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At least 1,171 records · Page 65Linked to original sources
PubMed2001

Surgical treatment for thoracic spinal stenosis.

OBJECTIVES: To describe the underlying causes, surgical results and prognostic factors in thoracic stenosis causing myelopathy. METHODS: The underlying causes and surgical results were analyzed retrospectively in 28 cases of thoracic spinal stenosis which caused myelopathy. Degenerative spondylosis was the most common cause, and three cases were associated with systemic diseases. Decompressive laminectomy was performed in 24 cases, anterior decompression in five cases, and combined decompression in one case. Ossification of ligamentum flavum was found in 18 cases, facet hypertrophy in 13, ossification of posterior longitudinal ligament in six, and ventral spur in four. Postoperatively 16 patients improved and four patients worsened. Follow-up ranged from 2 months to 5 years and 8 months). Statistical analysis was performed using a chi(2) test to investigate the relationship between subjects. Multivariant analysis (general linear model) was used to determine the factors which influence surgical outcome. RESULTS: There were neurological improvements in 16 patients, in whom Nurick grade changed from 3.3 preoperatively to 1.8 postoperatively. Eight patients showed no significant change in functional grade and four patients deteriorated after decompressive laminectomy. The group of which initial symptom duration was less than 2 years showed better results (P=0.006). The group with sufficient decompression and no additional proximal stenosis had better treatment outcome (P=0.005, P=0.002). CONCLUSION: Chronic severe myelopathy caused by thoracic spinal stenosis can be reversible with appropriate decompression. Surgical outcome was dependent on initial symptom duration, sufficient decompression and presence of additional proximal stenosis. SPONSORSHIP: This study was supported by a grant No. 02-1997-071-0 from the Seoul National University Hospital Research Fund.

Adolescent↗
PubMed2003

Fixed vs dynamic plate complications following multilevel anterior cervical corpectomy and fusion with posterior stabilization.

STUDY DESIGN: Comparison of fixed vs dynamic plate complications in cervical surgery. SETTING: : New York, USA. METHODS: Anterior cervical plate-related complications were evaluated following 66 anterior cervical corpectomy and fusion (ACF) with posterior stabilization (PWF) procedures performed in patients with ossification of the posterior longitudinal ligament (OPLL). Clinical data were comparable for both patient populations. Patients averaged between 52 and 53 years of age. The male to female ratio was approximately 2:1. Surgery addressed MR and CT documented multilevel OPLL in all patients accompanied by spondylosis and stenosis. Preoperatively average Nurick Grades ranged from 3.6 to 3.7. Anterior cervical corpectomies included an average of 2.6-3.0 vertebral bodies, while PWF covered seven levels. Fixed plates were applied in the initial 38 patients, while the latter 28 patients had dynamic plates (ABC, Aesculap, Tuttlingen, Germany) applied. Halo devices were used until fusion was documented on both X-ray and 2D-CT studies. Patients were followed-up for an average of 5.4 years in the fixed-plated groups, and 2.7 years in the dynamic-plated population. RESULTS: CT and dynamic X-ray confirmed that fusion occurred an average of 4.5-4.9 months postoperatively. Five (13%) fixed plates (Medtronic, Sofamor Danek, Memphis, TN, USA) failed warranting secondary surgery, while only one (3.6%) dynamic-plated patient developed a pseudarthrosis and required secondary posterior fusion. DISCUSSION/CONCLUSION: Higher failure rates follow multilevel ACF as compared with anterior diskectomy and fusion required to resect multilevel OPLL. Vaccaro et al observed a 9% failure rate following two-level ACFs and 50% failure rate following three-level ACFs performed with fixed plates. In this series, the plate extrusion rate was reduced to 3.6% when dynamic plates were applied.

Adult↗
PubMed2003

Laminectomy for cervical myelopathy.

