[Determination and elimination of N-acetyl-p-aminophenol depending on kidney function following administration of phenacetin].
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This study assessed the effects of resistive training (RT) with or without chromium picolinate (Cr-pic) supplementation on the 24-h urinary excretions of myo-inositol, D-chiro-inositol, and pinitol, as well as clinical indices of kidney and liver functions. Thirty-two nondiabetic subjects, age 62 +/- 4 y, performed RT twice weekly for 12 wk and consumed either 924 ug Cr/d as Cr-pic (n = 17) or a placebo (n = 15). Whole-body strength increased in all subjects by 20 % and urinary chromium excretion increased 47-fold in the Cr-pic group. Urinary myo-inositol, D-chiro-inositol, and pinitol were not changed with RT or influenced by Cr-pic. Serum indices of kidney and liver functions were within clinically normal ranges at baseline and the end of the study. These results suggest that RT did not influence the urinary excretions of inositols. High dose Cr-pic did not influence the urinary excretion of inositols and the selected indices of kidney and liver functions in conjunction with RT.
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In patients with acute destructive pancreatitis, the kidney lesion is conditioned by pronounced volemic disorders, and damage of renal parenchyma resulting from the action of enzymes and toxic metabolites as well. Their effective elimination by means of hemosorption performed in supplementation of the circulating blood and plasma volumes leads to rapid normalization of functional state of the kidneys, thus facilitating reduction of lethality, shortening of the duration of treatment and rehabilitation of the patients. In destructive pancreatitis, the performance of repeated hemosorption after 24-48 h is indicated.
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