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Inhibition of tooth eruption through calcium-phosphate ceramic granules in the rat.

This experiment investigated the reason for disturbances of tooth eruption through hydroxylapatite (HA) granules. HA granules of compact and porous structure were implanted in the pathway of erupting teeth in 14 five-day-old rats. The results demonstrate that the use of this material can result in tooth retention and malformed tooth crowns. Tooth crown malformation can be traced to the formation of ceramo-dentinous complexes which promote bacterial invasion of the pulp cavity, resulting in arrest of the tooth eruption process.

Alveolar Process↗

Bronchioloalveolar carcinoma and the air bronchogram sign: a new pathologic explanation.

Bronchioloalveolar carcinoma (BAC) is one of the few lung tumors known to demonstrate the air bronchogram sign. Production of this valuable radiologic sign by this tumor has been ascribed to an "alveolar" filling process in which tumor grows along alveolar walls with preservation of the architecture and secretes copious amounts of mucus. Thus, aerated bronchi are surrounded by alveoli that are filled with mucus and tumor. We present a case in which the air bronchogram sign and pulmonary consolidation are associated with a nonsecretory BAC. Alternative mechanisms that may produce the air bronchogram sign in BAC are offered.

Adenocarcinoma, Bronchiolo-Alveolar↗

In vitro evaluation of extracts of mineralized tissues for their application in attachment of fibrous tissue.

A primary objective in the treatment of periodontal diseases is attachment of fibrous tissue to root surfaces. An in vitro method was used to evaluate agents for their potential in enhancing this attachment process. Guanidine EDTA protein extracts of alveolar bone, cementum, and dentin in culture media were added to petri dishes and incubated at 37 degrees C for 1 hour. Human gingival fibroblasts were added to the dishes and incubated for an additional 90 minutes. Following incubation, cells attaching to the dish were quantified electronically, using a Coulter Counter. Extracts of alveolar bone and cementum enhanced cell attachment while dentin extract had no effect. These results indicate that both cementum and bone contain attachment proteins which could prove beneficial for attachment of fibrous tissue to root surfaces.

Alveolar Process↗

Enhancement of the damaged edentulous ridge to receive dental implants: a combination of allograft and the GORE-TEX membrane.

A severely damaged edentulous ridge frequently obviates the placement of dental implants or results in placing them at an angle that compromises the prosthetic restoration. This paper demonstrates the repair of severely resorbed edentulous ridges by a combination of bone allografting and the placement of a barrier membrane. The damaged edentulous ridge is treated first in this two-stage process. The implants are then installed at a second surgery.

Adult↗

Ridge preservation utilizing an alloplast prior to implant placement--clinical and histological case reports.

A calcified copolymer alloplast (Bioplant HTR, Bioplant Inc., South Norwalk, CT) was utilized to fill osseous defects in five patients. Hard tissue cores were obtained from the grafted sites and prepared for biopsy. In one patient, the lining of a soft tissue flap was biopsied 8 months postgrafting. Histological evaluation of the specimens revealed that the copolymer particles placed adjacent to the bony defect walls served as an osteoconductive material in which vital remodeling bone and marrow formed and fused to the surface of the particles. This process of bone deposition and remodeling was present 11 years following grafting.

Adult↗