STUDY DESIGN: Cervical laminectomy with or without fusion, or laminoplasty, successfully address congenital or acquired stenosis, multilevel spondylosis, ossification of the posterior longitudinal ligament (OPLL), and ossification of the yellow ligament (OYL). To optimize surgical results, however, these procedures should be applied to carefully selected patients. OBJECTIVES: To determine the clinical, neurodiagnostic, appropriate posterior cervical approaches to be employed in patients presenting with MR- and CT-documented multilevel cervical disease. To limit perioperative morbidity, dorsal decompressions with or without fusions should be performed utilizing awake intubation and positioning and continuous intraoperative somatosensory-evoked potential monitoring. SETTING: United States of America. METHODS: The clinical, neurodiagnostic, and varied dorsal decompressive techniques employed to address pathology are reviewed. Techniques, including laminectomy, laminoforaminotomy, and laminoplasty are described. Where preoperative dynamic X-rays document instability, simultaneous fusions employing wiring or lateral mass plate/screw or rod/screw techniques may be employed. Nevertheless, careful patient selection remains one of the most critical factors to operative success as older individuals with prohibitive comorbidities or fixed long-term neurological deficits should not undergo these procedures. RESULTS: Short- and long-term outcomes following dorsal decompressions with or without fusions vary. Those with myelopathy over 65 years of age often do well in the short-term, but demonstrate greater long-term deterioration. Factors that correlated with greater susceptibility to deterioration include advanced age (>70 years at the time of the first surgery), severe original myelopathy, and recent trauma. CONCLUSIONS: Success rates of laminectomy with or without fusion, or laminoplasty may be successfully employed to address multilevel cervical pathology in a carefully selected population of patients.

Bone Wires↗
PubMed2001

Chronic urticaria associated with intra-articular methylprednisolone.

Reports of allergic reactions following treatment with systemic corticosteroids are rare, despite their widespread use. A 47-year-old man developed widespread urticaria, resistant to antihistamines, coinciding with injections of local anaesthetic and methylprednisolone for cervical spondylosis. He underwent immediate and delayed hypersensitivity tests. Intradermal tests showed immediate-type sensitivity to methylprednisolone and hydrocortisone. Patch tests were positive to 21 of 26 corticosteroids tested. A diagnosis of both an immediate and a delayed-type hypersensitivity to corticosteroids was made. With avoidance of all corticosteroids he has been free from urticarial rash for 9 months and has been able to stop all medication.

Administration, Topical↗
PubMed2002

Increased incidence of parathyroid adenomas following X-ray treatment of benign diseases in the cervical spine in adult patients.

OBJECTIVE: To determine whether or not exposure to ionizing radiation as an adult increases the risk of developing parathyroid adenomas. DESIGN AND PATIENTS: A cohort of 27 415 patients had received X-ray treatment to palliate pain originating from arthrosis and spondylosis from 1950 to 1964. In a subcohort of 8144 patients the cervical spine was the target, or one of the targets for the treatment. With the technique used it could be assumed that, as a rule, the parathyroid glands had been included in the treated volume. Patients with parathyroid adenomas were obtained from the Swedish Cancer Register from 1958 to 1995. The standardized incidence ratio (SIR) was calculated. RESULTS: The number of person-years at risk was 180 492 in the cohort exposed at the cervical spine, and 412 994 in the control cohort irradiated only at other sites. The calculated dose in the parathyroid region in the study cohort was about 1 Gy. The observed number of parathyroid adenomas in the study cohort was 22, and 24 in the control cohort. Expected numbers based on population data were 12.0 and 24.7, respectively, giving an SIR of 1.83 (95% CI 1.14-2.76) and 0.97 (CI 0.62-1.45), respectively. Mean age at exposure was 48.9 years (SD 10.2) and at diagnosis 71.5 years (SD 8.3). The time from exposure to diagnosis varied from 2 to 34 years (median 26 years). The excess relative risk was about 0.8 per Gy. CONCLUSION: Exposure to ionizing radiation to the cervical spine in adult age seems to be associated with an increased risk of developing parathyroid adenomas.

Adenoma↗
PubMed1999

Pathological changes of the spinal cord in centenarians.

In order to study the changes that occur in the spinal cords of the aged, 19 centenarian spinal cords from two men and 17 women (age range, 100-116 years at death; mean, 103 years) were pathologically examined. Cross-sections at each segmental level of the 19 autopsied spinal cords were examined for histopathological changes. The cross-sectional area and flattening ratio at the level of the C7 segment were measured. The size of the cords had some negative correlation with age, but the individual variation was considerably large. Among the 19 centenarians, macroscopic anteroposterior flattening appeared in the lower cervical cords in six individuals. In these cases, various degrees of neuron loss were observed in the anterior horn. White matter degeneration appeared frequently, especially in the posterior column. In 12 cases, myelin loss in the fasciculus of Goll at the cervical level was observed. The degeneration of the fasciculus of Goll was considered to be upward wallerian degeneration secondary to posterior root damage at the lumbosacral level. These changes seemed to be produced by disorders in the spinal canal or surrounding tissue, such as cervical spondylosis, degeneration of the intervertebral disk and spinal canal stenosis. Argyrophilic structures such as neurofibrillary tangles and neuropil threads were observed in 16 cases; however, this incidence was less than in the brain. Medial thickening of the anterior spinal artery was found in four cords. Amyloidangiopathy was noted in only one cord. Necrosis and hemorrhage due to vascular disturbance were not found.

