Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Spatial Behavior”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,171 records · Page 65Linked to original sources
PubMed2001

Perceptual aspects of two-dimensional and stereoscopic display techniques in endoscopic surgery: review and current problems.

The aim of this review is to analyze the perceptual aspects of endoscopic imaging systems. After discussing depth perception in natural settings, the problems of perceiving depth in 2-dimensional representations are investigated. We discuss the impact of stereoscopic video systems on the cerebral perceptual system, emphasising the fact that despite the addition of binocular disparity information, existing stereoscopic video systems are still different from normal 3-dimensional vision. Both 2-dimensional and stereoscopic video systems require a rescaling of visual information to guide motor behavior. A review of the growing number of papers comparing 2-dimensional and stereoscopic video systems shows that only about 50% of investigators found a significant benefit for stereoscopic systems. It is unlikely that image display technology for endoscopic surgery can ever progress to the stage where it is equivalent to normal vision. Within this limitation, progress will result from a multidisciplinary approach, involving technological advances in the quality of the displayed image together with psychovisuomotor and ergonomics research, which facilitates the cerebral rescaling and perception process by the endoscopic surgeon.

Data Display↗
PubMed2006

Gaze behaviors of goaltenders under spatial-temporal constraints.

It is still not known what underlies successful performance in goaltending. Some studies have reported that advanced cues from the shooter's body (hip, kicking leg or support leg) are most important (Savelsbergh, G. J. P., Williams, A. M., Van der Kamp, J., & Ward, P. (2002). Visual search, anticipation and expertise in soccer goalkeepers. Journal of Sports Sciences, 20, 279-287; Savelsbergh, G. J. P., Williams, A. M., Van der Kamp, J., & Ward, P. (2005). Anticipation and visual search behaviour in expert soccer goalkeepers. Ergonomics, 48, 1686-1697; Williams, A. M., & Burwitz, L. (1993). Advanced cue utilization in soccer. In T. Reilly, J. Clarys, & A. Stibbe (Eds.), Science and football II (pp. 239-243). London, England: E&FN Spon), while others have found that the early tracking of the object prior to and during flight is most critical (Bard, C., & Fleury, M. (1981). Considering eye movement as a predictor of attainment. In: I. M. Cockerill, & W. M. MacGillvary (Eds.), Vision and Sport (pp. 28-41). Cheltenham, England: Stanley Thornes (Publishers) Ltd.). These results are similar to those found in a number of interceptive timing studies (Land, M. F., & McLeod, P. (2000). From eye movements to actions: How batsmen hit the ball. Nature Neuroscience, 3, 1340-1345; Ripoll and Fleurance, 1988; Vickers, J. N., & Adolphe, R. M. (1997). Gaze behaviour during a ball tracking and aiming skill. International Journal of Sports Vision, 4, 18-27). The coupled gaze and motor behavior of elite goaltenders were determined while responding to wrist shots taken from 5 m and 10 m on ice. The results showed that the goalies faced shots that were significantly different in phase durations due to distance (5 versus 10 m), but this was not a factor in making saves. Instead, the ability to stop the puck was dependent on the location, onset and duration of the final fixation/tracking gaze (or quiet eye) prior to initiating the saving action. The relative onset of quiet eye was significantly (p<.001) earlier (8.6%) and the duration was longer on saves (M=80.5%; 952.3 ms) compared to goals (onset 18.86%; M=70.1%, 826.1 ms). The quiet eye was located on the puck/stick during the preparation and execution of the shot in 70.53% of all trials, or on the ice in front of the release point of the puck (25.68%) and rarely on the body of the shooter (2.1%). The results are discussed within the context of current research on goaltending with specific emphasis on the timing of critical cues and the effect of tasks constraints.

Adult↗
PubMed2006

Modulation of adult hippocampal neurogenesis by thyroid hormones: implications in depressive-like behavior.

