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An analysis of cue reactivity among persons with and without schizophrenia who are addicted to cocaine.

OBJECTIVE: Persons with schizophrenia who are addicted to cocaine experience more psychiatric and substance abuse relapses and worse long-term outcomes than persons with only one of these conditions. This study examined whether individuals with cocaine dependence and schizophrenia experience more cue-elicited craving than those without schizophrenia. METHODS: Ninety-one cocaine-dependent participants who had been abstinent from cocaine for at least 72 hours were recruited from substance abuse treatment programs in the Veterans Affairs New Jersey Health Care System. The study used a cue-exposure paradigm to stimulate cocaine craving. A self-report instrument was used to measure changes from baseline in four areas: craving intensity, happy or depressed mood, increased or decreased energy, and physical health or sickness. RESULTS: The participants with schizophrenia (N=35) reported significantly more cocaine craving than those without schizophrenia (N=56). When data for participants who were cue reactive were analyzed without regard to diagnosis, 97 percent of the cocaine-dependent participants with schizophrenia were cue reactive, compared with 43 percent of those without schizophrenia. CONCLUSIONS: Future research on cocaine dependence should focus on craving, particularly among patients with coexisting psychiatric disorders.

Adult↗

The effects of tape-recorded self-instruction cues on the mathematics performance of students with learning disabilities.

The effects of tape-recorded self-instruction cues on the mathematics performance of students with learning disabilities (LD) were investigated. Nine students were assigned to one of three conditions: an experimental condition, in which students attended two training sessions in self-instruction (SIT); an observer condition, wherein students observed SIT but did not participate; and a control condition, wherein students received neither training nor the opportunity to observe. Using a multiple probe design, data (problems attempted, problems completed correctly, and time for task performance) were collected across two baseline phases, two brief instructional periods, and two generalization phases. Without access to taped cues, experimental and observer students did not successfully utilize the SIT after the first self-instructional training. However, when experimental students were trained to use taped cues, they demonstrated the ability to accurately solve their problems. More important, they were able to successfully use SIT procedures when the taped cues were faded.

Child↗

Selective cognitive processing of drug cues in heroin dependence.

Previous studies provide evidence for the selective processing of disorder related stimuli on anxiety, depression, and eating disorders. There exist some preliminary indications that selective processing of drug cues may be involved in drug craving and relapse that deserve further investigation. In order to investigate the role of processing bias in an abnormal motivational system, the attentional bias for drug related stimuli was studied in a heroin dependent population. Heroin dependent participants (n = 21) and control participants (n = 30) performed a supra- and subliminal heroin Stroop task and heroin craving was assessed. Heroin dependent participants showed a considerable attentional bias for supraliminally presented heroin cues. However, there was no evidence for a preattentive bias on the subliminal presented cues. Reaction time on heroin cues was significantly predicted by heroin craving-levels. Results indicate that selective processing may be related to motivational induced states in general. The finding are discussed in the context of selective information processing in general psychopathology and in motivational processes as addiction specifically.

Adult↗

Two new neurophysiological indices of cocaine craving: evoked brain potentials and cue modulated startle reflex.

Craving for cocaine is one of the hallmarks of cocaine dependence. One of the problems with craving is its measurement. Traditional psychophysiological indices such as skin conductance and heart rate have yielded contradictory results. These measures of craving were found to correlate only moderately with self-reported craving. In the present study, event-related brain potentials (ERPs) and the cue modulated startle response (CMSR) are evaluated as indices for cocaine craving. Twenty-one abstinent cocaine-dependent subjects were divided into high and low cravers group based on the median split of self-reported craving scores. ERPs and CMSR were measured when subjects watched neutral, pleasant, unpleasant and cocaine-related pictures. Overall, it was found that cocaine-dependent subjects showed augmented slow-positive waves (SPWs) of the ERP on the cocaine pictures compared to neutral pictures. Only high cravers showed larger SPWs on the cocaine cues, suggesting an association between cue-elicited SPWs and self-reported cocaine craving. By contrast to the ERP measures, CMSR did not differentiate between cocaine pictures and neutral pictures. In addition, no differences between the low- and high cravers on the CMSR measure were found. The present results show that the evoked-potentials paradigm provides promising results to index cue-elicited craving. The use of startle modulation deserves further investigation.

