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Wavelength shifts correlation between near infrared and ultraviolet regions of the LHII bacteriochlorophyll spectrum from Ectothiorhodospira sp.

Bacteriochlorophyll a has a maximum at 258 nm previously related to the ring E ester system interacting with the pi-system of the macrocycle. In this work, we compared the effect of lauryldimethylamine-N-oxide (LDAO) and alkaline pH on both the near infrared and the ultraviolet region of the LHII spectrum from Ectothiorhodospira sp. While LDAO induces only a shift of the 850 nm band arising from the Qy transition of the bacteriochlorophyll a, alkaline pH also causes a concomitant and reversible 10-nm shift from 258 to 248 nm. Both shifts have similar apparent pKs (12.3 and 12.6, respectively). Interestingly, the presence of NaCl reduces these pKs values to 11.4 and 11.7.

Bacteriochlorophylls↗
PubMed1975

Prolonged antioestrogenic activity of ICI 46, 474 in the ovariectomized mouse.

Subcutaneous administration of ICI 46,474 (3 mg) to ovariectomized mice was found to produce vaginal refractoriness to subcutaneously administered oestradiol for up to 6 weeks. Tritiated oestradiol-17 beta accumulated in the uterus and vagina of the ovariectomized mouse, with maximum accumulation at 3 to 4 hr. This property of the target tissues was used to investigate the binding of tritiated oestradiol after the administration of 3 mg ICI 46,474 to ovariectomized mice. Radioactivity in the vagina was found to be comparable to control values 6 weeks after ICI 46,474 administration; uterine levels of radioactivity returned to control values by 10 weeks. Administration of ICI 46,474 had an oestrogenic effect upon the mouse uterus whereas the vagina appeared to be initially stimulated and was then unable to respond to or to bind oestradiol.

Animals↗
PubMed1981

A comparison of the elimination and biotransformation of dodecyldimethylamine oxide (DDAO) by rats, rabbits, and man.

1. The biotransformation of [1-14C]dodecyldimethylamine oxide (DDAO) was studied in rats, rabbits and humans. 2. Metabolites eliminated in 0-24 h urine after oral dosing were separated by cation exchange chromatography into at least ten separate peaks for each species. Several prominent urinary metabolites were identified using reverse isotope dilution, g.l.c.-mass spectrometry and n.m.r. 3. Metabolite structures suggested metabolic pathways that included omega, beta-oxidation of the aliphatic chain, amine oxide reduction, and aliphatic mid-chain hydroxylation. 4. Comparison was made of the 0-24 h urinary metabolites from males of each species. N,N-Dimethyl-4-aminobutyric acid and its N-oxide accounted for 28% of the dose in humans, 28% in rabbits and 23% in rats. These species excreted 44, 51 and 60% of the dose, respectively, in 24 h. Therefore, humans and rabbits were more efficient than rats in degrading the alkyl chain to compounds containing four-carbon acids. In contrast to rabbits and humans, rats excreted greater than 12% of the dose as long-chain compounds. At least half of these compounds were C-hydroxylated amino-alcohols. 5. Under the conditions employed, the rabbit more closely approximates the metabolism of DDAO by human than does the rat.

Animals↗