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At least 1,153 records · Page 64Linked to original sources
PubMed1988

[Immunogenetic examination of families with consanguineous marriages].

14 Uzbek cousin-marriage families have been immunologically examined. 13 persons have been identified, who are probably homozygous in HLA-D region (the results of the reaction in mixed lymphocyte culture). The members of cousin-marriage families, as compared to healthy Russian donors, had lower proliferative response to phytohemagglutinin and concanavalin A and decreased indexes of concanavalin A-induced suppression and natural killer activity against K562 targets (in children). At the same time natural killer activity in adults, T- and B-lymphocyte content and IgM, IgG and IgA levels are similar to the respective indexes in Russian donors.

Adult↗
PubMed1979

[Distribution and function of immunogenetic markers on epidermal cells].

Gene products of the major histocompatibility complex (MHC) are vital for the regulation of immunocompetent cell interactions and, thus, of the entire immune response. In this report, we describe the distribution of these MHC-encoded alloantigens on epidermal cells of different species and discuss their potential role in the generation of epidermal immune reactions.

Animals↗
PubMed1988

Immunogenetic and racial determinants of gold toxicity in rheumatoid arthritis.

Typing for antigens HLA-A,B,C and DR was performed on 165 rheumatoid arthritis patients (14 black, 151 white) who had received gold therapy to determine the relationship between HLA antigens and gold dermatitis, stomatitis, thrombocytopenia, and proteinuria. Dermatitis and stomatitis occurred in both black and white patients. Thrombocytopenia and proteinuria occurred only among the white patients studied. The absence of thrombocytopenia and proteinuria among the black patients was not statistically significant. Antigen HLA-DR7 was uncommon among black and white subjects with dermatitis (0 of 6 blacks, 4 of 48 whites), but this decrease in frequency was not statistically significant. Antigen HLA-DR3 was an important risk factor for thrombocytopenia (relative risk = 11.8, P = .0043) and proteinuria (RR = 5.8, P = .032). These results are consistent with previous studies of HLA-DR3 and gold toxicity. The only black patient with stomatitis possessed the A1B8DR3 phenotype. Future studies should examine whether the same HLA antigen confers risk of different gold toxicities in different racial groups, and whether there are HLA antigens that provide a protective effect.

Arthritis, Rheumatoid↗
PubMed1988

Immunogenetics of type II collagen autoimmunity and susceptibility to collagen arthritis.

The MHC restriction of the antibody response and development of arthritis after immunization with autologous or heterologous type II collagens in mice have been investigated. Mice from three different H-2q-carrying strains (DBA/1, NFR/N and B10.G) with different non-MHC genes, as well as B10-congenic strains carrying wild type H-2q-related or H-2r haplotypes, were susceptible for collagen arthritis. All strains tested developed an antibody response cross-reacting with autologous type II collagen after immunization with heterologous type II collagen; H-2q predisposes for a high response against chick, rat and bovine type II collagen, H-2r and H-2b for a high response against bovine type II collagen. Only mouse strains with H-2q, H-2r, H-2w3 or H-2w17 were responders to mouse type II collagen, and only these strains developed arthritis after immunization with heterologous or autologous type II collagens. These findings indicate that the ability to mount an immune response against autologous type II collagen is a prerequisite for the susceptibility to collagen arthritis. A cross-reactive autoimmune response after immunization with various heterologous type II collagen may enhance further the development of arthritis.

Animals↗
PubMed1988

Mithun cross siri hybrids: cyto- and immunogenetic examinations and characterisation of abnormal spermatogenesis.