Adult↗

Temporal pattern cues in vibrational risk assessment by embryos of the red-eyed treefrog, Agalychnis callidryas.

The embryos of red-eyed treefrogs, Agalychnis callidryas, use vibrations transmitted through their arboreal egg clutch to cue escape hatching behavior when attacked by egg-eating snakes. Hatching early increases the risk of predation in the water, so embryos should avoid it unless they are in danger. We exposed egg clutches to intermittent vibrations with different combinations of vibration duration and spacing to examine the role of simple temporal pattern cues in the escape hatching response. Stimuli were bursts of synthetic white noise from 0 to 100 Hz, including the range of frequencies with substantial energy in snake attacks, and had approximately rectangular amplitude envelopes. Embryos hatched in response to a small range of temporal patterns and not in response to many others, rather than hatching to most vibrations except for certain patterns perceived as safe. Neither cycle length nor duty cycle predicted hatching response, except at extreme values where no hatching occurred; the highest energy stimuli elicited little or no hatching. Both vibration duration and inter-vibration interval strongly affected the hatching response. The highest levels of hatching were to durations of 0.5 s combined with intervals of 1.5-2.5 s, and hatching decreased gradually with increasing difference of either duration or interval from these most effective stimuli. Vibration duration and interval appear to function as two necessary elements of a composite cue, rather than as redundant cues. This increases response specificity and reduces the range of stimuli that elicit hatching, likely reducing the chance of hatching unnecessarily in a benign disturbance. Vibration-cued hatching in A. callidryas embryos offers an opportunity to experimentally assess the behavioral decision rules underlying an effective and costly anti-predator defense.

Animals↗

Relaxed conditions can provide memory cues in both undergraduates and primary school children.

BACKGROUND: Memory can be impaired by changes between the contexts of learning and retrieval (context-dependent memory, CDM). However, the reminder properties of context have usually been investigated by experimental manipulation of cues in isolation, underestimating CDM that results from interactions between cues. AIMS: To test whether CDM can be demonstrated using multiple contextual cues combined to create relaxing versus neutral contexts at separate learning and memory testing stages of the experiments. SAMPLE: Forty university undergraduates (in Experiment 1), and forty 9-10 year-olds (in Experiment 2). METHODS: All participants were given age-appropriate tasks under either relaxing or neutral conditions. The next day they were tested for retrieval or practice effects, under the same or different (relaxing versus neutral) conditions. RESULTS: For both age groups, there was a (mostly asymmetric) CDM effect with performance generally best in the relaxing-relaxing condition. There was also some overall benefit of having learned under relaxed conditions. CONCLUSION: A relaxed learning environment can provide effective retrieval cues, as well as improve learning. COMMENT: For both primary school children and university students, the educational implication of these findings is that learning can be improved in a relaxed state. For this benefit to be fully manifest, the assessment of learning should also take place under relaxed conditions.

Adult↗

Effects of cueing and knowledge of results on workload and boredom in sustained attention.

Two models of recently reported high workload associated with vigilance tasks are the direct-cost and indirect-cost views. The former attributes high workload to the need for continuous observation in discriminating signals from neutral events; the latter attributes it to efforts to combat the boredom associated with monotonous vigilance tasks. These opposing views were tested by providing observers with reliable cueing, which rendered observation necessary only when low-probability critical signals were imminent, or with knowledge of results (KR) regarding performance efficiency. On the basis of cue and KR differences in elicited observation activity and motivational value, the direct-cost model led to the anticipation that cueing would result in a high-boredom, low-workload profile and a greater reduction in workload than KR. The indirect-cost model led to the prediction that cueing would result in a high-boredom, high-workload profile and a lesser reduction in workload than KR. The results clearly supported the direct-cost view that the workload of vigilance is task-induced. Consequently, efforts to combat high workload in complex automated systems requiring substantial monitoring by operators should focus specifically upon task-related determinants.

Acoustic Stimulation↗

Situational influences on cues used to judge intoxication.

