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Effect of functional appliances on jaw muscle activity.

The electromyographic (EMG) activity of masticatory muscles was monitored longitudinally with chronically implanted EMG electrodes to determine whether functional appliances produce a change in postural EMG activity of the muscles. Preappliance and postappliance EMG levels in four experimentals that had been fitted with functional appliances were compared against the background of EMG levels in controls without appliances. The insertion of two types of functional appliance to induce mandibular protrusion was associated with a decrease in postural EMG activity of the superior and inferior heads of the lateral pterygoid, superficial masseter, and anterior digastric muscles; the decrease in the first three muscles was statistically significant. This decreased postural EMG activity persisted for approximately 6 weeks, with a gradual return toward preappliance levels during a subsequent 6-week period of observation. Progressive mandibular advancement of 1.5 to 2 mm every 10 to 15 days did not prevent the decrease in postural EMG activity.

Activator Appliances↗

Acoustic analysis of the speaking voice after thyroidectomy.

Voices of 47 female patients were analyzed before and after thyroidectomy, with preservation of the recurrent and superior laryngeal nerves and normal vocal fold motility during the observation period. A mean decrease of the speaking fundamental frequency (SFF) of 12 Hz was found on day 4; in 8 patients the postoperative vocal pitch was more than 2 semitones lower. The distance between the highest and lowest F0 during speaking was diminished (speech was more monotone) and the vocal jitter was elevated. In the frequency spectrum, there was a diminished prominence of the harmonics. The other spectral parameters (as the slope of the spectrum and the H1/H2 ratio) were unchanged. All changes had disappeared the fifteenth day, except for a lower SFF (> 2 semitones) in 2 cases. It is concluded that after normal dissection of the laryngeal nerves, and in the absence of vocal fold paresis, other reasons for voice changes immediately after thyroidectomy remain: alterations in the neck muscles, in the laryngeal mucosa, and in the patient's general condition. Although the effects seem limited and of short duration, knowledge of them is helpful when informing the patient before thyroid surgery.

Female↗

Vestibular vocal fold behavior during phonation in unilateral vocal fold paralysis.

Voice quality in patients with vocal fold paralysis can be affected by several factors, such as the position of the paralyzed vocal fold, its degree of atrophy, the configuration of its free edge, and the level differences between both vocal folds. Depending on the related vocal deficiency the patient will attempt to compensate using different maneuvers, such as increment of vocal tract and neck muscle contraction to improve glottal closure. This is probably one of the reasons why ventricular folds are frequently requested. The objective of this study is to analyze the behavior of the homolateral and contralateral vestibular folds to delineate patterns of vestibular motion during sustained phonation, in cases of unilateral vocal fold paralysis.

Humans↗

Anatomical studies on the cuneocerebellar neurons in the gerbil by using HRP method.

The projection from the external cuneate nucleus (ECN) to the cerebellum was studied in the gerbil following the retrograde transport of minute injections (0.05-0.1 microliter, 30% solution) or implantations of horseradish peroxidase (HRP) in various folia of the cerebellar cortex and deep nuclei. The morphology of the labelled neurons, as well as their quantitative distribution, was also examined. The projections were in general bilateral but predominantly ipsilateral. A remarkable finding, however, was the predominant contralateral projection from the medial cell column of ECN representing the paw region. Topographically, the nuclear areas receiving the thoracic, shoulder and neck muscle afferents projected bilaterally to vermis lobules I-V and VIII-IX, lobulus simplex, crura Ia and Ib, paraflocculus and flocculus, and contralaterally to crus II and nucleus interpositus; the nuclear regions receiving the forelimb muscle afferents sent fibers bilaterally to vermis lobules V-VIII, paramedian lobule and copula pyramidis, and ipsilaterally to crus II and nucleus interpositus. Based on their somal size, three classes of neurons were distinguished: small, medium and large cells. The small and medium cells constituted 79 and 20% of the population of the labelled cells respectively, whereas the large cells were only occasionally identified. In the cell columns of the caudal ECN representing the forelimb (Lan et al. 1994), most labelled neurons were medium cells which made up 65% of the total labelled medium cells. In contrast, the majority (90%) of the labelled cells in the rostral ECN were of the small-sized variety. The functional significance of the segregation, both in the projection patterns and sizes of somata of the cuneocerebellar neurons is discussed.

Animals↗

Relative bioavailability of zinc methionine and two inorganic zinc sources fed to cattle.

