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PubMedDate not supplied

Determining the telomerase activity of exfoliated cells in intestinal lavage solution to detect colorectal carcinoma.

In order to make a definitive diagnosis of colorectal carcinoma, it is desirable to detect cancerous cells in stool samples. The detection of cancer gene products in stool samples, however, is said to be extremely difficult. The involvement of telomerase in the development of various malignancies has been reported. We therefore performed colonoscopy and thereby collected the intestinal lavage solution remaining in the lower portion of rectum to determine any possible signs of colorectal carcinoma. This fluid consisted of a combination of stool and exfoliated intestinal mucosa. We examined the telomerase activity of the intestinal lavage solution, collected from 19 colorectal carcinoma patients and from 11 volunteers (colonospically normal controls) based on the method of the telomeric repeat amplification protocol (TRAP) assay. All patients drank a polyethylene glycol-electrolyte lavage solution (PEG-ELS) before the examination. Sample solutions were collected by the colonoscope at the beginning of colonoscopy. Telomerase activity was thus found in 11 (57.9%) of the 19 intestinal lavage solution samples. In contrast, all eleven samples from the colonoscopically normal subjects were negative. These findings thus suggest that measuring telomerase activity of exfoliated cells in intestinal lavage solution may thus be useful as a new diagnostic method for colorectal carcinoma.

Aged↗
PubMed2000

Clinical evidence for the adenoma-carcinoma sequence, and the management of patients with colorectal adenomas.

A large body of clinical evidence supports the belief that over 95% of colorectal cancers arise in benign adenomatous polyps that develop and grow very slowly over many years. Interruption of the adenoma-carcinoma sequence by resecting adenomatous polyps is a powerful method of secondary prevention of colorectal cancer. Colonoscopy is the procedure of choice for the diagnosis and resection of colorectal polyps. Patients who have had colonoscopic resection of adenomas, and in some cases their close relatives, are at increased risk for developing metachronous polyps and cancer and may benefit from follow-up colonoscopic surveillance. This surveillance should be individually tailored to the perceived risk of each case depending on the features of the adenomas removed and other patient factors such as family history. Widespread adoption of current postpolypectomy guideline recommendations is protective and conserves medical resources.

Adenomatous Polyps↗
PubMed2000

[Late postoperative colonic stenosis caused by the biofragmentable anastomosis ring (BAR)].

The authors focused their attention on the prevalence of late postoperative stenoses of anastomoses following resection of the colon. In 42 patients the anastomosis was implemented by means of a Valtrac ring--i.e. by compressive biofragmentable seamless technique. Within an interval of 6 months after surgery the majority of these patients were subjected to colonoscopic examination with direct visualization of the intestinal anastomosis. The authors did not record any late postoperative stenoses of the BAR anastomosis of the colon. Moreover on colonoscopic examination in the majority of patients the original intestinal anastomosis was only difficult to detect.

Adult↗
PubMed2001

Endoscopic localization and management of colonic bleeding in patients with portal hypertension.

In patients with portal hypertension, vascular lesions in the colon may develop that have been collectively termed portal hypertensive colopathy. Endoscopic diagnosis of these lesions is now established, but the management of hemorrhage from them is not. We report five cases of endoscopic management of bleeding colonic vascular lesions in patients with portal hypertension. Endoscopy data from January 1, 1996 to June 30, 1999 identified 158 patients with portal hypertension who underwent colonoscopy. Forty-five of these 158 patients had portal hypertensive colopathy (angiodysplasias or varices). Those who had colonoscopic hemostasis attempted were identified and reviewed. Five patients underwent colonoscopic intervention for bleeding. Initial hemostasis was achieved in four of five cases. Repeat endoscopic intervention was necessary in three of the four cases. One patient required surgery. In patients with portal hypertension, colonic vascular lesions may develop. Hemorrhage from these lesions is rare. Colonoscopy is effective for localization and diagnosis of bleeding vascular lesions and permits simultaneous hemostatic intervention.

Adult↗
PubMed2002

[Endoscopic methods of treatment of precancerous lesions of the colon].