Subjects' perceptions of cues used to judge intoxication across different drinking settings were investigated. College students (N = 40) were presented with 12 one-paragraph scenarios, four for each of three types of drinking expectancy: tension reduction, social disinhibition and physical impairment. Pilot testing confirmed that the scenarios accurately represented these different expectancies. Subjects rated the importance of 18 cues to intoxication for judging intoxication in each of the 12 scenarios. Results indicated that 15 of the 18 cues were perceived to be differentially important in the three types of situations. These results suggest that subjects apply cues to intoxication differently in different situations.

Adolescent↗

Individual differences in temptation and responses to alcohol cues.

OBJECTIVE: Research on the Temptation and Restraint Inventory has established that the Temptation factor is associated with greater use of alcohol, more alcohol-related problems, and more severe symptoms of alcohol dependence. However, there is little known about the mechanisms by which Temptation may be associated with these higher levels of alcohol involvement. The present study was designed to examine how individual differences in Temptation are associated with responses to alcohol cues. METHOD: Eighty-nine hazardous drinkers were exposed to the sight and smell of their favorite alcoholic beverage, attempted to control their urges, and then participated in a beer taste test. Subjective experience, alcohol-related cognitive processing, and behavioral responses were assessed in the context of these cues. RESULTS: Hierarchical regression analyses showed that Temptation was associated with stronger urges to drink alcohol, greater difficulty controlling urges, and increased alcohol consumption, even when controlling for alcohol consumption in the past month. CONCLUSIONS: The findings suggest that Temptation has utility for predicting responses to alcohol cues among hazardous drinkers even when the effects of typical drinking patterns are accounted for. Moreover, the results suggest that individuals who exhibit high levels of Temptation may be particularly reactive to anticipatory cues for alcohol consumption.

Affect↗

Attention and cue-producing behavior in the monkey.

Explicit cue-producing responses were employed to study attending behavior in the monkey. The subjects learned a discrimination based on compound stimuli, a vertical bar embedded on a red ground versus a horizontal bar on a green ground. On some trials only one of the two stimulus components was presented (red versus green or vertical versus horizontal bar), and the animals had the option of responding on the basis of the component presented or transforming it to the compound discriminanda by means of a cue-producing response. Analysis of the choice and cue-producing response behavior showed that (a) both monkeys acquired the discrimination between the compound cues solely on the basis of the color component, (b) mastery of this discrimination did not confer any "habit loading" (discriminative control) on the bar component, and (c) the monkey may prefer to respond on the basis of one component (color) even though it is capable of using both components equally effectively.

Animals↗

Association of food location with biological cues in the macaque monkey.

Many animal species including humans are endowed with the ability to use biological cues and can extract information by observing other individuals. This study explored whether the macaque monkey could use biological cue to find a hidden target. When the experimenter hid food in one hand and crossed and uncrossed hands quickly, the monkey had no difficulty in finding the food and correctly reached for the baited hand. However, when the food was hidden in one of two cups and the cups were shuffled, the monkey could correctly select the baited cup only at an equal level of luck. These results indicate that the macaque monkey could associate the location of food with a biological cue better than a non-biological cue and keep it in memory when the target was unseen.

Animals↗

Determinants of personal space in young children: perception of distance cues.

Two methods of assessing personal space in young children were examined in a group of 24 boys and 24 girls, aged 3 to 6 yr. When sex of peer figures and affect attributed to them were varied, 3-yr.-olds made distance-cue judgements based on affect but failed to use affect cues in structuring personal space. However, 4- to 6-yr.-olds readily perceived and used distance to communicate the affective quality of peer relations. On both measures, perception of distance cues increased with age. Only girls also used sex of figures as a social cue in depicting appropriate distances.

Affect↗

Interactive effects of musical and visual cues on time perception: an application to waiting lines in banks.

