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Tissue reaction following endobronchial application of iopamidol and ioxithalamate in rats.

Lung tissue reaction to endobronchial application of iopamidol and ioxithalamate were compared by chest radiograph and histological examination in the rat. Radiographs cleared within hours in both groups. Tissue reaction after ioxithalamate application was significantly more pronounced than with iopamidol and included macrophage response, partial atelectasis, and intra-alveolar and interstitial oedema. Different from iopamidol, ioxithalamate induced a significantly stronger reaction than tracheotomy alone. Because no important significant side effects were observed on chest radiographs or in lung histology, iopamidol is recommended for the radiological examination of the gastrointestinal tract in patients with an increased risk of aspiration.

Animals↗

Postmyelographic cauda equina syndrome in an asymptomatic acquired spinal stenosis of a young acromegalic.

Early postmyelographic cauda equina syndrome in an asymptomatic young acromegalic is presented. The patient was asymptomatic for more than 1 yr despite myelographic evidence of acquired spinal stenosis at the L2-L4 level. Radiographic and/or myelographic findings should be clinically correlated. It is postulated that, in acromegaly, the combined simultaneous bony apposition-remodeling resorption mechanism is involved in the spine as platyspondyly, hyperostosis of spinous processes and vertebral scalloping to counteract soft tissue hyperplasia within the spinal canal; entrapment myelopathy, cauda equina syndrome and/or radiculopathy are ascribed to a soft tissue edematous mechanism superimposed on congenital or degenerative spinal stenosis, traumatic or postoperative spondylolisthesis, postmyelographic and/or postoperative arachnoiditis and a traumatic swollen or protrused intervertebral disc.

Acromegaly↗

Electrophysiological effects of contrast media.

The effect of two low osmolar contrast media (sodium ioxitalamate and sodium ioxaglate) and two nonionic media (iohexol and iopamidol) on cellular electrophysiological properties of sheep myocardium and Purkinje fibres was studied at two concentrations of each medium. Neither sodium ioxitalamate nor ioxaglate had significant effects on any of the parameters measured. Iohexol (10 mL/L) caused a loss of resting potential, a decrease in action potential and duration, and a decrease in refractory period of the myocardium. No change in Purkinje fibres was observed. Iopamidol induced an increase in relative refractory period in both myocardium and Purkinje fibres at 1 mL/L and had a significant effect on all parameters studied at 10 mL/L. Automaticity was not observed after perfusion with any agent at either concentration.

Animals↗

Computer processed fluoroscopic images for digital intravenous renal angiography.

We investigated intravenous digital angiography using computer processed fluoroscopic images. Computer processed fluoroscopy (CPF) was compared to conventional digital subtraction angiography (DSA) in 39 patients referred for renal vessel evaluation. For assessment of CPF the anterior-posterior images were compared with the corresponding digital subtraction angiograms. 79% percent of DSA and 71% of CPF studies were diagnostic. Peripheral injection of contrast medium caused deterioration of CPF images. Skin dose measurements were obtained in 24 patients. The median dose for DSA was 8.2 rad, compared to 1.1 rad for CPF. It is concluded that sophisticated algorithms should be investigated for digital angiography, so that high image quality can be achieved with a reduced radiation exposure.

Adult↗

[Comparison between isteropac and a new non-ionic contrast medium for hysterosalpingography (B-15000)].

The authors refer the results of a double blind hysterosalpingographic study with a traditional ionic contrast medium (Isteropac) and a new non-ionic one (B-15000). Both the contrast have provided good quality images, without significant intolerance. Moreover the new non-ionic contrast medium has shown an easier utero-tubal transit with a sensible reduction of the examination length and a better diagnostic result.

Adult↗

[Nephrotoxicity of ionic and nonionic contrast media in selective renovasography].

Nephrotoxic effect of ionic and non-ionic contrast media was examined in a doubleblind study by evaluation of serum creatinine, blood urea nitrogen, urine volume, urinary protein excretion and erythrocyturia before and after selective renovasography. In 19 of 22 patients reliable results were obtained. With optimal hydration before and after renovasography no significant differences between both administered contrast media (Rayvist 300 and Omnipaque 300) could be found by evaluation of the aforementioned parameters. In 3 patients with preexistent proteinuria (greater than 200 mg/l) urine protein excretion remained at the same or a lower level after application of the non-ionic contrast medium Omnipaque 300. Three patients with proteinuria tended to increase the proteinuria after administration of the ionic contrast medium (Rayvist 300) up to 48 h after angiography indicating a higher nephrotoxic potential of ionic contrast media in patients with preexistent renal disease. The constant values of urine volume and serum creatinine indicate an absence of clinically relevant nephrotoxicity of both contrast media in this study when administered in well-hydrated patients. This emphasizes the importance of sufficient hydration in prophylaxis of nephrotoxic effects, especially in patients with risk factors.

Adult↗