Hormonal imbalances are involved in many of the age-related pathologies, as neurodegenerative and psychiatric diseases. Specifically, thyroid state alterations in the adult are related to psychological changes and mood disorders as depression. The dentate gyrus of the hippocampal formation undergoes neurogenesis in adult mammals including humans. Recent evidence suggests that depressive disorders and their treatment are tightly related to the number of newly born neurons in the dentate gyrus. We have studied the effect of thyroid hormones (TH) on hippocampal neurogenesis in adult rats in vivo. A short period of adult-onset hypothyroidism impaired normal neurogenesis in the subgranular zone of the dentate gyrus with a 30% reduction in the number of proliferating cells. Hypothyroidism also reduced the number of newborn neuroblasts and immature neurons (doublecortin (DCX) immunopositive cells) which had a severely hypoplastic dendritic arborization. To correlate these changes with hippocampal function, we subjected the rats to the forced swimming and novel object recognition tests. Hypothyroid rats showed normal memory in object recognition, but displayed abnormal behavior in the forced swimming test, indicating a depressive-like disorder. Chronic treatment of hypothyroid rats with TH not only normalized the abnormal behavior but also restored the number of proliferative and DCX-positive cells, and induced growth of their dendritic trees. Therefore, hypothyroidism induced a reversible depressive-like disorder, which correlated to changes in neurogenesis. Our results indicate that TH are essential for adult hippocampal neurogenesis and suggest that mood disorders related to adult-onset hypothyroidism in humans could be due, in part, to impaired neurogenesis.

Analysis of Variance↗
PubMed1986

Lateralized and compulsive exteroceptive orientation in rats treated with apomorphine.

A new behavioral test afforded the original demonstration of a compulsive and extremely lateralized taxis for edges in a minority (16%) of rats treated with the dopamine (DA) receptor agonist apomorphine (APO) (1.25 mg/kg, s.c.). APO also induced a reliable lateralization of locomotor direction in a rotometer in 29% of rats. The lateralizing effects of the drug on taxis for edges and rotational direction were not reliably associated, however, suggesting that these effects of APO are independent of each other. Interhemispheric asymmetries of DA receptors in functionally distinctive brain regions may underlie the diverse lateralizing effects of APO in subpopulations of rats.

Animals↗
PubMed2003

Effects of visual information and task constraints on intersegmental coordination in playground swinging.

The authors investigated how and to what extent visual information and associated task constraints are negotiated in the coordinative structure of playground swinging. Participants (N = 20) were invited to pump a swing from rest to a prescribed maximal amplitude under 4 conditions: normal vision, no vision, and 2 visual conditions involving explicit phasing constraints. In the latter conditions, participants were presented with a flow pattern consisting of a periodically expanding and contracting optical structure. They were instructed to phase the swing motion so that the forward turning point coincided with either the maximal size (enhanced optical flow) or the minimal size (reduced optical flow) of the presented flow pattern. Removal of visual information clearly influenced the swinging behavior, in that intersegmental coordination became more stereotyped, reflecting a general stiffening of the swinger. The conditions involving explicit phasing requirements also affected the coordination, but in an opposite way: The coordination became less stereotyped. The two phasing instructions had differential effects: The intersegmental coordination deviated more from normal swinging (i.e., without phasing constraints) when optical flow was enhanced than when it was reduced. Collectively, those findings show that visual information plays a formative role in the coordinative structure of swinging, in that variations of visual information and task constraints were accompanied by subtle yet noticeable changes in intersegmental coordination.

Adult↗
PubMed2004

Activity density in the open field: a measure for differentiating the effect of psychostimulants.

Traditional open-field activity measures do not provide a sharp behavioral differentiation across psychomotor stimulants such as d-amphetamine (AMPH) and cocaine (COC) in the mouse. We used Software for the Exploration of Exploration (SEE) to investigate and develop a novel behavioral endpoint to characterize the "structure" of AMPH- and COC-induced locomotor behavior in two inbred strains of mouse, C57BL/6 (B6) and DBA/2 (D2). We suggest a measure we term "activity density" as a means to differentiate the behavioral effects of COC and AMPH. Activity density is defined as the activity divided by the range over which it took place. It characterizes the restriction of behavioral repertoire that does not result merely from inactivity. In both the B6 and D2 mice, AMPH increased activity density in a dose-dependent fashion by restricting the range of activity compared with COC doses producing the same level of activity. While AMPH restricted the range in both genotypes, characterizing the geographical region in which the restriction took place further differentiated the genotypes. The newly developed activity density measure thus provides a more general measure than stereotypy of the path, and can differentiate the effects of AMPH and COC both within and across genotypes.

