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At least 1,153 records · Page 64Linked to original sources
PubMed1977

Clinical evaluation of a new anthelmintic - C. 9333 Go./CGP 4540 in human hookworm infection.

A new antihookworm compound, C.9333 Go./CGP 4540, was evaluated clinically in 65 adult patients with hookworm infection. Several dosage schedules were evaluated to determine an effective, well tolerated and convenient regime. The lowest effective dose was 125 mg administered at four-hourly intervals for three doses. The compound was generally well tolerated; mild giddiness was observed in nine patients and severe giddiness was present in one patient. Clinical and biochemical monitoring revealed no other toxicity of the compound.

Ancylostoma↗
PubMedDate not supplied

A population dynamic approach to the cost-effectiveness analysis of mass anthelmintic treatment: effects of treatment frequency on Ascaris infection.

This study examines the cost-effectiveness of different frequencies of mass chemotherapy in reducing helminth infection and morbidity at the community level. The cost-effectiveness framework utilities a dynamic model of helminth transmission which permits the effectiveness of treatment to be expressed as some long-term reduction in infection and disease. Cost analysis is incorporated into this framework using an itemized cost menu and cost data from an actual control programme. The cost-effectiveness of mass treatment is investigated using epidemiological measures considered appropriate to Ascaris lumbricoides infection in both a high and low transmission area. The optimal strategy for control is shown to be dependent on the control objectives, the rate of transmission, and existing budget constraints. The analysis suggests that if the aim of control is to reduce morbidity due to ascariasis and mass treatment is the approach selected, then it is more cost-effective to intervene in a high transmission area than in a low transmission area, and that relatively long intervals between treatments offer the most cost-effective strategy.

Animals↗
PubMed1985

Enzymes of isolated brush border membrane of Cotugnia digonopora, and their insensitivity to anthelmintics in vitro.

Purified brush border membrane of Cotugnia digonopora showed the presence of a number of phosphohydrolases. Among these, alkaline phosphatase was extremely active. Other enzymes such as glucose-6-phosphatase, fructose-1,6-diphosphatase, cAMP-phosphodiesterase, 5'-nucleotidase and adenosine-triphosphatase were also active. Observations were made on the activities of various ATPases; whereas the enzyme was activated by Ca++ and Mg++ in an additive manner, its sensitivity to ouabain was negligible. Furthermore, in the presence of EDTA the enzyme activity was quite significant. The treatment of isolated brush border membrane with mebendazole, niclosamide and praziquantel in vitro did not alter the activity of these enzymes. However, treatment of intact worms drastically affected the integrity of the membrane.

3',5'-Cyclic-AMP Phosphodiesterases↗
PubMed1986

Control of trichostrongylid pasture infestation in spring by the periparturient anthelmintic treatment of housed ewes prior to or at the time of turn out.

Ewes, housed in late November and lambing in late February and March, were divided into three groups of eight, six and eight animals, and received a single treatment with ivermectin (approximately 200 micrograms kg-1) in late February (Group I), on 15 April (Group II), or on 1 May (Group III), respectively. The egg output of the ewes and, subsequently, of eight lambs (Group IV) was measured at 2-weekly intervals by counting and identifying the larvae after culture. Group I showed a small rise in larva output in March, with counts less than 100 larvae per gram of faeces (l.p.g.) whereas the other groups showed considerable increase with counts greater than 500 l.p.g. Treatment of Groups II and III just before turn out in April and May reduced the output to zero for at least 6 wk. The lambs did not show any evidence of trichostrongylid infection until the middle of July. The major parasite identified was Haemonchus contortus. The results of this trial demonstrate that 1) ivermectin treatment in February reduced but did not completely eliminate a spring rise in egg output and 2) treatment in mid-April eliminated further egg output. Ewes treated and turned out in mid-April or later were not a significant cause of pasture contamination in spring or early summer.

Animals↗
PubMed1990

Anthelmintic efficacy of febantel paste in naturally infected calves.

The purpose of the present study was to verify results of the lowest dose (5 mg kg-1) of febantel evaluated in an earlier trial in which there were no differences in efficacies of three dose rates (5, 7.5 and 10 mg kg-1 body weight) against natural gastrointestinal nematode infections of cattle. Fourteen Angus calves (mean weight and age of 155 kg and 525 days, respectively), from the same farm, with relatively heavy (mean of 448 eggs g-1 feces (epg] parasite burdens were selected. After an adjustment period of 8 days in drylot, beginning on 25 July, seven calves were treated with a 45.5% paste formulation of febantel. On Day 7 post-treatment, calves were necropsied for determination of residual worms. Rectal fecal samples were obtained prior to adjustment, at treatment, 5 days post-treatment and at necropsy. On both Day 5 post-treatment and at necropsy a mean of less than 1 epg was recovered from treated calves compared with 765 and 1566 epg, respectively, in control calves. Worms counts at necropsy revealed an efficacy of 98.5% against all adult abomasal worms (Haemonchus placei, 100%, P less than 0.02; Trichostrongylus axei, 99.4%, P less than 0.0001; Ostertagia ostertagi, 90.5%, P less than 0.0002). Treatment was 100% efficacious against adult small and large intestinal worms. However, numbers of Bunostomum phlebotomum, O. radiatum and Trichuris spp. recovered in the control calves were too low to enable a reliable test of drug efficacy. Treatment was not effective against either mucosal or luminal fourth stage larvae of abomasal O. ostertagi.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1991