A 12-week experiment was conducted to compare supplemental ZnMet, ZnSO4, and ZnO on Zn, Cu and metallothionein (MT) concentrations in various fluids and tissues of 32 yearling cattle. Supplemental Zn (360 mg per day) was fed for four weeks, withdrawn for four weeks, and then resumed for another four weeks. Mineral (Zn and Cu) concentrations were determined in serum, liver, pancreas, kidney, bone, bone marrow (metacarpus), hair, hoof and neck muscle (sterno mandibularis), and Zn only in erythrocytes, skin and cornea. Metallothionein levels were determined in liver, pancreas and kidney. There were no treatment differences (p > 0.05) in serum or erythrocyte Zn content for all days of collection. Serum Cu concentrations tended to decrease with all treatments. There were no treatment differences (p > 0.05) in Zn and Cu tissue concentrations and liver, kidney and pancreas MT concentrations. Tissue Cu concentrations did not drop in the supplemented treatments when compared to controls. At adequate levels of dietary Zn, bioavailability of supplemental Zn sources may be less important than under conditions of limited dietary Zn or if very high levels of supplemental Zn are fed.

Animal Feed↗

Abnormalities in alpha-, beta- and gamma-sarcoglycan in patients with limb-girdle muscular dystrophy.

We have identified 12 cases from a group of 45 patients with early onset limb-girdle muscular dystrophy (LGMD), who have a deficiency of the 50 kDa dystrophin-associated glycoprotein, alpha-sarcoglycan. An additional male sibling of one case was also studied clinically. All 12 patients showed a concomitant, but variable, deficiency of alpha-, beta- and gamma-sarcoglycan. None of our patients had a defect in only one component of the sarcoglycan complex. Molecular analysis confirmed that a total absence of one sarcoglycan, associated with reduced expression of the other two, indicates a primary defect. Immunocytochemistry is thus useful for directing molecular studies. Morphological features not usually observed in Xp21 dystrophies were peripheral accumulations of mitochondria, discrete core-like areas, and nemaline rods in one case. Clinical severity and progression was variable between and within families but early loss of ambulation, at or before the age of 12 years, was associated with a total absence of gamma-sarcoglycan. Common clinical features were calf hypertrophy, contractures of the tendo achilles, lumbar lordosis, winging of the scapulae, weak hamstrings and weak neck muscles. All cases had grossly elevated serum creatine kinase. In contrast to patients with Duchenne muscular dystrophy (DMD), our patients with sarcoglycan deficiencies had normal early motor milestones, normal intellect, and good respiratory and cardiac function. Our data confirm that the sarcoglycan complex acts as a unit and that morphological and clinical features can distinguish patients with defects in the sarcoglycans from those with Xp21 dystrophy. In our group of patients prognosis is better than in DMD, but clinical variability makes this difficult to predict in isolated cases.

Age of Onset↗

Analysis of adaptation in anteroposterior dynamics of human postural control.

To quantify the postural adjustments over time, twelve normal subjects were investigated with posturography during vibration either toward the calf or the paraspinal neck muscles; with eyes open vs. eyes closed. The stimulus response adjustments over time were found to be almost identical for all test conditions, though the responses were smaller during eyes open conditions. To determine the response adjustments and thus the dynamics of postural control, a system identification methodology incorporating both step response and dynamic feedback components was developed. This methodology can be used to quantify both short-term stimulus response and postural adaptive adjustments when evaluating postural control performance. Copyright 1998 Elsevier Science B.V.

Journal Article↗

Differences in responses to nociceptive stimulation of the oral and aboral oesophagus.

The present study examined the role of vagal innervation of the rat esophagus in nociception. Electromyographic recordings from neck muscles were used as indicators of pseudoaffective reactions in lightly anaesthetized animals; responses were obtained during mechanical (distension) and chemical (HCl) nociceptive stimulation of the upper cervical (4.5 cm from incisors) and midthoracic (7 cm from incisors) esophagus. Compared to midthoracic esophageal stimulation, stimulation of the upper esophagus produced more vigorous responses. Bilateral transections of the cervical vagus and superior laryngeal nerves led to a gradual diminution of responses to upper stimulation, while the same manoeuvre increased responses to lower esophagus stimulation. These results suggest a contribution of vagal afferents to pseudoaffective responses elicited by noxious stimulation of the upper esophagus.

