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At least 1,153 records · Page 64Linked to original sources
PubMed1994

[Successful VEP-IFN-alpha therapy in a case of non-secretory plasma cell leukemia (BJ-kappa type)].

Plasma cell leukemia is a rare disorder with poor prognosis. We present a case of non-secretory primary plasma cell leukemia (Bence-Jones kappa type), which was treated successfully by VEP-IFN-alpha therapy. A 82-year old man was admitted to Kanazawa Medical University in May 1991, because of emaciation and dehydration. Clinical findings showed decreased level of gamma-globulin (IgG, IgA and IgM were all decreased markedly), hypercalcemia, renal dysfunction and increased serum beta-2 microglobulin. The peripheral blood leukocyte count was 30,100/microliters with 64% plasma cells, and 80.4% plasma cells were also observed in the bone marrow. Only light chain-kappa was detected in plasma cells by an immunohistochemical staining method, but immunoelectrophoresis showed no M-bow either in serum or urine. Electron microscopy revealed typical plasma cells with prominently developed rough endoplasmic reticulum. From these results, the diagnosis of non-secretory primary plasma cell leukemia was established. He was treated with VEP-IFN-alpha regimen, and plasma cells decreased markedly in both peripheral blood and bone marrow. Serum immunoglobulin recovered to within the normal range. After 6 courses of VEP-IFN-alpha, complete remission was achieved and the remission was maintained until he died of an unrelated event, bronchial obstruction due to misswallowing, in April 1992.

Aged↗
PubMedDate not supplied

[Actinomycosis of the pelvic organs in a woman].

A case of female patient operated for a tumour in pelvis is presented. The patient was critically emaciated. Macroscopic examination suggested inoperable neoplasma. Histologic examination of the collected specimen has shown actinomycosis. The patient used intrauterine device for one year. Antibiotics produced complete improvement.

Actinomycosis↗
PubMed1993

Mycoplasmal arthritis and meningitis in calves.

A disease entity slightly different from, and appearing at an earlier age than, the syndrome known as mycoplasmal pneumo-arthritis was diagnosed in sucking calves. The disease, which had probably originated from intrauterine infection and manifested itself as polyarthritis occasionally accompanied by meningitis, caused huge economic losses due to a substantial reduction of the calf crop on the farm involved. Severe clinical signs were often observed already in the first days after birth. Besides an elevated body temperature reaching 40-41 degrees C, the affected calves showed striking deformities which made most of them unable to stand up or suck; as a result, they became emaciated and died at an age of 1-3 weeks. The gross pathological picture was dominated by serofibrinous arthritis involving several joints. In the articular cavities a large volume of straw-coloured, transparent synovial fluid accumulated which contained thick, confluent, white fibrin films. In some cases a similar exudate was observed in the thoracic cavity, pericardium and cerebral ventricles, too. Histopathological examination revealed serofibrinous inflammation of the synovial membrane of the joints, the pericardium, the pleura, the leptomeninges and the ependyma lining the cerebral ventricles. Our diagnosis was confirmed by the electron-microscopic detection of mycoplasmas from the pathologically altered organs and the isolation of a pathogen identified as Mycoplasma bovis.

Animals↗
PubMed1993

[A 77-year-old woman with myoclonus and epilepsy].

We present a 77-year-old woman with myoclonus and epilepsy. She was well until 35 years of age, when she noted an onset of trembling of the legs upon standing. Her symptom slowly progressed, and she felt a difficulty in standing when she was 39-year-old. She had a major motor seizure without an apparent focal onset when she was 46-year-old. She also developed tremor in her hands, and she felt difficulty in holding a glass filled with water. She was admitted to our service for the first time in 1965 when she was 51-year-old. She showed wide-based ataxic gait with truncal titubation. In finger to nose test, myoclonic jerks were induced in the upper extremities. Otherwise neurological examination was unremarkable. She was treated with primidone and phenobarbital, and was discharged for out patient follow up. Her symptoms slowly progressed, and gait and station became more difficult. Mentally she was sound. Three months prior to the present admission, she developed more difficulty in gait, and decrease in food intake. On the 14th of September in 1991, she was seen by a local physician who found an abnormal shadow in her chest X-ray, and she was admitted to our service for further work-up on September 18, 1991. On admission, the patient was a chronically ill and emaciated woman. Her blood pressure was 140/84 mmHg, heart rate 115/minutes and regular, and the body temperature 36.9 degrees C. The palpebral conjunctivae were anemic. No cervical adenopathy was noted. The lung fields were clear, and no heart murmur was audible. The abdomen was soft, and no organomegaly was present. On neurologic examination, she looked somnolent with disorientation to time and place. Her memory was poor, and she could not do well serial 7s. The disc was flat and the ocular movements appeared intact. Other cranial nerves were also unremarkable. She showed diffuse muscle wasting. She was unable to stand or walk. Maintaining the sitting position was also difficult. She was able to raise her arms, but almost unable to move her lower extremities. The precise muscle testing was impossible. No abnormal involuntary movement was seen. Finger to nose test could not be performed.(ABSTRACT TRUNCATED AT 400 WORDS)

