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PubMed1986

National Survey of Hospital Data Processing--1985.

The National Survey of Hospital Data Processing contains a great wealth of information that the hospitals have contributed in respect to the trends and changes that are now occurring within our hospital data-processing environment. 2-5 We wish to thank all of those hospitals that have participated in this study and have been willing to provide the kind of information that is so essential in tabulating these results. It is our hope that this report will provide some measure of return on your investment and that it will supply some answers to you as you face the difficult questions of planning and projecting for the future. A great deal more information is contained within the study, but it cannot be presented because of the sheer volume of information that remains. For this reason, the survey has been structured as an on-line database rather than a report. We ask that those who have interests in seeking more in-depth information from these files contact our publishing office so that we can advise you of ways that this information can be conveniently made available to you for your special project. There will be a follow-up report for 1986 when that database is complete. For those who wish to do longitudinal studies, a parallel volume was published in August 1985 that should provide a 4-year perspective on the field of hospital data processing.

Clinical Laboratory Information Systems↗
PubMed1981

Advantages and drawbacks of some ERG stimulation and data-processing methods.

In each group of diseases, electroretinographic (ERG) diagnosis requires optimal stimulation parameters and detection techniques that clearly evidence any deviations from normal values. Television tube light stimulator assemblies and stimulation techniques applying methods of the control theory are very suitable for the dynamic separation of gross ERG components. The advantages and drawbacks of flicker ERG, frequency-characteristic methods and the frequency ranges that provide useful information in data processing are discussed.

Animals↗
PubMed1993

Podocytic cytoskeletal disaggregation and basement-membrane detachment in puromycin aminonucleoside nephrosis.

Puromycin aminonucleoside--(PAN) treated rats develop acute nephrotic syndrome, mimicking human minimal lesion disease. In PAN nephrosis, podocyte detachment from the glomerular basement membrane (GBM) is the most likely cause of massive proteinuria in this model. To elucidate further the mechanisms of PAN-induced cellular dysfunction, new methods were employed to visualize podocyte cytoskeletal aggregation and to measure fibrillar attachment to the GBM. Adult Sprague-Dawley rats (n = 4/group) received a single tail-vein injection of PAN (75 mg/kg). On days 1, 2, 3, and 5 following injection, 24-hour urine collections were obtained for creatinine clearance, albuminuria, and total proteinuria. Then kidneys from each group were fixed by perfusion. Podocytic cytoskeleton was visualized by scanning electron microscopy. Subepithelial GBM staining and attachment fiber number, observed on digitized images of transmission electron micrographs, were quantitated with computer-based density analysis. A significant reduction in attachment fiber number in the GBM lamina rara externa occurred by day 5. On scanning electron micrographs, the secondary and tertiary podocytic processes were observed to be formed by highly aggregated cytoskeleton, which became partially disaggregated by day 3, was totally absent by day 5, and normalized by day 20. Immunogold staining revealed that actin and vinculin localized to the tertiary podocytic processes in the normal state were dispersed into the cell body following PAN. Podocyte cytoskeletal disaggregation precedes, and detachment from the GBM occurs simultaneously with, the onset of massive proteinuria in the PAN model.

Actins↗
PubMed2004

[Electronic data capture. Impact on the quality of the clinical research].

Electronic data capture helps improving the quality of clinical research; mainly yielding a more reliable data collection process, but also introducing new resources for controlling the execution of clinical trials and facilitating the monitoring tasks. The protocol can be implemented rather than followed, and tools are at hand to help minimising the human error. The principal difficulty in the use of the electronic data capture lays in a more complex set up. This forces the adaptation of the people involved in the execution of clinical trials to a different workflow. In the future, most of the clinical research will use electronic data capture systems, and the paper shall be left for a few particular cases.

Biomedical Research↗