Animals↗

The platysma myocutaneous flap for oral reconstruction. Experience with MacFee's cervical incision.

The present study was performed to demonstrate and evaluate the effectiveness of the Platysma Myocutaneous Flap in conjunction with MacFee's cervical incision (MacFee, 1960) for reconstruction after oral cancer excision. Ten squamous cell carcinoma cases were provided for postoperative evaluation of tongue movement and aesthetic problems of the cervical skin. It was found that the thickness of the skin island was adequate for covering the oral defects and was not a hindrance to proper postoperative function. MacFee's incision improved the condition of the scar caused by flap elevation. The procedure for preparing the muscle pedicle beneath the cervical skin tunnel was carried out without much difficulty by carefully preparing the surgical field.

Adult↗

Electronic thermography for the assessment of mild and moderate temporomandibular joint dysfunction.

Today facial heat emission patterns may be rapidly obtained and quantified with the use of advanced electronic thermography units that have the promise of being a nonionizing, noninvasive, low-cost diagnostic alternative for the evaluation of temporomandibular joint disorders. This study design measured the use of electronic thermography as a tool to select between asymptomatic (control) subjects and a patient group with mild to moderate temporomandibular joint disorders. Study populations consisted of 24 asymptomatic (control) subjects and 20 patients with (1) either locked or unlocked temporomandibular joints, (2) varying degrees of limitation of mouth opening, (3) mild to moderate muscle pain, and (4) mild to moderate temporomandibular joint arthralgia. The results indicated that the control group demonstrated a high level of thermal symmetry over the temporomandibular joint region. The patient group demonstrated a low level of thermal symmetry with a delta T value of 0.4 degrees C. The control group was selected from the patient group with 85% sensitivity (17 of 20), and 92% specificity (22 of 24), and 89% overall accuracy (39 of 44), when selecting among the 44 subjects used in this study. The conclusion therefore is that electronic thermography shows promise as a method of diagnosing mild to moderate temporomandibular joint disorders.

Adult↗

Sexual asphyxia by hanging--a case report and a review of the literature.

A case of sexual asphyxial death by hanging is presented. A 35-year-old male, found dead lying on his face in a bed of a truck cab, had hanged himself from a window frame using a leather belt. He was completely naked. There were pornographic and sadomasochistic magazines beneath his face, opened to pages depicted nude photographs of a woman. Autopsy findings revealed a ligature mark on the neck and petechial hemorrhages in the conjunctivae, but there were no hemorrhages in the neck muscles or fractures of the hyoid bone or the thyroid cartilage. The alcohol levels in the blood and urine were 0.78 and 0.45 mg/ml, respectively. The circumstances suggested that his death was accidental, and due to asphyxia by hanging performed to enhance sexual gratification during masturbation. Sexual asphyxia is reviewed and discussed.

Accidents↗

Clinicians' perceptions of minor cervical instability.

Appropriate musculoskeletal physiotherapy management of spinal conditions requires recognition of clinical patterns in order to make a provisional diagnosis. This study aimed to assist the recognition of minor cervical instability (MCI) by surveying clinicians experienced in the management of neck conditions. A total of 153 Australian physiotherapists with postgraduate qualifications in manipulative physiotherapy and experience in the management of neck conditions completed a questionnaire that required them to indicate the importance of 15 clinical findings in the diagnosis of MCI. The responses were examined descriptively then subjected to factor analysis to identify possible groupings of findings. Clinical findings considered by greater than 50% of respondents to be either very important or vitally important in the diagnosis of MCI were: a history of major trauma; reports of the neck catching or locking or giving way; poor muscular control; signs of hypermobility on X-ray; excessively free end-feel on passive motion testing and unpredictability of symptoms. The factor analysis resulted in four distinct factors, each clinically interpretable. Therapists treating patients with neck conditions should at least consider the possibility of MCI when presented with any of the six findings reported above or with any of the groupings of findings identified by the factor analysis.

Cervical Vertebrae↗

African tick bite fever.

African tick bite fever is an acute febrile illness that is frequently accompanied by headache, prominent neck muscle myalgia, inoculation eschars, and regional lymphadenitis. The disease is caused by Rickettsia africae, a recently identified spotted fever group rickettsia, which is transmitted by ungulate ticks of the Amblyomma genus in rural sub-Saharan Africa and the French West Indies. Whereas reports on African tick bite fever in indigenous populations are scarce, the number of reported cases in travellers from Europe and elsewhere has recently increased significantly. Treatment with doxycycline is associated with rapid recovery in most patients. An immunofluorescence assay is recommended for the diagnosis but seroconversion is commonly delayed and this limits the usefulness of the test. Travellers to endemic areas should be informed of the risk of contracting African tick bite fever and be encouraged to take personal protective measures against tick bites.

