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Validity of methods for model selection, weighting for model uncertainty, and small sample adjustment in capture-recapture estimation.

In log-linear capture-recapture approaches to population size, the method of model selection may have a major effect upon the estimate. In addition, the estimate may also be very sensitive if certain cells are null or very sparse, even with the use of multiple sources. The authors evaluated 1) various approaches to the issue of model uncertainty and 2) a small sample correction for three or more sources recently proposed by Hook and Regal. The authors compared the estimates derived using 1) three different information criteria that included Akaike's Information Criterion (AIC) and two alternative formulations of the Bayesian Information Criterion (BIC), one proposed by Draper ("two pi") and one by Schwarz ("not two pi"); 2) two related methods of weighting estimates associated with models; 3) the independent model; and 4) the saturated model, with the known totals in 20 different populations studied by five separate groups of investigators. For each method, we also compared the estimate derived with or without the proposed small sample correction. At least in these data sets, the use of AIC appeared on balance to be preferable. The BIC formulation suggested by Draper appeared slightly preferable to that suggested by Schwarz. Adjustment for model uncertainty appears to improve results slightly. The proposed small sample correction appeared to diminish relative log bias but only when sparse cells were present. Otherwise, its use tended to increase relative log bias. Use of the saturated model (with or without the small sample correction) appears to be optimal if the associated interval is not uselessly large, and if one can plausibly exclude an all-source interaction. All other approaches led to an estimate that was too low by about one standard deviation.

Bayes Theorem↗

Pitfalls and modelling inconsistencies in computational radiation dosimetry: lessons learnt from the QUADOS intercomparison. Part I: Neutrons and uncertainties.

The QUADOS EU cost shared action conducted an intercomparison on the usage of numerical methods in radiation protection and dosimetry. The eight problems proposed were intended to test the usage of Monte Carlo and deterministic methods by assessing the accuracy with which the codes are applied and also the methods used to evaluate uncertainty in the answer gained through these methods. The overall objective was to spread good practice through the community and give users information on how to assess the uncertainties associated with their calculated results.

Bayes Theorem↗

The hidden truths of the belly: the uncertainties of pregnancy in early modern Europe. (Society for the Social History of Medicine Student Prize Essay 1999, runner-up.).

For early modern men and women and their medical practitioners, the experience and understanding of pregnancy was primarily uncertain. This uncertainty extended to the whole process of pregnancy--from the moment of conception to delivery, the detection and bearing of a 'true fruit' was doubtful. This 'uncertainty' was heightened by the fact that both body and language could conceal the truth. The woman herself was frequently uncertain and could be mistaken in her interpretation of the condition of her belly. This ambiguity is expressed in the vague and faltering language used to describe such experiences. Women's bodies were believed to conceal the truth more readily than their male counterparts. Equally a woman's physical narrative was more likely to be distrusted. Tensions surrounding the appropriate nature of women's 'knowledge' of such hidden 'secrets' also affected the ways in which women and their practitioners described the 'truths' of the belly. This article traces the ambiguities faced by women and their midwives/accoucheurs through three areas of pregnancy: quickening, false conceptions, and the threat of miscarriage. The much-neglected source of medical texts and observations is drawn upon, alongside letters and diaries and judicial material.

Diagnosis↗

Uncertainty in knowing the operating rooms in which cases were performed has little effect on operating room allocations or efficiency.

UNLABELLED: At many US surgical facilities, applying the previously published method that maximizes the efficiency of use of operating room (OR) time is an effective way to optimize the allocation of OR time. Results are resistant to small errors in recorded OR times. However, at some facilities, the OR information systems data have as much as a 10% error in the correct OR where each case took place. This decreases the total OR time attributed to each service, which is the basis for the allocation method. Such errors could result in incorrect OR allocations and increased OR staffing costs. Expensive and time-consuming data-cleaning steps may be required to resolve the actual OR allocation for each case. We used 1 yr of data from a large, tertiary academic hospital to investigate, through simulation, how increasing levels of error in the correct OR affect OR efficiency and allocations. To apply noise to the data, the actual ORs were changed randomly to unique, "unknown" rooms. At a 30% error level, OR allocations decreased by 4.8%, and costs increased by 1.4% relative to knowing the actual location of every case. Only 1 of 11 surgical services had an allocation decrease at room error rates of less than 25%. We conclude that, in most circumstances, data-cleaning steps to resolve uncertainty in OR locations are not necessary to make accurate OR allocations. IMPLICATIONS: Up to a 30% uncertainty in knowing the actual operating room (OR) in which cases were performed had a minor effect on OR allocations to maximize OR efficiency and on the resulting staffing costs. Thus, facilities with this common error in their OR information systems data will generally be able to use their existing data for accurate OR allocations.