Aged↗
PubMedDate not supplied

Leprechaunism (Donohue's syndrome): a case report.

Features of leprechaunism, including low-birth weight, a grotesque elfin face with clubbed nose, hirsutism, large low-set ears, enlarge external genitalia, distended abdomen with emaciated extremities, and growth and motor retardation were present in a 3-month-old girl. Because of parental consanguinity in this patient, a recessive mode of inheritance seems likely.

Abnormalities, Multiple↗
PubMedDate not supplied

[Splenic rupture in chronic pancreatitis. A clinical case. Observations].

The paper reports a case of splenic rupture during the course of chronic pancreatitis, an event rarely reported in the literature. The anatomical arrangement of organs and peripancreatic vessels is a predisposing factor for this complication. There are essentially three different but correlated pathogenetic hypotheses. The first refers to thrombosis of the splenic vein with portal hypertension documented by some researchers even in angiographical terms: during the course of chronic pancreatitis the spleen is sometimes palpable. Thrombosis and/or vascular compression make the spleen more fragile and its rupture more likely: this is particularly true during the course of calcific chronic pancreatitis and cases involving the tail. An enzymatic factor may also be responsible and this appears more clearly in pancreatitis with pseudocysts. In this case it is the direct action of pancreatic enzymes on the ileum or splenic parenchyma, which may also affect all organs surrounding the pancreas, which leads to hemorrhage or hematoma. Sometimes the cause of bleeding is a pseudoaneurysm of the splenic artery which is eroded by the contents of the pseudocysts themselves. There is also a mechanical hypothesis which some authors consider the sole possibility: in chronic pancreatitis the splenic compartment presents severe perisplenitis which fixes the spleen making it more vulnerable and even a mini-trauma will cause rupture. The patient is almost always an emaciated young alcoholic suffering from chronic pancreatic pathology.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1976

Functional and morphologic changes during experimental Rocky Mountain spotted fever in guinea pigs.

Experimental Rocky Mountain spotted fever was studied in guinea pigs following intraperitoneal inoculation of 10(7) Rickettsia rickettsii. After a 2-day incubation period, animals developed fever, progressive emaciation, and scrotal swelling with necrosis. Vasculitis, with increased small vessel permeability for colloidal carbon, was evident in cremaster muscles as early as 1 day after inoculation. Inflammatory changes in vessels became progressively more severe as numbers of circulating rickettsiae increased. Thrombosis and vascular occlusion were first evident on day 4. Mild thrombocytopenia developed, coinciding with the development of vasculitis, and preceding the appearance of either fibrin-split products in blood or thrombi in vessels. Rickettsiae were first detected in blood on day 2; peak rickettsemia occurred on days 5 to 8. Rickettsiae were demonstrated in inflamed vessels on day 5 and later, but not at earlier stages. Serum lysozyme concentration was moderately elevated and hemolytic complement was moderately depressed throughout the illness. Agglutinating antibody was present in low titers on days 3 to 10. Antibody titers increased on days 12 to 16 after the rickettsiae were cleared from blood. These studies indicate that vasculitis seen early in the course of Rocky Mountain spotted fever is the result of rickettsial infection, but is not dependent on the presence of rickettsiae in endothelial cells or other blood vessel components.

Agglutination Tests↗
PubMed1993

Obturator hernia: a report of eight cases.

Obturator hernia is a rare problem that occurs predominantly in elderly, emaciated women. The diagnosis of obturator hernia is difficult to establish in most patients before an operation is performed. Both delayed diagnosis and delayed surgical intervention contribute to high mortality. From 1978 to 1992, eight cases of obturator hernia involved elderly females who had received operations at this hospital. Resection of the incarcerated bowel was required. The often debilitated condition of these patients and the frequent delay of diagnosis combined to produce significant operative mortality.