Aged↗
PubMed2002

Radiofrequency neurolysis for facet arthropathy: a retrospective case series and review of the literature.

CONTEXT: Facet arthropathy is a common cause of spine-related pain. Typically resulting from spondylosis, trauma, including surgical trauma or post surgical stress is also a significant cause. Radiofrequency thermocoagulation or neurolysis may be an effective modality providing long-term improvement. OBJECTIVES: To evaluate the success rates for radiofrequency neurolysis for facet arthropathy in a large retrospective case series in a single pain practice setting. DESIGN: A retrospective case series involving chart reviews and patient follow-up visits or telephone contacts of radiofrequency neurolytic procedures performed for facet arthropathy over a 4-year period. SETTING: Private practice pain clinic with academic affiliation in Tulsa, OK. PARTICIPANTS: One hundred forty eight patients with confirmed facet arthropathy refractory to conservative measures underwent 230 radiofrequency neurolysis procedures and were followed for a minimum of 1 year post procedure. For cervical facet procedures: 63 patients (106 procedures); age range F: 27-84 years old; M: 33-65 years old. For lumbar facet procedures: 85 patients (124 facet procedures); age range F: 19-81 years old; M: 20-77 years old. MAIN OUTCOME MEASURES: After the radiofrequency procedure, patients were followed with periodic visits or telephone contacts. Outcome measures were McGill short form pain questionnaire, VAS pain scores, muscle spasm scores, tenderness, range of motion and patient subjective global responses. RESULTS: Subjective patient responses were graded as follows: excellent:greater than 70% improvement, good: 50% to 70% improvement, fair: 30% to 49%, and poor: less than 30%. One hundred six radiofrequency procedures were performed in the 63 cervical cases and 124 in the 85 lumbar cases with those patients who had good to excellent responses undergoing repeat procedures. Of the patients with cervical facet radiofrequency procedures, 38 (37%), 51 (48%), 4 (3%) and 13 (12%) had excellent, good, fair or poor responses, respectively. Of the lumbar facet radiofrequency cases, 37 (30%), 52 (41%), 13 (10%) and 22 (19%) had excellent, good, fair or poor responses, respectively. Excellent responders noted an average duration of 10.8 months (range 3-34 months before dropping below 70% improvement level) for cervical cases and 7.9 months (range 3-20) for lumbar. Good responders noted an average duration of 6.5 months (range 3-22 months before dropping below 50% improvement level) for cervical and 6.8 months (range 3-48) for lumbar radiofrequency procedures. No significant side effects were experienced (short-term neuritis was seen in 2 patients who had cervical and 1 who had lumbar RFTC, but resolved in each case after a few weeks). CONCLUSIONS: In summary, 85% of cervical and 71% of lumbar RFTC cases had at least a 50% improvement in symptoms for extended periods. RFTC of median branches for facet arthropathy is a safe and efficacious modality with the potential for long-term benefit.

Journal Article↗
PubMed2001

Control of non-malignant chronic pain conditions in Japan and the possible future role of tramadol.

Pharmacological treatment is the most common treatment for non-malignant chronic pain diseases such as lumbar and/or cervical spondylosis and osteoarthritis of the knee or hip joint. In Japan, opioid analgesics cannot be used for non-malignant chronic pain syndromes because of the strict regulations for opioid use by the Ministry of Health and Welfare. Non-steroidal anti-inflammatory drugs (NSAIDs) do not have sufficient effect as analgesics for some painful conditions as well as having possible serious side-effects on the gastrointestinal tract and kidneys. According to the Japanese Rheumatism Foundation report on NSAID-induced gastrointestinal lesions in 1991, gastric ulcers were found in 15.5% of 1008 patients who underwent endoscopic examinations. In multicentric questionnaire research, it was discovered that 63% received NSAIDs for longer than 3 months. New drugs having stronger effects for chronic pain and less severe adverse side-effects are expected within the decade. Tramadol hydrochloride controlled-release is a long- and centrally-acting analgesic without serious side-effects for which we are currently going on to the phase II trial in collaborative studies between Japan and the United States for non-malignant chronic pain diseases.

Analgesics, Opioid↗
PubMed2002

Osteological and morphometric observations on intervertebral joints in the canine pre-diaphragmatic thoracic spine (Th1-Th9).

