimetry (SLP) using variable corneal polarization compensation with standard red-free photography for detection of RNFL damage in glaucoma. METHODS: This observational, cross-sectional study included 1 eye of each of 42 patients with open-angle glaucoma, 32 patients suspected of having glaucoma, and 40 healthy subjects. The RNFL measurements using SLP with variable corneal compensation were obtained within 3 months of red-free photographs. Two independent observers graded RNFL photographs using a standardized protocol. Superior and inferior hemiretinas were scored separately, and a global score was obtained by averaging scores from each hemiretina. MAIN OUTCOME MEASURES: The RNFL photography scores were compared with RNFL thickness measurements obtained with SLP. The receiver operating characteristic (ROC) curves were constructed to assess the abilities of the different methods to differentiate glaucoma patients from healthy subjects. RESULTS: The RNFL thickness decreased with increased RNFL damage as assessed by photographs in both hemiretinas (R(2) = 15%-47%). The area under the ROC curve for the best SLP parameter, Nerve Fiber Indicator, was significantly greater than the area under the ROC curve for the global RNFL photography score (0.91 vs 0.84, P =.03). CONCLUSIONS: A moderate correlation was found between RNFL thickness measurements obtained with SLP and RNFL scores from red-free photographs. Compared with semiquantitative RNFL photography scores, the best SLP parameter had a higher diagnostic accuracy to separate glaucoma patients from healthy subjects.

Aged↗
PubMed1996

Longitudinal study of the effects of pregnancy and other factors on detection of HPV.

OBJECTIVE: An epidemiologic study of 108 pregnant and 192 non-pregnant women was carried out to determine the effects of pregnancy and other factors on the detection of HPV infection, since both or larger numbers of pregnancies and HPV infection are known to be risk factors for cervical cancer. PATIENTS AND METHODS: Study participants were followed up at 3-months intervals for a period of 15 months (1-6 months after delivery). At each visit, two cervical specimens were taken, one for routine cytology and a second for HPV DNA hybridization using Virapap/Viratype, and a 5-ml blood sample was taken and a self-administered questionnaire was completed. RESULTS: In cervical specimens of the initial examination, HPV DNA was detected among 5.0% of pregnant and 5.2% of nonpregnant women, whereas HPV 16/18 was found in 80% of the HPV-positive specimens. Using multiple cervical specimens taken over time, 13.9% of the pregnant and 15.1% of the nonpregnant women tested positive for HPV DNA at least once. Adjusted for study group, age, and the number of available cervical specimens, ever detection of HPV infection (any type) was associated with more sexual partners and larger numbers of cigarettes smoked daily. An autoregressive generalized linear model was used to analyze the time-dependent multiple observations per study subject. Adjusting for age and trimester of pregnancy, the determinants of detecting high-risk HPV types (16/18 and 31/33/35) in the cervical specimen were an abnormal Pap smear, a positive HPV result in a preceding specimen, more than six sexual partners in the lifetime, and currently smoking more than 20 cigarettes per day with odds ratios of 10.9, 5.6, 3.2, and 2.7, respectively. CONCLUSION: Our data provide no evidence for a higher detection rate of HPV during pregnancy.

Adult↗
PubMed1998

Free/total serum prostate-specific antigen ratio: how helpful is it in detecting prostate cancer?

OBJECTIVE: To determine whether the use of free/total (f/t) serum prostate specific antigen (PSA) ratio would help reduce the number of prostate biopsies performed without compromising the detection of prostate cancer. in the setting of a transrectal ultrasonography (TRUS) clinic. PATIENTS AND METHODS: The study included 93 consecutive patients referred to the clinic for TRUS and biopsy. Serum samples were assessed for total PSA and free PSA, and the f/t PSA ratio calculated: 70 biopsies were taken. Patients over the age of 70 years with TRUS findings consistent with benign prostatic hyperplasia and with PSA levels < 10 ng/mL were not biopsied. RESULTS: Tumour was detected in 23 patients; receiver operating characteristic curves showed no advantage for the f/t PSA ratio when compared with total PSA in detecting prostate cancer. If a f/t PSA ratio of < 0.15 had been used to determine the necessity for biopsy in the group with a total PSA of 4-10 ng/mL, then two-thirds of all tumours would have been undetected. CONCLUSION: The f/t PSA ratio had no advantage over total PSA in improving specificity at a given sensitivity for detecting prostate cancer. Therefore, it cannot be recommended as a means of decreasing unnecessary biopsies in patients with a raised PSA level and/or an abnormal digital rectal examination. This applied particularly to the group of patients with a total PSA of 4-10 ng/mL.