Aged↗
PubMedDate not supplied

The role of protein malnutrition in the pathogenesis of ulcerative "Lazarine" leprosy.

1. Clinical and necropsy observations in lepromatous leprosy associated with severe emaciation and accompanying hypoproteinemia suggest that protein deprivation may be of pathogenic significance in the ulcerative phenomenon that is designated "Lazarine leprosy". 2. An experimental utilizing Wiersung rats infected with Mycobacterium lepraemurium and maintained on a protein-free diet was developed for the purpose of studying the effect of protein starvation on the course of chronic mycobacterial disease similar to lepromatous leprosy with respect to pathogen and host inflammatory response. 3. It was possible to maintain the experimental animals on a protein-free diet for up to 18 weeks of concomitant M. lepraemurium infection. This was long enough for the infection to disseminate to a degree that was evident in control animals only several weeks later. 4. The protein-deprived animals showed decreased inflammatory response to the pathogen, presented more rapid dissemination of the infection and harbored more bacilli per macrophage than did animals similarly infected but maintained on a protein adequate diet. This indicates impairment of native cellular immunity by protein deprivation through decrease in ability of macrophages to inhibit bacillary multiplication. 5. There was no evidence of impairment of macrophage ability to phagocytose the pathogens. 6. Morphologically the increased dissemination of pathogens and decrease in inflammatory response was similar to the increase in number and extent of visceral lesions seen in Lazarine leprosy. Decreased ability to dispose of the infecting bacilli was similar in the two models, human and animal. The animal model does not, as does lepromatous leprosy, involve the skin in the infection. Hence comparable ulcerative phenomena were not replicated in the animals. 7. It is suggested that Lazarine leprosy may result from enhanced lepromatous leprous infection occurring as a result of protein malnutrition. The pathogenic mechanism appears to be impairment of cellular immunity probably enhanced by concomitant impairment of humoral antibody immunity resulting also in decreased resistance to pyogenic and other secondary pathogens. The tissue edema attendant on decreased serum osmotic pressure due to lowering of the serum protein fractions enhances the probability of ulceration.

Animals↗
PubMed1993

Severe flea infestation in dairy calves.

An investigation was conducted of a severe flea infestation in Holstein dairy calves. Inspection of the dairy revealed hundreds of cat fleas, Ctenocephalides felis, on 23 calves, and thousands of fleas in the barn where the calves were housed. During the investigation, > 92,000 fleas were collected from the barn. The barn also was inhabited by 30 to 35 flea-infested domesticated and feral cats. Several calves appeared emaciated, and analysis of blood samples from 10 calves revealed that 8 were anemic. A control program was initiated, consisting of insecticide and insect-growth regulator treatment of calves and premises, along with removal of straw bedding from the barn. In addition, domesticated cats were to be treated and feral cats were to be removed by live trapping. Nine weeks after a complete control program was initiated, fleas were not evident on calves or in the barn.

Anemia, Hypochromic↗
PubMed1993

[Diencephalic syndrome. Case report and review of literature].

We report the case of a twenty-three month old, normally eating child, affected by organic macies and severe dystrophy. After the negative response of blood and laboratory examinations let us exclude a malabsorption syndrome, only the performance of neuro-radiologic exams showed evidence of a subthalamic tumor as the cause of a "Diencephalic syndrome". Diencephalic syndrome or Russel's syndrome is a diencephalic tumor induced disease, which sets in the first three years of life. The disease clinical markers are a severe emaciation with appetite preservation and absence or very scarce evidence of any telltale neurological sign. the tumoral histo-pathology most frequently shows a low grade of malignancy astrocytoma, whose eradication is very often difficult because of the particular anatomic site. Choice treatment includes an excisional biopsy associated to chemotherapy and to radiotherapy.

Astrocytoma↗
PubMed1993

[The epizootiology of BVD virus infections in Hessian dairy cattle stock].

Clinical manifestation and course of disease caused by BVD virus infection in 77 BVD-infected dairy cattle stocks in Middle Hessia are described. In 17 herds, serological and virological status of the animals was determined, and the results of an eradication program based on vaccination were evaluated. In animals with mucosal disease, a decrease in typical mucosal and interdigital lesions and an increase in respiratory symptoms with emaciation and a less specific pattern of disease could be observed.