Animals↗
PubMed2005

Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model.

In Alzheimer disease, increased beta-secretase (BACE1) activity has been associated with neurodegeneration and accumulation of amyloid precursor protein (APP) products. Thus, inactivation of BACE1 could be important in the treatment of Alzheimer disease. In this study, we found that lowering BACE1 levels using lentiviral vectors expressing siRNAs targeting BACE1 reduced amyloid production and the neurodegenerative and behavioral deficits in APP transgenic mice, a model of Alzheimer disease. Our results suggest that lentiviral vector delivery of BACE1 siRNA can specifically reduce the cleavage of APP and neurodegeneration in vivo and indicate that this approach could have potential therapeutic value for treatment of Alzheimer disease.

Alzheimer Disease↗
PubMed2005

A robust solution for dealing with environmental changes in intercepting moving balls.

The authors tested whether a simple model based on the cancellation of the rate of change in bearing angle could account for the behavioral adaptations produced when individuals intercept moving balls while walking. In Experiment 1, the place of arrival of the ball and the angle of approach were varied. In accord with the model, velocity regulations were earlier and more pronounced the larger the angle of approach. In Experiment 2, ball speed unexpectedly changed during a trial, once again highlighting participants' functional velocity adaptations. A direct test of the model on the basis of each individual trial (N = 256) revealed that, on average, 70% of the total variance could be explained. Together, those results confirm the usefulness of such a robust strategy in the control of interceptive tasks.

Adaptation, Psychological↗
PubMed2002

Spatial and nonspatial Morris maze learning: impaired behavioral flexibility in mice with ectopias located in the prefrontal cortex.

About half of BXSB/MpJ-Yaa (BXSB) mice have neocortical ectopias (misplaced clusters of neurons located in layer I of cortex). Previous behavioral studies have suggested that ectopic mice have superior spatial, but equivalent nonspatial, reference memory learning. However, since spatial and nonspatial learning were not assessed in the same apparatus and with the same testing procedure, it is unclear if this conclusion is accurate. We have created a new nonspatial Morris maze for mice that differs from the spatial task only in the type of cues that must be utilized to efficiently locate the platform (intra-maze black/white patterns vs. extra-maze room cues) and does not differ in the level of task complexity or the presence of objects within the maze. Ectopic mice were very good in utilizing extra-maze cues when learning the spatial version and in utilizing intra-maze cues when learning the nonspatial version of the Morris maze, while non-ectopics were not, suggesting that ectopics have superior spatial and nonspatial reference memory. Ectopias in BXSB mice are usually located in prefrontal and/or motor cortex. The prefrontal cortex is involved in behavioral flexibility (e.g. being able to easily switch from using spatial to nonspatial cues). Only ectopic mice with ectopias specifically located in the prefrontal region of cortex demonstrated difficulty switching from using extra-maze to intra-maze cues and vice versa. Thus, the presence of one or more ectopias in the prefrontal region of cortex disrupted one of the normal functions of the prefrontal cortex.

Animals↗
PubMed1982

Gaze and proximity as turn regulators within three-party and two-party child conversations.

Gaze and proximity as nonverbal turn-taking behaviors were investigated within the three-party and two-party conversations of normal children. Subjects were six 4-year-old girls matched for familiarity. Alternations of 20-min three-party and 15-min two-party interactions were videotaped and transcribed. The data indicate that within nonsimultaneous language events, gaze and proximity relate to changes in speaker turn and conversational role, with gaze functioning as a current-speaker-selects-next-speaker turn option and proximity functioning as both a current-speaker-selects-next-speaker and a listener self-selection turn option. The data are discussed in terms of the sociocentric character of children's conversations.

Child Language↗
PubMed2001

Grasping objects by their handles: a necessary interaction between cognition and action.

