Stamps in cardiology: de Musset sign.
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At the beginning of the 19th century, medicine underwent an important metamorphosis. The emphasis shifted from function to structure, and from organism to organ. This went hand in hand with the development of the physical examination. The founders of the new movement were Italian and French. In Great Britain, Richard Bright (1789-1858) was an important pioneer. In his books Reports of medical cases, published in 1827 and 1831, with many colour plates, Bright correlated clinical features with morphological changes found at autopsy. He became most famous for showing the relationship of dropsy, coagulable urine and kidney changes. Acute glomerulonephritis is named after him. With Addison and Hodgkin he contributed to the fame of Guy's Hospital in London.
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The "Alice in Wonderland syndrome includes an array of symptoms involving altered perception of shape (meta-morphopsia) of objects or persons who appear to be smaller (micropsia) or larger (macropsia) than normal, of impaired sense of passage of time, of zooming of the environment. This unusual neurological picture which can be confused with psychosis or drug intoxication has been found to accompany cerebral lesions mainly temporo-occipital or parietal-occipital temporal epilepsy and migraine. Todd gave the syndrome its literary name in his report in 1955, describing a singular group of symptoms closely associated with migraine and epilepsy. However the first description of the condition was made by Lippman in 1952. This syndrome is so called because of the resemblance of its symptoms to the fluctuations in size and shape that plague the main character in Lewis Carrol's 1865 novel Alice in Wonderland. Cases of "Alice in Wonderland" syndrome have been described associated with infectious mononucleosis. In each clinical case, the classical infectious mononucleosis symptoms and diagnosis followed the onset of visual aberration. Nuclear medicine techniques are able to demonstrate changes in cerebral perfusion and may be used to detect abnormal cerebral areas in patients with AIWS.
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This paper offers some interesting biographic information on the two men from whom the Knight-Taylor spinal orthosis takes its name. James Knight and Charles Taylor were two orthopedists from New York City who were interested in spinal care. They prescribed and fashioned their distinctive braces, aspects of which were combined by others, thus linking these two men in orthopedic hyphenated history.
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Born in 1655 in Copenhagen to a renowned family, Gaspard Bartholin had the good fortune during his stay in Paris to meet Joseph Guichard du Verney, a French anatomist who had discovered the glandula vestibuloris major. Back in Copenhagen he was appointed professor of anatomy at the age of 21 described the physiology of the glandula vestibuloris major, later known as Batholin's gland. Ennobled, laden with honours, he was later appointed personal physician to the king of Denmark until his death in 1738.
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