Adult↗

Post-traumatic cervical dystonia: a distinct entity?

BACKGROUND/OBJECTIVE: The incidence of head/neck trauma preceding cervical dystonia (CD) has been reported to be 5-21%. There are few reports comparing the clinical characteristics of patients with and without a history of injury. Our aim was to compare the clinical characteristics of idiopathic CD (CD-I) to those with onset precipitated by trauma (CD-T). METHODS: We evaluated 114 consecutive patients with CD over a 9-month period. All patients were interviewed using a detailed questionnaire and had a neurological examination. Their clinical charts were also reviewed. RESULTS: Fourteen patients (12%) had mild head/neck injury within a year preceding the onset of CD. Between the two groups (CD-I and CD-T), the gender distribution (F:M of 3:2), family history of movement disorders (32% vs. 29%), the prevalence of gestes antagonistes (65% vs. 64%), and response to botulinum toxin were similar. There were non-specific trends, including an earlier age of onset (mean ages 43.3 vs. 37.6), higher prevalence of neck pain (86% vs. 100%), head tremor (67% vs. 79%), and dystonia in other body parts (23% vs. 36%) in CD-T. CONCLUSIONS: CD-I and CD-T are clinically similar. Trauma may be a triggering factor in CD but this was only supported by non-significant trends in its earlier age of onset.

Adult↗

Studies of the presence of verocytotoxic Escherichia coli O157 in bovine faeces submitted for diagnostic purposes in England and Wales and on beef carcases in abattoirs in the United Kingdom.

A survey of beef carcases in abattoirs in the UK was carried out in order to estimate the prevalence of contamination with verocytotoxin-producing Escherichia coli (VTEC) serogroup O157. Contamination with verocytotoxin-producing E. coli (VTEC) O157 was confirmed in 0.47% of the 4067 (95% confidence limits 0.22-1.00%) of neck muscle samples. A significant tendency for carcases present in the same abattoir on the same day to have similar results was found, thus suggesting cross contamination. VTEC O157 was found in 0.83% of 6495 bovine faeces samples routinely submitted for diagnostic purposes to Veterinary Investigation Centres in England and Wales. Of the samples from cattle less than 6 months old, 3.7% of 68 samples from animals without gastrointestinal disease were positive for E. coli O157, in contrast to 0.75% of 2321 samples from cases of gastrointestinal disease. No association with season or herd type (beef or dairy) was found.

Abattoirs↗

Ontogeny of feeding motor patterns in infant rats: an electromyographic analysis of suckling and chewing.

During mammalian ontogeny, there is a transition from suckling to the chewing of food. The question was asked: Is suckling a neuromuscular precursor to chewing, or are suckling and chewing independent systems? Electromyograms (EMGs) were recorded in rat pups of ages 6, 9, 12, 15, 18, and 21 days from the superficial masseter, anterior digastric, sternohyoideus, and genioglossus muscles during suckling and chewing. The EMG patterns of the 3 components of suckling behavior (nipple attachment, rhythmic sucking and the stretch response) are distinctive from one another and reflect the musculoskeletal biomechanics of suckling. Chewing EMGs are present by 12 days of age and attain the adult pattern by 18-21 days of age. During nipple attachment, pups exhibit a motor pattern that is similar to that of adult chewing, but other aspects of suckling differ from chewing in some EMG features. Comparison of EMGs between behaviors and between ages allowed interpretation of the degree of contunity of muscular activity across the suckling-to-chewing transition.

Aging↗

The rat as an experimental model for sleep neurophysiology.

The aim of this study was to develop a sleep-wake recording system for rats that would yield results more comparable to those obtained from cats than those that are usually reported. For 18 male Sprague-Dawley rats, the authors combined measures of cortical and hippocampal electroencephalogram (EEG) and neck muscle electromyogram with the electrooculogram and pontine EEG, so that the behavioral states could be identified with greater confidence with the use of polygraphic criteria developed in the cat and so that the distinctive phasic events of REM sleep could be more easily studied in the rat. The results suggest that for many neurophysiological studies, the rat is a suitable alternative to the cat.

Animals↗