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At least 1,153 records · Page 64Linked to original sources
PubMed1982

Effects of diazo-oxo-norleucine on cell kinetics and odontoblast differentiation in cultured embryonic mouse molars.

Diazo-oxo-norleucine (DON), an analogue of glutamine, prevented odontoblast differentiation in cultured tooth germs. Diazo-oxo-norleucine added after the onset of odontoblast differentiation, did not affect the secretion of predentine or the functional differentiation of ameloblasts. DON decreased explant volume and modified cell kinetics, decreasing mitotic index, labelling index and number of grains per nucleus; the 5 phase of the cell cycle was lengthened. These modifications of cell kinetics should be considered when interpreting the effects of DON on odontoblast differentiation.

Animals↗
PubMed1986

A study of post-secretory maturation ameloblasts in the cat by transmission and freeze-fracture electron-microscopy.

Permanent canine and molar tooth germs of kittens were processed for thin-sectioning and freeze-fracture replication. Maturation ameloblasts were divided into ruffle-ended (RA), smooth-ended (SA) and intermediate (IA). RA had an extensive distal ruffled border consisting of deep membrane invaginations, forming complicated extracellular channels. Adjacent RA were connected by extensive distal junctional complexes (zonulae occludentes). The SA had flattened distal cell surfaces and few coated and smooth vesicles in the distal cytoplasm. Adjacent SA were connected by proximal zonulae occludentes, but had only maculae occludentes at their distal ends so permitting broad lateral extracellular spaces to communicate directly with the enamel surface. IA near the RA layer had a ruffled border consisting of deep and narrow membrane invaginations and pinosomes filled with granular material. IA next to the SA layer had no ruffled border but had pinosomes that seemed to originate directly from the distal cell surfaces. IA were polarized and connected by proximal and distal junctional complexes consisting of either zonulae or fasciae occludentes and associated gap junctions.

Ameloblasts↗
PubMed1989

Differentiation of odontoblasts in grafted recombinants of murine epithelial root sheath and dental mesenchyme.

The epithelial root sheath (ERS) was isolated from first molars of 5-day-old post-natal CD-1 mice using trypsin. After isolation, ERS cells remained viable in vitro and immunohistochemical examination of cultures confirmed the epithelial phenotype and the absence of mesenchymal contamination. Recombinants of isolated ERS and dental papilla resulted in odontoblast differentiation within cells of the dental papilla, and the formation of root-like fragments of dentine after 2 weeks of intra-ocular grafting. These findings indicate the inductive influence of the ERS on dental papilla cells.

Animals↗