Anthelmintic activity of paraherquamide in dogs.

Paraherquamide, an oxindole alkaloid metabolite of Penicillium paraherquei and Penicillium charlesii, was tested against the common gastrointestinal nematodes of dogs at a single oral dosage of 0.5, 1.0, or 2.0 mg kg-1. Efficacy was poor (less than 85%) against Ancylostoma caninum, Uncinaria stenocephala, Toxascaris leonina, Trichuris vulpis, and Strongyloides stercoralis at the low- and mid-dosage levels. At the high dosage level, good efficacy (91%) was observed only against S. stercoralis. Adverse reactions were observed in all dogs at every dosage level and included depression, ataxia, and protrusion of the nictitating membrane.

Animals↗
PubMed1992

Experiments on anthelmintic control of Fasciola hepatica in Brazil.

Two separate field trials involving naturally infected cattle were carried out on two farms known to have a history of Fasciola hepatica infection. On the first farm, 15 animals per group were allocated as follows: G1, triclabendazole (TCBZ) four times a year; G2, TCBZ twice a year (May and September); G3, untreated control. All groups grazed together and after 3.5 years the animals were slaughtered and their livers examined by federal meat inspectors who condemned 100% of livers in G3 and 8.3% in G2 owing to the presence of lesions of fasciolosis. In G1 no livers were condemned. Significant differences in weight gains were not detected and fluke counts remained at low levels in the treated groups. Also, in the control group, egg counts started to decrease when animals were 2 years old. On the second farm, groups of 20 animals were treated as follows: G1, TCBZ three times a year (May, September and December); G2, TCBZ twice a year (May and September); G3, nitroxynil twice a year (May and September); G4, rafoxanide twice a year (May and September); G5, untreated controls. All animals were weighed and faecal samples examined at approximately 28-day intervals. During the period of the study, larger weight gains were detected in the TCBZ treated groups than in the others. TCBZ treatment kept F. hepatica egg counts at a lower level for longer periods than the other drugs and significant differences in weight gains were only obtained between the group receiving TCBZ three times a year and the control group.

Animals↗
PubMed1992

Anthelmintic activity of paraherquamide in calves.

Paraherquamide, an oxindole alkaloid metabolite of Penicillium paraherquei and Penicillium charlesii, was tested against the adult stages of nine common gastrointestinal and lung nematodes of calves at single, oral dosages of 0.5, 1.0, 2.0 or 4.0 mg kg-1. At dosages 1.0-4.0 mg kg-1 there was 95% or more removal of Haemonchus placei, Ostertagia ostertagi, Trichostrongylus axei, Trichostrongylus colubriformis, Cooperia oncophora, Nematodirus helvetianus, Oesophagostomum radiatum, and Dictyocaulus viviparus. Cooperia punctata, the dosage-limiting species, was virtually unaffected by any dosage except the highest, which produced an efficacy of 89%. The 0.5 mg kg-1 dosage was 95% or more efficacious against H. placei, O. ostertagi, C. oncophora, and D. viviparus, but weaknesses were evident against the other five species. No adverse reaction was observe in any calf.

Animals↗
PubMed1993

Detection of anthelmintic resistance by culture in vitro of parasitic stages of ovine nematodes.

Exsheathed L3 larvae of Haemonchus contortus were cultured at 38.5 degrees C in a complex medium supporting growth to adult worms. Although there was a clear difference in response between susceptible and benzimidazole/ivermectin/closantel resistant H. contortus using thiabendazole, the test failed to differentiate satisfactorily between the strains using ivermectin or closantel.

Animals↗
PubMed1996

Anthelmintic resistance in India.

Five sheep farms located in different geo-climatic regions were surveyed for resistance in gastrointestinal nematodes to albendazole, levamisole and ivermectin. Resistance to albendazole and levamisole was evident on all the farms. Albendazole reduced faecal egg counts by 0-73% and levamisole by 0-61%. No eggs were detected after treatment with ivermectin.

Albendazole↗