Age Distribution↗
PubMed2001

[Partial sequence of sporogony stage-specific 18S ribosomal DNA of Plasmodium yoelii and its application for detection of parasites].

OBJECTIVE: To determine sequence of sporogony stage-specific (S type) 18S ribosomal RNA gene of Plasmodium yoelii (P. y) By265 strain, and by using it to detect the malaria parasites within vector mosquito. METHODS: A pair of conserved DNA primers, universe primer (Pu) and reverse transcription one (Pr), was designed and synthesized according to sequence of the 18S rRNA gene of Plasmodium berghei (P. b). The segment of the S type 18S rDNA of P. y was amplified by reverse transcript-polymerase chain reaction (RT-PCR) from dissected midguts of Anopheles stephensi infected with P. y on the 7th day after infective blood-meal, and its sequence was then determined. One P. y sporogony stage-specific primer (Pys) was selected according to the sequence. Using this primer and Pr, the parasites within mosquitoes were semi-quantitatively detected through RT-PCR between 1-7 d post-infection. RESULTS: The length of the amplified segment was 920 bp. Alignment in match region of the 18S rDNA among S type of P. y (PyS), S type of P. b (PbS) and asexual blood stage-specific one of P. y (PyA) revealed that the similarity between the former and the latter two reached 95.3% and 94.0% respectively. The density of amplified band was significantly concordance with the intensity of oocyst in the midgut. Sensitivity of RT-PCR method was higher than that of the traditional dissection and oocyst observation also. The assay could detect the 18S rRNA molecule of the parasites on the third day post-infection while their oocysts were difficult to be recognized under an optical microscope at that time. CONCLUSION: This S type 18S rDNA sequence in P. y species was first reported (AF266261). As a molecular marker, it could be applied to monitoring the parasite development in its vector at an earlier stage semi-quantitatively with an adequate sensitivity and specificity.

Animals↗
PubMed1996

Comparison of synovial tissue and synovial fluid as the source of nucleic acids for detection of Chlamydia trachomatis by polymerase chain reaction.

OBJECTIVE: Difficulties in detecting Chlamydia trachomatis in human joints by polymerase chain reaction (PCR) may be related to whether synovial tissue or synovial fluid (SF) is used as the source of DNA in PCR amplification. In this study, a new PCR assay was developed and used to compare chlamydial DNA in paired samples of SF and synovial tissue from patients with arthritis. METHODS: The PCR assay targeted the ribosomal RNA operons, which are present in 2 copies on the C trachomatis chromosome. DNA from several relevant bacteria and chlamydial serovars was used for testing this screening system. The detection of chlamydial DNA in nucleic acid preparations from matched samples of SF and synovial tissue was compared by PCR assay. Samples were obtained from 55 patients, including patients with reactive arthritis, Reiter's syndrome, and other arthropathies. RESULTS: Testing of the PCR screening system confirmed it to be highly specific and sensitive. Use of this assay to screen DNA from SF and synovial tissue samples showed that 29 (53%) of 55 synovial tissue preparations were positive for chlamydial DNA, but only 16 (29%) of the matched SF samples from these 29 patients were similarly positive. Five (9%) of 55 SF samples, but not their tissue counterparts, were positive for chlamydial DNA by PCR. CONCLUSION: Detection of chlamydial DNA in the joints of patients by PCR gives positive results more often when synovial tissue rather than SF is the source of target nucleic acids. Although synovial tissue is the source of choice for the most reliable determination of chlamydia in the joint, both synovial tissue and SF should be assayed if possible.

