Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Muscle Rigidity”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,171 records · Page 65Linked to original sources
PubMed1987

Rigidity in rats due to radio frequency decerebration and effects of chlorpromazine and mephenesin.

Bilateral radio frequency (RF) lesions of the midbrain were produced in an attempt to establish a non-bleeding method of producing decerebrate rigidity in rats. Marked extensor rigidity occurred with a high reproducibility in hindlimbs without the appearance of voluntary movement. Stretch reflex tension induced by repetitive dorsiflexion of the hindfeet was employed as a measure of the intensity of rigidity. Chlorpromazine-HCl (0.1-1 mg/kg, i.v.) and mephenesin (10-50 mg/kg, i.v.) which depress intercollicular decerebrate rigidity, reduced the RF decerebrate rigidity. These results suggest that RF decerebrate rigidity can be used instead of intercollicular transection rigidity in the pharmacological and physiological studies.

Animals↗
PubMed1989

Optimal indices for testing parkinsonian rigidity.

We assessed parkinsonian rigidity objectively at the wrist to determine the optimal angular velocity and displacement for detecting abnormality. The wrist was moved passively with a torque motor and the average work done for one complete cycle was computed. This objective rigidity score (ORS) was compared with a clinical rigidity score (CRS). ORS was more pronounced at faster movement velocities in parkinsonian patients, whereas in normal subjects there was only a modest increase in the score. Angular velocities of 140 to 190 degrees/second and displacements of +/- 25 to +/- 30 degrees were most sensitive for detecting parkinsonian rigidity and had good correlation with the CRS.

Adult↗
PubMed1980

Some extrapyramidal motor signs in cases of undifferentiated amentia.

A group of 50 mentally handicapped patients who were without gross motor deficit and had never been on anti-psychotic drugs were examined for signs of Parkinsonism and compared with a matched control group of non-handicapped people who were also examined. There was a very significant increase in masking, positive glabella tap, absence of arm swing, rigidity and hypokinesis.

Adult↗
PubMedDate not supplied

[Role of the hypothalamus in organizing the wakefulness-primary sleep cycle in the frog Rana temporaria].

New data are presented on the role of the hypothalamus in re-arrangement of tonus of the vegetative nervous system during three forms of rest of the primary sleep in the frog. Temporal organization of the cycle " awakefulness -primary sleep" depends on interaction of the anterior and posterior hypothalamus. The anterior hypothalamus is responsible for manifestation of two forms of rest of the primary sleep, i.e. diurnal resting form (P-1) which is associated with the increase in plastic tone of skeletal muscles, and the other resting form (P-3) which is associated with the decrease in muscle tonus. These forms of rest are accompanied by the predominance of parasympathetic tonus of the vegetative nervous system. The posterior hypothalamus is associated with manifestation of the resting form which includes the increase in the rigidity of muscle tonus (P-2) and transient phasic increase in the heart rate, the latter being observed at all forms of the primary sleep. Statistical treatment of the ECG revealed specific pattern of two-dimensional density of distribution of probabilities of R-R intervals for the resting forms of the primary sleep which is important for identification of different phases in the " awakefulness -primary sleep" cycle in vertebrates.

Animals↗
PubMed2005

Disposition of 2,6-di-tert-butyl-4-nitrophenol (DBNP), a submarine atmosphere contaminant, in male Sprague-Dawley rats.

The phenol 2,6-di-tert-butyl-4-nitrophenol (DBNP) is a contaminant found onboard submarines and is formed by the nitration of an antioxidant present in turbine lubricating oil TEP 2190. DBNP has been found on submarine interior surfaces, on eating utensils and dishes, and on the skin of submariners. DBNP exposure is a potential health concern because it is an uncoupler of mitochondrial oxidative phosphorylation. Adult male rats were dosed once by oral gavage with 15 or 40 mg/kg DBNP mixed with 14C-DBNP in kanola oil and 0.8% v/v DMSO (n = 16/group). The distribution of 14C in major tissues was measured over time for up to 240 h post-dose. Unexpectedly, 6/16 (40%) of the rats gavaged with 40 mg/kg DBNP died within 24 h of dosing. Prostration, no auditory startle response, reduced locomotor activity, and muscular rigidity persisted in survivors for up to 8 days after dosing. For animals dosed with 15 mg/kg DBNP, radioactivity levels were significantly elevated in the following tissues 24h after dosing: fat>>>liver>kidneys>heart>lungs>brain>striated muscle>spleen. Radioactivity levels were elevated for fat, liver, kidney, heart, and lungs of animals euthanized 144 h post-dosing and in the liver of animals euthanized 240 h post-dosing. These findings suggest that DBNP may accumulate in the body as a result of continuous or repeat exposures of short interval to DBNP.

