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Results for “Intestinal Neoplasms”

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At least 1,171 records · Page 65Linked to original sources
PubMed1997

Flecked chorioretinopathy associated with Birt-Hogg-Dubé syndrome.

BACKGROUND: Birt-Hogg-Dubé's syndrome is a rare skin disease characterized by multiple trichofibromas of the skin and polyps of the intestine. Ophthalmologic manifestations associated with the syndrome have not been reported in detail. CASE REPORTS AND METHODS: Two siblings suffering from Birt-Hogg-Dubé syndrome were examined clinically. Electrooculography and electroretinography were performed according to international standards. Color fundus photographs were taken as well as fluorescein angiograms. The two patients showed multiple perifollicular fibromas and trichodiscomas of the skin of the head. Funduscopy and fluorescein angiography revealed a flecked chorioretinopathy in one patient with progressive constriction of visual fields and severely reduced electroretinographic responses. Ophthalmoscopy in his sister showed peripheral pigmentary changes with only minor functional abnormalities. CONCLUSION: These findings suggest that Birt-Hogg-Dubé syndrome may be associated with a progressive flecked chorioretinopathy with constricted visual fields and that patients with the syndrome should undergo ophthalmological examination.

Aged↗
PubMed1975

American Burkitt's lymphoma: a clinicopathologic study of 30 cases. II. Pathologic correlations.

Thirty cases of malignant lymphoma, undifferentiated, Burkitt's type are reviewed. An older median age and a predominance of presentation in abdominal and pelvic sites rather than in the jaw distinguishes this series of American patients from those reported from endemic regions in Africa. Bone marrow involvement invariably consisted of massive infiltration recognizable in smear, clot and biopsy preparations. Involvement of the central nervous system or bone marrow was always associated with short survival. In all eight long-term survivors lymphoma was apparently confined to a single site at presentation. At autopsy, the most consistent finding was widespread multiorgan involvement without predilection for lymphoreticular structures. The histologic appearance of the tumor changed after chemotherapy, varying from diffuse necrosis within 48 hours of initial therapy to extreme pleomorphism of tumor cells after 9 months of therapy. In one patient, there was almost complete absence of lymphoma at autopsy in an organ site shown clinically to have been extensively involved by tumor prior to treatment. The diagnostic and therapeutic implications of these findings are discussed.

Abdomen↗
PubMed2003

Impaired expression of acyl-CoA-synthetase 5 in epithelial tumors of the small intestine.

Fatty acids are implicated in tumorigenesis, but data are limited concerning endogenous fatty acid metabolism of tumor cells in adenomas and adenocarcinomas of the small intestine. The recently cloned human acyl-CoA-synthetase 5 (ACS5) is predominantly found in the small intestine and represents a key enzyme in providing cytosolic acyl-CoA thioesters. Protein synthesis and mRNA expression of ACS5 were studied in human intestinal tissues using different methods, including a newly established monoclonal antibody. In the healthy small intestine, expression of ACS5 was restricted to the villus surface epithelium but was not detectable in enterocytes lining crypts. ACS5 protein and mRNA were progressively diminished in epithelial cells of adenomas and adenocarcinomas of the small intestine. In conclusion, altered expression of ACS5 is probably related to the adenoma-carcinoma sequence of small intestinal epithelial tumors due to an impaired acyl-CoA thioester synthesis.

Adenocarcinoma↗
PubMedDate not supplied

CT of malignant melanoma: patterns of small bowel and mesenteric involvement.

Abdominal CT of 230 patients (310 CT examinations) with a diagnosis of malignant melanoma was retrospectively reviewed for the evaluation of small bowel and mesenteric involvement. Seventeen (7.4%) patients had evidence of small bowel and mesenteric involvement on CT. There were four distinct patterns of disease: (a) intraluminal masses in 3 patients; (b) ulcerating lesions in 2; (c) diffuse infiltration in 6; (d) implants in 10. Four patients had more than two patterns of involvement. Of the 10 patients with tumor implants, carcinomatosis was noted in 2. Two patients had intussusception and 4 had extensive mesenteric nodal involvement. Of the 17 patients, 12 (71%) had at least one symptom referable to the gastrointestinal tract, while 5 (29%) were clinically asymptomatic. Fourteen of the 17 patients (82%) had additional intraabdominal metastases to sites other than small bowel and mesentery.

Adult↗
PubMed1984

Malignant tumors of the small bowel.

The four common types of small bowel malignancies have different clinical presentations, routes of metastatic spread, and prognoses, and may require selective treatment. A review of our experience over a 16-year period revealed 45 cases: 16 adenocarcinomas, 13 carcinoids, nine leiomyosarcomas, five lymphomas, and two fibrosarcomas. Adenocarcinomas tend to occur in the upper part of the small intestine, cause obstruction and occult blood loss, and metastasize to the regional nodes and liver. Carcinoids generally begin in the distal portion of the small bowel, may form rather large metastatic masses and cause obstruction from a metastatic mass or intussusception, and are often multiple. Leiomyosarcomas develop in any part of the bowel, may present a primary mass, gross hemorrhage, or perforation, and have blood-borne metastases. Lymphomas tend to occur in the distal part of the small bowel, with pain or mass formation, and spread via the lymphatics. Critical analysis of the clinical presentation and findings should allow preoperative recognition of the specific pathologic type.