Animals↗
PubMed1977

[Tentative organisation of disease recording in the poultry production. Collection and processing of condemnation results from 6 poultry slaughterhouses in Northern Jutland (author's transl)].

According to condemnation lists collected from 6 poultry slaughterhouses in northern Jutland there has been an increase in condemnation rate for broilers from 0.8 to 1.0% (Table I). The most important causes of condemnation have been emaciation, CRD, hock disorder and enteritis (Table II). Only a few slaughterhouses were involved in processing of hens, turkeys and web-footed birds showing inconstant distributions (Tables III and IV). Variation among slaughterhouses appears from Tables II-IV. The cause of variation and the value of central disease recording are discussed.

Abattoirs↗
PubMed1993

Proventriculotomy in ostriches: 18 cases (1990-1992).

Over a 3-year period, proventriculotomy was performed on 18 ostriches to relieve impaction of the proventriculus. Diagnosis was confirmed by abdominal palpation, abdominal radiography, and in some cases, exploratory proventriculotomy. In addition to proventriculotomy, an esophagotomy was performed in 5 birds that were debilitated to allow force-feeding during the postoperative period. The median age of ostriches treated surgically for proventricular impaction was 7.5 months (range, 3 months to 18 years). Impactions consisted of sand, rocks, or gravel in combination with grass, leaves, wood, or other fibrous materials. In 7 birds, small pieces of wire or nails were also removed from the proventriculus. In 1 bird, a large metal punch was removed via the proventriculotomy. Six ostriches died at the hospital in the immediate postoperative period. Four of these died within 24 hours of surgery. All 4 birds were emaciated and in a severely weakened condition at admission, and they continued to deteriorate after surgery. One bird died 8 days after surgery as a result of complications associated with a septic joint unrelated to the proventriculotomy procedure. Another bird was euthanatized 6 days after surgery because its condition failed to improve and the owners did not want to pursue further treatment because of expense. Follow-up information was obtained for 12 surviving ostriches 1 week to 29 months (median, 5.5 months) after they were discharged from the hospital. Four of the 12 birds died within 30 days of discharge from the hospital. The remaining 8 birds (44%) were alive at follow-up evaluation (median, 10.5 months after surgery; range, 5 to 29 months).(ABSTRACT TRUNCATED AT 250 WORDS)

Age Factors↗
PubMed1977

Triglyceride storage disease: a defect in activation of lipolysis in adipose tissue.

A child, aged 6 years 3 months, with a triglyceride storage disorder in peripheral adipose tissue, microcephaly, and gross emaciation has been studied at autopsy. The mean triglyceride content of adipocytes in hand and foot was 0.17 +/- 0.02 mug/cell and 0.18 +/- 0.02 mug/cell. Adipocytes from abdominal tissue were small, irregular, and difficult to measure accurately, reflecting the degree of cachexia. Basal tissue contents of cyclic AMP and release of glycerol and fatty acid from peripheral tissue of the child were in the same range as adult tissues. None of these measurements, however, were increased by incubation with isoprenaline (10(-5 M), compared to a three- to seven-fold increment in adult subcutaneous tissues and to a four- to ten-fold increment of glycerol and cyclic AMP in peripheral adipose tissue of a control child aged 10 years. We postulate that the proband may have had a defect of adenyl cyclase or catecholamine receptor, which has a role in the abnormal storage of triglyceride in peripheral adipose tissue.

Adenylyl Cyclases↗
PubMed1993

Determination of virulence and pathogenesis of a canine strain of Leishmania leishmania infantum in hamsters and dogs.

