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[Effect of the early postnatal induction of microsomal enzymes on their activity and the cholesterol content in the blood of adult mice from a hypercholesteremic line].

Activity of microsomal enzymes and the patterns of cholesterol metabolism were studied in mice of WSR/y strain, characterized by spontaneous development of atherosclerosis within the later periods of life, after early postnatal administration of an inductor of the enzymes 3-acetate-16 alpha-isothiocyanopregnenolone (ATCP). Administration of ATCP into newborn mice of SWR/y strain, from the 2nd up to 16th day after birth, led to a stable increase in activity of arylhydrocarbonate hydroxylase (an enzyme participating in unspecific metabolism of drugs), which was observed during the whole experimental period (4 months). The treatment with ATCP caused also a distinct increase in activity of cholesterol-7 alpha-hydroxylase (a key enzyme of cholesterol biotransformation and elimination) as well as a considerable decrease in content of cholesterol and lipoprotein atherogenic fractions in blood serum. The rate of cholesterol biosynthesis was similar both in mice treated with ATCP and in the control animals.

Age Factors↗
PubMed1984

Induction of malic enzyme in explants of human adipose tissue by L-3,5,3'-triiodothyronine.

The influence of L-3,5,3'-triiodothyronine (triiodothyronine), dexamethasone and insulin on malic enzyme was investigated in cultures of explants of adipose tissue from mammae of healthy female subjects. The enzyme was present mainly in adipose tissue; connective tissue possessed very low activity. After preincubation of explants of adipose tissue from five different subjects for 96 h to deplete endogenous thyroid hormones addition of triiodothyronine (final concentration 1.0 microM) stimulated enzyme activity by 16 to 72%. Dexamethasone (170 nM) increased enzyme activity by 32%; a combination of triiodothyronine and dexamethasone did not lead to an increase beyond that observed for dexamethasone alone. Insulin (final concentration 0.7 I. U./ml) alone stimulated malic enzyme activity minimally, but together with triiodothyronine stimulation was additive. Simultaneous treatment of explants with actinomycin D or cycloheximide and triiodothyronine abolished the stimulatory influence of the latter on malic enzyme. These results suggest that human white adipose tissue is a suitable model to study the effects of triiodothyronine on lipid metabolism. The triiodothyronine stimulated malic enzyme may play an important role in providing reducing equivalents for lipogenesis in human adipose tissue.

Adult↗