The endoscopic method--colonoscope, has become the tool of choice for diagnosing many colonic disorders, including the acute and chronic inflammatory bowel disease, lower gastrointestinal bleeding, benign and malignant tumors, and various others abnormalities appearing on the radiographs. The colonoscope is also useful and become the main confirmation method in screening for and monitoring colonic cancer. In the same time, colonoscopy offers numerous therapeutic options. The colonic polyps, well-known colonic precancerous lesions, with incidence ranges from 7 to 50%, can be removed completely during the colonoscopy, with a snare or biopsy forceps (polypectomy). Early cancers limited to the mucosal layer (intraepithelial cancer or carcinoma in situ) can be treated endoscopically too (mucosectomy), as well as various gastrointestinal bleeding (with sclerotherapy, electrocoagulation, APC, laser-fotocoagulation), inflammatory and postsurgical strictures (endoscopic dilation), and foreign bodies in the rectum and sigma (endoscopic extraction).

Colonic Neoplasms↗
PubMedDate not supplied

[Microscopic colitis].

BACKGROUND: Microscopic colitis is responsible for a proportion of difficult diagnosis cases with chronic diarrhea. Diagnosis is clinically suspected when chemical and macroscopic examination result negative and is made only by histopathologic findings. OBJECTIVE: To describe clinical, biochemical, colonoscopic, and histologic features and the treatment response of four cases with microscopic colitis. METHODS: We inform on the findings in four females patients presenting with chronic watery diarrhea with normal biochemical and colonoscopic tests. RESULTS: In these cases, diagnoses mode were lymphocytic colitis two and collagenous colitis two. The long term duration of watery diarrhea was 5 months. The average number of depositions were 10 in 24 h. Diagnosis was made after microscopic examination of the colonic mucosa in the absence of endoscopic abnormalities and normal chemistries. All patients had a satisfactory response to treatment. CONCLUSIONS: The diagnosis of microscopic colitis is made by histopathology findings. The therapeutic response is generally satisfactory.

Adult↗
PubMed2002

A novel lymphatic mapping technique to improve localization and staging of early colon cancer during laparoscopic colectomy.

Encouraging results from our previous studies of sentinel lymph node (SLN) mapping in colorectal cancer (CRC) prompted investigation of its feasibility and accuracy during laparoscopic colectomy for early CRC. Between 1996 and 2000, 14 patients with clinically localized colorectal neoplasms underwent colonoscopic tattooing of the primary site and SLN mapping. In each case 0.5 to 1 cm3 of isosulfan blue dye was injected submucosally via the colonoscope. The blue-stained lymphatics were visualized through the laparoscope and followed to the SLN, which was marked with a clip, and laparoscopic colectomy was completed in the routine fashion. All lymph nodes were examined by hematoxylin and eosin (H&E) staining; in addition each SLN was subjected to focused examination by multisectioning and immunohistochemical staining using cytokeratin antibody. In all 14 patients the primary neoplasm and an SLN were identified laparoscopically. An average of 13.5 total lymph nodes and 1.7 SLNs per patient were identified. The SLN correctly reflected the tumor status of the nodal basin in 93 per cent of the cases. In four cases with unexpected lymphatic drainage, the extent of mesenteric resection was altered. In two cases (14%), nodal involvement was micrometastatic, confined to an SLN, and identified only by immunohistochemical staining. Lymphatic mapping caused no complications and added only 10 to 15 minutes to the overall operative time. Comparison of results in this group with results for a matched group of 14 patients undergoing SLN mapping during open colon resection showed that the laparoscopic technique had similar rates of accuracy and success. These preliminary findings indicate that colonoscopic/laparoscopic SLN mapping during laparoscopic colon resection is a feasible and technically simple means of identifying the primary colorectal neoplasm and its SLN. Focused pathologic examination of this node can upstage CRC and thereby may improve selection of patients for adjuvant chemotherapy.