Visceral leishmaniasis was experimentally induced in hamsters by the intracardiac inoculation of 10(7) amastigotes of Leishmania leishmania infantum of canine origin. At postinoculation (PI) days 7, 21, 42, and 63, hamsters were euthanatized. Body weights and total parasite numbers of the liver and spleen were determined. Gross and histologic evaluations of tissues were done. Dogs also were inoculated IV with 10(8) amastigotes/kg of body weight. Samples were obtained from dogs prior to infection and at biweekly PI intervals for CBC and serum chemical analysis, for lymphocyte blastogenic assay by use of blood leukocytes, and for ELISA to determine antileishmanial antibody titers. At PI week 12, dogs were necropsied; organ weights, tissue imprints of the liver and spleen, and histologic interpretations of tissues were obtained. Hamsters developed high parasite numbers within 7 days after inoculation, at which time the total parasite numbers in the liver (3.51 x 10(7) amastigotes) was observed to be approximately 11 times that in the spleen (2.93 x 10(6)). The liver had the highest parasite numbers throughout the infection period. Some infected hamsters became either cachectic and emaciated or ascitic. Two of the 10 infected hamsters died at PI days 54 and 58. Moderate to severe hepatosplenomegaly with granulomatous inflammatory reactions characterized by the presence of varied numbers of parasitized macrophages, giant cells, and hepatic Schaumann bodies were observed in infected hamsters. Infected dogs developed significantly altered hematologic values consisting of mild anemia and moderate leukopenia at PI weeks 8 to 12. Hyperproteinemia characterized by hyperglobulinemia (4.5 g/dl) was noticed at PI week 4.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1993

Obturator hernia: a continuing diagnostic challenge.

BACKGROUND: The rare obturator hernia has a high incidence of potentially lethal complications. This report reviews this condition and stresses the dangers of unrecognized obturator hernia. METHODS: Thirteen patients with 14 obturator hernias were seen during a 5-year period. All the patients were emaciated and elderly, and 12 were women. They all had clinical features of small bowel obstruction. The classic Howship-Romberg sign was present in only three patients. The diagnosis was made before surgery in five patients. RESULTS: All hernial sacs contained small bowel. Ileum were present in 11 instances. Richter-type hernia was present in 10 cases. Bowel resection for gangrenous loop was required in seven instances. Apart from associated poor medical conditions, delay in presentation and operation also contributed to the high morbidity and mortality rates. Five patients (38.5%) had postoperative complications, and two patients (15.4%) died of chest infections. CONCLUSIONS: The need for awareness of the condition is stressed and the diagnosis of obturator hernia should be strongly suspected in a thin, elderly woman who has small bowel obstruction and no previous abdominal surgery.

Aged↗
PubMed1993

Comparative susceptibility of African green monkeys (Cercopithecus aethiops) to experimental infection with Leishmania leishmania donovani and Leishmania leishmania infantum.

The leishmaniases are global health problems that affect both humans and animals. The availability of nonhuman primate models is desirable for such important areas as testing candidate vaccines and newly developed chemo- and immunotherapeutic agents. Visceral leishmaniasis was experimentally induced in African green monkeys (Cercopithecus aethiops) by intravenously inoculating 10(7) amastigotes/kg of body weight of either Leishmania leishmania donovani of human origin (group 1) or L. l. infantum of canine origin (group 2). The infected monkeys were monitored for 12 weeks. The monkeys developed persistent infections, became emaciated, and lost between 9 and 22% of their body weights. Splenomegaly developed by 6 to 10 weeks postinfection. All infected monkeys developed normocytic, normochromic anemia (3.5 to 3.8 x 10(6)/microliters), leukopenia (3,000 to 3,700/microliters), and neutropenia of varying severity. Hyperproteinemia with hyperglobulinemia (5.22 to 6.12 g/dl) was present in all monkeys to various degrees. Antibody responses gradually increased to peak values at 2 weeks postinfection in the L. l. donovani group and by 6 weeks postinfection in the L. l. infantum group. Lymphocyte blastogenesis proliferation responses were mildly decreased in all infected monkeys at 10 to 12 weeks postinfection. Parasite numbers were consistently higher in the livers than in spleens, and parasites were present in smears or cultures of the liver, spleen, bone marrow, and lymph nodes. Contrasting data between the two groups included 20-fold-higher parasite numbers in the livers (3.23 to 9.48 x 10(9)) and 39-fold-higher parasite numbers in the spleens (6.7 x 10(8) to 2.69 x 10(9)) of group 1. Granulomatous inflammatory reactions of various severity and intensity were observed in the liver, spleen, lymph nodes, thymus, and bone marrow of all infected monkeys. Within the granulomatous inflammatory reactions, clusters of macrophages, often containing amastigotes, were present. The morphologic changes in the bone marrow suggested a myelophthisic disease and those in lymph nodes and spleen suggested a B-cell proliferation. The clinicopathologic changes, mild suppression of cell-mediated immunity, and high antibody response in all infected monkeys indicated that African green monkeys can be a useful laboratory model for studying the clinicopathologic and immunopathologic changes induced by both L. l. donovani and L. l. infantum.

Animals↗