The incidence of facet aplasia was investigated in three groups of pure-bred dogs. We examined large breeds (Rough Collies, Doberman Pinschers, Rottweilers, Bernese Mountain Dogs, German Shepherd Dogs), chondrodystrophic breeds (Dachshunds, Pekinese dogs), and small breeds (Yorkshire Terriers, Maltese dogs). Uni- or bilateral aplasia of zygapophyseal (facet) joints was exclusively found in juvenile and adult small dogs, in which the incidence of aplasia ranged from between 26% (Th1) and 63% (Th8). There was no evidence that aplasia of zygapophyseal joints increases the risk of developing intervertebral disc disease or deformative spondylosis in small breeds. By applying the findings of previous empirical studies on intervertebral disc geometry and its biomechanical behaviour on the present morphometric results, there was an indication that the intervertebral disc may well compensate for the functional loss of aplastic zygapophyseal joints in small dogs. Biomechanical factors and their potential role as inducing agents of facet aplasia in the pre-diaphragmatic thoracic spine are also discussed.

Aging↗
PubMed2000

Symptomatic epineural ganglion cyst of the ulnar nerve in the cubital tunnel: a case report and brief review of the literature.

An unusual case of pain and weakness in the hand and forearm due to a ganglion cyst of the ulnar nerve at the elbow is presented. The patient was managed initially as a case of cervical disc disease and cervical spondylosis and later as a case of carpal tunnel syndrome at an another institution. Cervical radiography and cervical magnetic resonance imaging scans were inconclusive. Neurosurgical referral revealed tenderness at the right cubital tunnel, weakness of the right hand and forearm muscles, and sensory deficit along the medial border of the forearm and the hand. The diagnosis of ulnar nerve compression at the elbow was made. Nerve conduction studies of the ulnar nerve at the elbow confirmed the diagnosis. A ganglion cyst of the ulnar nerve was excised microsurgically with a complete postoperative sensory motor recovery.

Adult↗
PubMed2001

Outcome following anterior cervical discectomy in compensation patients.

This is a retrospective study aimed to analyse the clinical outcomes of patients following anterior cervical decompression and fusion for radiculopathy in worker's compensation, third party and non-compensable group. The outcome of 224 cases operated between 1991 to 1998 were analysed. Only patients with radiculopathy due to a cervical disc protrusion and spondylosis were included. There were 140 non-compensable patients, 58 worker's compensation and 26 third party. There was no statistical difference in radiological fusion between the three groups (P=0.46). The worker's compensation and third party claimant groups, had an 'excellent' outcome at 65% and 69% respectively, compared to the non-compensation group at 79% (P=0.042). Rates of poor outcome were high in the worker's compensation group (9%) compared with third party (4%) and the non-compensable group (5%). Financial incentives seem to significantly influence the outcome of cervical disc surgery in our patient population.

Cervical Vertebrae↗
PubMed1978

Acute central and intermediate cervical cord injury.

Six cases with cervical cord contusion are described. All were over 50 years old, had an hyperextension injury of their cervical spine, suffered from tetraparesis predominant in the upper limbs and showed no X-ray evidence of injury to the cervical spine. Marked cervical spondylosis was present in five cases, one also had a narrow spinal canal. Cases No. 3 and 4 had an atypical recovery pattern. Shoulder and elbow movements improved last or not at all, while in the classic cases the hand muscles recovered last. Upper motor neuron damage was thought to be the cause, a result of intermediate instead of central cord traumatic necrosis or ischaemia. Pathological findings in case No. 5 emphasizes the possible diagnostic importance of taking lateral X-rays of the cervical spine in hyperextension. It also shows why laminectomy and/or myelotomy cannot help. Case No. 6 shows the noxious effect of shock and the effectiveness of steroid therapy.

Aged↗
PubMed1978

Diffuse enthesopathic hyperostosis--anatomical and radiological study on a macerated skeleton.

Anatomico-radiological study of a macerated skeleton in a 43-year-old diabetic woman. An important spondylosis with hyperostosis of the cervical, thoracic and lumbar vertebrae was seen. There were associated changes of insertional hyperostosis at various levels, particularly at the iliac crests. Paget's disease of the left iliac crest was also noted in the corresponding hyperostosis. This case presentation offers an opportunity to discuss local mechanical factors (observed at the tendinous insertions) as well as generalized considerations on the "terrain" of diabetes and perhaps malnutrition. It also demonstrates the interest that an anatomico-radiological comparison on macerated specimens can have for certain osteoarticular research, teaching and paleopathology.

Adult↗
PubMed1999

[The x-ray follow-up study of the cervical spine after anterior fusion with titanium disk implants].