This study explores the interactive effects of musical and visual cues on time perception in a specific situation, that of waiting in a bank. Videotapes are employed to stimulate the situation; a 2 x 3 factorial design (N = 427) is used: 2 (high vs low) amounts of visual information and 2 (fast vs slow) levels of musical tempo in addition to a no-music condition. Two mediating variables are tested in the relation between the independent variables (musical and visual ones) and the dependent variable (perceived waiting time), mood and attention. Results of multivariate analysis of variance and a system of simultaneous equations show that musical cues and visual cues have no symmetrical effects: the musical tempo has a global (moderating) effect on the whole structure of the relations between dependent, independent, and mediating variables but has no direct influence on time perception. The visual cues affect time perception, the significance of which depends on musical tempo. Also, the "Resource Allocation Model of Time Estimation" predicts the attention-time relation better than Ornstein's "storage-size theory." Mood state serves as a substitute for time information with slow music, but its effects are cancelled with fast music.

Adult↗

Supporting independent indoor travel of people with blindness and intellectual disability with reduced frequencies of auditory cues.

This study evaluated the feasibility of supporting independent indoor travel using reduced frequencies of auditory cues with two persons having total blindness and profound intellectual disability. For these persons, who had acquired satisfactory travel performance with cues occurring every 8 sec., the cue frequencies were reduced to one-half or one-third of the original level. Analysis showed that both participants could manage accurate travel under the new cue conditions, even though their travel time (efficiency) seemed negatively affected. Implications of the findings were discussed.

Adolescent↗

Improving accuracy of veracity judgment through cue training.

The ability to make judgments of veracity was investigated to see if training individuals on visual, vocal, or verbal content cues of deception would increase their ability to judge whether a message was truthful. The overall rate of accuracy of judging veracity was significantly greater for subjects trained on verbal content cues. More specifically, for detecting truthful messages, subjects trained on verbal content cues had significantly greater accuracy than subjects who received no cue training, whereas for detecting deceptive messages, there were no significant differences in accuracy among conditions.

Adolescent↗

Effect of conflicting and no conflicting cues on a rule-switching task.

This study investigated effects of stimuli in the dimensional change card-sorting task (DCCS task) of Zelazo and colleagues. There is evidence that young preschoolers' difficulty on this task is caused by conflicting first-phase cues for the target cards, but these findings have not been replicated. We examined whether conflicting first-phase cues for the target cards caused young children's (N=44, M=43.3 mo., SD=2.5) perseveration errors. In the present experiment, we compared a No Conflict condition, in which children did not encounter conflicting first-phase cues, with a Conflict condition (standard task). Analysis indicated that children in the No Conflict condition showed significantly better performance than those in the Conflict condition. This result suggested that children's perseveration errors on the task were, in part, caused by the conflicting first-phase cues for the target cards.

Child Behavior↗

Cue reactivity in addictive behaviors: theoretical and treatment implications.

Several learning theory based models propose that substance users may have conditioned reactions to stimuli (cues) associated with substance use and that these reactions may increase the probability of relapse. The conditioned withdrawal, conditioned compensatory response, and appetitive motivational models were evaluated in light of empirical evidence from cue reactivity studies with alcoholics, smokers, opiate users, and cocaine users. The nature of the stimuli that elicit reactivity and the nature of the responses elicited are most consistent with an appetitive motivational model and do not appear to support the other two models. A few studies have been conducted or are underway that investigate the use of cue exposure with response prevention as a treatment to decrease cue reactivity. Preliminary work with alcoholics, opiate users and cocaine users is promising but insufficient evidence exists to evaluate this approach. The implications for theory and treatment are discussed.

Alcoholism↗

Relative distance cues contribute to scaling depth from motion parallax.

The visual system scales motion parallax signals with information about absolute distance (M. E. Ono, Rivest, & H. Ono, 1986). The present study was designed to determine whether relative distance cues, which intrinsically provide information about relative distance, contribute to this scaling. In two experiments, two test stimuli, containing an equal extent of motion parallax, were presented simultaneously at a fixed viewing distance. The relative distance cues of dynamic occlusion and motion parallax in the areas surrounding the test stimuli (background motion parallax) and/or relative size were manipulated. The observers reported which of the two parallactic test stimuli appeared to have greater depth, and which appeared to be more distant. The results showed that the test stimulus specified, by the relative distance cues, as being more distant was perceived as having more depth and as being more distant. This indicates that relative distance cues contribute to scaling depth from motion parallax by modifying the information about the absolute distance of objects.

Adult↗