Efficiency↗

A Bayesian analysis or scientific judgment of uncertainties in estimating risk due to 222Rn in U.S. public drinking water supplies.

The elements which contribute to the range of values or uncertainties for the lifetime risk and dose equivalent due to 222Rn in U.S. public drinking water supplies are estimated and discussed here. From imperfect scientific knowledge, reasonable upper and lower bounds are placed on these estimates through the use of a semiquantitative Bayesian approach to uncertainty analysis. The factors considered are: occurrence of 222Rn in drinking water, indoor air 222Rn concentrations as a function of drinking water concentration, equilibrium state of the progeny, fraction of daughter products attached to aerosol particles, anatomical and dosimetric variables, epidemiological studies and choice of latency period, plateau period and effects of age. For Rn in U.S. public drinking water supplies, it is estimated that the best estimate for the lifetime lung cancer risk factor is 5 X 10(-9) excess cases of lung cancer per becquerel of Rn per m3 of water (2 X 10(-7) excess cases of lung cancer per picocurie of Rn per liter of water), with an estimated range between 2 X 10(-9) and 2 X 10(-8) excess cases per becquerel of Rn per m3 of water (5 X 10(-8) and 7 X 10(-7) excess cases per picocurie of Rn per liter). The best estimate of the lifetime population risk due to 222Rn in U.S. public drinking water supplies is estimated to be 6,000 excess lung cancers, with a reasonable range of 1,000 to 30,000.

Air Pollutants, Radioactive↗

Measurement uncertainties of long-term 222Rn averages at environmental levels using alpha track detectors.

More than 250 replicate measurements of outdoor Rn concentration integrated over quarterly periods were made to estimate the random component of the measurement uncertainty of Track Etch detectors (type F) under outdoor conditions. The measurements were performed around three U mill tailings piles to provide a range of environmental concentrations. The measurement uncertainty was typically greater than could be accounted for by Poisson counting statistics. Average coefficients of variation of the order of 20% for all measured concentrations were found. It is concluded that alpha track detectors can be successfully used to determine annual average outdoor Rn concentrations through the use of careful quality control procedures. These include rapid deployment and collection of detectors to minimize unintended Rn exposure, careful packaging and shipping to and from the manufacturer, use of direct sunlight shields for all detectors and careful and secure mounting of all detectors in as similar a manner as possible. The use of multiple (at least duplicate) detectors at each monitoring location and an exposure period of no less than one quarter are suggested.

Air Pollutants↗

Uncertainty and variability in updated estimates of potential dose and risk at a U.S. nuclear test site--Bikini Atoll.

Uncertainty and interindividual variability were assessed in estimated doses for a rehabilitation scenario for Bikini Island at Bikini Atoll, in which the top 40 cm of soil would be removed in the housing and village area, and the rest of the island would be treated with potassium fertilizer, prior to an assumed resettlement date of 1999. Doses were estimated for ingested 137Cs and 90Sr, external gamma-exposure, and inhalation+ingestion of 241Am + 239+240Pu. Two dietary scenarios were considered: imported foods are available (IA); imported foods are unavailable with only local foods consumed (IUA). After approximately 5 y of Bikini residence under either IA or IUA assumptions, upper and lower 95% confidence limits on interindividual variability in calculated dose were estimated to lie within a approximately threefold factor of its in population-average value; upper and lower 95% confidence limits on uncertainty in calculated dose were estimated to lie within a approximately twofold factor of its expected value. For reference, the expected values of population-average dose at age 70 y were estimated to be 16 and 52 mSv under IA and IUA dietary assumptions, respectively. Assuming that 200 Bikini resettlers would be exposed to local foods (under both IA and IUA assumptions), the maximum 1-y dose received by any Bikini resident is most likely to be approximately 2 and 8 mSv under the IA and IUA assumptions, respectively. Under the most likely dietary scenario, involving access to imported foods, this analysis indicates that it is most likely that no additional cancer fatalities (above those normally expected) would arise from the increased radiation exposures considered.

Animals↗

Hot particle detection using uncertainties in activity measurements of soil.