PURPOSE: We examined the postoperative changes of the cervical spine after treatment of cervical nerve root compression with anterior cervical discectomy and fusion with a new titanium intervertebral disc. PATIENTS AND METHODS: 37 patients were examined prior to, as well as 4 days, 6 weeks, and 7 months after surgery. Lateral view X-rays and functional imaging were used to evaluate posture and mobility of the cervical spine, the position of the implants, and the reactions of adjacent bone structures. RESULTS: Implantation of the titanium disc led to post-operative distraction of the intervertebral space and slight lordosis. Within the first 6 months a slight loss of distraction and re-kyphosis due to impression of the implants into the vertebral end-plates were found in all patients. We noted partial infractions into the vertebral end-plates in 10/42 segments and slight mobility of the implants in 14/42 segments. Both groups of patients showed reactive spondylosis and local symptoms due to loosening of the implants. The pain subsided after onset of bone bridging and stable fixation of the loosened discs. CONCLUSIONS: The titanium intervertebral disc provides initial distraction of the fusion segments with partial recurrence of kyphosis during the subsequent course. Loosening of the implants with local symptoms can be evaluated with follow-up X-rays and functional imaging.

Adult↗
PubMed2001

[Value of kinematic MRI in the evaluation of patients with exacerbated pain in cervical spine motion compared with static MRI].

OBJECTIVE: To assess the clinical value of kinematic MR imaging in patients with cervical radiculopathy and increasing symptoms after provocative maneuvers at flexion, extension, axial rotation and coupled motion of the cervical spine. METHODS: Thirty-five patients with cervical disc herniation or cervical spondylosis in whom symptoms were elicited at flexion, extension, axial rotation and coupled motion were studied inside a positioning device using T2-weighted TSE, 2D-FLASH, and reformatted 3D DESS and 3D-FISP sequences. The images were evaluated for the size of disc herniations, the foraminal size and cervical cord displacement at provocative position compared with neutral position (0 degree). In addition, the value of kinematic MR images were interpretated with regard to changes in the therapeutic procedure and intraoperative patient positioning. RESULTS: Compared with the neutral position (0 degree) a change in disc herniations was not found in any (0%) of the provocative positions. In five patients (14%) cervical cord displacement was noted at axial rotation. The foraminal size varied depending on the provocative position, increasing at flexion and decreasing at extension. CONCLUSION: Kinematic MR imaging in patients with cervical radiculopathy and increasing symptoms at provocative maneuvers provides no additional information for the therapeutic decision-making process.

Biomechanical Phenomena↗
PubMed2001

Titanium or polymethylmethacrylate in cervical disc surgery? A prospective study.

In 200 patients with either isolated protrusion of disc or with spondylosis a cervical discectomy in one or two levels was performed from a ventral approach. In 100 patients the removed disc was replaced with an implant of polymethylmethacrylat (PMMA). In 100 patients interbodyfusion was done with a titanium cage. Both groups were analysed in a prospective study. Clinical outcome was assessed after surgery. Results were similar in terms of complications and clinical outcome. As the PMMA surgery took longer and the costs of titanium are higher, there is no marked advantage of one implant material over the other.

Bone Substitutes↗
PubMed2006

[Hyperextension injuries of the thoracolumbar spine].

A group of 965 patients treated for thoracolumbal spine injury in the period 1998 till 2003 were analysed. 307 fractures were operated on. Out of this number, 4 fractures were type B3 according to Magerl's classification, i. e. 0.21 % of the admitted and 1.31 % of the operated patients. All 4 patients were operated by stabilization with internal fixator and posterior or combined fusion. Fractures were diagnosed in older patients, age average being 63.75 years, with the range of 57-72 years. All patients were obese, average body mass index being 32.75, with the range of 30.9 to 36.4. Fractures ensued two times in patients with heavy spondylarthrosis and spondylosis, once in ankylosing spondylitis and once in intact spine. Only one patient was injured by heavy trauma, the others sustained the injury during ordinary falls. One of the predisposing factors for occurrence of this injury is probably the increased body mass index resulting in increased moment of deceleration hyperextension force.

Accidental Falls↗
PubMed1989

[Sudden deafness and the craniocervical transition].

Morphological alterations of the cranio-cervical junction as a basilar impression, a ponticulus posterior, an atlas assimilation, an intervertebral narrowing, and spondylosis deformans were found radiologically. There was no difference to a healthy population. This means there are no correlations between static morphological changes of the craniocervical junction and sudden deafness. However, there was a statistically significant reduced mobility in the upper cervical spine in patients suffering from sudden deafness. Especially very high standard deviations in the atlanto-occipital and the atlanto-dental joint are interpreted as hypermobile as well hypomobile atlas joints. These results indicate a correlation between sudden deafness and functional pathology of the craniocervical junction.

Adult↗