Animals↗
PubMedDate not supplied

Rigidity in parkinsonism: characteristics and influences of passive exercise and electrical nerve stimulation.

Rigidity was measured during sinusoidal passive movements of the ankle joint in 7 patients with parkinsonism. Velocity-dependent changes were observed, less marked than in spasticity and expressed in a different way in flexor and extensor muscles: a mild decrease in resistive torques at faster stretching of dorsal flexors and an increase in resistance on stretching of plantar flexors. Dorsal flexors also frequently showed shortening reactions. Passive exercises and electrical stimulation of the peroneal nerve resulted in decreased electromyographic responses to stretch, smoother passive movements and in improved voluntary contraction.

Aged↗
PubMed1983

Motility, rigidity and turnover of dopamine in the striatum after administration of morphine to rats: a re-evaluation of their mechanisms.

Whether the delayed behavioural activation and the increase in dopamine (DA) turnover in the striatum reflect signs of rebound effects or of counter-regulatory processes directed against locomotor depression and/or muscular rigidity was studied in rats. Administration of a large dose of morphine (30 mg/kg i.p.) induced strong muscular rigidity, which was measured as tonic activity in the electromyogram (EMG). This effect was maximal after one hour and disappeared during the fourth hour. The locomotor activity, on the other hand, disappeared after 30 min and re-appeared during the fourth hour, followed by a locomotor stimulation with a maximum after 4.5 hr. Striatal lesions produced with kainic acid did not affect the complete locomotor depression (akinesia), except by slightly prolonging this effect, and did not influence the delayed locomotor stimulation. These lesions did not inhibit, but, on the contrary, enhanced the increase in striatal concentration of 3,4-dihydroxyphenylacetic acid (DOPAC). Injections of morphine (10 micrograms) into the substantia nigra led to an increase in the level of DOPAC in the ipsilateral, but not the contralateral striatum. These results, in conjunction with those of other authors, suggest that the increase in DA turnover in the striatum and the delayed locomotor stimulation ought to be regarded as actions of morphine on sites different from those mediating muscular rigidity.

3,4-Dihydroxyphenylacetic Acid↗
PubMed1976

Extrapyramidal side effects in lithium maintenance therapy.

The authors neurologically examined 36 patients who had been maintained on lithium therapy for periods ranging from 6 months to 7 years to determine the presence of parkinson-like side effects. Only a few patients demonstrated rigidity, including cogweel rigidity, and this was at a low level of severity. These results do not support the previously reported frequent occurrence of cogwheel rigidity in patients on lithium maintenance.

Basal Ganglia Diseases↗
PubMed2000

[Details and indications of pallidotomy and thalamotomy for Parkinson's disease].

Pallidotomy has recently regained acceptance as an effective treatment for Parkinson's disease. From our 50 cases of unilateral pallidotomy and 10 cases of staged bilateral pallidotomy, details and indications of the procedure is described. The unilateral pallidotomy is quite effective for L-dopa induced dyskinesia, which usually completely disappears soon after the operation. The effect is long-lasting. When on-off phenomenon exists, unilateral pallidotomy improves off-stage rigidity or akinesia. Symptoms during on-stage are not changed. Indications of pallidotomy is that(1) L-dopa induced dyskinesia, and(2) on-off phenomenon. Bilateral pallidotomy, even by staged one, causes severe drooling, or speech disturbance(the volume of the voice decreases and the articulation worsens), and is not recommended. Vim thalamotomy is, on the other hand, the established treatment for tremor of Parkinson's disease or of essential tremor. The effect is long-lasting. Rigidity or akinesia is not expected to be improved so much.

Dyskinesia, Drug-Induced↗