Adult↗
PubMedDate not supplied

[COLORECTAL MALIGNANT POLYP: RESULTS OF TREATMENT AND FOLLOW-UP]

We present the results of the treatment and five year or more follow-up of patients with malignant polyp removed by colonoscopic polypectomy. They were 17 male and 9 female, between 25-85 years old, mean 60.4 years. 29 malignant polyps removed had well differentiated or moderated well differentiated adenocarcinoma; 10 patients had 36 synchronous lesions, 77% of them were adenomas. 22 patients had only polypectomy, and 4 polypectomy and colon resection, whose surgical specimen was tumor free in the site of polypectomy, without metastatic nodes. During the follow-up, two patients died of other causes than malignant polyp; one did not return; and 23 remain free of tumor. Colonoscopic polypectomy can be an excellent treatment for malignant colorectal polyp if the risk factors -endoscopic, pathological of the invasive carcinoma and the general clinical conditions of patients- are strictly applied.

Journal Article↗
PubMed1976

Colonoscopy and polypectomy.

Experience with 100 colonoscopies in 88 patients in a community hospital is presented. The instrument used was the F09000PL 165 cm ACMI colonoscope for the first 88 cases, and the F9A 160 cm ACMI colonoscope for the last 12. There were no complications. The preparation of the patient and the technique of colonoscopy and polypectomy are detailed. Indications and contraindications are outlined and discussed. Colonoscopy in this series has definitely saved 16 patients and possibly another 20 patients from laparotomy.

Adult↗
PubMed2002

Colorectal cancer screening in asymptomaic adults: comparison of colonoscopy, sigmoidoscopy and fecal occult blood tests.

BACKGROUND AND PURPOSE: Fecal occult blood tests (FOBT) and flexible sigmoidoscopy have previously been recommended for colon cancer screening. More recently, studies have recommended colonoscopy due to the high rates of advanced neoplasm not detected by FOBT and sigmoidoscopy. Previous studies of the effectiveness of colonoscopic screening in Taiwan were limited to families of patients with colorectal cancer. This study compared colonoscopy, sigmoidoscopy and FOBT for colorectal cancer screening in asymptomatic adults. METHODS: Screening colonoscopies and FOBT were performed in asymptomatic adults enrolled in our health-screening program between January 1997 and December 2000. Advanced neoplasm was defined as the presence of a polyp larger than 1 cm, polyps with villous or severe dysplastic features, or cancer. The junction of the splenic flexure and descending colon was defined as the boundary of the proximal and distal colon, and it was presumed that the distal colon would be examined using sigmoidoscopy in all patients. Data on the prevalence of polyps, advanced neoplasm, and cancer among different age groups were obtained. The results of chemical and immunologic FOBT were compared. The anatomic distributions of advanced neoplasm and cancer were analyzed. RESULTS: A total of 7,411 colonoscopic examinations were included in the analysis. Advanced neoplasms were present in 93 examinations (1.3%), including 16 cancers (0.2%). Chemical FOBT detected 20.2% of advanced neoplasms and 37.5% of cancers. Immunologic FOBT detected 48.3% of advanced neoplasms and 87.5% of cancers. If sigmoidoscopy had been performed in place of colonoscopy, 26.9% of advanced neoplasms and 12.5% of cancers would not have been detected. CONCLUSIONS: Colonoscopy can detect neoplastic lesions undetectable by FOBT and sigmoidoscopy in asymptomatic subjects. These results suggest that colonoscopy should be the method of choice in colon cancer screening.

Adult↗
PubMed1976

The diagnosis of colitis by colonoscopy with biopsy and X-ray examination. A blind comparative study.

The examinations were performed in 40 outpatients, of whom 21 were women. From the rectal and colonic mucosa 185 biopsies were obtained. The X-ray examination was performed within one week from the colonoscopy, using a conventional barium enema. A complete agreement between the colonoscopic diagnosis and that of the directed biopsy was found in 33 cases (80 per cent), and minor disagreements in 3 cases. A complete agreement between the colonoscopic and X-ray diagnoses was obtained in 22 patients (55 per cent), and minor disagreements in 16 cases, most of whom showed "unspecific" non-ulcerative colitis. In 3 cases with ulcerative colitis a normal colon was found by X-ray. A higher percentage of cases showed decreased haustration by X-ray examination than by colonoscopy, whereas a fairly equal percentage of ulceration was detected by the two methods. Erosions, mucus covering, oedema, vascular injection, and bleedings were not detected by X-ray examination.

Adult↗
PubMed2003

[Comparison of the effectiveness and tolerability of the saccharosum-sennosid-B solution and sodium-picosulfate in preparation for colonoscopy. Prospective, multicenter, randomized study].

