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PubMed2001

Correspondence re: Y. Yamada et al., frequent beta-catenin gene mutations and accumulations of the protein in the putative preneoplastic lesions lacking macroscopic aberrant crypt foci appearance, in rat colon carcinogenesis. Cancer Res., 60: 3323-3327, 2000; and sequential analysis of morphological and biological properties of beta-catenin-accumulated crypts, provable premalignant lesions independent of aberrant crypt foci in rat colon carcinogenesis. Cancer Res., 61: 1874-1878, 2001.

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Animals↗
PubMed1992

[Intracellular bile acid activities in colon cancer and normal colon mucosa].

Bile acids are thought to be involved in the etiology and development of colo-rectal cancers. In this study, the intracellular bile acid activities both in colo-rectal cancers and normal colo-rectal mucosa in 12 patients were measured with a new bile acid ion selective microelectrodes. The results demonstrated that bile acid activities of colo-rectal mucosa cells were 5.0 +/- 3.7 x 10(-5) mol/L and those in colo-rectal cancer cells were 17.6 +/- 9.6 x 10(-5) mol/L, which is three times as high. This demonstrates that bile acids are closely related to the development of colo-rectal cancers. The intracellular bile acid activities remain stationary with age and sex.

Adult↗