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At least 1,153 records · Page 64Linked to original sources
PubMed2000

Prostaglandin E2 predominantly induces production of hepatocyte growth factor/scatter factor in human dental pulp in acute inflammation.

Hepatocyte growth factor (HGF), which is also known as the scatter factor, is a broad-spectrum and multifunctional cytokine, mediates epithelial-mesenchyme interaction, and is shown to be involved in the development and regeneration of various tissues, including tooth. Here, we report that HGF was present in adult human dental pulps, and its levels increased during acute inflammation of the tissue. Levels of HGF mRNA in dental pulps also increased with inflammation, as determined by reverse-transcription/polymerase chain-reaction. The production of HGF in fibroblasts from dental pulps in culture was dose-dependently stimulated by inflammatory cytokines such as interleukin (IL)-1alpha and tumor necrosis factor (TNF)-alpha, and by prostaglandin (PG) E2, as determined by an enzyme-linked immunosorbent assay. We also showed that indomethacin did not affect the increase in HGF production by the cells with IL-1alpha, TNF-alpha, and PGE2. The levels of HGF mRNA in the cells were simultaneously increased by these stimulants, as determined by Northern blotting. Since the production of PGs is known to increase at the beginning of inflammation, PGE2 may be involved in the regeneration of dental pulps by the induction of HGF expression after inflammation.

Adolescent↗
PubMedDate not supplied

Primate pulpal response to ultraviolet light-polymerized direct-bonding material systems.

The results of this study, plus those of a previous study, show that a layer of CaOH lining the floor of the tooth cavity will protect the dental pulp against toxic irritants inherent to an UV light-polymerized cavity liner and a UV light-polymerized composite restorative resin. This study also showed that a layer of CaOH lining the floor of the cavity will protect the dental pulp against acid irritants inherent in the enamel etching solution. It is recommended to restorative dentistry that all primary dentin within clinically accessible areas of the cavity preparation be covered with a layer of CaOH before the enamel is etched with the acid-conditioning solution. Precautionary protection of primary dentin in this manner affords a margin of safety should the conditioning solution inadvertently spill onto the primary dentin during the enamel-etching procedure. Second, if the conditioning solution does accidentally spill onto the previously placed protective layer of CaOH during the enamel-etching procedure, then it logically follows that this acid-contaminated layer of CaOH should be mechanically removed and a new layer of CaOH that completely lines at least the floor of the tooth cavity should be placed before the resins are applied.

Acid Etching, Dental↗
PubMed1977

Morphological changes in lymphatic vessels in pulpal inflammation.

Noncarious, carious, and restored human teeth obtained from individuals 20 to 65 years of age were used to study the differences in lymphatic drainage between healthy and inflamed pulps. In carious teeth, the lymphatic vessels located within and/or surrounding the inflammatory lesion were distended, a situation not demonstrable in pulps of noncarious and restored teeth.

Adult↗
PubMed1978

Bacterial penetration, pulpal reaction and the inner surface of Concise enamel bond. Composite fillings in etched and unetched cavities.

The sealing properties of resin-composite resin material applied to acid-etched cavities and adjacent enamel were studied in 40 contralateral tooth pairs. This treatment was found to reduce considerably the risk of ingrowth of microorganisms from the surface of the tooth. The resin material did not have any appreciable irritative effect on the pulp; the same was true for the etching procedure. Etching of lateral enamel walls and margins with an acid gel after the application of a liner on dentinal walls was considered to be the procedure recommended before the application of the combination of unfilled resin and composite resin.

Acid Etching, Dental↗