The uncertainty in gamma spectroscopic activity measurements is investigated for soil containing hot particles. A radioactivity inhomogeneity uncertainty needs to be taken into account, which depends on the density of hot particles in the sample geometry, the distribution of their activities, and the specific source-detector geometry. The maximum activity error due to hot particles in our sampled Chernobyl soil with a 137Cs activity of 100 kBq kg(-1) soil was 6% for our source detector geometry. The methodology presented might have a practical application in nuclear power plants to detect hot particles in a large quantity of dust or dirt. The number of hot particles present can be estimated if the activity of all particles is assumed to be similar. With this assumption 100 g of the investigated soil sample would contain about 500 hot particles with an approximate activity of 20 Bq each.

Computer Simulation↗

Age-specific uncertainty of the 131I ingestion dose conversion factor.

The production of weapons-grade nuclear materials and their by-products has resulted in a number of releases from United States Department of Energy facilities. 131I, a fission by-product, is one of the most common radionuclides generated and released to the environment. It is known that there are differences in various physiological parameters over all age groups when considering biokinetic modeling of iodine. The establishment of age-specific dose conversion factor uncertainty is necessary for accurate internal dose assessment. The 131I dose conversion factor determined herein is log-normally distributed with varying age-specific distribution characteristics. The two most important parameters for determination of the dose conversion factor, in all age groups, are thyroid mass and iodine uptake fraction. These parameters are assumed to be highly correlated with a relationship that is quite important to dose conversion factor uncertainty. Dose estimates to individuals exposed to radioiodine can be determined more accurately with an increased understanding of the correlation between thyroid mass and uptake fraction. Improved dose estimates following oral intakes of 131I can be made from the consideration of age-specific dose conversion factors and their input parameters.

Administration, Oral↗

An estimate of spatial uncertainty of mean concentrations predicted by Gaussian dispersion models.

Atmospheric dispersion models based on statistical theory predict the stochastic mean concentration at fixed points downwind. The uncertainty in the computed concentration, often expressed as a peak-to-mean ratio, is known to vary between two and five for Gaussian dispersion models. This paper shows that this can be correlated to uncertainty in the predicted location of a fixed concentration, and that in the centerline of the plume it is related to sigma(theta), the standard deviation of the observed horizontal wind direction. Practical formulae and methods are given that may be applied in the post-dispersion calculation phase of the risk assessment to ascertain the likely hazard zones.

Air Pollution, Radioactive↗

Testing an uncertainty model for women with multiple sclerosis.

This study sought to explain adaptation to the uncertainty of multiple sclerosis (MS) in women. A casual model, developed from the literature and from interviews with four women with MS, was tested on a sample of 90 women with MS. Successful adaptation was measured by self-esteem and mastery. The model accounted for 26% of the variance in mastery, with an empirical model accounting for a higher degree of variance (41%). Findings suggest that the negative impact of uncertainty in women with MS is significantly reduced by their spiritual and social relationships.

Adaptation, Psychological↗

Uncertainty about the clinical detection of sepsis.

Clinicians use clinical symptom, blood culture, and central venous catheter (CVC) culture data to detect CVC-related sepsis. The lack of clear and consistent definitions for what constitutes accurate clinical symptom assessments, coupled with the different combinations for blood and CVC culture results, contribute to clinicians' uncertainty about the presence of CVC-related sepsis. When clinical symptoms do not correlate with laboratory culture results, patients are exposed to risks associated with CVC manipulation and inappropriate antibiotic therapy. Clinicians must recognize the sources of uncertainty when assessing patients for CVC-related sepsis.

Bacteriological Techniques↗

Uncertainty and the role of the credible authority during an ostomy experience.

The associated stress of an ostomy experience can threaten a patient's security and sense of control. One major stressor is the influence of uncertainty, when patients lack a clear perception of what will happen and are unable to define meaning or personally interpret information bombarding them from the complex health care system. Mishel's Uncertainty in Illness Theory offers the ET nurse a practical framework for understanding how the patient attaches meaning to illness cues and how the ET nurse can positively affect the desired adaptation process. Because the patient trusts the ET nurse's expertise and experience, the nurse can help the patient to understand the ostomy experience and perceive its structure. As a credible authority, the ET nurse has the expert power to facilitate patient coping and adaptation by minimizing ambiguity through individualized education, counseling, and support while simultaneously constructing a sense of order and predictability for both patient and family.

Attitude to Health↗

A modified ICRP 66 iodine gas uptake model and its parametric uncertainty.