Adenocarcinoma↗
PubMed2002

Malignant intestinal non-Hodgkin's lymphoma from the surgical point of view.

BACKGROUND: Primary intestinal non-Hodgkin's lymphoma (I-NHL) is much less frequent than gastric lymphoma and has hardly been studied in prospective trails. To the surgeon, patients frequently present with abdominal emergencies. PATIENTS AND METHODS: A consecutive series of patients subjected to surgery because of I-NHL between 1998 and 1999 was evaluated retrospectively for characteristic clinical, radiographic and intraoperative findings. Patients with gastric lymphoma were not considered. RESULTS: 10 patients, 8 males and 2 females, with I-NHL were subjected to first-line surgery because of painful abdominal tumor, intestinal hemorrhage, obstruction or perforation. I-NHL was located most often in the small bowel (n = 7). It was rare in the colon (n = 2) and the duodenum (n = 1). Median postoperative follow-up was 28 months. Perioperative mortality was 10% (n = 1). Probability of survival 3 years after surgery was 60%. CONCLUSIONS: Patients with I-NHL frequently present with complications of tumor growth, requiring urgent surgical treatment. Irrespective of surgical complications we advocate surgery in cases of resectable disease as first-line treatment. Adjuvant treatment is indicated with respect to resection status and histopathological staging.

Adult↗
PubMed1976

[Primary malignant tumours of the small intestine (author's transl)].

In the years between 1936 and 1973 19 patients with malignant tumours of the small intestine were admitted to the 2nd Department of Surgery, University of Vienna. Analogous to the findings of large-scale investigations adenocarcinomas (7 cases) preponderate in the upper small intestine in our case material, while lymphosarcomas and carcinoids mainly occur in the ileum. A radical surgical procedure was possible in 11 cases. The adenocarcinomas have the most unfavourable prognosis, whilst survival times of up to 10 years were found with lymphosarcomas and carcinoid tumours.

Adenocarcinoma↗
PubMed1976

[Complications of benign nonepithelial tumors of the gastrointestinal tract].

The results of observations over 8 patients with complicated forms of benign nonepithelial tumors of abdominal organs are reported, including leiomyoma--in 7 cases and neurinoma--in 1. Isocomplications of this group of tumors in 5 patients were as follows: invagination of the small intestin--in 1, perforation and malignant transformation of the tumor--in 1. The patients were treated surgically. Resection of the organ involved seems to be preferable.

Adult↗
PubMedDate not supplied

Metastatic amelanotic melanoma.

We report a 60 year-old-man who presented with generalized abdominal colicky pain. He had a history of left great toe dysarticulation done for amelanotic melanoma one year ago. Investigations were suggestive of metastases of melanoma to the small intestine. Exploratory laparotomy with segmental ileal resection and anastomosis was performed. Histological examination showed features of amelanotic melanoma characterized by absence of melanin pigment.

Humans↗
PubMed1992

Flexible sigmoidoscopy in asymptomatic patients with negative fecal occult blood tests.

BACKGROUND: Although the American Cancer Society and others have established guidelines for colorectal cancer screening, questions of who and how to screen still exist. METHODS: A 60-cm flexible sigmoidoscopy was performed on 1000 asymptomatic patients, 45 years of age or older, with negative fecal occult blood tests, who presented for routine physical examinations. Patients with clinically significant lesions were referred for colonoscopy. The proportion of lesions that would not have been found if the 24-cm rigid or the 30-cm flexible sigmoidoscope had been used was identified. RESULTS: Using the 60-cm flexible sigmoidoscope, lesions were found in 3.6% of the patients. Eighty percent of the significant lesions were beyond the reach of the 24-cm rigid sigmoidoscope and 37% were beyond the reach of the 30-cm sigmoidoscope. Thirty-six patients with lesions were referred for colonoscopy; additional lesions were found in 14%. A total of 62 lesions were discovered, including tubular adenomas, villous adenomas, tubular villous adenomas (23 of the adenomas with atypia), and one adenocarcinoma. The highest percentage of lesions discovered were in the sigmoid colon and the second highest percentage were in the ascending colon. CONCLUSIONS: The 60-cm flexible sigmoidoscope was able to detect more lesions than either the 24-cm or 30-cm sigmoidoscope when used in asymptomatic patients, 45 years of age and over, with negative fecal occult blood tests. When significant lesions are discovered by sigmoidoscopy, colonoscopy should be performed.

Adenocarcinoma↗
PubMed1988

[Carcinoid tumors of the small intestine].

Operations were performed on 15 patients for carcinoid tumours in their small intestines. Prognosis of tumour localisation in the small intestine was confirmed to be worse, as compared to other tumour sites. Only four patients were initially free of metastases. Such unfavourable point of departure supported the need for radical surgery, with a view to alleviating the locally delimited symptoms of the primary tumour and the complaints caused by the carcinoid syndrome.

Adult↗
PubMed1988

[Primary intestinal lymphomas. Review of the literature apropos of a clinical case].

A rare case of primary lymphoma of the bowel in a 26 year old woman is reported and the complex problems of diagnosis and treatment are examined. The importance of establishing the primary or secondary nature of this tumour of the small bowel is emphasised. This is because primary intestinal tumours require the most radical treatment possible even in advanced stages of the disease in order to avoid complications and to identify the areas involved in the proliferative process. Finally the importance of continuing surgery with drug and radiation treatment in order to improve prognosis is emphasised.

Adult↗