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PubMed1992

[Contraception in climacteric].

The problems of an adequate contraception around the age of 40 are not yet solved in our time. On one hand the women are afraid of unexpected pregnancies during this life period, at the other hand the hormonal contraceptives are not anymore optimal at this time. The various contraceptive methods with its positive and negative effects during this period are discussed in this paper.

Climacteric↗
PubMed1992

[A main symptom of the climacteric manifestation complex: arthropathia climacteria].

In the last few years several studies have been published raising the question whether hormonal factors are co-responsible for the female prevalence of certain joint diseases. From our own clinical experience we know that more than half of the women seen at our outpatients department because of disorders of the post menopausal syndrome complain about arthralgies (especially of the PIP-joints). We have introduced the term "arthropathia climacterica" for it. Moreover the positive results of two clinical studies on which effects hormone replacement therapy had on these complaints indicate a relation between estrogens and joints.

Arthritis, Rheumatoid↗
PubMed1992

[Bone density screening in females in climacteric].

Bonestability is not only determined by the content but also by the construction of the mineral part and the biochemical structure. In addition the organic parts are important, too. Result of the measurements shows only the bone-quantity. The development of several measurement techniques (highquality quantitative computertomography [QCT]) allow us diagnoses concerning the bone quality. Single photon absorptionsdensitometry (SPA), DPA (dual photon absorptiometry), DEXA (dual energy X-ray absorptiometry) and QCT (quantitative computertomography, peripher and central) are todays measurement techniques. In the meantime SPA looses the importance, also DPA-method is displaced by DEXA.

Bone Density↗
PubMed1992

[Incidence of gynecologic diseases in multiparae during the climacteric period].

The structure and incidence of gynecologic diseases were studied in 796 women aged 40 to 60. The results were computer-processed. A significant (by 3.5 times) increase of the incidence of atrophic changes of the vagina and vulva and genital dystopia were revealed in multiparae, which fact evidenced unqualified labor management and neglect of hygienic measures in the postpartum period. Cervix uteri abnormalities were also more often detected in multiparae. A direct correlation between the number of pregnancies, deliveries, and abortions, on the one hand, and incidence of diseases of the cervix uteri, on the other, was revealed; uterine myoma was more frequently found in multiparae than in women who had one or two deliveries. A direct relationship was established between the duration of lactation period and incidence of ovarian tumors. Mammary diseases were more frequently detected in women with a history of one or two deliveries.

Adult↗
PubMed1991

[Cyclic ethinyl estradiol and medroxyprogesterone in climacteric women. Their clinicAL efficacy and patterns of uterine bleeding].

The study evaluated the clinical efficacy substitutive hormonotherapy regime in a group of 40 postmenopausal, women with moderate to severe symptomatology and negative progesterone challenge test. Each cycle consisted in the administration of 15 micrograms of ethinyl estradiol during 21 days, plus 10 mg medroxyprogesterone acetate (MPA) the last 10 days. Each patient received four cycles of therapy with 10 days of interval between them. The global clinical response was evaluated as favorable (excellent and good responses) in 97.5% of the patients. All the patients showed an improvement of the vaginal trophism (colpocytology). The great majority of the women experimented cyclical bleeding as consequence of the treatment. The post-therapeutic bleeding (Withdrawal) was the predominant bleeding pattern. This fact suggests that the 10 mg of MPA added daily during 10 days could allow a suitable opposition to the estrogenic proliferative effect inducing an adequate secretory response and the subsequent endometrial desquamation.

Climacteric↗