Intakes via inhalation may occur from radionuclides released in the form of a gas. The chemical characteristics pertaining to the release influence the intake and subsequent dose to an exposed individual. Gases are taken up or absorbed in the entire respiratory tract and the associated uptake mechanisms are quite different from deposition of particulates. Gaseous iodine can exist in various chemical forms, e.g., elemental iodine, inorganic, and organic iodine compounds. These different chemical species play an integral role in the gaseous uptake o f iodine in t he respiratory tract. Gas uptake in the various regions of the respiratory tract results in the intake of iodinated material into the body. The radioactive iodine taken up in the gas-exchange tissues is absorbed into the bloodstream of an individual and subsequently transferred to other organs. Iodine in the circulatory system can then be taken up by the thyroid gland, with resulting dose to the thyroid. The magnitude and uncertainty in regional gas uptake is important in the assessment of individuals exposed to airborne releases of radioiodine. The current ICRP 66 model is rudimentary and estimates regional gas uptake based on solubility and reactivity of the different radionuclides entering the respiratory tract. The modified model proposed here employs methodology and a mathematical structure to determine estimates of fractional gas uptake rather than defaulting to literature values, as in the current ICRP model. Model parameters have been assigned input distributions and estimates of uncertainty have been determined. A sensitivity analysis of these parameters has been performed to demonstrate the importance of each of these parameters. The sensitivity analysis ranks the model-input parameters by their importance to estimates of regional gas uptake. The model developed herein may be used for improved estimation of gas uptake in the respiratory tract and subsequent dose estimates from the different chemical forms of radioiodine.

Adult↗

Fitting bioassay data and performing uncertainty analysis with BIOKMOD.

We have developed a computer code called BIOKMOD that we have applied to analyze several sources of uncertainties in the evaluation of internal exposures using bioassay data: (1) Multiple constant and random intakes in occupational exposures taking into account periods without intake (weekends, holidays, etc.) are evaluated, and they are compared with chronic intakes showing that the chronic approximation is not always good; (2) An analytical method to evaluate the statistical uncertainties associated with the biokinetic model is described; and (3) Non linear techniques are applied to estimate intakes using bioassay data, where not only the quantities taken in are assumed unknown but also other non linear parameters (AMAD, f1, etc). The methods described are accompanied with examples. Some of the most usual features of BIOKMOD can be run directly, using BIOKMODWEB, at the Web site: http://www3.enusa.es/webMathematica/Public/biokmod.html .

Algorithms↗

Role of uncertainty in sensorimotor control.

Neural signals are corrupted by noise and this places limits on information processing. We review the processes involved in goal-directed movements and how neural noise and uncertainty determine aspects of our behaviour. First, noise in sensory signals limits perception. We show that, when localizing our hand, the central nervous system (CNS) integrates visual and proprioceptive information, each with different noise properties, in a way that minimizes the uncertainty in the overall estimate. Second, noise in motor commands leads to inaccurate movements. We review an optimal-control framework, known as 'task optimization in the presence of signal-dependent noise', which assumes that movements are planned so as to minimize the deleterious consequences of noise and thereby minimize inaccuracy. Third, during movement, sensory and motor signals have to be integrated to allow estimation of the body's state. Models are presented that show how these signals are optimally combined. Finally, we review how the CNS deals with noise at the neural and network levels. In all of these processes, the CNS carries out the tasks in such a way that the detrimental effects of noise are minimized. This shows that it is important to consider effects at the neural level in order to understand performance at the behavioural level.

Humans↗

Combining control measures for more effective management of fisheries under uncertainty: quotas, effort limitation and protected areas.

We consider combinations of three types of control measures for the management of fisheries when the input information for policy decisions is uncertain. The methods considered include effort controls, catch quotas and area closures. We simulated a hypothetical fishery loosely based on the Icelandic cod fishery, using a simple spatially explicit dynamic model. We compared the performance with respect to conserving the resource and economic return for each type of control measure alone and in combination. In general, combining more than one type of primary direct control on fishing provides a greater buffer to uncertainty than any single form of fishery control alone. Combining catch quota control with a large closed area is a most effective system for reducing the risk of stock collapse and maintaining both short and long-term economic performance. Effort controls can also be improved by adding closed areas to the management scheme. We recommend that multiple control methods be used wherever possible and that closed areas should be used to buffer uncertainty. To be effective, these closed areas must be large and exclude all principal gears to provide real protection from fishing mortality.

Animals↗

Entropy and local uncertainty of data from sensory neurons.

We present an empirical comparison between neural interspike interval sequences obtained from two different kinds of sensory receptors. Both differ in their internal structure as well as in the strength of correlations and the degree of predictability found in the respective spike trains. As a further tool in this context, we suggest the local uncertainty, assigning a well-defined predictability to individual spikes. The local uncertainty is demonstrated to reveal significant patterns within the interspike interval sequences, even when its overall structure is (almost) random. Our approach is based on the concept of symbolic dynamics and information theory.

Animals↗