INTRODUCTION: The effectivity, evaluability of the colonoscopic procedure depends greatly on the preparation and the cleanliness of the colon. A large scale of laxatives used for colon preparation are also available in our country (phenolphtalein, Karlsbad-salt, saccharosum + sennosid-B solution, bisacodyl, powder mixtures). AIMS: The authors examined in 5 gastroenterology centres the tolerability and effectivity of two frequently used laxatives--saccharosum + sennosid-B solution and Na-picosulphate--during colonoscopic preparation in 157 patients. METHODS: Exclusion criteria were: severe anemia, renal insufficiency, cardiac failure, active ulcerative colitis and Crohn's disease, possible stenotising colonic process and hypersensibility to one of the compounds. The patients were randomised prospectively. In the case of the saccharosum + sennosid-B solution the colon preparation was performed according to the manufacturers prescriptions, in the case of the Na-pikosulfate the investigator's own procedure was used based on literature data. The tolerability of the preparation was assessed using a questionnaire. The investigators made their statements concerning the cleanliness of the different colon sections based on uniform criteria. RESULTS: Both methods showed good efficacy concerning the cleanliness of the colon. The patients considered the Na-picosulphate better tolerable--based on the questionnaire data. The authors consider the analysis of further laxatives to help improve the work of their fellow endoscopists.

Adult↗
PubMed2003

Postpolypectomy and post-cancer resection surveillance.

Recent guidelines on postpolypectomy surveillance have focused on identifying patients with adenomas who are at high risk for development of significant neoplasms (cancer or "advanced adenoma") after clearing colonoscopy and should undergo frequent follow-up examinations and those at low risk who require infrequent follow-up examinations. This article reviews the guideline recommendations from the American College of Gastroenterology, American Gastroenterological Association consortium, and the American Cancer Society, and discusses the rationale for the recommended intervals of colonoscopic examinations in low and high-risk postpolypectomy patients. When colorectal cancer is identified, the initial colonoscopic goal in the peri-operative period is to clear the colon of synchronous neoplasms. After this is accomplished, the goal shifts to performance of colonoscopy at intervals that are appropriate for prevention and early detection of second cancers. These intervals often approximate those used in postpolypectomy surveillance. An exception to this approach is patients with rectal cancer operated by traditional blunt dissection techniques, for which there is a rationale for interval flexible sigmoidoscopy and/or rectal ultrasound to look for local recurrences.

Adenocarcinoma↗
PubMedDate not supplied

Does colitis associated with primary sclerosing cholangitis represent an actual subset of ulcerative colitis?

BACKGROUND/AIMS: The clinical course and endoscopic features of colitis associated with primary sclerosing cholangitis have not been well documented. METHODOLOGY: Since 1980, a total of 485 patients with ulcerative colitis have been seen in our departments. During this period, we experienced 6 patients with primary sclerosing cholangitis, 4 of whom had ulcerative colitis concomitantly. RESULTS: Colitis preceded primary sclerosing cholangitis in 3 of the 4 patients. There were 2 males and 2 females. One patient had left-sided colitis while 3 had total colitis, 1 with a first attack and 3 with relapsing-remitting type. Two of the 4 patients had colonoscopically dominant inflammation in the proximal colon with continuous histological inflammation from the rectum to the proximal colon. Three colitic patients have been well controlled with oral sulfasalzine or mesalazine administration. Only 1 female patient had been hospitalized twice for moderately severe attacks of ulcerative colitis that required systemic prednisolone administration, however, this patient quickly responded to this treatment for each admission. CONCLUSIONS: Colitis associated with primary sclerosing cholangitis exhibited atypical colonoscopic findings and exhibited milder disease activity than ulcerative colitis without primary sclerosing cholangitis.

Adult↗
PubMed2003

Retained rectal foreign bodies.