Research has illustrated dissociations between "cognitive" and "action" systems, suggesting that different representations may underlie phenomenal experience and visuomotor behavior. However, these systems also interact. The present studies show a necessary interaction when semantic processing of an object is required for an appropriate action. Experiment 1 demonstrated that a semantic task interfered with grasping objects appropriately by their handles, but a visuospatial task did not. Experiment 2 assessed performance on a visuomotor task that had no semantic component and showed a reversal of the effects of the concurrent tasks. In Experiment 3, variations on concurrent word tasks suggested that retrieval of semantic information was necessary for appropriate grasping. In all, without semantic processing, the visuomotor system can direct the effective grasp of an object, but not in a manner that is appropriate for its use.

Acoustic Stimulation↗
PubMed2002

Covert orienting of visuospatial attention in the early stages of aging.

Electrophysiological and behavioral responses were recorded in healthy young (19-23 years) and older (56-66 years) subjects during the execution of a visuospatial attention task. The objective was to test whether covert orienting of visuospatial attention (COVAT) is sensitive to the early stages of aging. All subjects responded faster to targets following valid than invalid cues. The amplitude of the P1 component of visual event-related potentials (ERP) was larger to targets following central valid cues at all SOAs. Subtle age-related changes were observed in P1 amplitude under peripheral cueing. Furthermore, older subjects presented longer reaction times (RTs) and lower P1 amplitudes regardless of the attention condition.

Adult↗
PubMed1999

Williams syndrome: use of chromosomal microdeletions as a tool to dissect cognitive and physical phenotypes.

In Williams syndrome (WS), a deletion of approximately 1.5 Mb on one copy of chromosome 7 causes specific physical, cognitive, and behavioral abnormalities. Molecular dissection of the phenotype may be a route to identification of genes important in human cognition and behavior. Among the genes known to be deleted in WS are ELN (which encodes elastin), LIMK1 (which encodes a protein tyrosine kinase expressed in the developing brain), STX1A (which encodes a component of the synaptic apparatus), and FZD3. Study of patients with deletions or mutations confined to ELN showed that hemizygosity for elastin is responsible for the cardiological features of WS. LIMK1 and STX1A are good candidates for cognitive or behavioral aspects of WS. Here we describe genetic and psychometric testing of patients who have small deletions within the WS critical region. Our results suggest that neither LIMK1 hemizygosity (contrary to a previous report) nor STX1A hemizygosity is likely to contribute to any part of the WS phenotype, and they emphasize the importance of such patients for dissecting subtle but highly penetrant phenotypes.

Adult↗
PubMed2001

Spatial-temporal imaging of bacterial infection and antibiotic response in intact animals.

We describe imaging the luminance of green fluorescent protein (GFP)-expressing bacteria from outside intact infected animals. This simple, nonintrusive technique can show in great detail the spatial-temporal behavior of the infectious process. The bacteria, expressing the GFP, are sufficiently bright as to be clearly visible from outside the infected animal and recorded with simple equipment. Introduced bacteria were observed in several mouse organs including the peritoneal cavity, stomach, small intestine, and colon. Instantaneous real-time images of the infectious process were acquired by using a color charge-coupled device video camera by simply illuminating mice at 490 nm. Most techniques for imaging the interior of intact animals may require the administration of exogenous substrates, anesthesia, or contrasting substances and require very long data collection times. In contrast, the whole-body fluorescence imaging described here is fast and requires no extraneous agents. The progress of Escherichia coli-GFP through the mouse gastrointestinal tract after gavage was followed in real-time by whole-body imaging. Bacteria, seen first in the stomach, migrated into the small intestine and subsequently into the colon, an observation confirmed by intravital direct imaging. An i.p. infection was established by i.p. injection of E. coli-GFP. The development of infection over 6 h and its regression after kanamycin treatment were visualized by whole-body imaging. This imaging technology affords a powerful approach to visualizing the infection process, determining the tissue specificity of infection, and the spatial migration of the infectious agents.

Administration, Oral↗
PubMed1997

Visuomotor imagery and rehabilitation of neglect.