Adult↗
PubMed2003

Searching for nodules: what features attract attention and influence detection?

RATIONALE AND OBJECTIVES: The goal of the study was to determine whether there are certain physical features of pulmonary nodules that attract visual attention and contribute to increased recognition and detection by observers. MATERIALS AND METHODS: A series of posteroanterior chest images with solitary pulmonary nodules were searched by six radiologists as their eye-position was recorded. The signal-to-noise ratio, size, conspicuity, location, and calcification status were measured for each nodule. Dwell parameters were correlated with nodule features and related to detection rates. RESULTS: Only nodule size (F = 5.08, P = .0254) and conspicuity (F = 4.625, P = .0329) influenced total dwell time on nodules, with larger, more conspicuous nodules receiving less visual attention than smaller, less conspicuous nodules. All nodule features examined influenced overall detection performance (P < .05) even though most did not influence visual search and attention. CONCLUSION: Individual nodule features do not attract attention as measured by "first hit" fixation data, but certain features do tend to hold attention once the nodule has been fixated. The combination of all features influences whether or not it is detected.

Attention↗
PubMed1997

Rapid polymerase chain reaction analysis of St14 (DXS52) VNTR: carrier detection of hemophilia A.

OBJECTIVE: To determine the frequency of St14 VNTR allele in Koreans as a marker of the hemophilia A and to evaluate the efficacy of this marker for carrier detection of hemophilia A METHODS: PCR amplified RFLP analysis of St14 VNTR was done in 312 X-chromosomes of 122 unrelated Korean males and 95 females and the same method was applied to carrier detection in the 2 hemophilia A families. RESULTS: There were 13 alleles of different sizes of St14 VNTR locus appeared in 312 X-chromosomes of unrelated Koreans. For carrier detection of hemophilia A, in the family A, the mother showed 1390/ 1330 bp alleles and the father showed 700 bp allele. The affected son has inherited 1390 bp allele from his mother. The daughter at risk showed 1330/700 bp alleles. In family B, the mother showed 1280/700 bp alleles and the stepfather showed 1390 bp allele. The affected son has inherited 1280 bp allele. The daughter at risk showed 1390/700 bp alleles. And so the daughters of the 2 families were not carriers for hemophilia A. CONCLUSION: PCR analysis of St14 VNTR was a useful tool for carrier detection of hemophilia A.

Alleles↗
PubMed1991

Detecting hypertension: screening versus case finding in Norway.

OBJECTIVE: Evaluation of detection of hypertension in adults in the county of Nord-Trøndelag, Norway. DESIGN: Cross sectional survey with clinical follow up examinations. SETTING: Health survey by screening teams from the national health screening service, and examinations by all 106 general practitioners in the county. SUBJECTS: During 1984-6, 74,977 persons (88.1% of those aged 20 years and over) participated in the health survey. MAIN OUTCOME MEASURES: Hypertension (when assessed by standardised recording and by questionnaires on drug treatment for hypertension) according to the blood pressure thresholds used in the Norwegian treatment programme. Subjects positive on screening were grouped after clinical examination into treatment groups. RESULTS: In all, 2399 subjects were positive for hypertension. Before screening 6210 (8.3%) patients reported taking antihypertensive drugs and another 3849 (5.1%) had their blood pressure monitored regularly. All who screened positive were referred to their general practitioner and evaluated according to a standard programme. As a result, drug treatment was started in 406 (0.5%) participants screened and blood pressure monitoring in another 1007 (1.3%). Of all patients taking antihypertensive drugs after the screening, 6399 (94.0%) had been diagnosed before screening, and of those whose blood pressure was monitored after the screening, 79.3% had been diagnosed before screening. CONCLUSIONS: At the blood pressure screening thresholds used, and when hypertension is defined by an overall clinical diagnosis, the results indicate that general practitioners can find and diagnose hypertensive patients with the case finding strategy.

Adult↗