BACKGROUND: Retained rectal foreign bodies have been encountered more frequently and present a dilemma for management. Most of the reports on these cases were documented in the form of case report and from Western countries. The present study was a review on the authors' experiences in such cases. METHODS: Data from January 1979 to January 2000 were extracted from a computerized database of Taipei Veterans General Hospital. The clinical features, treatment strategies and outcomes were analyzed. RESULTS: Ten male patients (mean age: 57.0 years) with 12 presentations of retained rectal foreign bodies were collected. Glass bottles and vibrators were the most common objects encountered, while anal eroticism was reported as the reason for insertion in 50% of the cases. The majority of the objects were extracted by non-surgical methods through either anoscope (n = 4), rigid sigmoidoscope (n = 2) or colonoscope (n = 1). Obstetric forceps was utilized to remove an incarcerated bowling bottle. Emergent laparotomies were performed in cases with overt peritonitis (n = 2), pelvic sepsis (n = 1) and an impacted high-lying glass bottle. Minor complications, such as mucosal abrasion or superficial tear, were found in 62.5% of the non-surgically treated cases. Delayed bleeding was found in 2 of them. There was no mortality in our series. CONCLUSIONS: Despite its rarity, the retained rectal foreign body had varying clinical features. Most of the uncomplicated rectal foreign bodies could be simply extracted transanally under adequate anesthesia. Fiberoptic colonoscopic extraction provided an alternative choice. Open surgery should be reserved only for those patients with overt peritonitis or pelvic sepsis.

Adult↗
PubMedDate not supplied

[Acute pseudo-obstruction of the colon (Ogilvie syndrome). Apropos of a case].

An additional case of acute colonic pseudo-obstruction (Ogilvie's syndrome) is reported. Conservative management was successful. Etiology of this syndrome is still uncertain. The aim of the treatment is to stop natural evolution to ischemia or perforation. Medical therapy, colonoscopic decompression and surgery are employed following prognostic criteria (age, cecal diameter, therapeutical delay). Mortality rate remains high, especially if complications occur. Colonoscopic decompression is a safe and efficacious first line of treatment when cecum is less than diameter 12 cm. Surgery is mandatory when perforation or ischemia are suspected and colonoscopy failed or is contraindicated.

Acute Disease↗
PubMedDate not supplied

Clinicopathologic differences among subtypes of serrated adenomas of the colorectum.

BACKGROUND/AIMS: Serrated adenomas (SAs) of the colorectum can be broadly divided into two subtypes: type I more closely mimicking hyperplastic polyps, and type II unequivocal traditional adenomas. The aim of this study was to clarify their differential clinicopathologic and colonoscopic features. METHODOLOGY: A total of 127 SAs (53 type I, 52 type II and 22 admixed type I+II) were investigated and colonoscopic surface patterns were divided into three categories: speckled, granular and cerebriform. RESULTS: The cerebriform pattern was most frequently observed in all SA types. Types I+II (median size, 7.5 mm) or type II SAs (median size, 10 mm) were generally sessile or pedunculated polyps in the rectosigmoid colon whereas some type I lesions (median size, 5 mm) demonstrated a flat-elevated morphology and were found in the ascending colon and cecum. Co-existing (2/127: 1.6%) invasive carcinomas were only detected with type II SAs. In contrast, synchronous invasive carcinomas distant from SAs were more frequently observed with type I (31%) than types I+II (5%) or II (12%). CONCLUSIONS: Clinicopathologic differences are apparent among the types of SAs. A type II SA-invasive carcinoma sequence might exist. We stress recognition of type I SA as a neoplastic, rather than a hyperplastic lesion, often accompanying invasive carcinomas at a distance from the SA.

Adenoma↗
PubMed2005

[Diagnostic principles of colonoscopy in ulcerative colitis].

Colonoscopy plays a most important role in the diagnosis and management of ulcerative colitis (UC). It is generally performed in UC for defining the degree of disease activity, grading endoscopic disease severity, and surveillance to detect early cancer and/or dysplasia. Colonoscopic findings of UC are characterized by diffuse and continuous inflammation of mucosa. Loss of vascular pattern, erythema, petechiae and mucosal friability are features of relatively mild disease. As the severity of inflammation increases, spontaneous bleeding, erosions and/or ulcerations are observed. Although UC can be easily diagnosed by these typical findings, colonoscopic findings are modified in a variable and complicated manner at the different clinical stages. Thus it is important for endoscopists to understand the findings in each clinical stage of UC.

Colitis, Ulcerative↗