OBJECTIVE: To assess the effectiveness of visuomotor imagery training in the rehabilitation of unilateral neglect. DESIGN: Before-after trial. Behavioral analysis of single cases. SETTING: Neurologic rehabilitation unit of a university hospital. PATIENTS: Two patients with acquired brain injury who were suffering from severe and long-lasting unilateral neglect consequent to large lesions of cortical and subcortical right-brain. INTERVENTION: A behavioral training program consisting of visual and movement imagery exercises. Forty experimental sessions, each lasting 50 minutes, were delivered. MAIN OUTCOME MEASURES: Six neuropsychological tests evaluating unilateral neglect: seven "functional" tests assessing neglect behavior under daily life conditions; a questionnaire (filled out by the patients' relatives) concerning the patients' disability in the family context attributable to neglect. All the outcome measures were recorded at three different times: before, soon after, and 6 months after the end of the experimental training. RESULTS: The visuomotor "imagery training" ameliorated the deficit in performance related to neglect in both patients. All the outcome measures (neuropsychological and functional tests and the questionnaire) were positively influenced by the treatment. Moreover, the improvement was stable over a 6-month period, suggesting that the treatment had a long-term effect. CONCLUSIONS: The results show the possible effectiveness of a training method based on visuomotor imagery in diminishing impairment and functional disability associated with contralateral neglect.

Activities of Daily Living↗
PubMed2006

Surgical lesion of the anterior optic tract abolishes polarotaxis in tethered flying locusts, Schistocerca gregaria.

Many insects can detect the polarization pattern of the blue sky and rely on polarization vision for sky compass orientation. In laboratory experiments, tethered flying locusts perform periodic changes in flight behavior under a slowly rotating polarizer even if one eye is painted black. Anatomical tracing studies and intracellular recordings have suggested that the polarization vision pathway in the locust brain involves the anterior optic tract and tubercle, the lateral accessory lobe, and the central complex of the brain. To investigate whether visual pathways through the anterior optic tract mediate polarotaxis in the desert locust, we transected the tract on one side and tested polarotaxis (1) with both eyes unoccluded and (2) with the eye of the intact hemisphere painted black. In the second group of animals, but not in the first group, polarotaxis was abolished. Sham operations did not impair polarotaxis. The experiments show that the anterior optic tract is an indispensable part of visual pathways mediating polarotaxis in the desert locust.

Animals↗
PubMed1975

Pharmacological studies of drug action on CNS, with special reference to effects of maprotiline.

The effects of maprotiline, mainly on the CNS, were examined and compared with those of imipramine, methamphetamine and chlorpromazine. In the repeated administration and the stroboscope studies, maprotiline exhibited actions to increase behavioral activities of animals, just like amphetamine and imipramine. This appears to attest to pharmacological effects of maprotiline as an anti-depressant. It is noted, however, that whereas maprotiline shows a slight anti-apomorphine action in dogs and an inhibition of the spinal reflex action potential in cats, such actions are not recognized in other anti-depressants of the tricyclic groups including imipramine, amitriptyline, etc. These differences suggest the tranquilizing action of maprotiline at work, probably forming a specific pharmacological feature of maprotiline. Also, maprotiline increases body weight of rats strikingly, which seems to offer a wide range of clinical applications of this drug.

Action Potentials↗
PubMed2006

Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease.

Although there are no proven ways to delay onset or slow progression of Alzheimer's disease (AD), studies suggest that diet can affect risk. Pomegranates contain very high levels of antioxidant polyphenolic substances as compared to other fruits and vegetables. Polyphenols have been shown to be neuroprotective in different model systems. We asked whether dietary supplementation with pomegranate juice (PJ) would influence behavior and AD-like pathology in a transgenic mouse model. Transgenic mice (APP(sw)/Tg2576) received either PJ or sugar water control from 6 to 12.5 months of age. PJ-treated mice learned water maze tasks more quickly and swam faster than controls. Mice treated with PJ had significantly less (approximately 50%) accumulation of soluble Abeta42 and amyloid deposition in the hippocampus as compared to control mice. These results suggest that further studies to validate and determine the mechanism of these effects, as well as whether substances in PJ may be useful in AD, should be considered.

Alzheimer Disease↗