Cytogenetic studies of the mithun (Bos frontalis), the siri (Bos indicus) and their hybrids, as well as histological examinations of testes and epididymis of siri and hybrids were undertaken to throw further light on male hybrid infertility and interspecies incompatibility, in order to facilitate the possible development of a stable interspecies crossbreed which would be similar to the highly profitable jatsum, the female mithun cross siri hybrid. In both species there are distinct centromeric heteromorphisms which should provide a rich source of genetic markers for tracing chromosomes in controlled hybrid programmes. The nucleolar organisers in the F1 hybrids were derived from both parents, in contrast to other interspecies hybrids where the nucleolar organisers of one species tend to be suppressed by the other. This indicates a relatively close relationship between mithun and siri and supports the prospect of success for developing a stable crossbreed. Transferrins which may also be a useful source of genetic markers were identified and differences between siris and mithuns noted, especially in the D-bands. No A-bands were found in the siris and no E-bands in the mithuns. Whether this is a breed or species characteristic will have to be confirmed by examination of more animals. The findings on blood groups and haemoglobins, including differences between the two species, were similar to results obtained previously. In meiosis the sex vesicles were intact which indicates that infertility and incompatibility factors should be located in autosomes. In cytogenetic and histological examinations the testes of the siris were comparable to those of European cattle, while in all hybrids spermatogenetic activity was deficient although there were great differences between and within generations. While the exact mechanism of this diversity is not known at this stage, it should make it possible to select for increased male hybrid fertility which would be a prerequisite for developing a stable interspecies crossbreed. This selection would be facilitated by correlating infertility and incompatibility with genetic profiles and markers. A mithun cross siri crossbreed would also serve as a model for other interspecies breeding.

Animals↗
PubMed1988

[Immunogenetic markers of disseminated sclerosis in western Siberia].

The contents of class 1 HLA antigens was compared in patients with disseminated sclerosis, their first-grade relatives and healthy donors. Patients, as compared to healthy persons, had higher occurrence rate of A1, A9, B7, A0/B0, A9/B7, A1/B7, A1/B12, A2/B7, B7, 27, B5, 0, B7, 12, B7, 15, B5, 7, and lower A28, B13, Bw22, B35, 40, B7, 35, A2, w19, A0/B35, A0/B13, A2/B15, A3/B35. In male patients, as compared to female patients, B40 and A1/B15 were more frequent, and B12 less frequent. The subgroup of patients with the diseases onset before 20 years considerably differed from other patients in their rates of A1, A1, 2, A1w19, A1/B0 increased and A3 and A9/B17 decreased. Compared to donor group, the patients' relatives had differences similar to those between patients and relatives. High relative risk values were characteristic of some of the above associations.

Adult↗
PubMedDate not supplied

HBsAg positive secondary autoimmune active chronic hepatitis. Immunogenetic aspects.

Observations were made in a group of 120 patients with active chronic hepatitis (ACH), using demonstration of HBsAg presence, structural study of the peripheral blood mononuclear cell population by means of scanning electron microscopy (SEM) and typing of HLA-A, B and C antigens. From the whole group 22 patients were proved to have an autoimmune form of ACH secondary to infection with hepatitis B virus (HBV). The authors consider that the diagnostic value of the ratio between B and T lymphocytes (studied by SEM) is relative but the demonstration of an increased percentage of monocytomacrophage cells and the presence of "killing phenomenon" clearly reflect a more severe hepatic inflammation. A higher incidence of the HLA-Bw35-Cw4 was observed particularly in the HBsAg positive forms of ACH and in the HBsAg positive secondary autoimmune forms. The authors discuss the utility of these observations when the opportunity of corticotherapy has to be established.

Adult↗
PubMedDate not supplied

Immunological and immunogenetic investigation of recurrent spontaneous abortion.

Investigations have been performed in 80 couples with unexplained recurrent spontaneous abortions and no live birth (1 degree RSA), as well as in 33 couples with unexplained RSA following one live birth (2 degrees RSA), compared with control couples with no history of repeated early pregnancy failure. A significant bias towards a family history was given for 1 degree RSA women. Elevated total serum IgE levels and tissue-reactive autoantibodies were not significantly more prevalent in the RSA groups, and both 1 degrees and 2 degrees RSA patients had a similar incidence of serum lymphocytotoxic antibody. HLA typing indicated a trend towards parental HLA sharing which did not achieve clear significance at any locus, whereas there was significant apparent HLA-B locus homozygosity for 1 degree RSA women. An elevated prevalence of HLA-A2, B12 haplotypes was also noted for 2 degrees RSA, which may indicate some form of linkage disequilibrium in this population. These results, overall, did not provide evidence to identify a major subgroup of unexplained RSA patients.

Abortion, Habitual↗